Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.

Abstract: To reconcile the current tensions between high and low redshift observations, we perform the first constraints on the Finslerian cosmological models including the effective dark matter and dark energy components. We find that all the four Finslerian models could alleviate effectively the Hubble constant (H-0) tension and the amplitude of the root-mean-square density fluctu-ations (s(8)) tension between the Planck measurements and the local Universe observations at the 68% confidence level. The addition of a massless sterile neutrino and a varying total mass of active neutrinos to the base Finslerian two-parameter model, respectively, reduces the H-0 tension from 3.4s to 1.9s and alleviates the s8 tension better than the other three Finslerian models. Computing the Bayesian evidence, with respect to ACDM model, our analysis shows a weak preference for the base Finslerian model and moderate preferences for its three one-parameter extensions. Based on the model-independent Gaussian Processes, we propose a new linear relation which can describe the current redshift space distortions data very well. Using the most stringent constraints we can provide, we have also obtained the limits of typical model parameters for three one-parameter extensional models.

Abstract: The Belle II experiment at the SuperKEKB electron-positron collider aims to collect an unprecedented data set of 50 ab-1 to study CP-violation in the B-meson system and to search for Physics beyond the Standard Model. SuperKEKB is already the world's highest-luminosity collider. In order to collect the planned data set within approximately one decade, the target is to reach a peak luminosity of 6 x 1035 cm-2 s-1by further increasing the beam currents and reducing the beam size at the interaction point by squeezing the betatron function down to betay* = 0.3 mm. To ensure detector longevity and maintain good reconstruction performance, beam backgrounds must remain well controlled. We report on current background rates in Belle II and compare these against simulation. We find that a number of recent refinements have significantly improved the background simulation accuracy. Finally, we estimate the safety margins going forward. We predict that backgrounds should remain high but acceptable until a luminosity of at least 2.8 x 1035 cm-2 s-1is reached for betay* = 0.6 mm. At this point, the most vulnerable Belle II detectors, the Time-of-Propagation (TOP) particle identification system and the Central Drift Chamber (CDC), have predicted background hit rates from single-beam and luminosity backgrounds that add up to approximately half of the maximum acceptable rates.

Abstract: We discuss how tensor polarizations of gravitational waves can suffer Landau damping in the presence of velocity birefringence, when parity symmetry is explicitly broken. In particular, we analyze the role of the Nieh-Yan and Chern-Simons terms in modified theories of gravity, showing how the gravitational perturbation in collisionless media can be characterized by a subluminal phase velocity, circumventing the well-known results of General Relativity and allowing for the appearance of the kinematic damping. We investigate in detail the connection between the thermodynamic properties of the medium, such as temperature and mass of the particles interacting with the gravitational wave, and the parameters ruling the parity violating terms of the models. In this respect, we outline how the dispersion relations can give rise in each model to different regions of the wavenumber space, where the phase velocity is subluminal, superluminal or does not exist. Quantitative estimates on the considered models indicate that the phenomenon of Landau damping is not detectable given the sensitivity of present-day instruments.

Abstract: Many extensions of the Standard Model predict the production of dark matter particles at the LHC. Sufficiently light dark matter particles may be produced in decays of the Higgs boson that would appear invisible to the detector. This Letter presents a statistical combination of searches for H & RARR; invisible decays where multiple production modes of the Standard Model Higgs boson are considered. These searches are performed with the ATLAS detector using 139 fb-1 of proton-proton collisions at a centre-of-mass energy of & RADIC;s = 13 TeV at the LHC. In combination with the results at & RADIC;s = 7 TeV and 8 TeV, an upper limit on the H & RARR; invisible branching ratio of 0.107 (0.077) at the 95% confidence level is observed (expected). These results are also interpreted in the context of models where the 125 GeV Higgs boson acts as a portal to dark matter, and limits are set on the scattering cross-section of weakly interacting massive particles and nucleons.