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Author |
Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Muñoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G. |
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Title |
Influence of the background in Compton camera images for proton therapy treatment monitoring |
Type |
Journal Article |
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Year  |
2023 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
68 |
Issue |
14 |
Pages |
144001 - 16pp |
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Keywords |
Compton imaging; Compton camera; proton therapy; treatment monitoring; Monte Carlo simulation; image reconstruction; background |
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Abstract |
Objective. Background events are one of the most relevant contributions to image degradation in Compton camera imaging for hadron therapy treatment monitoring. A study of the background and its contribution to image degradation is important to define future strategies to reduce the background in the system. Approach. In this simulation study, the percentage of different kinds of events and their contribution to the reconstructed image in a two-layer Compton camera have been evaluated. To this end, GATE v8.2 simulations of a proton beam impinging on a PMMA phantom have been carried out, for different proton beam energies and at different beam intensities. Main results. For a simulated Compton camera made of Lanthanum (III) Bromide monolithic crystals, coincidences caused by neutrons arriving from the phantom are the most common type of background produced by secondary radiations in the Compton camera, causing between 13% and 33% of the detected coincidences, depending on the beam energy. Results also show that random coincidences are a significant cause of image degradation at high beam intensities, and their influence in the reconstructed images is studied for values of the time coincidence windows from 500 ps to 100 ns. Significance. Results indicate the timing capabilities required to retrieve the fall-off position with good precision. Still, the noise observed in the image when no randoms are considered make us consider further background rejection methods. |
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Address |
[Borja-Lloret, M.; Barrientos, L.; Bernabeu, J.; Lacasta, C.; Munoz, E.; Ros, A.; Roser, J.; Viegas, R.; Llosa, G.] Inst Fis Corpuscular IFIC, CSIC UV, Valencia, Spain, Email: Marina.Borja@csic.es |
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Publisher |
IOP Publishing Ltd |
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English |
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Edition |
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ISSN |
0031-9155 |
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Expedition |
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Conference |
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Notes |
WOS:001022671300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5571 |
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Author |
Caron, S.; Eckner, C.; Hendriks, L.; Johannesson, G.; Ruiz de Austri, R.; Zaharijas, G. |
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Title |
Mind the gap: the discrepancy between simulation and reality drives interpretations of the Galactic Center Excess |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
06 |
Issue |
6 |
Pages |
013 - 56pp |
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Keywords |
dark matter simulations; gamma ray experiments; Machine learning; millisecond pulsars |
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Abstract |
The Galactic Center Excess (GCE) in GeV gamma rays has been debated for over a decade, with the possibility that it might be due to dark matter annihilation or undetected point sources such as millisecond pulsars (MSPs). This study investigates how the gamma-ray emission model (-yEM) used in Galactic center analyses affects the interpretation of the GCE's nature. To address this issue, we construct an ultra-fast and powerful inference pipeline based on convolutional Deep Ensemble Networks. We explore the two main competing hypotheses for the GCE using a set of-yEMs with increasing parametric freedom. We calculate the fractional contribution (fsrc) of a dim population of MSPs to the total luminosity of the GCE and analyze its dependence on the complexity of the ryEM. For the simplest ryEM, we obtain fsrc = 0.10 f 0.07, while the most complex model yields fsrc = 0.79 f 0.24. In conclusion, we find that the statement about the nature of the GCE (dark matter or not) strongly depends on the assumed ryEM. The quoted results for fsrc do not account for the additional uncertainty arising from the fact that the observed gamma-ray sky is out-of-distribution concerning the investigated ryEM iterations. We quantify the reality gap between our ryEMs using deep-learning-based One-Class Deep Support Vector Data Description networks, revealing that all employed ryEMs have gaps to reality. Our study casts doubt on the validity of previous conclusions regarding the GCE and dark matter, and underscores the urgent need to account for the reality gap and consider previously overlooked “out of domain” uncertainties in future interpretations. |
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Address |
[Caron, Sascha; Hendriks, Luc] Radboud Univ Nijmegen, Theoret High Energy Phys, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands, Email: scaron@nikhef.nl; |
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Publisher |
IOP Publishing Ltd |
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Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001025516000009 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5576 |
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Author |
Beaulieu, L.; Ballester, F.; Granero, D.; Tedgren, A.C.; Haworth, A.; Lowenstein, J.R.; Ma, Y.Z.; Mourtada, F.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; Sloboda, R.S.; Smith, R.L.; Thomson, R.M.; Verhaegen, F.; Fonseca, G.; Vijande, J. |
