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Borja-Lloret, M., Barrientos, L., Bernabeu, J., Lacasta, C., Muñoz, E., Ros, A., et al. (2023). Influence of the background in Compton camera images for proton therapy treatment monitoring. Phys. Med. Biol., 68(14), 144001–16pp.
Abstract: Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods.
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Oliver, S., Vijande, J., Tejedor-Aguilar, N., Miro, R., Rovira-Escutia, J. J., Ballester, F., et al. (2023). Monte Carlo flattening filter design to high energy intraoperative electron beam homogenization. Radiat. Phys. Chem., 212, 111102–6pp.
Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.
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Beaulieu, L., Ballester, F., Granero, D., Tedgren, A. C., Haworth, A., Lowenstein, J. R., et al. (2023). AAPM WGDCAB Report 372: A joint AAPM, ESTRO, ABG, and ABS report on commissioning of model-based dose calculation algorithms in brachytherapy. Med. Phys., 50(8), e946–e960.
Abstract: The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged.
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Capozzi, F., Ferreira, R. Z., Lopez-Honorez, L., & Mena, O. (2023). CMB and Lyman-alpha constraints on dark matter decays to photons. J. Cosmol. Astropart. Phys., 06(6), 060–23pp.
Abstract: Dark matter energy injection in the early universe modifies both the ionization history and the temperature of the intergalactic medium. In this work, we improve the CMB bounds on sub-keV dark matter and extend previous bounds from Lyman-& alpha; observations to the same mass range, resulting in new and competitive constraints on axion-like particles (ALPs) decaying into two photons. The limits depend on the underlying reionization history, here accounted self-consistently by our modified version of the publicly available DarkHistory and CLASS codes. Future measurements such as the ones from the CMB-S4 experiment may play a crucial, leading role in the search for this type of light dark matter candidates.
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Belchior, F. M., Moreira, A. R. P., Maluf, R. V., & Almeida, C. A. S. (2023). 5D Elko spinor field non-minimally coupled to nonmetricity in f (Q) gravity. Phys. Lett. B, 843, 138029–8pp.
Abstract: This paper aims to investigate the localization of the five-dimensional spinor field known as Elko (dual-helicity eigenspinors of the charge conjugation operator) by employing a Yukawa-like geometrical coupling in which the Elko field is non-minimally coupled to nonmetricity scalar Q. We adopt the braneworld scenarios in which the first-order formalism with sine-Gordon and linear superpotentials is employed to obtain the warp factors. A linear function supports the zero-mode trapping within the geometric coupling, leading to the same effective potential as the scalar field. Moreover, an exotic term must be added to obtain real-valued massive modes. Such modes are investigated through the Schrodinger-like approach.
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Batra, A., Bharadwaj, P., Mandal, S., Srivastava, R., & Valle, J. W. F. (2023). Phenomenology of the simplest linear seesaw mechanism. J. High Energy Phys., 07(7), 221–48pp.
Abstract: The linear seesaw mechanism provides a simple way to generate neutrino masses. In addition to Standard Model particles, it includes quasi-Dirac leptons as neutrino mass mediators, and a leptophilic scalar doublet seeding small neutrino masses. Here we review its associated physics, including restrictions from theory and phenomenology. The model yields potentially detectable μ-> e gamma rates as well as distinctive signatures in the production and decay of heavy neutrinos ( N-i) and the charged Higgs boson (H-+/-) arising from the second scalar doublet. We have found that production processes such as e(+) e(-) -> NN, e- gamma -> NH- and e(+) e(-) -> H (+) H- followed by the decay chain H-+/--> l(+/-) (i) N, N -> l`(+/-) (j) W (-/+) leads to striking lepton number violation signatures at high energies which may probe the Majorana nature of neutrinos.
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Araujo Filho, A. A. (2023). Thermodynamics of massless particles in curved spacetime. Int. J. Geom. Methods Mod. Phys., 12(13), 2350226–40pp.
Abstract: This work is devoted to study the behavior of massless particles within the context of curved spacetime. In essence, we investigate the consequences of the scale factor C(?) of the Friedmann-Robertson-Walker metric in the Einstein-aether formalism to study photon-like particles. To do so, we consider the system within the canonical ensemble formalism in order to derive the following thermodynamic state quantities: spectral radiance, Helmholtz free energy, pressure, entropy, mean energy and the heat capacity. Moreover, the correction to the Stefan-Boltzmann law and the equation of states are also provided. Particularly, we separate our study within three distinct cases, i.e. s = 0, p = 0; s = 1, p = 1; s = 2, p = 1. In the first one, the results are derived numerically. Nevertheless, for the rest of the cases, all the calculations are accomplished analytically showing explicitly the dependence of the scale factor C(?) and the Riemann zeta function ?(s). Furthermore, our analyses are accomplished in general taking into account three different regimes of temperature of the universe, i.e. the inflationary era (T = 10(13)GeV), the electroweak epoch (T = 10(3)GeV) and the cosmic microwave background (T = 10(-13)GeV).
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Brzezinski, K. et al. (2023). Detection of range shifts in proton beam therapy using the J-PET scanner: a patient simulation study. Phys. Med. Biol., 68(14), 145016–17pp.
Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.
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Bombacigno, F., Moretti, F., Boudet, S., & Olmo, G. J. (2023). Landau damping for gravitational waves in parity-violating theories. J. Cosmol. Astropart. Phys., 02(2), 009–29pp.
Abstract: We discuss how tensor polarizations of gravitational waves can suffer Landau damping in the presence of velocity birefringence, when parity symmetry is explicitly broken. In particular, we analyze the role of the Nieh-Yan and Chern-Simons terms in modified theories of gravity, showing how the gravitational perturbation in collisionless media can be characterized by a subluminal phase velocity, circumventing the well-known results of General Relativity and allowing for the appearance of the kinematic damping. We investigate in detail the connection between the thermodynamic properties of the medium, such as temperature and mass of the particles interacting with the gravitational wave, and the parameters ruling the parity violating terms of the models. In this respect, we outline how the dispersion relations can give rise in each model to different regions of the wavenumber space, where the phase velocity is subluminal, superluminal or does not exist. Quantitative estimates on the considered models indicate that the phenomenon of Landau damping is not detectable given the sensitivity of present-day instruments.
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ATLAS Collaboration(Aad, G. et al), Amos, K. R., Aparisi Pozo, J. A., Bailey, A. J., Cabrera Urban, S., Cantero, J., et al. (2023). Search for heavy resonances decaying into a Z or W boson and a Higgs boson in final states with leptons and b-jets in 139 fb(-1) of pp collisions at root s=13 TeV with the ATLAS detector. J. High Energy Phys., 06(6), 016–68pp.
Abstract: This article presents a search for new resonances decaying into a Z or W boson and a 125 GeV Higgs boson h, and it targets the v (v) over barb (b) over bar, l(+)l(-) b (b) over bar, or l(+/-) vb (b) over bar final states, where l – e or mu, in proton-proton collisions at root s – 13 TeV. The data used correspond to a total integrated luminosity of 139 fb(-1) collected by the ATLAS detector during Run 2 of the LHC at CERN. The search is conducted by examining the reconstructed invariant or transverse mass distributions of Zh or Wh candidates for evidence of a localised excess in the mass range from 220 GeV to 5TeV. No significant excess is observed and 95% confidence-level upper limits between 1.3 pb and 0.3 fb are placed on the production cross section times branching fraction of neutral and charged spin-1 resonances and CP-odd scalar bosons. These limits are converted into constraints on the parameter space of the Heavy Vector Triplet model and the two-Higgs-doublet model.
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