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Author Torres-Espallardo, I.; Diblen, F.; Rohling, H.; Solevi, P.; Gillam, J.; Watts, D.; Espana, S.; Vandenberghe, S.; Fiedler, F.; Rafecas, M.
Title Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring Type Journal Article
Year 2015 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.
Volume (down) 60 Issue 9 Pages N187-N208
Keywords PET; in-beam; RPC; particle therapy; TOF; range deviation; partial-ring
Abstract Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scannerbeam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options. based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron
Address [Torres-Espallardo, I.; Solevi, P.; Gillam, J.; Rafecas, M.] UV, CSIC, Inst Fis Corpuscular IFIC, E-46071 Valencia, Spain, Email: irene.torres@uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9155 ISBN Medium
Area Expedition Conference
Notes WOS:000354104700003 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2227
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Author Hueso-Gonzalez, F.; Vijande, J.; Ballester, F.; Perez-Calatayud, J.; Siebert, F.A.
Title A simple analytical method for heterogeneity corrections in low dose rate prostate brachytherapy Type Journal Article
Year 2015 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.
Volume (down) 60 Issue 14 Pages 5455-5469
Keywords brachytherapy; low dose rate; heterogeneities; prostate; calcifications
Abstract In low energy brachytherapy, the presence of tissue heterogeneities contributes significantly to the discrepancies observed between treatment plan and delivered dose. In this work, we present a simplified analytical dose calculation algorithm for heterogeneous tissue. We compare it with Monte Carlo computations and assess its suitability for integration in clinical treatment planning systems. The algorithm, named as RayStretch, is based on the classic equivalent path length method and TG-43 reference data. Analytical and Monte Carlo dose calculations using Penelope2008 are compared for a benchmark case: a prostate patient with calcifications. The results show a remarkable agreement between simulation and algorithm, the latter having, in addition, a high calculation speed. The proposed analytical model is compatible with clinical real-time treatment planning systems based on TG-43 consensus datasets for improving dose calculation and treatment quality in heterogeneous tissue. Moreover, the algorithm is applicable for any type of heterogeneities.
Address [Hueso-Gonzalez, Fernando; Vijande, Javier; Ballester, Facundo] Univ Valencia, Dept Atom Mol & Nucl Phys, E-46100 Burjassot, Spain, Email: Javier.Vijande@uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9155 ISBN Medium
Area Expedition Conference
Notes WOS:000357620400009 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2296
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Author Solevi, P.; Magrin, G.; Moro, D.; Mayer, R.
Title Monte Carlo study of microdosimetric diamond detectors Type Journal Article
Year 2015 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.
Volume (down) 60 Issue 18 Pages 7069-7083
Keywords ion-beam therapy; microdosimetry; diamonds; GATE
Abstract Ion-beam therapy provides a high dose conformity and increased radiobiological effectiveness with respect to conventional radiation-therapy. Strict constraints on the maximum uncertainty on the biological weighted dose and consequently on the biological weighting factor require the determination of the radiation quality, defined as the types and energy spectra of the radiation at a specific point. However the experimental determination of radiation quality, in particular for an internal target, is not simple and the features of ion interactions and treatment delivery require dedicated and optimized detectors. Recently chemical vapor deposition (CVD) diamond detectors have been suggested as ion-beam therapy microdosimeters. Diamond detectors can be manufactured with small cross sections and thin shapes, ideal to cope with the high fluence rate. However the sensitive volume of solid state detectors significantly deviates from conventional microdosimeters, with a diameter that can be up to 1000 times the height. This difference requires a redefinition of the concept of sensitive thickness and a deep study of the secondary to primary radiation, of the wall effects and of the impact of the orientation of the detector with respect to the radiation field. The present work intends to study through Monte Carlo simulations the impact of the detector geometry on the determination of radiation quality quantities, in particular on the relative contribution of primary and secondary radiation. The dependence of microdosimetric quantities such as the unrestricted linear energy L and the lineal energy y are investigated for different detector cross sections, by varying the particle type (carbon ions and protons) and its energy.
Address [Solevi, Paola; Magrin, Giulio; Mayer, Ramona] EBG MedAustron, A-2700 Wiener Neustadt, Austria, Email: paola.solevi@ovgu.de
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9155 ISBN Medium
Area Expedition Conference
Notes WOS:000361124000004 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2379
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Author n_TOF Collaboration (Guerrero, C. et al); Domingo-Pardo, C.; Tain, J.L.