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Title |
AAPM WGDCAB Report 372: A joint AAPM, ESTRO, ABG, and ABS report on commissioning of model-based dose calculation algorithms in brachytherapy |
Type |
Journal Article |
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Year |
2023 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
50 |
Issue |
8 |
Pages |
e946–e960 |
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Keywords |
brachytherapy; commissioning; dose calculation; model-based dose calculation; Monte Carlo; TG-186 |
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Abstract |
The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged. |
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Address |
[Beaulieu, Luc; Ma, Yunzhi] CHU Quebec Univ Laval, Serv Phys Med & Radioprotect, Quebec City, PQ, Canada, Email: beaulieu@phy.ulaval.ca |
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Thesis |
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Publisher |
Wiley |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001026540300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5579 |
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Author |
Pompa, F.; Schwetz, T.; Zhu, J.Y. |
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Title |
Impact of nuclear matrix element calculations for current and future neutrinoless double beta decay searches |
Type |
Journal Article |
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Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
06 |
Issue |
6 |
Pages |
104 - 29pp |
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Keywords |
Baryon; Lepton Number Violation; Neutrino Interactions |
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Abstract |
Nuclear matrix elements (NME) are a crucial input for the interpretation of neutrinoless double beta decay data. We consider a representative set of recent NME calculations from different methods and investigate the impact on the present bound on the effective Majorana mass m(& beta;& beta;) by performing a combined analysis of the available data as well as on the sensitivity reach of future projects. A crucial role is played by the recently discovered short-range contribution to the NME, induced by light Majorana neutrino masses. Depending on the NME model and the relative sign of the long- and short-range contributions, the current 3 & sigma; bound can change between m(& beta;& beta;)< 40 meV and 600 meV. The sign-uncertainty may either boost the sensitivity of next-generation experiments beyond the region for m(& beta;& beta;) predicted for inverted mass ordering or prevent even advanced setups to reach this region. Furthermore, we study the possibility to distinguish between different NME calculations by assuming a positive signal and by combining measurements from different isotopes. Such a discrimination will be impossible if the relative sign of the long- and short-range contribution remains unknown, but can become feasible if m(& beta;& beta;) & GSIM; 40 meV and if the relative sign is known to be positive. Sensitivities will be dominated by the advanced Ge-76 and Xe-136 setups assumed here, but NME model-discrimination improves if data from a third isotope is added, e.g., from Te-130 or Mo-100. |
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Address |
[Pompa, Federica] Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Parc Cientif UV, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: zhujingyu@sjtu.edu.cn |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
ISBN |
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Conference |
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Notes |
WOS:001016276900003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5580 |
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Author |
Fadel, M.; Yadin, B.; Mao, Y.P.; Byrnes, T.; Gessner, M. |
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Title |
Multiparameter quantum metrology and mode entanglement with spatially split nonclassical spin ensembles |
Type |
Journal Article |
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Year |
2023 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
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Volume |
25 |
Issue |
7 |
Pages |
073006 - 25pp |
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Keywords |
quantum metrology; Bose-Einstein condensates; spin-squeezing; Fisher information matrix; mode and particle entanglement |
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Abstract |
We identify the multiparameter sensitivity of entangled spin states, such as spin-squeezed and Dicke states that are spatially distributed into several addressable spatial modes. Analytical expressions for the spin-squeezing matrix of families of states that are accessible by current atomic experiments reveal the quantum gain in multiparameter metrology, as well as the optimal strategies to maximize the sensitivity gain for the estimation of any linear combination of parameters. We further study the mode entanglement of these states by deriving a witness for genuine k-partite mode entanglement from the spin-squeezing matrix. Our results highlight the advantage of mode entanglement for distributed sensing, and outline optimal protocols for multiparameter estimation with nonclassical spatially-distributed spin ensembles. We illustrate our findings with the design of a protocol for gradient sensing with a Bose-Einstein condensate in an entangled spin state in two modes. |
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Address |
[Fadel, Matteo] Swiss Fed Inst Technol, Dept Phys, CH-8093 Zurich, Switzerland, Email: fadelm@phys.ethz.ch; |
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Corporate Author |
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Thesis |
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Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1367-2630 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001026518600001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5582 |
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