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Author |
Peris, J.B.; Davis, P.; Cuevas, J.M.; Nebot, M.; Sanjuan, R. |
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Title  |
Distribution of Fitness Effects Caused by Single-Nucleotide Substitutions in Bacteriophage f1 |
Type |
Journal Article |
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Year |
2010 |
Publication |
Genetics |
Abbreviated Journal |
Genetics |
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Volume |
185 |
Issue |
2 |
Pages |
603-U308 |
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Keywords |
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Abstract |
Empirical knowledge of the fitness effects of mutations is important for understanding many evolutionary processes, yet this knowledge is often hampered by several sources of measurement error and bias. Most of these problems can be solved using site-directed mutagenesis to engineer single mutations, an approach particularly suited for viruses due to their small genomes. Here, we used this technique to measure the fitness effect of 100 single-nucleotide substitutions in the bacteriophage f1, a filamentous single-strand DNA virus. We found that approximately one-fifth of all mutations are lethal. Viable ones reduced fitness by 11% on average and were accurately described by a log-normal distribution. More than 90% of synonymous substitutions were selectively neutral, while those affecting intergenic regions reduced fitness by 14% on average. Mutations leading to amino acid substitutions had an overall mean deleterious effect of 37%, which increased to 45% for those changing the amino acid polarity. Interestingly, mutations affecting early steps of the infection cycle tended to be more deleterious than those affecting late steps. Finally, we observed at least two beneficial mutations. Our results confirm that high mutational sensitivity is a general property of viruses with small genomes, including RNA and single-strand DNA viruses infecting animals, plants, and bacteria. |
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Address |
[Peris, Joan B.; Davis, Paulina; Cuevas, Jose M.; Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
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Genetics Soc Am |
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English |
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ISSN |
0016-6731 |
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Notes |
ISI:000281905200017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
383 |
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Author |
ATLAS Collaboration (Aad, G. et al); Amoros, G.; Cabrera Urban, S.; Campabadal Segura, F.; Castillo Gimenez, V.; Costa, M.J.; Escobar, C.; Fassi, F.; Ferrer, A.; Fuster, J.; Garcia, C.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Perez Garcia-Estañ, M.T.; Ros, E.; Salt, J.; Sanchis-Lozano, M.A.; Solans, C.A.; Sospedra Suay, L.; Sanchez, J.; Torro Pastor, E.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M.; Wildauer, A. |
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Title |
Drift Time Measurement in the ATLAS Liquid Argon Electromagnetic Calorimeter using Cosmic Muons |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
70 |
Issue |
3 |
Pages |
755-785 |
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Abstract |
The ionization signals in the liquid argon of the ATLAS electromagnetic calorimeter are studied in detail using cosmic muons. In particular, the drift time of the ionization electrons is measured and used to assess the intrinsic uniformity of the calorimeter gaps and estimate its impact on the constant term of the energy resolution. The drift times of electrons in the cells of the second layer of the calorimeter are uniform at the level of 1.3% in the barrel and 2.8% in the endcaps. This leads to an estimated contribution to the constant term of (0.29(-0.04)(+0.05))% in the barrel and (0.54(-0.04)(+0.06))% in the endcaps. The same data are used to measure the drift velocity of ionization electrons in liquid argon, which is found to be 4.61 +/- 0.07 mm/mu s at 88.5 K and 1 kV/mm. |
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Address |
[Aad, G.; Ahles, F.; Aktas, A.; Anders, C. F.; Beckingham, M.; Bernhard, R.; Bianchi, R. M.; Bitenc, U.; Bruneliere, R.; Caron, S.; Christov, A.; Dietrich, J.; Dingfelder, D. J.; Duehrssen, M.; Eckert, S.; Hartert, J.; Herten, G.; Horner, S.; Jakobs, K.; Janus, M.; Joos, D.; Kononov, A. I.; Kuehn, S.; Lai, S.; Landgraf, U.; Lohwasser, K.; Ludwig, I.; Ludwig, J.; Lumb, D.; Mahboubi, K.; Mazur, M.; Meirose, B.; Messmer, I.; Mohr, W.; Nilsen, H.; Parzefall, U.; Pfeifer, B.; Piacquadio, G.; Bueso, X. Portell; Schumacher, M.; Stoerig, K.; Sundermann, J. E.; Thoma, S.; Tobias, J.; Venturi, M.; Vivarelli, I.; von Radziewski, H.; Warsinsky, M.; Webel, M.; Weiser, C.; Werner, M.; Wiik, L. A. M.; Xie, S.; Zimmermann, S.] Univ Freiburg, Fak Math & Phys, D-79104 Freiburg, Germany, Email: atlas.secretariat@cern.ch |
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Springer |
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English |
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ISSN |
1434-6044 |
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Notes |
ISI:000285200000012 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
305 |
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Author |