Title Study of Photon Strength Function of Actinides: the Case of (235)U, (238)Np and (241)Pu Type Journal Article
Year 2011 Publication Journal of the Korean Physical Society Abbreviated Journal J. Korean Phys. Soc.
Volume (down) 59 Issue 2 Pages 1510-1513
Keywords Photon/Gamma strength functions; Pygmy; Scissor mode; n_TOF; Total absorption calorimeter; TAC; Neutron capture
Abstract The decay from excited levels in medium and heavy nuclei can be described in a statistical approach by means of Photon Strength Functions and Level Density distributions. The study of electromagnetic cascades following neutron capture based on the use of high efficiency detectors has been shown to be well suited for probing the properties of the Photon Strength Function of heavy (high level density) and/or radioactive (high background) nuclei. In this work we have investigated for the first time the validity of the recommended PSF of actinides, in particular (235)U, (238)Np and (241)Pu. Our study includes the search for resonance structures in the PSF below S(n) and draws conclusions regarding their existence and their characteristics in terms of energy, width and electromagnetic nature.
Address [Guerrero, C; Alvarez-Velarde, F; Ano-Ott, DC; Martinez, T; Mendoza, E; Villamarin, D] Ctr Invest Energet Medioambientales & Technol CIE, Madrid, Spain, Email: carlos.guerrero@ciemat.es
Corporate Author Thesis
Publisher Korean Physical Soc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0374-4884 ISBN Medium
Area Expedition Conference
Notes WOS:000294080700013 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 731
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Author Yoshida, T.; Hagura, N.; Umezu, R.; Algora, A.; Tain, J.L.; Jordan, D.; Tachibana, T.
Title Impact of TAGS Measurement on FP Decay Data and Decay Heat Calculations Type Journal Article
Year 2011 Publication Journal of the Korean Physical Society Abbreviated Journal J. Korean Phys. Soc.
Volume (down) 59 Issue 2 Pages 1543-1546
Keywords Fission product; Decay data; JENDL; Beta decay; TAGS; Gross theory; Pandemonium
Abstract Nuclear level schemes are usually constructed from the high-resolution data of the gamma-ray transitions which immediately follow the beta-decay of their parents. It is recognized that this procedure may lead to the “pandemonium problem”. If we use the decay data suffering from the pandemonium problem for the decay heat calculations the beta-ray component will be overestimated and the gamma-ray component underestimated. The beta-feeding data obtained by the total absorption gamma-ray spectroscopy (TAGS) is proved to be free from this problem. In the case of the Japanese data base for the FP decay heat calculation, the theoretical values based on the gross theory of beta-decay are widely introduced to circumvent the pandemonium problem. The gross theory, however, is not good at describing any beta-transition exclusively concentrating to a single level in the daughter nucleus. The TAGS method is also proved to be able to save this situation. Further, we have to change our comprehension over the currently published decay schemes.
Address [Yoshida, T; Hagura, N; Umezu, R] Tokyo City Univ, Fac Engn, Tokyo 1585778, Japan, Email: tyoshida@tcu.ac.jp
Corporate Author Thesis
Publisher Korean Physical Soc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0374-4884 ISBN Medium
Area Expedition Conference
Notes WOS:000294080700022 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 732
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Author Piersanti, L.; Bellini, F.; Bini, F.; Collamati, F.; De Lucia, E.; Durante, M.; Faccini, R.; Ferroni, F.; Fiore, S.; Iarocci, E.; La Tessa, C.; Marafini, M.; Mattei, I.; Patera, V.; Ortega, P.G.; Sarti, A.; Schuy, C.; Sciubba, A.; Vanstalle, M.; Voena, C.
Title Measurement of charged particle yields from PMMA irradiated by a 220 MeV/u C-12 beam Type Journal Article
Year 2014 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.
