LHCb Collaboration(Aaij, R. et al), Garcia Martin, L. M., Henry, L., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., et al. (2018). Evidence for the Rare Decay Sigma(+) -> p mu(+)mu(-). Phys. Rev. Lett., 120(22), 221803–10pp.
Abstract: A search for the rare decay Sigma(+) -> p mu(+)mu(-) is performed using pp collision data recorded by the LHCb experiment at center-of-mass energies root s = 7 and 8 TeV, corresponding to an integrated luminosity of 3 fb(-1). An excess of events is observed with respect to the background expectation, with a signal significance of 4.1 standard deviations. No significant structure is observed in the dimuon invariant mass distribution, in contrast with a previous result from the HyperCP experiment. The measured Sigma(+) -> p mu(+)mu(-) branching fraction is (2.2(-1.3)(+1.8)) x 10(-8), where statistical and systematic uncertainties are included, which is consistent with the standard model prediction.
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LHCb Collaboration(Aaij, R. et al), Garcia Martin, L. M., Henry, L., Martinez-Vidal, F., Oyanguren, A., Remon Alepuz, C., et al. (2018). Amplitude Analysis of the Decay (B)over-bar(0 )-> K-S(0)pi(+)pi(- )and First Observation of the CP Asymmetry in (B)over-bar(0 )-> K* (892)(-)pi(+). Phys. Rev. Lett., 120(26), 261801–10pp.
Abstract: The time-integrated untagged Dalitz plot of the three-body hadronic charmless decay (B) over bar (0 )-> K-S(0)pi(+)pi(- ) is studied using a pp collision data sample recorded with the LHCb detector, corresponding to an integrated luminosity of 3.0 fb(-1). The decay amplitude is described with an isobar model. Relative contributions of the isobar amplitudes to the (B) over bar (0 )-> K-S(0)pi(+)pi(- ) decay branching fraction and CP asymmetries of the flavor-specific amplitudes are measured. The CP asymmetry between the conjugate (B) over bar (0 )-> K* (892)(-)pi(+) and (B) over bar (0 )-> K* (892)(-)pi(+) decay rates is determined to be -0.308 +/- 0.062.
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Davesne, D., Pastore, A., & Navarro, J. (2021). Linear response theory with finite-range interactions. Prog. Part. Nucl. Phys., 120, 103870–55pp.
Abstract: This review focuses on the calculation of infinite nuclear matter response functions using phenomenological finite-range interactions, equipped or not with tensor terms. These include Gogny and Nakada families, which are commonly used in the literature. Because of the finite-range, the main technical difficulty stems from the exchange terms of the particle-hole interaction. We first present results based on the so-called Landau and Landau-like approximations of the particle-hole interaction. Then, we review two methods which in principle provide numerically exact response functions. The first one is based on a multipolar expansion of both the particle-hole interaction and the particle-hole propagator and the second one consists in a continued fraction expansion of the response function. The numerical precision can be pushed to any degree of accuracy, but it is actually shown that two or three terms suffice to get converged results. Finally, we apply the formalism to the determination of possible finite-size instabilities induced by a finite-range interaction.
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Carrasco-Ribelles, L. A., Pardo-Mas, J. R., Tortajada, S., Saez, C., Valdivieso, B., & Garcia-Gomez, J. M. (2021). Predicting morbidity by local similarities in multi-scale patient trajectories. J. Biomed. Inform., 120, 103837–9pp.
Abstract: Patient Trajectories (PTs) are a method of representing the temporal evolution of patients. They can include information from different sources and be used in socio-medical or clinical domains. PTs have generally been used to generate and study the most common trajectories in, for instance, the development of a disease. On the other hand, healthcare predictive models generally rely on static snapshots of patient information. Only a few works about prediction in healthcare have been found that use PTs, and therefore benefit from their temporal dimension. All of them, however, have used PTs created from single-source information. Therefore, the use of longitudinal multi-scale data to build PTs and use them to obtain predictions about health conditions is yet to be explored. Our hypothesis is that local similarities on small chunks of PTs can identify similar patients concerning their future morbidities. The objectives of this work are (1) to develop a methodology to identify local similarities between PTs before the occurrence of morbidities to predict these on new query individuals; and (2) to validate this methodology on risk prediction of cardiovascular diseases (CVD) occurrence in patients with diabetes. We have proposed a novel formal definition of PTs based on sequences of longitudinal multi-scale data. Moreover, a dynamic programming methodology to identify local alignments on PTs for predicting future morbidities is proposed. Both the proposed methodology for PT definition and the alignment algorithm are generic to be applied on any clinical domain. We validated this solution for predicting CVD in patients with diabetes and we achieved a precision of 0.33, a recall of 0.72 and a specificity of 0.38. Therefore, the proposed solution in the diabetes use case can result of utmost utility to secondary screening.
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Baran, J. et al, & Brzezinski, K. (2024). Feasibility of the J-PET to monitor the range of therapeutic proton beams. Phys. Medica, 118, 103301–9pp.
Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.
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Pich, A. (2021). Precision physics with inclusive QCD processes. Prog. Part. Nucl. Phys., 117, 103846–41pp.
Abstract: The inclusive production of hadrons through electroweak currents can be rigorously analysed with short-distance theoretical tools. The associated observables are insensitive to the involved infrared behaviour of the strong interaction, allowing for very precise tests of Quantum Chromodynamics. The theoretical predictions for sigma(e(+)e(-) -> hadrons) and the hadronic decay widths of the tau lepton and the Z, W and Higgs bosons have reached an impressive accuracy of O(alpha(4)(s)). Precise experimental measurements of the Z and tau hadronic widths have made possible the accurate determination of the strong coupling at two very different energy scales, providing a highly significant experimental verification of asymptotic freedom. A detailed discussion of the theoretical description of these processes and their current phenomenological status is presented. The most precise determinations of alpha(s) from other sources are also briefly reviewed and compared with the fully-inclusive results.
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Barrientos, L., Borja-Lloret, M., Casaña, J. V., Dendooven, P., Garcia Lopez, J. G., Hueso-Gonzalez, F., et al. (2024). Gamma-ray sources imaging and test-beam results with MACACO III Compton camera. Phys. Medica, 117, 103199–10pp.
Abstract: Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s.
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ANTARES Collaboration(Albert, A. et al), Barrios-Marti, J., Hernandez-Rey, J. J., Illuminati, G., Lotze, M., Tönnis, C., et al. (2020). Model-independent search for neutrino sources with the ANTARES neutrino telescope. Astropart Phys., 114, 35–47.
Abstract: A novel method to analyse the spatial distribution of neutrino candidates recorded with the ANTARES neutrino telescope is introduced, searching for an excess of neutrinos in a region of arbitrary size and shape from any direction in the sky. Techniques originating from the domains of machine learning, pattern recognition and image processing are used to purify the sample of neutrino candidates and for the analysis of the obtained skymap. In contrast to a dedicated search for a specific neutrino emission model, this approach is sensitive to a wide range of possible morphologies of potential sources of high-energy neutrino emission. The application of these methods to ANTARES data yields a large-scale excess with a post-trial significance of 2.5 sigma. Applied to public data from IceCube in its IC40 configuration, an excess consistent with the results from ANTARES is observed with a post-trial significance of 2.1 sigma.
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KM3NeT Collaboration(Aiello, S. et al), Barrios-Marti, J., Calvo, D., Coleiro, A., Colomer, M., Gozzini, S. R., et al. (2019). Sensitivity of the KM3NeT/ARCA neutrino telescope to point-like neutrino sources. Astropart Phys., 111, 100–110.
Abstract: KM3NeT will be a network of deep-sea neutrino telescopes in the Mediterranean Sea. The KM3NeT/ARCA detector, to be installed at the Capo Passero site (Italy), is optimised for the detection of high-energy neutrinos of cosmic origin. Thanks to its geographical location on the Northern hemisphere, KM3NeT/ARCA can observe upgoing neutrinos from most of the Galactic Plane, including the Galactic Centre. Given its effective area and excellent pointing resolution, KM3NeT/ARCA will measure or significantly constrain the neutrino flux from potential astrophysical neutrino sources. At the same time, it will test flux predictions based on gamma-ray measurements and the assumption that the gamma-ray flux is of hadronic origin. Assuming this scenario, discovery potentials and sensitivities for a selected list of Galactic sources and to generic point sources with an E(-2 )spectrum are presented. These spectra are assumed to be time independent. The results indicate that an observation with 3 sigma significance is possible in about six years of operation for the most intense sources, such as Supernovae Remnants RX J1713.7-3946 and Vela Jr. If no signal will be found during this time, the fraction of the gamma-ray flux coming from hadronic processes can be constrained to be below 50% for these two objects.
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Wilkinson, C., & Garcia Soto, A. (2024). Low-ν method with LHC neutrinos. Phys. Rev. D, 109(3), 033010–19pp.
Abstract: The Forward Physics Facility (FPF) plans to use neutrinos produced at the Large Hadron Collider to make a variety of measurements at previously unexplored TeV energies. Its primary goals include precision measurements of the neutrino cross section and using the measured neutrino flux both to uncover information about far-forward hadron production and to search for various beyond standard model scenarios. However, these goals have the potential to conflict: Extracting information about the flux or cross section relies upon an assumption about the other. In this paper, we demonstrate that the FPF can use the low-nu method-a technique for constraining the flux shape by isolating neutrino interactions with low energy transfer to the nucleus-to break this degeneracy. We show that the low-nu method is effective for extracting the nu μflux shape, in a model-independent way. We discuss its application for extracting the nu over bar μflux shape but find that this is significantly more model dependent. Finally, we explore the precision to which the nu μflux shape could be constrained at the FPF for a variety of proposed detector options. We find that the precision would be sufficient to discriminate between various realistic flux models.
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