Abstract: This report summarises some of the activities of the HiggsTools initial training network working group in the period 2015-2017. The main goal of this working group was to produce a document discussing various aspects of state-of-the-art Higgs physics at the large hadron collider (LHC) in a pedagogic manner The first part of the report is devoted to a description of phenomenological searches for new physics (NP) at the LHC. All of the available studies of the couplings of the new resonance discovered in 2012 by the ATLAS and CMS experiments (Aad et al (ATLAS Collaboration) 2012 Phys. Lett. B 716 1-29; Chatrchyan et al (CMS Collaboration) 2012 Phys. Lett. B 716 30-61) conclude that it is compatible with the Higgs boson of the standard model (SM) within present precision. So far the LHC experiments have given no direct evidence for any physical phenomena that cannot be described by the SM. As the experimental measurements become more and more precise, there is a pressing need for a consistent framework in which deviations from the SM predictions can be computed precisely. Such a framework should be applicable to measurements in all sectors of particle physics, not only LHC Higgs measurements but also electroweak precision data, etc. We critically review the use of the k-framework, fiducial and simplified template cross sections, effective field theories, pseudoobservables and phenomenological Lagrangians. Some of the concepts presented here are well known and were used already at the time of the large electron-positron collider (LEP) experiment. However, after years of theoretical and experimental development, these techniques have been refined, and we describe new tools that have been introduced in order to improve the comparison between theory and experimental data. In the second part of the report, we propose Phi(eta)* as a new and complementary observable for studying Higgs boson production at large transverse momentum in the case where the Higgs boson decays to two photons. The Phi(eta)* variable depends on measurements of the angular directions and rapidities of the two Higgs decay products rather than the energies, and exploits the information provided by the calorimeter in the detector. We show that, even without tracking information, the experimental resolution for Phi(eta)* is better than that of the transverse momentum of the photon pair, particularly at low transverse momentum. We make a detailed study of the phenomenology of the Phi(eta)* variable, contrasting the behaviour with the Higgs transverse momentum distribution using a variety of theoretical tools including event generators and fixed order perturbative computations. We consider the theoretical uncertainties associated with both p TH and Phi(eta)* distributions. Unlike the transverse momentum distribution, the Phi(eta)* distribution is well predicted using the Higgs effective field theory in which the top quark is integrated out-even at large values of Phi(eta)*-thereby making this a better observable for extracting the parameters of the Higgs interaction. In contrast, the potential of the Phi(eta)* distribution as a probe of NP is rather limited, since although the overall rate is affected by the presence of additional heavy fields, the shape of the Phi(eta)* distribution is relatively insensitive to heavy particle thresholds.

Abstract: Purpose: Initial auto-adjustment of the window level WL and width WW applied to mammographic images. The proposed intensity windowing (IW) method is based on the maximization of the mutual information (MI) between a perceptual decomposition of the original 12-bit sources and their screen displayed 8-bit version. Besides zoom, color inversion and panning operations, IW is the most commonly performed task in daily screening and has a direct impact on diagnosis and the time involved in the process. Methods: The authors present a human visual system and perception-based algorithm named GRAIL (Gabor-relying adjustment of image levels). GRAIL initially measures a mammogram's quality based on the MI between the original instance and its Gabor-filtered derivations. From this point on, the algorithm performs an automatic intensity windowing process that outputs the WL/WW that best displays each mammogram for screening. GRAIL starts with the default, high contrast, wide dynamic range 12-bit data, and then maximizes the graphical information presented in ordinary 8-bit displays. Tests have been carried out with several mammogram databases. They comprise correlations and an ANOVA analysis with the manual IW levels established by a group of radiologists. A complete MATLAB implementation of GRAIL is available at . Results: Auto-leveled images show superior quality both perceptually and objectively compared to their full intensity range and compared to the application of other common methods like global contrast stretching (GCS). The correlations between the human determined intensity values and the ones estimated by our method surpass that of GCS. The ANOVA analysis with the upper intensity thresholds also reveals a similar outcome. GRAIL has also proven to specially perform better with images that contain micro-calcifications and/or foreign X-ray-opaque elements and with healthy BI-RADS A-type mammograms. It can also speed up the initial screening time by a mean of 4.5 s per image. Conclusions: A novel methodology is introduced that enables a quality-driven balancing of the WL/WW of mammographic images. This correction seeks the representation that maximizes the amount of graphical information contained in each image. The presented technique can contribute to the diagnosis and the overall efficiency of the breast screening session by suggesting, at the beginning, an optimal and customized windowing setting for each mammogram.