Volume (down) 59 Issue 7 Pages 1857-1872
Keywords drift chamber; LYSO; hadrontherapy; carbon ion beam; dose monitoring
Abstract The radiation used in hadrontherapy treatments interacts with the patient body producing secondary particles, either neutral or charged, that can be used for dose and Bragg peak monitoring and to provide a fast feedback on the treatment plans. Recent results obtained from the authors on simplified setups (mono-energetic primary beams interacting with homogeneous tissue like target) have already indicated the correlation that exists between the flux of these secondaries coming from the target (e.g. protons and photons) and the position of the primary beam Bragg peak. In this paper, the measurements of charged particle fluxes produced by the interaction of a 220 MeV/u carbon ion beam at GSI, Darmstadt, with a polymethyl methacrylate target are reported. The emission region of protons (p), deuterons (d) and tritons (t) has been characterized using a drift chamber while the particle time-of-flight, used to compute the kinetic energy spectra, was measured with a LYSO scintillator.The energy released in the LYSO crystal was used for particle identification purposes. The measurements were repeated with the setup at 60 degrees and 90 degrees with respect to the primary beam direction. The accuracy on the fragments emission profile reconstruction and its relationship with the Bragg peak position have been studied. Based on the acquired experimental evidence, a method to monitor the dose profile and the position of the Bragg peak inside the target is proposed.
Address [Piersanti, L.; De Lucia, E.; Iarocci, E.; Mattei, I.; Sarti, A.] Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy, Email: vincenzo.patera@lnf.infn.it
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9155 ISBN Medium
Area Expedition Conference
Notes WOS:000333186200020 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 1735
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Author ANTARES Collaboration (van Haren, H. et al); Aguilar, J.A.; Bigongiari, C.; Dornic, D.; Emanuele, U.; Gomez-Gonzalez, J.P.; Hernandez-Rey, J.J.; Mangano, S.; Salesa, F.; Toscano, S.; Yepes, H.; Zornoza, J.D.; Zuñiga, J.
Title Acoustic and optical variations during rapid downward motion episodes in the deep north-western Mediterranean Sea Type Journal Article
Year 2011 Publication Deep-Sea Research Part I-Oceanographic Research Papers Abbreviated Journal Deep-Sea Res. Part I-Oceanogr. Res. Pap.
Volume (down) 58 Issue 8 Pages 875-884
Keywords Acoustic ADCP observations; Optical photo-multiplier observations; Deep Mediteranean; ANTARES neutrino telescope; Episodic downward current; Bioluminescence; Dense water formation; Northern boundary current
Abstract An Acoustic Doppler Current Profiler (ADCP) was moored at the deep-sea site of the ANTARES neutrino telescope near Toulon, France, thus providing a unique opportunity to compare high-resolution acoustic and optical observations between 70 and 170 m above the sea bed at 2475 m. The ADCP measured downward vertical currents of magnitudes up to 0.03 m s(-1) in late winter and early spring 2006. In the same period, observations were made of enhanced levels of acoustic reflection, interpreted as suspended particles including zooplankton, by a factor of about 10 and of horizontal currents reaching 0.35 m s(-1). These observations coincided with high light levels detected by the telescope, interpreted as increased bioluminescence. During winter 2006 deep dense-water formation occurred in the Ligurian subbasin, thus providing a possible explanation for these observations. However, the 10-20 days quasi-periodic episodes of high levels of acoustic reflection, light and large vertical currents continuing into the summer are not direct evidence of this process. It is hypothesized that the main process allowing for suspended material to be moved vertically later in the year is local advection, linked with topographic boundary current instabilities along the rim of the 'Northern Current'.
Address [van Haren, H] Royal Netherlands Inst Sea Res NIOZ, NL-1797 SZ T Horntje, Texel, Netherlands, Email: hans.van.haren@nioz.nl
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0967-0637 ISBN Medium
Area Expedition Conference
Notes WOS:000295115400006 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 770
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Author Bouhova-Thacker, E.; Kostyukhin, V.; Koffas, T.; Liebig, W.; Limper, M.; Piacquadio, G.N.; Prokofiev, K.; Weiser, C.; Wildauer, A.
Title Expected Performance of Vertex Reconstruction in the ATLAS Experiment at the LHC Type Journal Article
Year 2010 Publication IEEE Transactions on Nuclear Science Abbreviated Journal IEEE Trans. Nucl. Sci.
