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Author |
Solevi, P.; Magrin, G.; Moro, D.; Mayer, R. |
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Title |
Monte Carlo study of microdosimetric diamond detectors |
Type |
Journal Article |
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Year |
2015 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
60 |
Issue |
18 |
Pages |
7069-7083 |
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Keywords |
ion-beam therapy; microdosimetry; diamonds; GATE |
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Abstract |
Ion-beam therapy provides a high dose conformity and increased radiobiological effectiveness with respect to conventional radiation-therapy. Strict constraints on the maximum uncertainty on the biological weighted dose and consequently on the biological weighting factor require the determination of the radiation quality, defined as the types and energy spectra of the radiation at a specific point. However the experimental determination of radiation quality, in particular for an internal target, is not simple and the features of ion interactions and treatment delivery require dedicated and optimized detectors. Recently chemical vapor deposition (CVD) diamond detectors have been suggested as ion-beam therapy microdosimeters. Diamond detectors can be manufactured with small cross sections and thin shapes, ideal to cope with the high fluence rate. However the sensitive volume of solid state detectors significantly deviates from conventional microdosimeters, with a diameter that can be up to 1000 times the height. This difference requires a redefinition of the concept of sensitive thickness and a deep study of the secondary to primary radiation, of the wall effects and of the impact of the orientation of the detector with respect to the radiation field. The present work intends to study through Monte Carlo simulations the impact of the detector geometry on the determination of radiation quality quantities, in particular on the relative contribution of primary and secondary radiation. The dependence of microdosimetric quantities such as the unrestricted linear energy L and the lineal energy y are investigated for different detector cross sections, by varying the particle type (carbon ions and protons) and its energy. |
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Address |
[Solevi, Paola; Magrin, Giulio; Mayer, Ramona] EBG MedAustron, A-2700 Wiener Neustadt, Austria, Email: paola.solevi@ovgu.de |
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Publisher |
Iop Publishing Ltd |
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Language |
English |
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Edition |
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ISSN  |
0031-9155 |
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Conference |
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Notes |
WOS:000361124000004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2379 |
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Author |
Bernabeu, J.; Martinez-Vidal, F. |
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Title |
Colloquium: Time-reversal violation with quantum-entangled B mesons |
Type |
Journal Article |
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Year |
2015 |
Publication |
Reviews of Modern Physics |
Abbreviated Journal |
Rev. Mod. Phys. |
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Volume |
87 |
Issue |
1 |
Pages |
165-182 |
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Keywords |
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Abstract |
Symmetry transformations have been proven a bedrock tool for understanding the nature of particle interactions, formulating, and testing fundamental theories. Based on the up to now unbroken CPT symmetry, the violation of the CP symmetry between matter and antimatter by weak interactions, discovered in the decay of kaons in 1964 and observed more recently in 2001 in B mesons, strongly suggests that the behavior of these particles under weak interactions must also be asymmetric under time reversal T. However, until recent years there has not been a direct detection of the expected time-reversal violation in the time evolution of any system. This Colloquium examines the field of time-reversal symmetry breaking in the fundamental laws of physics. For transitions, its observation requires an asymmetry with exchange of initial and final states. A discussion is given of the conceptual basis for such an exchange with unstable particles, using the quantum properties of Einstein-Podolsky-Rosen entanglement available at B meson factories combined with the decay as a filtering measurement. The method allows a clear-cut separation of different transitions between flavor and CP eigenstates in the decay of neutral B mesons. These ideas have been implemented for the experiment by the BABAR Collaboration at SLAC's B factory. The results, presented in 2012, prove beyond any doubt the violation of time-reversal invariance in the time evolution between these two states of the neutral B meson. |
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Address |
[Bernabeu, J.; Martinez-Vidal, F.] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: Jose.Bernabeu@uv.es; |
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Publisher |
Amer Physical Soc |
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English |
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ISSN |
0034-6861 |
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Notes |
WOS:000352076500001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
2179 |
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Author |
XENON Collaboration (Aprile, E. et al); Orrigo, S.E.A. |
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Title |
Exclusion of leptophilic dark matter models using XENON100 electronic recoil data |
Type |
Journal Article |
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Year |
2015 |
Publication |
Science |
Abbreviated Journal |
Science |
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Volume |
349 |
Issue |
6250 |
Pages |
851-854 |
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Keywords |
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Abstract |
