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Author |
Carrasco-Ribelles, L.A.; Pardo-Mas, J.R.; Tortajada, S.; Saez, C.; Valdivieso, B.; Garcia-Gomez, J.M. |
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Title |
Predicting morbidity by local similarities in multi-scale patient trajectories |
Type |
Journal Article |
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Year |
2021 |
Publication |
Journal of Biomedical Informatics |
Abbreviated Journal |
J. Biomed. Inform. |
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Volume |
120 |
Issue |
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Pages |
103837 - 9pp |
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Keywords |
Patient trajectory; Risk prediction; Local alignment; Dynamic programming; Diabetes; Cardiovascular disease |
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Abstract |
Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening. |
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Address |
[Carrasco-Ribelles, Lucia A.; Pardo-Mas, Jose Ramon; Saez, Carlos; Garcia-Gomez, Juan M.] Univ Politecn Valencia, Biomed Data Sci Lab BDSLAB, Inst Tecnol Informat & Comunicac ITACA, Camino Vera S-N, Valencia 46022, Spain, Email: lucarri@etsii.upv.es; |
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Publisher |
Academic Press Inc Elsevier Science |
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English |
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ISSN |
1532-0464 |
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Notes |
WOS:000683527500003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4934 |
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Permanent link to this record |
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Author |
Fanchiotti, H.; Garcia Canal, C.A.; Mayosky, M.; Veiga, A.; Vento, V. |
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Title |
Measuring the Hannay geometric phase |
Type |
Journal Article |
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Year |
2022 |
Publication |
American Journal of Physics |
Abbreviated Journal |
Am. J. Phys. |
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Volume |
90 |
Issue |
6 |
Pages |
430-435 |
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Keywords |
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Abstract |
The Hannay geometric phase is the classical analog of the well-known Berry phase. Its most familiar example is the effect of the latitude lambda on the motion of a Foucault pendulum. We describe an electronic network whose behavior is exactly equivalent to that of the pendulum. The circuit can be constructed from off-the-shelf components using two matched transconductance amplifiers that comprise a gyrator to introduce the non-reciprocal behavior needed to mimic the pendulum. One may precisely measure the dependence of the Hannay phase on lambda by circuit simulation and by laboratory measurements on a constructed circuit. |
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Address |
[Fanchiotti, H.; Canal, C. A. Garcia] Univ Nacl La Plata, IFLP, CONICET, CC67, RA-1900 La Plata, Argentina |
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Publisher |
AIP Publishing |
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English |
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ISSN |
0002-9505 |
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Notes |
WOS:000804547100009 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5276 |
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Author |
Bernabeu, J.; Sabulsky, D.O.; Sanchez, F.; Segarra, A. |
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Title |
Neutrino mass and nature through its mediation in atomic clock interference |
Type |
Journal Article |
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Year |
2024 |
Publication |
AVS Quantum Science |
Abbreviated Journal |
AVS Quantum Sci. |
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Volume |
6 |
Issue |
1 |
Pages |
014410 - 8pp |
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Abstract |
The absolute mass of neutrinos and their nature are presently unknown. Aggregate matter has a coherent weak charge leading to a repulsive interaction mediated by a neutrino pair. The virtual neutrinos are non-relativistic at micron distances, giving a distinct behavior for Dirac versus Majorana mass terms. This effective potential allows for the disentanglement of the Dirac or Majorana nature of the neutrino via magnitude and distance dependence. We propose an experiment to search for this potential based on the concept that the density-dependent interaction of an atomic probe with a material source in one arm of an atomic clock interferometer generates a differential phase. The appropriate geometry of the device is selected using the saturation of the weak potential as a guide. The proposed experiment has the added benefit of being sensitive to gravity at micron distances. A strategy to suppress the competing Casimir-Polder interaction, depending on the electronic structure of the material source, as well as a way to compensate the gravitational interaction in the two arms of the interferometer is discussed. |
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Address |
[Bernabeu, Jose; Segarra, Alejandro] Univ Valencia, Dept Theoret Phys, E-46100 Valencia, Spain, Email: jose.bernabeu@uv.es |
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AIP Publishing |
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English |
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Conference |
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Notes |
WOS:001186930100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6118 |
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Permanent link to this record |
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Author |
Aguiar, P.; Rafecas, M.; Ortuño, J.E.; Kontaxakis, G.; Santos, A.; Pavia, J.; Rosetti, M. |
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Title |
Geometrical and Monte Carlo projectors in 3D PET reconstruction |
Type |
Journal Article |
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Year |
2010 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
37 |
Issue |
11 |
Pages |
5691-5702 |
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Keywords |
3D PET; iterative reconstruction; list-mode reconstruction; ray-tracing techniques; Monte Carlo simulation; system response matrix |
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Abstract |
Purpose: In the present work, the authors compare geometrical and Monte Carlo projectors in detail. The geometrical projectors considered were the conventional geometrical Siddon ray-tracer (S-RT) and the orthogonal distance-based ray-tracer (OD-RT), based on computing the orthogonal distance from the center of image voxel to the line-of-response. A comparison of these geometrical projectors was performed using different point spread function (PSF) models. The Monte Carlo-based method under consideration involves an extensive model of the system response matrix based on Monte Carlo simulations and is computed off-line and stored on disk. Methods: Comparisons were performed using simulated and experimental data of the commercial small animal PET scanner rPET. Results: The results demonstrate that the orthogonal distance-based ray-tracer and Siddon ray-tracer using PSF image-space convolutions yield better images in terms of contrast and spatial resolution than those obtained after using the conventional method and the multiray-based S-RT. Furthermore, the Monte Carlo-based method yields slight improvements in terms of contrast and spatial resolution with respect to these geometrical projectors. Conclusions: The orthogonal distance-based ray-tracer and Siddon ray-tracer using PSF image-space convolutions represent satisfactory alternatives to factorizing the system matrix or to the conventional on-the-fly ray-tracing methods for list-mode reconstruction, where an extensive modeling based on Monte Carlo simulations is unfeasible. |
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Address |
[Aguiar, Pablo] Univ Santiago de Compostela, Dept Fis Particulas, Complexo Hosp Univ Santiago de Compostela, Fdn IDICHUS IDIS, Santiago De Compostela, Spain, Email: pablo.aguiar.fernandez@sergas.es |
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Corporate Author |
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Thesis |
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Publisher |
Amer Assoc Physicists Medicine Amer Inst Physics |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
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Notes |
ISI:000283747600015 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
338 |
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Permanent link to this record |
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Author |
Cases, R.; Ros, E.; Zuñiga, J. |
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Title |
Measuring radon concentration in air using a diffusion cloud chamber |
Type |
Journal Article |
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Year |
2011 |
Publication |
American Journal of Physics |
Abbreviated Journal |
Am. J. Phys. |
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Volume |
79 |
Issue |
9 |
Pages |
903-908 |
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Keywords |
cloud chambers; diffusion; radiation effects; radon; student experiments |
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Abstract |
Radon concentration in air is a major concern in lung cancer studies. A traditional technique used to measure radon abundance is the charcoal canister method. We propose a novel technique using a diffusion cloud chamber. This technique is simpler and can easily be used for physics demonstrations for high school and university students. |
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Address |
[Cases, R; Ros, E; Zuniga, J] Univ Valencia, CSIC, IFIC, Valencia 22085, Spain, Email: ramon.cases@uv.es |
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Publisher |
Amer Assoc Physics Teachers Amer Inst Physics |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0002-9505 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000294064300003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
724 |
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Permanent link to this record |