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Assam, I., Vijande, J., Ballester, F., Perez-Calatayud, J., Poppe, B., & Siebert, F. A. (2022). Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants. Med. Phys., 49, 6195–6208.
Abstract: Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms.
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Bernigaud, J., Blanke, M., de Medeiros Varzielas, I., Talbert, J., & Zurita, J. (2022). LHC signatures of tau-flavoured vector leptoquarks. J. High Energy Phys., 08(8), 127–31pp.
Abstract: We consider the phenomenological signatures of Simplified Models of Flavourful Leptoquarks, whose Beyond-the-Standard Model (SM) couplings to fermion generations occur via textures that are well motivated from a broad class of ultraviolet flavour models (which we briefly review). We place particular emphasis on the study of the vector leptoquark Delta(mu) with assignments (3, 1, 2/3) under the SM's gauge symmetry, SU(3)(C) x SU(2)(L) x U(1)(Y), which has the tantalising possibility of explaining both R-K(*) and R-D(*) anomalies. Upon performing global likelihood scans of the leptoquark's coupling parameter space, focusing in particular on models with tree-level couplings to a single charged lepton species, we then provide confidence intervals and benchmark points preferred by low(er)-energy flavour data. Finally, we use these constraints to further evaluate the (promising) Large Hadron Collider (LHC) detection prospects of pairs of tau-flavoured Delta(mu), through their distinct (a)symmetric decay channels. Namely, we consider direct third-generation leptoquark and jets plus missing-energy searches at the LHC, which we find to be complementary. Depending on the simplified model under consideration, the direct searches constrain the Delta(mu), mass up to 1500-1770 GeV when the branching fraction of Delta(mu), is entirely to third-generation quarks (but are significantly reduced with decreased branching ratios to the third generation), whereas the missing-energy searches constrain the mass up to 1150-1700 GeV while being largely insensitive to the third-generation branching fraction.
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Coito, L., Faubel, C., Herrero-Garcia, J., Santamaria, A., & Titov, A. (2022). Sterile neutrino portals to Majorana dark matter: effective operators and UV completions. J. High Energy Phys., 08(8), 085–36pp.
Abstract: Stringent constraints on the interactions of dark matter with the Standard Model suggest that dark matter does not take part in gauge interactions. In this regard, the possibility of communicating between the visible and dark sectors via gauge singlets seems rather natural. We consider a framework where the dark matter talks to the Standard Model through its coupling to sterile neutrinos, which generate active neutrino masses. We focus on the case of Majorana dark matter, with its relic abundance set by thermal freeze-out through annihilations into sterile neutrinos. We use an effective field theory approach to study the possible sterile neutrino portals to dark matter. We find that both lepton-number-conserving and lepton-number-violating operators are possible, yielding an interesting connection with the Dirac/Majorana character of active neutrinos. In a second step, we open the different operators and outline the possible renormalisable models. We analyse the phenomenology of the most promising ones, including a particular case in which the Majorana mass of the sterile neutrinos is generated radiatively.
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Gola, S., Mandal, S., & Sinha, N. (2022). ALP-portal majorana dark matter. Int. J. Mod. Phys. A, 37, 2250131–14pp.
Abstract: Axion like particles (ALPs) and right-handed neutrinos (RHNs) are two well-motivated dark matter (DM) candidates. However, these two particles have a completely different origin. Axion was proposed to solve the strong CP problem, whereas RHNs were introduced to explain light neutrino masses through seesaw mechanisms. We study the case of ALP portal RHN DM (Majorana DM) taking into account existing constraints on ALPs. We consider the leading effective operators mediating interactions between the ALP and Standard Model (SM) particles and three RHNs to generate light neutrino masses through type-I seesaw. Further, ALP-RHN neutrino coupling is introduced to generalize the model which is restricted by the relic density and indirect detection constraint.
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Bas i Beneito, A., Herrero-Garcia, J., & Vatsyayan, D. (2022). Multi-component dark sectors: symmetries, asymmetries and conversions. J. High Energy Phys., 10(10), 075–31pp.
Abstract: We study the relic abundance of several stable particles from a generic dark sector, including the possible presence of dark asymmetries. After discussing the different possibilities for stabilising multi-component dark matter, we analyse the final relic abundance of the symmetric and asymmetric dark matter components, paying special attention to the role of the unavoidable conversions between dark matter states. We find an exponential dependence of the asymmetries of the heavier components on annihilations and conversions. We conclude that having similar symmetric and asymmetric components is a natural outcome in many scenarios of multi-component dark matter. This has novel phenomenological implications, which we briefly discuss.
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