Studen, A., Burdette, D., Chesi, E., Cindro, V., Clinthorne, N. H., Cochran, E., et al. (2010). Timing performance of the silicon PET insert probe. Radiat. Prot. Dosim., 139(1-3), 199–203.
Abstract: Simulation indicates that PET image could be improved by upgrading a conventional ring with a probe placed close to the imaged object. In this paper, timing issues related to a PET probe using high-resistivity silicon as a detector material are addressed. The final probe will consist of several (four to eight) 1-mm thick layers of silicon detectors, segmented into 1 x 1 mm(2) pads, each pad equivalent to an independent p + nn+ diode. A proper matching of events in silicon with events of the external ring can be achieved with a good timing resolution. To estimate the timing performance, measurements were performed on a simplified model probe, consisting of a single 1-mm thick detector with 256 square pads (1.4 mm side), coupled with two VATAGP7s, application-specific integrated circuits. The detector material and electronics are the same that will be used for the final probe. The model was exposed to 511 keV annihilation photons from an Na-22 source, and a scintillator (LYSO)-PMT assembly was used as a timing reference. Results were compared with the simulation, consisting of four parts: (i) GEANT4 implemented realistic tracking of electrons excited by annihilation photon interactions in silicon, (ii) calculation of propagation of secondary ionisation (electron-hole pairs) in the sensor, (iii) estimation of the shape of the current pulse induced on surface electrodes and (iv) simulation of the first electronics stage. A very good agreement between the simulation and the measurements were found. Both indicate reliable performance of the final probe at timing windows down to 20 ns.
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Hoeschen, C., Mattsson, S., Cantone, M. C., Mikuz, M., Lacasta, C., Ebel, G., et al. (2010). Minimising activity and dose with enhanced image quality by radiopharmaceutical administrations. Radiat. Prot. Dosim., 139(1-3), 250–253.
Abstract: Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are administered to the patient, meaning not only a radiation exposure to the diseased tissue but also to the healthy tissues of large parts of the body. 'Minimizing Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations' (MADEIRA) is a project cofunded by the European Commission within the Seventh Euratom Framework Programme that aims to improve three-dimensional (3D) nuclear medical imaging technologies significantly. MADEIRA is aiming to improve the efficacy and safety of 3D PET and SPECT functional imaging by optimising the spatial resolution and the signal-to-noise ratio, improving the knowledge of the temporal variation of the radiopharmaceuticals' uptake in and clearance from tumourous and healthy tissues, and evaluation of the corresponding patient dose. Using an optimised imaging procedure that improves the information gained per unit administered dose, MADEIRA aims especially to reduce the dose to healthy tissues of the patient. In this paper, an overall summary of the current achievements will be presented.
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ATLAS Collaboration(Aad, G. et al), Aikot, A., Amos, K. R., Aparisi Pozo, J. A., Bailey, A. J., Bouchhar, N., et al. (2024). Search for New Phenomena in Two-Body Invariant Mass Distributions Using Unsupervised Machine Learning for Anomaly Detection at root s=13 TeV with the ATLAS Detector. Phys. Rev. Lett., 132(8), 081801–23pp.
Abstract: Searches for new resonances are performed using an unsupervised anomaly-detection technique. Events with at least one electron or muon are selected from 140 fb-1 of pp collisions at p ffi s ffi= 13 TeV recorded by ATLAS at the Large Hadron Collider. The approach involves training an autoencoder on data, and subsequently defining anomalous regions based on the reconstruction loss of the decoder. Studies focus on nine invariant mass spectra that contain pairs of objects consisting of one light jet or b jet and either one lepton (e; mu), photon, or second light jet or b jet in the anomalous regions. No significant deviations from the background hypotheses are observed. Limits on contributions from generic Gaussian signals with various widths of the resonance mass are obtained for nine invariant masses in the anomalous regions.
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ATLAS Collaboration(Aad, G. et al), Amos, K. R., Aparisi Pozo, J. A., Bailey, A. J., Bouchhar, N., Cabrera Urban, S., et al. (2024). Observation of WZγ Production in pp Collisions at √s=13 TeV with the ATLAS Detector. Phys. Rev. Lett., 132(2), 021802–21pp.
Abstract: This Letter reports the observation of WZ gamma production and a measurement of its cross section using 140.1 +/- 1.2 fb(-1) of proton-proton collision data recorded at a center-of-mass energy of 13 TeV by the bosons decaying leptonically, pp -> WZ gamma -> l'(perpendicular to)nu l(+) l(-)gamma (l(')(+) = e, mu), is measured in a fiducial phasespace region defined such that the leptons and the photon have high transverse momentum and the photon is isolated. The cross section is found to be 2.01 +/- 0.30(stat) +/- 0.16(syst) fb. The corresponding standard model predicted cross section calculated at next-to-leading order in perturbative quantum chromodynamics and at leading order in the electroweak coupling constant is 1.50 +/- 0.06 fb. The observed significance of the WZ gamma signal is 6.3 sigma, compared with an expected significance of 5.0 sigma.
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ATLAS and CMS Collaborations(Aad, G. et al), Aikot, A., Amos, K. R., Aparisi Pozo, J. A., Bailey, A. J., Bouchhar, N., et al. (2024). Evidence for the Higgs Boson Decay to a Z Boson and a Photon at the LHC. Phys. Rev. Lett., 132(2), 021803–32pp.
Abstract: The first evidence for the Higgs boson decay to a Z boson and a photon is presented, with a statistical significance of 3.4 standard deviations. The result is derived from a combined analysis of the searches performed by the ATLAS and CMS Collaborations with proton -proton collision datasets collected at the CERN Large Hadron Collider (LHC) from 2015 to 2018. These correspond to integrated luminosities of around 140 fb-1 for each experiment, at a center -of -mass energy of 13 TeV. The measured signal yield is 2.2 +/- 0.7 times the standard model prediction, and agrees with the theoretical expectation within 1.9 standard deviations.
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