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Author |
Amaldi, U.; Bonomi, R.; Braccini, S.; Crescenti, M.; Degiovanni, A.; Garlasche, M.; Garonna, A.; Magrin, G.; Mellace, C.; Pearce, P.; Pitta, G.; Puggioni, P.; Rosso, E.; Verdu-Andres, S.; Wegner, R.; Weiss, M.; Zennaro, R. |
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Title |
Accelerators for hadrontherapy: From Lawrence cyclotrons to linacs |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume  |
620 |
Issue |
2-3 |
Pages |
563-577 |
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Keywords |
Medical accelerators; Linac; Cyclotron; Synchrotron; Cyclinac; Radiation oncology; Hadrontherapy; Particle therapy; Proton therapy; Carbon ion therapy; Dose delivery |
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Abstract |
Hadrontherapy with protons and carbon ions is a fast developing methodology in radiation oncology. The accelerators used and planned for this purpose are reviewed starting from the cyclotrons used in the thirties. As discussed in the first part of this paper, normal and superconducting cyclotrons are still employed, together with synchrotrons, for proton therapy while for carbon ion therapy synchrotrons have been till now the only option. The latest developments concern a superconducting cyclotron for carbon ion therapy, fast-cycling high frequency linacs and 'single room' proton therapy facilities. These issues are discussed in the second part of the paper by underlining the present challenges, in particular the treatment of moving organs. |
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Address |
[Amaldi, U.; Bonomi, R.; Braccini, S.; Crescenti, M.; Degiovanni, A.; Garlasche, M.; Garonna, A.; Magrin, G.; Mellace, C.; Pearce, P.; Pitta, G.; Puggioni, P.; Rosso, E.; Andres, S. Verdu; Wegner, R.; Weiss, M.; Zennaro, R.] TERA Fdn, Novara, Italy, Email: Saverio.Braccini@cern.ch |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000280601700058 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
401 |
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Author |
ATLAS Collaboration (Adragna, P. et al); Castelo, J.; Castillo Gimenez, V.; Cuenca, C.; Ferrer, A.; Fullana, E.; Gonzalez, V.; Higon-Rodriguez, E.; Poveda, J.; Ruiz, A.; Salvachua, B.; Sanchis, E.; Solans, C.; Torres, J.; Valero, A.; Valls Ferrer, J.A. |
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Title |
Measurement of pion and proton response and longitudinal shower profiles up to 20 nuclear interaction lengths with the ATLAS Tile calorimeter |
Type |
Journal Article |
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Year |
2010 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
615 |
Issue |
2 |
Pages |
158-181 |
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Keywords |
Calorimeter; Test-beam; ATLAS; Monte Carlo simulation; GEANT4; Hadronic shower development; Pion-proton response; Longitudinal shower profile for hadrons |
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Abstract |
The response of pions and protons in the energy range of 20-180 GeV, produced at CERN's SPS H8 test-beam line in the ATLAS iron-scintillator Tile hadron calorimeter, has been measured. The test-beam configuration allowed the measurement of the longitudinal shower development for pions and protons up to 20 nuclear interaction lengths. It was found that pions penetrate deeper in the calorimeter than protons. However, protons induce showers that are wider laterally to the direction of the impinging particle. Including the measured total energy response, the pion-to-proton energy ratio and the resolution, all observations are consistent with a higher electromagnetic energy fraction in pion-induced showers. The data are compared with GEANT4 simulations using several hadronic physics lists. The measured longitudinal shower profiles are described by an analytical shower parametrization within an accuracy of 5-10%. The amount of energy leaking out behind the calorimeter is determined and parametrized as a function of the beam energy and the calorimeter depth. This allows for a leakage correction of test-beam results in the standard projective geometry. |
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Address |
[Hakobyan, H.; Simonyan, M.] Yerevan Phys Inst, Yerevan 375036, Armenia, Email: Margar.Simonyan@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000276299900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
252 |
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Author |
Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Lopez, J.G.; Jimenez-Ramos, M.C.; Hueso-Gonzalez, F.; Ros, A.; Llosa, G. |
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Title |
Characterization of a Compton camera based on the TOFPET2 ASIC |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
202 |
Issue |
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Pages |
110507 - 11pp |
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Keywords |
Compton camera; Hadron therapy; LaBr3; PETsys TOFPET2; Silicon photomultipliers |
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Abstract |
