| |
Records |
Links |
|
Author |
NA64 Collaboration (Andreev, Y.M. et al); Molina Bueno, L.; Tuzi, M. |
|
| |
Title |
First constraints on the Lμ – Lτ explanation of the muon g-2 anomaly from NA64-e at CERN |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume  |
07 |
Issue |
7 |
Pages |
212 - 15pp |
|
| |
Keywords |
Beyond Standard Model; Fixed Target Experiments; Dark Matter |
|
| |
Abstract |
The inclusion of an additional U(1) gauge L-mu – L-tau symmetry would release the tension between the measured and the predicted value of the anomalous muon magnetic moment: this paradigm assumes the existence of a new, light Z ' vector boson, with dominant coupling to μand tau leptons and interacting with electrons via a loop mechanism. The L-mu – L-tau model can also explain the Dark Matter relic abundance, by assuming that the Z ' boson acts as a “portal” to a new Dark Sector of particles in Nature, not charged under known interactions. In this work we present the results of the Z ' search performed by the NA64-e experiment at CERN SPS, that collected similar to 9 x 10(11) 100 GeV electrons impinging on an active thick target. Despite the suppressed Z ' production yield with an electron beam, NA64-e provides the first accelerator-based results excluding the g – 2 preferred band of the Z ' parameter space in the 1 keV < m(Z ') less than or similar to 2 MeV range, in complementarity with the limits recently obtained by the NA64-mu experiment with a muon beam. |
|
| |
Address |
[Antonov, A.; Bisio, P.; Celentano, A.; Marini, A.; Marsicano, L.] INFN Sez Genova, I-16147 Genoa, Italy, Email: luca.marsicano@ge.infn.it |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001276265700010 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6218 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Agius, D.; Essig, R.; Gaggero, D.; Scarcella, F.; Suczewski, G.; Valli, M. |
|
| |
Title |
Feedback in the dark: a critical examination of CMB bounds on primordial black holes |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
|
| |
Volume |
07 |
Issue |
7 |
Pages |
003 - 36pp |
|
| |
Keywords |
accretion; cosmological parameters from CMBR; dark matter theory; primordial black holes |
|
| |
Abstract |
If present in the early universe, primordial black holes (PBHs) would have accreted matter and emitted high-energy photons, altering the statistical properties of the Cosmic Microwave Background (CMB). This mechanism has been used to constrain the fraction of dark matter that is in the form of PBHs to be much smaller than unity for PBH masses well above one solar mass. Moreover, the presence of dense dark matter mini -halos around the PBHs has been used to set even more stringent constraints, as these would boost the accretion rates. In this work, we critically revisit CMB constraints on PBHs taking into account the role of the local ionization of the gas around them. We discuss how the local increase in temperature around PBHs can prevent the dark matter mini -halos from strongly enhancing the accretion process, in some cases significantly weakening previously derived CMB constraints. We explore in detail the key ingredients of the CMB bound and derive a conservative limit on the cosmological abundance of massive PBHs. |
|
| |
Address |
[Agius, Dominic] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, E-46980 Paterna, Spain, Email: dominic.agius@ific.uv.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
IOP Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1475-7516 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001262242300001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6187 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Beltran, R.; Bolton, P.D.; Deppisch, F.F.; Hati, C.; Hirsch, M. |
|
| |
Title |
Probing heavy neutrino magnetic moments at the LHC using long-lived particle searches |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
07 |
Issue |
7 |
Pages |
153 - 44pp |
|
| |
Keywords |
Neutrino Interactions; Non-Standard Neutrino Properties; Sterile or Heavy Neutrinos; Lepton Flavour Violation (charged) |
|
| |
Abstract |
We explore long-lived particle (LLP) searches using non-pointing photons at the LHC as a probe for sterile-to-sterile and active-to-sterile transition magnetic dipole moments of sterile neutrinos. We consider heavy sterile neutrinos with masses ranging from a few GeV to several hundreds of GeV. We discuss transition magnetic dipole moments using the Standard Model effective field theory and low-energy effective field theory extended by sterile neutrinos (NRSMEFT and NRLEFT) and also provide a simplified UV-complete model example. LLP searches at the LHC using non-pointing photons will probe sterile-to-sterile dipole moments two orders of magnitude below the current best constraints from LEP, while an unprecedented sensitivity to sterile neutrino mass of about 700 GeV is expected for active-to-sterile dipole moments. For the UV model example with one-loop transition magnetic moments, the searches for charged lepton flavour violating processes in synergy with LLP searches at the LHC can probe new physics at several TeV mass scales and provide valuable insights into the lepton flavour structure of new physics couplings. |
|
| |
Address |
[Beltran, Rebeca; Hati, Chandan; Hirsch, Martin] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: rebeca.beltran@ific.uv.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001271719800003 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6217 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Centelles Chulia, S.; Herrero-Brocal, A.; Vicente, A. |
|
| |
Title |
The Type-I Seesaw family |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
07 |
Issue |
7 |
Pages |
060 - 35pp |
|
| |
Keywords |
