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Valdes-Cortez, C., Niatsetski, Y., Perez-Calatayud, J., Ballester, F., & Vijande, J. (2022). A Monte Carlo study of the relative biological effectiveness in surface brachytherapy. Med. Phys., 49, 5576–5588.
Abstract: Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value.
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Assam, I., Vijande, J., Ballester, F., Perez-Calatayud, J., Poppe, B., & Siebert, F. A. (2022). Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants. Med. Phys., 49, 6195–6208.
Abstract: Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms.
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PANDA Collaboration(Davi, F. et al), & Diaz, J. (2022). Technical design report for the endcap disc DIRC. J. Phys. G, 49(12), 120501–128pp.
Abstract: PANDA (anti-proton annihiliation at Darmstadt) is planned to be one of the four main experiments at the future international accelerator complex FAIR (Facility for Antiproton and Ion Research) in Darmstadt, Germany. It is going to address fundamental questions of hadron physics and quantum chromodynamics using cooled antiproton beams with a high intensity and and momenta between 1.5 and 15 GeV/c. PANDA is designed to reach a maximum luminosity of 2 x 10(32) cm(-2) s. Most of the physics programs require an excellent particle identification (PID). The PID of hadronic states at the forward endcap of the target spectrometer will be done by a fast and compact Cherenkov detector that uses the detection of internally reflected Cherenkov light (DIRC) principle. It is designed to cover the polar angle range from 5 degrees to 22 degrees and to provide a separation power for the separation of charged pions and kaons up to 3 standard deviations (s.d.) for particle momenta up to 4 GeV/c in order to cover the important particle phase space. This document describes the technical design and the expected performance of the novel PANDA disc DIRC detector that has not been used in any other high energy physics experiment before. The performance has been studied with Monte-Carlo simulations and various beam tests at DESY and CERN. The final design meets all PANDA requirements and guarantees sufficient safety margins.
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Agostini, P. et al, & Mandal, S. (2021). The Large Hadron-Electron Collider at the HL-LHC. J. Phys. G, 48(11), 110501–364pp.
Abstract: The Large Hadron-Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operations. This report represents an update to the LHeC's conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton-nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron-hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
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Li, H. P., Yi, J. Y., Xiao, C. W., Yao, D. L., Liang, W. H., & Oset, E. (2024). Correlation function and the inverse problem in the BD interaction. Chin. Phys. C, 48(5), 053107–7pp.
Abstract: We study the correlation functions of the (BD+)-D-0, (B+D0) system, which develops a bound state of approximately 40MeV, using inputs consistent with the T-cc(3875) state. Then, we address the inverse problem starting from these correlation functions to determine the scattering observables related to the system, including the existence of the bound state and its molecular nature. The important output of the approach is the uncertainty with which these observables can be obtained, considering errors in the (BD+)-D-0, (B+D0) correlation functions typical of current values in correlation functions. We find that it is possible to obtain scattering lengths and effective ranges with relatively high precision and the existence of a bound state. Although the pole position is obtained with errors of the order of 50% of the binding energy, the molecular probability of the state is obtained with a very small error of the order of 6%. All these findings serve as motivation to perform such measurements in future runs of high energy hadron collisions.
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Rinaldi, M., & Vento, V. (2020). Pure glueball states in a light-front holographic approach. J. Phys. G, 47(5), 055104–12pp.
Abstract: A phenomenological analysis of the scalar glueball and scalar meson spectra is carried out by using the AdS/QCD framework in the bottom-up approach. The resulting spectra are in good agreement for glueballs with lattice QCD results and for mesons with PDG data. We make use of the relation between the mode functions in AdS/QCD and the wave functions in Light-Front QCD to discuss the mixing of glueballs and mesons. The results of our investigation point out that above 2 GeV scalar particles will appear in almost degenerate pairs of unmixed glueball and mesons states leading to an interesting phenomenology whereby gluon dynamics could be well investigated.
