Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.

Abstract: Dark matter energy injection in the early universe modifies both the ionization history and the temperature of the intergalactic medium. In this work, we improve the CMB bounds on sub-keV dark matter and extend previous bounds from Lyman-& alpha; observations to the same mass range, resulting in new and competitive constraints on axion-like particles (ALPs) decaying into two photons. The limits depend on the underlying reionization history, here accounted self-consistently by our modified version of the publicly available DarkHistory and CLASS codes. Future measurements such as the ones from the CMB-S4 experiment may play a crucial, leading role in the search for this type of light dark matter candidates.

Abstract: The linear seesaw mechanism provides a simple way to generate neutrino masses. In addition to Standard Model particles, it includes quasi-Dirac leptons as neutrino mass mediators, and a leptophilic scalar doublet seeding small neutrino masses. Here we review its associated physics, including restrictions from theory and phenomenology. The model yields potentially detectable μ-> e gamma rates as well as distinctive signatures in the production and decay of heavy neutrinos ( N-i) and the charged Higgs boson (H-+/-) arising from the second scalar doublet. We have found that production processes such as e(+) e(-) -> NN, e- gamma -> NH- and e(+) e(-) -> H (+) H- followed by the decay chain H-+/--> l(+/-) (i) N, N -> l`(+/-) (j) W (-/+) leads to striking lepton number violation signatures at high energies which may probe the Majorana nature of neutrinos.

Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.

Abstract: This article presents a search for new resonances decaying into a Z or W boson and a 125 GeV Higgs boson h, and it targets the v (v) over barb (b) over bar, l(+)l(-) b (b) over bar, or l(+/-) vb (b) over bar final states, where l – e or mu, in proton-proton collisions at root s – 13 TeV. The data used correspond to a total integrated luminosity of 139 fb(-1) collected by the ATLAS detector during Run 2 of the LHC at CERN. The search is conducted by examining the reconstructed invariant or transverse mass distributions of Zh or Wh candidates for evidence of a localised excess in the mass range from 220 GeV to 5TeV. No significant excess is observed and 95% confidence-level upper limits between 1.3 pb and 0.3 fb are placed on the production cross section times branching fraction of neutral and charged spin-1 resonances and CP-odd scalar bosons. These limits are converted into constraints on the parameter space of the Heavy Vector Triplet model and the two-Higgs-doublet model.