Laboratory experiments searching for galactic dark matter particles scattering off nuclei have so far not been able to establish a discovery. We use data from the XENON100 experiment to search for dark matter interacting with electrons. With no evidence for a signal above the low background of our experiment, we exclude a variety of representative dark matter models that would induce electronic recoils. For axial-vector couplings to electrons, we exclude cross sections above 6 x 10(-35) cm(2) for particle masses of m(chi) = 2 GeV/c(2). Independent of the dark matter halo, we exclude leptophilic models as an explanation for the long-standing DAMA/LIBRA signal, such as couplings to electrons through axial-vector interactions at a 4.4 sigma confidence level, mirror dark matter at 3.6 sigma, and luminous dark matter at 4.6 sigma. |
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Publisher |
Amer Assoc Advancement Science |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0036-8075 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000359832700045 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2490 |
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Author |
Clausse, A.; Soto, L.; Tarifeño-Saldivia, A. |
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Title |
Influence of the Anode Length on the Neutron Emission of a 50 J Plasma Focus: Modeling and Experiment |
Type |
Journal Article |
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Year |
2015 |
Publication |
IEEE Transactions on Plasma Science |
Abbreviated Journal |
IEEE Trans. Plasma Sci. |
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Volume |
43 |
Issue |
2 |
Pages |
629-636 |
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Keywords |
Anode; fusion neutrons; modeling; plasma focus (PF); plasma pinch |
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Abstract |
A comprehensive set of electric data measured in a small plasma focus (PF) device of 50 J correlated with the corresponding neutron emissions is taken as the base for developing a semiempirical model of the current sheet dynamics and the neutron yield. The model is able to explain the dependence of the neutron yield with the pressure and anode length with good accuracy, and suggests a physical interpretation of the drive parameter commonly used in PF design. |
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Address |
[Clausse, Alejandro] Natl Univ Cent Buenos Aires, Natl Atom Energy Commiss, Natl Sci & Tech Res Council, RA-7000 Tandil, Argentina, Email: clausse@exa.unicen.edu.ar; |
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Publisher |
Ieee-Inst Electrical Electronics Engineers Inc |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0093-3813 |
ISBN |
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Medium |
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Area |
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Conference |
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Notes |
WOS:000352084400021 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2186 |
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Author |
Ballester, F.; Tedgren, A.C.; Granero, D.; Haworth, A.; Mourtada, F.; Fonseca, G.P.; Zourari, K.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; Sloboda, R.S.; Smith, R.L.; Thomson, R.M.; Verhaegen, F.; Vijande, J.; Ma, Y.Z.; Beaulieu, L. |
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Title |
A generic high-dose rate Ir-192 brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism |
Type |
Journal Article |
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Year |
2015 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
42 |
Issue |
6 |
Pages |
3048-3062 |
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Keywords |
Ir-192; HDR brachytherapy; Monte Carlo methods; model-based dose calculation; TG-186 |
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Abstract |
Purpose: In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) Ir-192 source and a virtual water phantom were designed, which can be imported into a TPS. Methods: A hypothetical, generic HDR Ir-192 source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic Ir-192 source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra (R) Brachy with advanced collapsed-cone engine (ACE) and BrachyVision AcuRos (TM)]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and pENELopE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201)(3) voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR Ir-192 source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by different investigators. MC results were then compared against dose calculated using TG-43 and MBDCA methods. Results: TG-43 and PSS datasets were generated for the generic source, the PSS data for use with the ACE algorithm. The dose-rate constant values obtained from seven MC simulations, performed independently using different codes, were in excellent agreement, yielding an average of 1.1109 +/- 0.0004 cGy/(h U) (k = 1, Type A uncertainty). MC calculated dose-rate distributions for the two plans were also found to be in excellent agreement, with differences within type A uncertainties. Differences between commercial MBDCA and MC results were test, position, and calculation parameter dependent. On average, however, these differences were within 1% for ACUROS and 2% for ACE at clinically relevant distances. Conclusions: A hypothetical, generic HDR Ir-192 source was designed and implemented in two commercially available TPSs employing different MBDCAs. Reference dose distributions for this source were benchmarked and used for the evaluation of MBDCA calculations employing a virtual, cubic water phantom in the form of a CT DICOM image series. The implementation of a generic source of identical design in all TPSs using MBDCAs is an important step toward supporting univocal commissioning procedures and direct comparisons between TPSs. |
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Address |
[Ballester, Facundo] Univ Valencia, Dept Atom Mol & Nucl Phys, E-46100 Burjassot, Spain, Email: Facundo.Ballester@uv.es |
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Thesis |
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Publisher |
Amer Assoc Physicists Medicine Amer Inst Physics |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000356998300031 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2315 |
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