Abstract: We present an updated and improved global fit analysis of current flavour and electroweak precision observables to derive bounds on unitarity deviations of the leptonic mixing matrix and on the mixing of heavy neutrinos with the active flavours. This new analysis is motivated by new and updated experimental results on key observables such as V-ud, the invisible decay width of the Z boson and the W boson mass. It also improves upon previous studies by considering the full correlations among the different observables and explicitly calibrating the test statistic, which may present significant deviations from a & chi;(2) distribution. The results are provided for three different Type-I seesaw scenarios: the minimal scenario with only two additional right-handed neutrinos, the next to minimal one with three extra neutrinos, and the most general one with an arbitrary number of heavy neutrinos that we parametrise via a generic deviation from a unitary leptonic mixing matrix. Additionally, we also analyze the case of generic deviations from unitarity of the leptonic mixing matrix, not necessarily induced by the presence of additional neutrinos. This last case relaxes some correlations among the parameters and is able to provide a better fit to the data. Nevertheless, inducing only leptonic unitarity deviations avoiding both the correlations implied by the right-handed neutrino extension as well as more strongly constrained operators is challenging and would imply significantly more complex UV completions.

Abstract: Haloscopes are resonant cavities that serve as detectors of dark matter axions when they are immersed in a strong static magnetic field. In order to increase the volume and improve space compatibility with dipole or solenoid magnets for axion searches, various haloscope design techniques for rectangular geometries are discussed in this study. The volume limits of two types of haloscopes are explored: those based on single cavities and those based on multicavities. In both cases, possibilities for increasing the volume of long and/or tall structures are presented. For multicavities, 1D geometries are explored to optimise the space in the magnets. Also, 2D and 3D geometries are introduced as a first step in laying the foundations for the development of these kinds of topologies. The results prove the usefulness of the developed methods, evidencing the ample room for improvement in rectangular haloscope designs nowadays. A factor of three orders of magnitude improvement in volume compared with a single cavity based on the WR-90 standard waveguide is obtained with the design of a long and tall single cavity. Similar procedures have been applied for long and tall multicavities. Experimental measurements are shown for prototypes based on tall multicavities and 2D structures, demonstrating the feasibility of using these types of geometries to increase the volume of real haloscopes.

Abstract: The Scotogenic model is a popular scenario that induces radiative Majorana neutrino masses and includes a weakly-interacting dark matter candidate. We classify all possible ultraviolet extensions of the Scotogenic model in which (i) the dark DOUBLE-STRUCK CAPITAL Z(2) parity emerges at low energies after the spontaneous breaking of a global U(1)(L) lepton number symmetry, and (ii) the low-energy effective theory contains a naturally small lepton number breaking parameter, suppressed by the mass of a heavy mediator integrated out at tree-level. We find 50 such models and discuss two of them in detail to illustrate our setup. We also discuss some general aspects of the phenomenology of the models in our classification, exploring possible lepton flavor violating signals, collider signatures and implications for dark matter. The phenomenological prospects of these scenarios are very rich due to the presence of additional scalar states, including a massless Goldstone boson.

Abstract: Objective. The Jagiellonian positron emission tomography (J-PET) technology, based on plastic scintillators, has been proposed as a cost effective tool for detecting range deviations during proton therapy. This study investigates the feasibility of using J-PET for range monitoring by means of a detailed Monte Carlo simulation study of 95 patients who underwent proton therapy at the Cyclotron Centre Bronowice (CCB) in Krakow, Poland. Approach. Discrepancies between prescribed and delivered treatments were artificially introduced in the simulations by means of shifts in patient positioning and in the Hounsfield unit to the relative proton stopping power calibration curve. A dual-layer, cylindrical J-PET geometry was simulated in an in-room monitoring scenario and a triple-layer, dual-head geometry in an in-beam protocol. The distribution of range shifts in reconstructed PET activity was visualized in the beam's eye view. Linear prediction models were constructed from all patients in the cohort, using the mean shift in reconstructed PET activity as a predictor of the mean proton range deviation. Main results. Maps of deviations in the range of reconstructed PET distributions showed agreement with those of deviations in dose range in most patients. The linear prediction model showed a good fit, with coefficient of determination r (2) = 0.84 (in-room) and 0.75 (in-beam). Residual standard error was below 1 mm: 0.33 mm (in-room) and 0.23 mm (in-beam). Significance. The precision of the proposed prediction models shows the sensitivity of the proposed J-PET scanners to shifts in proton range for a wide range of clinical treatment plans. Furthermore, it motivates the use of such models as a tool for predicting proton range deviations and opens up new prospects for investigations into the use of intra-treatment PET images for predicting clinical metrics that aid in the assessment of the quality of delivered treatment.

Abstract: To reconcile the current tensions between high and low redshift observations, we perform the first constraints on the Finslerian cosmological models including the effective dark matter and dark energy components. We find that all the four Finslerian models could alleviate effectively the Hubble constant (H-0) tension and the amplitude of the root-mean-square density fluctu-ations (s(8)) tension between the Planck measurements and the local Universe observations at the 68% confidence level. The addition of a massless sterile neutrino and a varying total mass of active neutrinos to the base Finslerian two-parameter model, respectively, reduces the H-0 tension from 3.4s to 1.9s and alleviates the s8 tension better than the other three Finslerian models. Computing the Bayesian evidence, with respect to ACDM model, our analysis shows a weak preference for the base Finslerian model and moderate preferences for its three one-parameter extensions. Based on the model-independent Gaussian Processes, we propose a new linear relation which can describe the current redshift space distortions data very well. Using the most stringent constraints we can provide, we have also obtained the limits of typical model parameters for three one-parameter extensional models.