Lepton Flavour Violation (charged); New Light Particles; Non-Standard Neutrino Properties; Specific BSM Phenomenology |
|
| |
Abstract |
We provide a comprehensive analysis of the Type-I Seesaw family of neutrino mass models, including the conventional type-I seesaw and its low-scale variants, namely the linear and inverse seesaws. We establish that all these models essentially correspond to a particular form of the type-I seesaw in the context of explicit lepton number violation. We then focus into the more interesting scenario of spontaneous lepton number violation, systematically categorizing all inequivalent minimal models. Furthermore, we identify and flesh out specific models that feature a rich majoron phenomenology and discuss some scenarios which, despite having heavy mediators and being invisible in processes such as μ-> e gamma, predict sizable rates for decays including the majoron in the final state. |
|
| |
Address |
[Centelles Chulia, Salvador] Max Planck Inst Kernphys, Saupfercheckweg 1, D-69117 Heidelberg, Germany, Email: chulia@mpi-hd.mpg.de; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001264784900001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6201 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Cepedello, R.; Esser, F.; Hirsch, M.; Sanz, V. |
|
| |
Title |
Fermionic UV models for neutral triple gauge boson vertices |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
07 |
Issue |
7 |
Pages |
275 - 28pp |
|
| |
Keywords |
Effective Field Theories; SMEFT; Specific BSM Phenomenology; Vector-Like Fermions |
|
| |
Abstract |
Searches for anomalous neutral triple gauge boson couplings (NTGCs) provide important tests for the gauge structure of the standard model. In SMEFT (“standard model effective field theory”) NTGCs appear only at the level of dimension-8 operators. While the phenomenology of these operators has been discussed extensively in the literature, renormalizable UV models that can generate these operators are scarce. In this work, we study a variety of extensions of the SM with heavy fermions and calculate their matching to d = 8 NTGC operators. We point out that the complete matching of UV models requires four different CP-conserving d = 8 operators and that the single CPC d = 8 operator, most commonly used by the experimental collaborations, does not describe all possible NTGC form factors. Despite stringent experimental constraints on NTGCs, limits on the scale of UV models are relatively weak, because their contributions are doubly suppressed (being d = 8 and 1-loop). We suggest a series of benchmark UV scenarios suitable for interpreting searches for NTGCs in the upcoming LHC runs, obtain their current limits and provide estimates for the expected sensitivity of the high-luminosity LHC. |
|
| |
Address |
[Cepedello, Ricardo] Univ Granada, Dept Fis Teor & Cosmos, Campus Fuentenueva, E-18071 Granada, Spain, Email: ricepe@ugr.es; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001282227200003 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6222 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Babak, S.; Caprini, C.; Figueroa, D.G.; Karnesis, N.; Marcoccia, P.; Nardini, G.; Pieroni, M.; Ricciardone, A.; Sesanah, A.; Torradol, J. |
|
| |
Title |
Stochastic gravitational wave background from stellar origin binary black holes in LISA |
Type |
Journal Article |
| |
Year |
2023 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
|
| |
Volume |
08 |
Issue |
8 |
Pages |
034 - 40pp |
|
| |
Keywords |
gravitational waves; experiments; sources |
|
| |
Abstract |
We use the latest constraints on the population of stellar origin binary black holes (SOBBH) from LIGO/Virgo/KAGRA (LVK) observations, to estimate the stochastic gravi-tational wave background (SGWB) they generate in the frequency band of LISA. In order to account for the faint and distant binaries, which contribute the most to the SGWB, we extend the merger rate at high redshift assuming that it tracks the star formation rate. We adopt different methods to compute the SGWB signal: we perform an analytical evaluation, we use Monte Carlo sums over the SOBBH population realisations, and we account for the role of the detector by simulating LISA data and iteratively removing the resolvable signals until only the confusion noise is left. The last method allows the extraction of both the expected SGWB and the number of resolvable SOBBHs. Since the latter are few for signal-to-noise ratio thresholds larger than five, we confirm that the spectral shape of the SGWB in the LISA band agrees with the analytical prediction of a single power law. We infer the probability dis-tribution of the SGWB amplitude from the LVK GWTC-3 posterior of the binary population model: at the reference frequency of 0.003 Hz it has an interquartile range of h(2 Omega)GW(f = 3 x 10(-3) Hz) is an element of [5.65, 11.5] x 10(-13), in agreement with most previous estimates. We then perform a MC analysis to assess LISA's capability to detect and characterise this signal. Ac-counting for both the instrumental noise and the galactic binaries foreground, with four years of data, LISA will be able to detect the SOBBH SGWB with percent accuracy, narrowing down the uncertainty on the amplitude by one order of magnitude with respect to the range of possible amplitudes inferred from the population model. A measurement of this signal by LISA will help to break the degeneracy among some of the population parameters, and pro-vide interesting constraints, in particular on the redshift evolution of the SOBBH merger rate. |
|
| |
Address |
[Torradol, Jesus] Univ Paris, CNRS, Astroparticule & Cosmol, F-75013 Paris, France, Email: stas@apc.in2p3.fr; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
