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Author |
Candela-Juan, C.; Niatsetski, Y.; van der Laarse, R.; Granero, D.; Ballester, F.; Perez-Calatayud, J.; Vijande, J. |
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Title |
Design and characterization of a new high-dose-rate brachytherapy Valencia applicator for larger skin lesions |
Type |
Journal Article |
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Year |
2016 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
43 |
Issue |
4 |
Pages |
1639-1648 |
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Keywords |
skin applicator; Valencia applicator; HDR brachytherapy; dosimetry; Monte Carlo |
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Abstract |
Purpose: The aims of this study were (i) to design a new high-dose-rate (HDR) brachytherapy applicator for treating surface lesions with planning target volumes larger than 3 cm in diameter and up to 5 cm in size, using the microSelectron-HDR or Flexitron afterloader (Elekta Brachytherapy) with a Ir-192 source; (ii) to calculate by means of the Monte Carlo (MC) method the dose distribution for the new applicator when it is placed against a water phantom; and (iii) to validate experimentally the dose distributions in water. Methods: The PENELOPE2008 MC code was used to optimize dwell positions and dwell times. Next, the dose distribution in a water phantom and the leakage dose distribution around the applicator were calculated. Finally, MC data were validated experimentally for a 192Ir mHDR-v2 source by measuring (i) dose distributions with radiochromic EBT3 films (ISP); (ii) percentage depth-dose (PDD) curve with the parallel-plate ionization chamber Advanced Markus (PTW); and (iii) absolute dose rate with EBT3 films and the PinPoint T31016 (PTW) ionization chamber. Results: The new applicator is made of tungsten alloy (Densimet) and consists of a set of interchangeable collimators. Three catheters are used to allocate the source at prefixed dwell positions with preset weights to produce a homogenous dose distribution at the typical prescription depth of 3 mm in water. The same plan is used for all available collimators. PDD, absolute dose rate per unit of air kerma strength, and off-axis profiles in a cylindrical water phantom are reported. These data can be used for treatment planning. Leakage around the applicator was also scored. The dose distributions, PDD, and absolute dose rate calculated agree within experimental uncertainties with the doses measured: differences of MC data with chamber measurements are up to 0.8% and with radiochromic films are up to 3.5%. Conclusions: The new applicator and the dosimetric data provided here will be a valuable tool in clinical practice, making treatment of large skin lesions simpler, faster, and safer. Also the dose to surrounding healthy tissues is minimal. |
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Address |
[Candela-Juan, C.; Perez-Calatayud, J.] La Fe Univ & Polytech Hosp, Dept Radiat Oncol, Valencia 46026, Spain, Email: ccanjuan@gmail.com |
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Publisher |
Amer Assoc Physicists Medicine Amer Inst Physics |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000373711000007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2620 |
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Permanent link to this record |
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Author |
Gimenez-Alventosa, V.; Ballester, F.; Vijande, J. |
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Title |
VoxelMages: a general-purpose graphical interface for designing geometries and processing DICOM images for PENELOPE |
Type |
Journal Article |
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Year |
2016 |
Publication |
Applied Radiation And Isotopes |
Abbreviated Journal |
Appl. Radiat. Isot. |
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Volume |
118 |
Issue |
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Pages |
251-257 |
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Keywords |
87.53.Bn; 87.53.Jw; 87.55.Qr; 87.55.km; 87.55.K |
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Abstract |
The design and construction of geometries for Monte Carlo calculations is an error-prone, time-consuming, and complex step in simulations describing particle interactions and transport in the field of medical physics. The software VoxelMages has been developed to help the user in this task. It allows to design complex geometries and to process DICOM image files for simulations with the general-purpose Monte Carlo code PENELOPE in an easy and straightforward way. VoxelMages also allows to import DICOM-RT structure contour information as delivered by a treatment planning system. Its main characteristics, usage and performance benchmarking are described in detail. |
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Address |
[Gimenez-Alventosa, V.; Ballester, F.; Vijande, J.] Univ Valencia, Dept Fis Atom Mol & Nucl, E-46100 Valencia, Spain |
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Publisher |
Pergamon-Elsevier Science Ltd |
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English |
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Edition |
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ISSN |
0969-8043 |
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Expedition |
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Conference |
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Notes |
WOS:000390736100039 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
2904 |
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Permanent link to this record |