The use of Compton cameras for medical imaging and its interest as a hadron therapy treatment monitoring has increased in the last decade with the development of silicon photomultipliers. MACACOp is a Compton camera prototype designed and assembled at the IRIS group of IFIC-Valencia. This Compton camera is based on monolithic Lanthanum (III) Bromide crystals and silicon photomultipliers, and employs the novel TOFPET2 ASIC as readout electronics. This system emerged as an alternative to MACACO II prototype, with the aim of improving its limited time resolution. To test the performance of the ASIC in a Compton camera setup, the prototype was characterized, both in laboratory and in-beam. A time resolution of 1.5 ns was obtained after time corrections, which improves greatly the performance of the MACACO II. Moreover, the results obtained at high photon energies demonstrate the ability of the system to obtain 1 mm displacements of the reconstructed spots. The results reinforce the potential of the system as a monitoring device for hadron therapy. |
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Address |
[Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casana, J., V; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Rita.Viegas@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Pergamon-Elsevier Science Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0969-806x |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000870840600006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5392 |
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Author |
Albaladejo, M.; Bibrzycki, L.; Dawid, S.M.; Fernandez-Ramirez, C.; Gonzalez-Solis, S.; Hiller Blin, A.N.; Jackura, A.W.; Mathieu, V.; Mikhasenko, M.; Make, V.I.; Passemar, E.; Pilloni, A.; Rodas, A.; Silva-Castro, J.A.; Smith, W.A.; Szczepaniak, A.P.; Winney, D. |
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Title |
Novel approaches in hadron spectroscopy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Progress in Particle and Nuclear Physics |
Abbreviated Journal |
Prog. Part. Nucl. Phys. |
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Volume |
127 |
Issue |
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Pages |
103981 - 75pp |
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Keywords |
Hadron spectroscopy; Exotic hadrons; Three-body scattering; Resonance production |
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Abstract |
The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy. |
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Address |
[Albaladejo, Miguel; Blin, Astrid N. Hiller; Jackura, Andrew W.; Mokeev, Victor, I; Passemar, Emilie; Rodas, Arkaitz; Szczepaniak, Adam P.] Thomas Jefferson Natl Accelerator Facil, Theory Ctr & Phys Div, Newport News, VA 23606 USA, Email: alessandro.pilloni@unime.it |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0146-6410 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000883770300003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5422 |
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Author |
Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Dendooven, P.; Garcia Lopez, J.G.; Hueso-Gonzalez, F.; Jiméeez-Ramos, M.C.; Perez-Curbelo, J.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G. |
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Title |
Gamma-ray sources imaging and test-beam results with MACACO III Compton camera |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physica Medica |
Abbreviated Journal |
Phys. Medica |
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Volume |
117 |
Issue |
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Pages |
103199 - 10pp |
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Keywords |
Hadron therapy; Compton camera; Scintillator crystals; Silicon photomultipliers |
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Abstract |
Hadron therapy is a radiotherapy modality which offers a precise energy deposition to the tumors and a dose reduction to healthy tissue as compared to conventional methods. However, methods for real-time monitoring are required to ensure that the radiation dose is deposited on the target. The IRIS group of IFIC-Valencia developed a Compton camera prototype for this purpose, intending to image the Prompt Gammas emitted by the tissue during irradiation. The system detectors are composed of Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. After an initial characterization in the laboratory, in order to assess the system capabilities for future experiments in proton therapy centers, different tests were carried out in two facilities: PARTREC (Groningen, The Netherlands) and the CNA cyclotron (Sevilla, Spain). Characterization studies performed at PARTREC indicated that the detectors linearity was improved with respect to the previous version and an energy resolution of 5.2 % FWHM at 511 keV was achieved. Moreover, the imaging capabilities of the system were evaluated with a line source of 68Ge and a point-like source of 241Am-9Be. Images at 4.439 MeV were obtained from irradiation of a graphite target with an 18 MeV proton beam at CNA, to perform a study of the system potential to detect shifts at different intensities. In this sense, the system was able to distinguish 1 mm variations in the target position at different beam current intensities for measurement times of 1800 and 600 s. |
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Address |
[Barrientos, L.; Borja-Lloret, M.; Casana, J. V.; Hueso-Gonzalez, F.; Perez-Curbelo, J.; Ros, A.; Roser, J.; Senra, C.; Viegas, R.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Luis.Barrientos@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Sci Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1120-1797 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001145147400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5892 |
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| Permanent link to this record |
