Abstract: We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy.

Abstract: We present a detailed study of the lowest-lying 1/2(-) and 3/2(-) Lambda Q resonances both in the heavy 2 2 quark (bottom and charm) and the strange sectors. We have paid special attention to the interplay between the constituent quark-model and chiral baryon-meson degrees of freedom, which are coupled using a unitarized scheme consistent with leading-order heavy quark symmetries. We show that the Lambda(b)(5912) [J(P) = 1/2(-)], Lambda(b)(5920) [J(P) = 3/2(-)] and the Lambda(c)(2625) [J(P) = 3/2-], and the Lambda(1520) [J(P) = 3/2(-)] admitting larger breaking corrections, are heavyquark spin-flavor siblings. They can be seen as dressed quark-model states with Sigma Q(()*()) pi molecular components of the order of 30%. The J(P)=1(-) Lambda(2595) has, however, a higher molecular 2 probability of at least 50%, and even values greater than 70% can be easily accommodated. This is because it is located almost on top of the threshold of the Sigma(c)pi pair, which largely influences its properties. Although the light degrees of freedom in this resonance would be coupled to spin-parity 1(-) as in the Lambda(b)(5912), Lambda(b)(5920) and Lambda(c)(2625), the Lambda(c)(2595) should not be considered as a heavy-quark spin-flavor partner of the former ones. We also show that the Lambda(1405) chiral two-pole pattern does not have analogs in the 1 – charmed and bottomed sectors, because the 2 N D-(*()) and N (B) over bar (()*()) channels do not play for heavy quarks the decisive role that the N (K) over bar does in the strange sector, and the notable influence of the bare quark-model states for the charm and bottom resonances. Finally, we predict the existence of two Lambda(b)(6070) and two Lambda(c)(2765) heavy-quark spin and flavor sibling odd parity states.