Abstract: PurposeA joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform calculations and comparisons with model-based dose calculation algorithms (MBDCAs). Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No. 186 (TG-186) for MBDCAs. To do so, in this work a hypothetical, generic high-dose rate (HDR) Ir-192 shielded applicator has been designed and benchmarked. MethodsA generic HDR Ir-192 shielded applicator was designed based on three commercially available gynecological applicators as well as a virtual cubic water phantom that can be imported into any DICOM-RT compatible treatment planning system (TPS). The absorbed dose distribution around the applicator with the TG-186 Ir-192 source located at one dwell position at its center was computed using two commercial TPSs incorporating MBDCAs (Oncentra((R)) Brachy with Advanced Collapsed-cone Engine, ACE, and BrachyVision ACUROS) and state-of-the-art Monte Carlo (MC) codes, including ALGEBRA, BrachyDose, egs_brachy, Geant4, MCNP6, and Penelope2008. TPS-based volumetric dose distributions for the previously reported source centered in water and source displaced test cases, and the new source centered in applicator test case, were analyzed here using the MCNP6 dose distribution as a reference. Volumetric dose comparisons of TPS results against results for the other MC codes were also performed. Distributions of local and global dose difference ratios are reported. ResultsThe local dose differences among MC codes are comparable to the statistical uncertainties of the reference datasets for the source centered in water and source displaced test cases and for the clinically relevant part of the unshielded volume in the source centered in applicator case. Larger local differences appear in the shielded volume or at large distances. Considering clinically relevant regions, global dose differences are smaller than the local ones. The most disadvantageous case for the MBDCAs is the one including the shielded applicator. In this case, ACUROS agrees with MC within [-4.2%, +4.2%] for the majority of voxels (95%) while presenting dose differences within [-0.12%, +0.12%] of the dose at a clinically relevant reference point. For ACE, 95% of the total volume presents differences with respect to MC in the range [-1.7%, +0.4%] of the dose at the reference point. ConclusionsThe combination of the generic source and generic shielded applicator, together with the previously developed test cases and reference datasets (available in the Brachytherapy Source Registry), lay a solid foundation in supporting uniform commissioning procedures and direct comparisons among treatment planning systems for HDR Ir-192 brachytherapy.

Abstract: It is assumed that the current cosmic acceleration is driven by a scalar field, the Lagrangian of which is a function of the kinetic term only, and that the luminosity distance is a given function of the red-shift. Upon comparison with baryon acoustic oscillations and cosmic microwave background data the parameters of the models are determined, and then the time evolution of the scalar field is determined by the dynamics using the cosmological equations. We find that the solution is very different than the corresponding solution when the non-relativistic matter is ignored, and that the universe enters the acceleration era at larger red-shift compared to the standard I > CDM model.

Abstract: Purpose: High dose rate (HDR) brachytherapy for treatment of small skin lesions using the Leipzig and Valencia applicators is a widely used technique. These applicators are equipped with an attachable plastic cap to be placed during fraction delivery to ensure electronic equilibrium and to prevent secondary electrons from reaching the skin surface. The purpose of this study is to report on the dosimetric impact of the cap being absent during HDR fraction delivery, which has not been explored previously in the literature. Methods: GEANT4 Monte Carlo simulations (version 10.0) have been performed for the Leipzig and Valencia applicators with and without the plastic cap. In order to validate the Monte Carlo simulations, experimental measurements using radiochromic films have been done. Results: Dose absorbed within 1 mm of the skin surface increases by a factor of 1500% for the Leipzig applicators and of 180% for the Valencia applicators. Deeper than 1 mm, the overdosage flattens up to a 10% increase. Conclusions: Differences of treating with or without the plastic cap are significant. Users must check always that the plastic cap is in place before any treatment in order to avoid overdosage of the skin. Prior to skin HDR fraction delivery, the timeout checklist should include verification of the cap placement. (C) 2016 American Association of Physicists in Medicine.