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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
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Title |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year  |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Public Library Science |
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Language |
English |
Summary Language |
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Original Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1545-7885 |
ISBN |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1446 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M.; Wildauer, A. |
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Title |
Measurements of top quark pair relative differential cross-sections with ATLAS in pp collisions at root s=7 TeV |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
73 |
Issue |
1 |
Pages |
2261 - 28pp |
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Keywords |
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Abstract |
Measurements are presented of differential cross-sections for top quark pair production in pp collisions at root s = 7 TeV relative to the total inclusive top quark pair production cross-section. A data sample of 2.05 fb(-1) recorded by the ATLAS detector at the Large Hadron Collider is used. Relative differential cross-sections are derived as a function of the invariant mass, the transverse momentum and the rapidity of the top quark pair system. Events are selected in the lepton (electron or muon) + jets channel. The background-subtracted differential distributions are corrected for detector effects, normalized to the total inclusive top quark pair production cross-section and compared to theoretical predictions. The measurement uncertainties range typically between 10 % and 20 % and are generally dominated by systematic effects. No significant deviations from the Standard Model expectations are observed. |
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Address |
SUNY Albany, Dept Phys, Albany, NY 12222 USA |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
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Expedition |
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Conference |
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Notes |
WOS:000318288100002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1447 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; March, L.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Search for pair-produced massive coloured scalars in four-jet final states with the ATLAS detector in proton-proton collisions at root s=7 TeV |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
73 |
Issue |
1 |
Pages |
2263 - 20pp |
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Keywords |
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Abstract |
A search for pair-produced massive coloured scalar particles decaying to a four-jet final state is performed by the ATLAS experiment at the LHC in proton-proton collisions at root s = 7 TeV. The analysed data sample corresponds to an integrated luminosity of 4.6 fb(-1). No deviation from the Standard Model is observed in the invariant mass spectrum of the two-jet pairs. A limit on the scalar gluon pair production cross section of 70 pb (10 pb) is obtained at the 95 % confidence level for a scalar gluon mass of 150 GeV (350 GeV). Interpreting these results as mass limits on scalar gluons, masses ranging from 150 GeV to 287 GeV are excluded at the 95 % confidence level. |
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Address |
Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318288100004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1448 |
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Author |
LHCb Collaboration (Aaij, R. et al); Oyanguren, A.; Ruiz Valls, P. |
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Title |
Precision measurement of the B-s(0)-(B)over-bar(s)(0) oscillation frequency with the decay B-s(0) -> D-s(-)pi(+) |
Type |
Journal Article |
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Year |
2013 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
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Volume |
15 |
Issue |
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Pages |
053021 - 15pp |
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Keywords |
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Abstract |
A key ingredient to searches for physics beyond the Standard Model in B-s(0) mixing phenomena is the measurement of the B-s(0)-(B) over bar (0)(s) oscillation frequency, which is equivalent to the mass difference Delta m(s) of the B-s(0) mass eigenstates. Using the world's largest B-s(0) meson sample accumulated in a dataset, corresponding to an integrated luminosity of 1.0 fb(-1), collected by the LHCb experiment at the CERN LHC in 2011, a measurement of Delta m(s) is presented. A total of about 34 000 B-s(0) -> D-s(-)pi(+) signal decays are reconstructed, with an average decay time resolution of 44 fs. The oscillation frequency is measured to be Delta m(s) = 17.768 +/- 0.023 (stat) +/- 0.006 (syst) ps(-1), which is the most precise measurement to date. |
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Address |
Ctr Brasileiro Pesquisas Fis, Rio De Janeiro, Brazil, Email: wandernoth@physi.uni-heidelberg.de |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1367-2630 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318853200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1449 |
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Author |
Garcia-Recio, C.; Geng, L.S.; Nieves, J.; Salcedo, L.L.; Wang, E.; Xie, J.J. |
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Title |
Low-lying even parity meson resonances and spin-flavor symmetry revisited |
Type |
Journal Article |
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Year |
2013 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
87 |
Issue |
9 |
Pages |
096006 - 18pp |
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Keywords |
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Abstract |
We review and extend the model derived in Garcia-Recio et al. [Phys. Rev. D 83, 016007 (2011)] to address the dynamics of the low-lying even-parity meson resonances. This model is based on a coupled-channels spin-flavor extension of the chiralWeinberg-Tomozawa Lagrangian. This interaction is then used to study the S-wave meson-meson scattering involving members not only of the pi octet, but also of the rho nonet. In this work, we study in detail the structure of the SU(6)-symmetry-breaking contact terms that respect (or softly break) chiral symmetry. We derive the most general local (without involving derivatives) terms consistent with the chiral-symmetry-breaking pattern of QCD. After introducing sensible simplifications to reduce the large number of possible operators, we carry out a phenomenological discussion of the effects of these terms. We show how the inclusion of these pieces leads to an improvement of the description of the J(P) = 2(+) sector, without spoiling the main features of the predictions obtained in the original model in the JP = 0(+) and J(P) = 1(+) sectors. In particular, we find a significantly better description of the I-G(J(PC)) =0(+)(2(++)), 1(-)(2(++)) and the I(JP)=1/2(2(+)) sectors, which correspond to the f(2)(1270), a(2)(1320), and K-2(*)(1430) quantum numbers, respectively. |
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Address |
Univ Granada, Dept Fis Atom Mol & Nucl, E-18071 Granada, Spain |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1550-7998 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000319059500004 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1450 |
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| Permanent link to this record |