Sarkar, S.; Sun, B.X.; Oset, E.; Vicente Vacas, M.J. |
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Title |
Dynamically generated resonances from the vector octet-baryon decuplet interaction |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
44 |
Issue |
3 |
Pages |
431-443 |
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Keywords |
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Abstract |
We study the interaction of the octet of vector mesons with the decuplet of baryons using Lagrangians of the hidden gauge theory for vector interactions. The unitary amplitudes in coupled channels develop poles that can be associated with some known baryonic resonances, while there are predictions for new ones at the energy frontier of the experimental research. The work offers guidelines on how to search for these resonances. |
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Address |
[Sarkar, Sourav; Sun, Bao-Xi; Oset, E.; Vicente Vacas, M. J.] Univ Valencia, Ctr Mixto, CSIC, Inst Invest Paterna,Dept Fis Teor, Valencia 46071, Spain, Email: sourav@veccal.ernet.in |
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Springer |
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English |
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ISSN |
1434-6001 |
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Notes |
ISI:000278159300010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
446 |
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Author |
Oset, E.; Ramos, A. |
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Title |
Dynamically generated resonances from the vector octet-baryon octet interaction |
Type |
Journal Article |
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Year |
2010 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
44 |
Issue |
3 |
Pages |
445-454 |
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Keywords |
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Abstract |
We study the interaction of vector mesons with the octet of stable baryons in the framework of the local hidden gauge formalism using a coupled-channels unitary approach. We examine the scattering amplitudes and their poles, which can be associated to known J(P) = 1/2(-), 3/2(-) baryon resonances, in some cases, or give predictions in other ones. The formalism employed produces doublets of degenerate J(P) = 1/2(-), 3/2(-) states, a pattern which is observed experimentally in several cases. The findings of this work should also be useful to guide present experimental programs searching for new resonances, in particular in the strange sector where the current information is very poor. |
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Address |
[Oset, E.] Univ Valencia, Ctr Mixto, CSIC, Inst Invest Paterna,Dept Fis Teor, Valencia 46071, Spain, Email: ramos@ecm.ub.es |
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Springer |
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English |
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ISSN |
1434-6001 |
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Notes |
ISI:000278159300011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
447 |
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Author |
Borja, E.F.; Diaz-Polo, J.; Garay, I.; Livine, E.R. |
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Title |
Dynamics for a 2-vertex quantum gravity model |
Type |
Journal Article |
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Year |
2010 |
Publication |
Classical and Quantum Gravity |
Abbreviated Journal |
Class. Quantum Gravity |
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Volume |
27 |
Issue |
23 |
Pages |
235010 - 34pp |
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Abstract |
We use the recently introduced U(N) framework for loop quantum gravity to study the dynamics of spin network states on the simplest class of graphs: two vertices linked with an arbitrary number N of edges. Such graphs represent two regions, in and out, separated by a boundary surface. We study the algebraic structure of the Hilbert space of spin networks from the U(N) perspective. In particular, we describe the algebra of operators acting on that space and discuss their relation to the standard holonomy operator of loop quantum gravity. Furthermore, we show that it is possible to make the restriction to the isotropic/homogeneous sector of the model by imposing the invariance under a global U(N) symmetry. We then propose a U(N)-invariant Hamiltonian operator and study the induced dynamics. Finally, we explore the analogies between this model and loop quantum cosmology and sketch some possible generalizations of it. |
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Address |
[Borja, Enrique F.; Garay, Inaki] Univ Erlangen Nurnberg, Inst Theoret Phys 3, D-91058 Erlangen, Germany, Email: etera.livine@ens-lyon.fr |
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Publisher |
Iop Publishing Ltd |
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English |
Summary Language |
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Edition |
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ISSN |
0264-9381 |
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Notes |
ISI:000284211600011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
341 |
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