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Beacham, J. et al, & Martinez-Vidal, F. (2020). Physics beyond colliders at CERN: beyond the Standard Model working group report. J. Phys. G, 47(1), 010501–114pp.
Abstract: The Physics Beyond Colliders initiative is an exploratory study aimed at exploiting the full scientific potential of the CERN's accelerator complex and scientific infrastructures through projects complementary to the LHC and other possible future colliders. These projects will target fundamental physics questions in modern particle physics. This document presents the status of the proposals presented in the framework of the Beyond Standard Model physics working group, and explore their physics reach and the impact that CERN could have in the next 10-20 years on the international landscape.
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NEXT Collaboration, Carcel, S., Carrion, J. V., Felkai, R., Kekic, M., Lopez-March, N., et al. (2020). Mitigation of backgrounds from cosmogenic Xe-137 in xenon gas experiments using He-3 neutron capture. J. Phys. G, 47(7), 075001–17pp.
Abstract: Xe-136 is used as the target medium for many experiments searching for 0 nu beta beta. Despite underground operation, cosmic muons that reach the laboratory can produce spallation neutrons causing activation of detector materials. A potential background that is difficult to veto using muon tagging comes in the form of Xe-137 created by the capture of neutrons on Xe-136. This isotope decays via beta decay with a half-life of 3.8 min and a Q(beta) of similar to 4.16 MeV. This work proposes and explores the concept of adding a small percentage of He-3 to xenon as a means to capture thermal neutrons and reduce the number of activations in the detector volume. When using this technique we find the contamination from Xe-137 activation can be reduced to negligible levels in tonne and multi-tonne scale high pressure gas xenon neutrinoless double beta decay experiments running at any depth in an underground laboratory.
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Khosa, C. K., Mars, L., Richards, J., & Sanz, V. (2020). Convolutional neural networks for direct detection of dark matter. J. Phys. G, 47(9), 095201–20pp.
Abstract: The XENON1T experiment uses a time projection chamber (TPC) with liquid xenon to search for weakly interacting massive particles (WIMPs), a proposed dark matter particle, via direct detection. As this experiment relies on capturing rare events, the focus is on achieving a high recall of WIMP events. Hence the ability to distinguish between WIMP and the background is extremely important. To accomplish this, we suggest using convolutional neural networks (CNNs); a machine learning procedure mainly used in image recognition tasks. To explore this technique we use XENON collaboration open-source software to simulate the TPC graphical output of dark matter signals and main backgrounds. A CNN turns out to be a suitable tool for this purpose, as it can identify features in the images that differentiate the two types of events without the need to manipulate or remove data in order to focus on a particular region of the detector. We find that the CNN can distinguish between the dominant background events (ER) and 500 GeV WIMP events with a recall of 93.4%, precision of 81.2% and an accuracy of 87.2%.
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Rinaldi, M., & Vento, V. (2020). Scalar spectrum in a graviton soft wall model. J. Phys. G, 47(12), 125003–16pp.
Abstract: In this study we present a unified phenomenological analysis of the scalar glueball and scalar meson spectra within an AdS/QCD framework in the bottom up approach. For this purpose we generalize the recently developed graviton soft-wall (GSW) model, which has shown an excellent agreement with the lattice QCD glueball spectrum, to a description of glueballs and mesons with a unique energy scale. In this scheme, dilatonic effects, are incorporated in the metric as a deformation of the AdS space. We apply the model also to the heavy meson spectra with success. We obtain quadratic mass equations for all scalar mesons while the glueballs satisfy an almost linear mass equation. Besides their spectra, we also discuss the mixing of scalar glueball and light scalar meson states within a unified framework: the GSW model. To this aim, the light-front (LF) holographic approach, which connects the mode functions of AdS/QCD to the LF wave functions, is applied. This relation provides the probabilistic interpretation required to properly investigate the mixing conditions.
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