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Author |
Granero, D.; Candela-Juan, C.; Vijande, J.; Ballester, F.; Perez-Calatayud, J.; Jacob, D.; Mourtada, F. |
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Title |
Technical Note: Dosimetry of Leipzig and Valencia applicators without the plastic cap |
Type |
Journal Article |
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Year |
2016 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
43 |
Issue |
5 |
Pages |
2087 - 4pp |
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Keywords |
Leipzig applicators; Valencia applicators; skin brachytherapy; Monte Carlo; dosimetry |
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Abstract |
Purpose: High dose rate (HDR) brachytherapy for treatment of small skin lesions using the Leipzig and Valencia applicators is a widely used technique. These applicators are equipped with an attachable plastic cap to be placed during fraction delivery to ensure electronic equilibrium and to prevent secondary electrons from reaching the skin surface. The purpose of this study is to report on the dosimetric impact of the cap being absent during HDR fraction delivery, which has not been explored previously in the literature. Methods: GEANT4 Monte Carlo simulations (version 10.0) have been performed for the Leipzig and Valencia applicators with and without the plastic cap. In order to validate the Monte Carlo simulations, experimental measurements using radiochromic films have been done. Results: Dose absorbed within 1 mm of the skin surface increases by a factor of 1500% for the Leipzig applicators and of 180% for the Valencia applicators. Deeper than 1 mm, the overdosage flattens up to a 10% increase. Conclusions: Differences of treating with or without the plastic cap are significant. Users must check always that the plastic cap is in place before any treatment in order to avoid overdosage of the skin. Prior to skin HDR fraction delivery, the timeout checklist should include verification of the cap placement. (C) 2016 American Association of Physicists in Medicine. |
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Address |
[Granero, D.] Hosp Gen Univ, Dept Radiat Phys, ERESA, Valencia 46014, Spain, Email: dgranero@eresa.com |
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Corporate Author |
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Thesis |
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Publisher |
Amer Assoc Physicists Medicine Amer Inst Physics |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000378924200010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2753 |
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Permanent link to this record |
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Author |
Vijande, J.; Valcarce, A.; Richard, J.M.; Sorba, P. |
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Title |
Search for doubly-heavy dibaryons in a quark model |
Type |
Journal Article |
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Year |
2016 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
94 |
Issue |
3 |
Pages |
034038 - 6pp |
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Keywords |
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Abstract |
We study the stability of hexaquark systems containing two heavy quarks and four light quarks within a simple quark model. No bound or metastable state is found. The reason stems from a delicate interplay between chromoelectric and chromomagnetic effects. Our calculation also provides information about anticharmed pentaquarks that are seemingly unbound in simple quark models. |
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Address |
[Vijande, J.] UV, Dept Fis Atom Mol & Nucl, E-46100 Valencia, Spain, Email: javier.vijande@uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000381893500004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2778 |
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Permanent link to this record |
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Author |
Carames, T.F.; Fontoura, C.E.; Krein, G.; Tsushima, K.; Vijande, J.; Valcarce, A. |
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Title |
Hadronic molecules with a (D)over-bar meson in a medium |
Type |
Journal Article |
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Year |
2016 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
94 |
Issue |
3 |
Pages |
034009 - 10pp |
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Keywords |
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Abstract |
We study the effect of a hot and dense medium on the binding energy of hadronic molecules with open-charm mesons. We focus on a recent chiral quark-model-based prediction of a molecular state in the N (D) over bar system. We analyze how the two-body thresholds and the hadron-hadron interactions are modified when quark and meson masses and quark-meson couplings change in a function of the temperature and baryon density according to predictions of the Nambu-Jona-Lasinio model. We find that in some cases the molecular binding is enhanced in medium as compared to their free-space binding. We discuss the consequences of our findings for the search for exotic hadrons in high-energy heavy-ion collisions as well as in the forthcoming facilities FAIR or J-PARC. |
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Address |
[Carames, T. F.; Valcarce, A.] Univ Salamanca, Dept Fis Fundamental, E-37008 Salamanca, Spain, Email: carames@usal.es; |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000380961500002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2780 |
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Permanent link to this record |