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Author |
Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. |
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Title |
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source |
Type |
Journal Article |
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Year  |
2024 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
14 |
Issue |
1 |
Pages |
11448 - 12pp |
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Keywords |
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Abstract |
Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range. |
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Address |
[Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es |
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Publisher |
Nature Portfolio |
Place of Publication |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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ISSN |
2045-2322 |
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Expedition |
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Conference |
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Notes |
WOS:001228252900017 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
6143 |
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Author |
Mendoza, E.; Alcayne, V.; Cano-Ott, D.; Gonzalez-Romero, E.; Martinez, T.; de Rada, A.P.; Sanchez-Caballero, A.; Balibrea-Correa, J.; Domingo-Pardo, C.; Lerendegui-Marco, J.; Calvino, F.; Guerrero, C. |
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Title |
Neutron capture measurements with high efficiency detectors and the Pulse Height Weighting Technique |
Type |
Journal Article |
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Year |
2023 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
1047 |
Issue |
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Pages |
167894 - 16pp |
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Keywords |
Neutron capture; Total energy detector; Pulse height weighting technique; 7-ray cascades |
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Abstract |
Neutron capture cross section measurements in time-of-flight facilities are usually performed by detecting the prompt 7-rays emitted in the capture reactions. One of the difficulties to be addressed in these measurements is that the emitted 7-rays may change with the neutron energy, and therefore also the detection efficiency. To deal with this situation, many measurements use the so called Total Energy Detection (TED) technique, usually in combination with the Pulse Height Weighting Technique (PHWT). With it, it is sought that the detection efficiency depends only on the total energy of the 7-ray cascade, which does not vary much with the neutron energy. This technique was developed in the 1960s and has been used in many neutron capture experiments to date. One of the requirements of the technique is that 7-ray detectors have a low efficiency. This has meant that the PHWT has been used with experimental setups with low detection efficiencies. However, this condition does not have to be fulfilled by the experimental system as a whole. The main goal of this work is to show that it is possible to measure with a high efficiency detection system that uses the PHWT, and how to analyze the measured data. |
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Address |
[Mendoza, E.; Alcayne, V; Cano-Ott, D.; Gonzalez-Romero, E.; Martinez, T.; Perez de Rada, A.; Sanchez-Caballero, A.] Ctr Invest Energet Medioambientales & Tecnol CIEM, Madrid, Spain, Email: emilio.mendoza@ciemat.es |
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Publisher |
Elsevier |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000908431800002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5468 |
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Author |
Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C. |
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Title |
Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification |
Type |
Journal Article |
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Year |
2022 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
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Volume |
137 |
Issue |
11 |
Pages |
1258 - 18pp |
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Keywords |
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Abstract |
We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy. |
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Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Springer Heidelberg |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2190-5444 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000886327900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5420 |
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| Permanent link to this record |
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Author |
Balibrea-Correa, J.; Lerendegui-Marco, J.; Calvo, D.; Caballero, L.; Babiano, V.; Ladarescu, I.; Redondo, M.L.; Tain, J.L.; Tolosa, A.; Domingo-Pardo, C.; Calvino, F.; Casanovas, A.; Tarifeño-Saldivia, A.; Alcayne, V.; Cano-Ott, D.; Martinez, T.; Guerrero, C.; Barbagallo, M.; Macina, D.; Bacak, M. |
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Title |
A first prototype of C6D6 total-energy detector with SiPM readout for neutron capture time-of-flight experiments |
Type |
Journal Article |
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Year |
2021 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
985 |
Issue |
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Pages |
164709 - 8pp |
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Keywords |
Silicon photomultiplier; Radiation detectors; Time-of-flight; Radiative capture; Total energy detector; Pulse-height weighting technique |
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Abstract |
Low efficiency total-energy detectors (TEDs) are one of the main tools for neutron capture cross section measurements utilizing the time-of-flight (TOF) technique. State-of-the-art TEDs are based on a C6D6 liquid-scintillation cell optically coupled to a fast photomultiplier tube. The large photomultiplier tube represents yet a significant contribution to the so-called neutron sensitivity background, which is one of the most conspicuous sources of uncertainty in this type of experiments. Here we report on the development of a first prototype of a TED based on a silicon-photomultiplier (SiPM) readout, thus resulting in a lightweight and much more compact detector. Apart from the envisaged improvement in neutron sensitivity, the new system uses low voltage (+28 V) and low current supply (-50 mA), which is more practical than the-kV supply required by conventional photomultipliers. One important difficulty hindering the earlier implementation of SiPM readout for this type of detector was the large capacitance for the output signal when all pixels of a SiPM array are summed together. The latter leads to long pulse rise and decay times, which are not suitable for time-of-flight experiments. In this work we demonstrate the feasibility of a Schottky-diode multiplexing readout approach, that allows one to preserve the excellent timing properties of SiPMs, hereby paving the way for their implementation in future neutron TOF experiments. |
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Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Calvo, D.; Caballero, L.; Babiano, V; Ladarescu, I; Redondo, M. Lopez; Tain, J. L.; Tolosa, A.; Domingo-Pardo, C.] Univ Valencia, Inst Fis Corpuscular, CSIC, Valencia, Spain, Email: dacaldia@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000592358200019 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4638 |
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Author |
n_TOF Collaboration (Guerrero, C. et al); Domingo-Pardo, C.; Tain, J.L. |
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Title |
Neutron Capture on the s-Process Branching Point Tm-171 via Time-of-Flight and Activation |
Type |
Journal Article |
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Year |
2020 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
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Volume |
125 |
Issue |
14 |
Pages |
142701 - 8pp |
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Keywords |
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Abstract |
The neutron capture cross sections of several unstable nuclides acting as branching points in the s process are crucial for stellar nucleosynthesis studies. The unstable Tm-171 (t(1/2) = 1.92 yr) is part of the branching around mass A similar to 170 but its neutron capture cross section as a function of the neutron energy is not known to date. In this work, following the production for the first time of more than 5 mg of Tm-171 at the high-flux reactor Institut Laue-Langevin in France, a sample was produced at the Paul Scherrer Institute in Switzerland. Two complementary experiments were carried out at the neutron time-of-flight facility (nTOF) at CERN in Switzerland and at the SARAF liquid lithium target facility at Soreq Nuclear Research Center in Israel by time of flight and activation, respectively. The result of the time -of-flight experiment consists of the first ever set of resonance parameters and the corresponding average resonance parameters, allowing us to make an estimation of the Maxwellian-averaged cross sections (MACS) by extrapolation. The activation measurement provides a direct and more precise measurement of the MACS at 30 keV: 384 (40) mb, with which the estimation from the nTOF data agree at the limit of 1 standard deviation. This value is 2.6 times lower than the JEFF-3.3 and ENDF/B-VIII evaluations, 25% lower than that of the Bao et al. compilation, and 1.6 times larger than the value recommended in the KAlloNiS (v1) database, based on the only previous experiment. Our result affects the nucleosynthesis at the A similar to 170 branching, namely, the Yb-171 abundance increases in the material lost by asymptotic giant branch stars, providing a better match to the available pre-solar SiC grain measurements compared to the calculations based on the current JEFF-3.3 model-based evaluation. |
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Address |
[Guerrero, C.; Lerendegui-Marco, J.; Quesada, J. M.; Cortes-Giraldo, M. A.; Millan-Callado, M. A.; Praena, J.; Rodriguez-Gonzalez, T.; Sabate-Gilarte, M.] Univ Seville, Seville, Spain, Email: cguerrero4@us.es |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0031-9007 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000574781200004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4551 |
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