IOP Publishing Ltd |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1475-7516 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001258137500008 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6177 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Maluf, R.V.; Mora-Perez, G.; Olmo, G.J.; Rubiera-Garcia, D. |
|
| |
Title |
Nonsingular, Lump-like, Scalar Compact Objects in (2+1)-Dimensional Einstein Gravity |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Universe |
Abbreviated Journal |
Universe |
|
| |
Volume |
10 |
Issue |
6 |
Pages |
258 - 13pp |
|
| |
Keywords |
Einstein gravity; compact objects; nonlinear scalar field |
|
| |
Abstract |
We study the space-time geometry generated by coupling a free scalar field with a noncanonical kinetic term to general relativity in (2+1) dimensions. After identifying a family of scalar Lagrangians that yield exact analytical solutions in static and circularly symmetric scenarios, we classify the various types of solutions and focus on a branch that yields asymptotically flat geometries. We show that the solutions within such a branch can be divided in two types, namely naked singularities and nonsingular objects without a center. In the latter, the energy density is localized around a maximum and vanishes only at infinity and at an inner boundary. This boundary has vanishing curvatures and cannot be reached by any time-like or null geodesic in finite affine time. This allows us to consistently interpret such solutions as nonsingular, lump-like, static compact scalar objects whose eventual extension to the (3+1)-dimensional context could provide structures of astrophysical interest. |
|
| |
Address |
[Maluf, Roberto V.; Olmo, Gonzalo J.] Univ Fed Ceara UFC, Dept Fis, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil, Email: r.v.maluf@fisica.ufc.br; |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Mdpi |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001256495600001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6169 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
|
| |
Title |
Search for lepton-flavour violation in high-mass dilepton final states using 139 fb-1 of pp collisions at √s=13 TeV with the ATLAS detector |
Type |
Journal Article |
| |
Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
10 |
Issue |
10 |
Pages |
082 - 50pp |
|
| |
Keywords |
Beyond Standard Model; Exotics; Flavour Physics; Hadron-Hadron Scattering |
|
| |
Abstract |
A search is performed for a heavy particle decaying into different-flavour, dilepton final states, using 139 fb(-1) of proton-proton collision data at root s = 13TeV collected in 2015-2018 by the ATLAS detector at the Large Hadron Collider. Final states with electrons, muons and hadronically decaying tau leptons are considered (e mu, e tau or μtau). No significant excess over the Standard Model predictions is observed. Upper limits on the production cross-section are set as a function of the mass of a Z' boson, a supersymmetric tau-sneutrino, and a quantum black-hole. The observed 95% CL lower mass limits obtained on a typical benchmark model Z' boson are 5.0TeV (e mu), 4.0TeV (e tau), and 3.9TeV (mu tau), respectively. |
|
| |
Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001257391700001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6192 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
ATLAS Collaboration (Aad, G. et al); Akiot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko,, M.; Escobar, C.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
|
| |
Title |
Search for magnetic monopoles and stable particles with high electric charges in √s=13 TeV pp collisions with the ATLAS detector |
Type |
Journal Article |
| |
Year |
2023 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
|
| |
Volume |
11 |
Issue |
11 |
Pages |
112 - 45pp |
|
| |
Keywords |
Beyond Standard Model; Exotics; Hadron-Hadron Scattering |
|
| |
Abstract |
We present a search for magnetic monopoles and high-electric-charge objects using LHC Run 2 root s = 13TeV proton-proton collisions recorded by the ATLAS detector. A total integrated luminosity of 138 fb(-1) was collected by a specialized trigger. No highly ionizing particle candidate was observed. Considering the Drell-Yan and photon-fusion pair production mechanisms as benchmark models, cross-section upper limits are presented for spin-0 and spin-1/2 magnetic monopoles of magnetic charge 1g(D) and 2g(D) and for high-electric-charge objects of electric charge 20 <= vertical bar z vertical bar <= 100, for masses between 200 GeV and 4000 GeV. The search improves by approximately a factor of three the previous cross-section limits on the Drell-Yan production of magnetic monopoles and high-electric charge objects. Also, the first ATLAS limits on the photon-fusion pair production mechanism of magnetic monopoles and high-electric-charge objects are obtained. |
|
| |
Address |
[Filmer, E. K.; Jackson, P.; Kong, A. X. Y.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1029-8479 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001257364300001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6185 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
|
| |
Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| |
Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
|
| |
Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
|
| |
Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
|
| |
Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
|
| |
Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Mdpi |
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
WOS:001269841000001 |
Approved |
no |
|
| |
Is ISI |
yes |
International Collaboration |
yes |
|
| |
Call Number |
IFIC @ pastor @ |
Serial |
6204 |
|
| Permanent link to this record |