Volume (down) 57 Issue 2 Pages 760-767
Keywords Data analysis; data reconstruction; high energy physics; pattern recognition; reconstruction algorithms; tracking; vertex detectors
Abstract In the harsh environment of the Large Hadron Collider at CERN (design luminosity of 10(34) cm(-2) s(-1)) efficient reconstruction of vertices is crucial for many physics analyses. Described in this paper is the expected performance of the vertex reconstruction used in the ATLAS experiment. The algorithms for the reconstruction of primary and secondary vertices as well as for finding photon conversions and vertex reconstruction in jets are described. The implementation of vertex algorithms which follows a very modular design based on object-oriented C++ is presented. A user-friendly concept allows event reconstruction and physics analyses to compare and optimize their choice among different vertex reconstruction strategies. The performance of implemented algorithms has been studied on a variety of Monte Carlo samples and results are presented.
Address [Bouhova-Thacker, Eva] Univ Lancaster, Lancaster LA1 4YB, England, Email: bouhova@mail.cern.ch
Corporate Author Thesis
Publisher Ieee-Inst Electrical Electronics Engineers Inc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0018-9499 ISBN Medium
Area Expedition Conference
Notes ISI:000276679200006 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 260
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Author Belver, D.; Cabanelas, P.; Castro, E.; Garzon, J.A.; Gil, A.; Gonzalez-Diaz, D.; Koenig, W.; Traxler, M.
Title Performance of the Low-Jitter High-Gain/Bandwidth Front-End Electronics of the HADES tRPC Wall Type Journal Article
Year 2010 Publication IEEE Transactions on Nuclear Science Abbreviated Journal IEEE Trans. Nucl. Sci.
Volume (down) 57 Issue 5 Pages 2848-2856
Keywords Charge to width algorithm; fast amplifying and digitizing electronics; front-end electronics; HADES; time of flight; timing RPC
Abstract A front-end electronics (FEE) chain for accurate time measurements has been developed for the new Resistive Plate Chamber (RPC)-based Time-of-Flight (TOF) wall of the High Acceptance Di-Electron Spectrometer (HADES). The wall covers an area of around 8 m(2) divided in 6 sectors. In total, 1122 4-gap timing RPC cells are read-out by 2244 time and charge sensitive channels. The FEE chain consists of 2 custom-made boards: a 4-channel Daughter BOard(DBO) and a 32-channel MotherBOard (MBO). The DBO uses a fast 2 GHz amplifier feeding a dual high-speed discriminator. The time and charge information are encoded, respectively, in the leading edge and the width of an LVDS signal. Each MBO houses up to 8 DBOs providing them regulated voltage supply, threshold values via DACs, test signals and, additionally, routing out a signal proportional to the channel multiplicity needed for a 1st level trigger decision. The MBO delivers LVDS signals to a multi-purpose Trigger Readout Board (TRB) for data acquisition. The FEE allows achieving a system resolution around 75 ps fulfilling comfortably the requirements of the HADES upgrade [1]. The commissioning of the whole RPC wall is finished and the 6 sectors are already mounted in their final position in the HADES spectrometer and ready to take data during the beam-times foreseen for 2010.
Address [Belver, Daniel; Cabanelas, P.; Castro, E.; Garzon, J. A.] Univ Santiago Compostela, LabCAF, Santiago De Compostela 15782, Spain, Email: daniel.belver@usc.es
Corporate Author Thesis
Publisher Ieee-Inst Electrical Electronics Engineers Inc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0018-9499 ISBN Medium
Area Expedition Conference
Notes ISI:000283440400007 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 349
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Author Verdu-Andres, S.; Amaldi, U.; Faus-Golfe, A.
Title CABOTO, a high-gradient linac for hadrontherapy Type Journal Article
Year 2013 Publication Journal of Radiation Research Abbreviated Journal J. Radiat. Res.
Volume (down) 54 Issue Pages 155-161
Keywords hadrontherapy; high-gradient linac; cyclinac; carbon ion therapy; multipainting
Abstract The field of hadrontherapy has grown rapidly in recent years. At present the therapeutic beam is provided by a cyclotron or a synchrotron, but neither cyclotrons nor synchrotrons present the best performances for hadrontherapy. The new generation of accelerators for hadrontherapy should allow fast active energy modulation and have a high repetition rate, so that moving organs can be appropriately treated in a reasonable time. In addition, a reduction of the dimensions and cost of the accelerators for hadrontherapy would make the acquisition and operation of a hadrontherapy facility more affordable, which would translate into great benefits for the potential hadrontherapy patients. The 'cyclinac', an accelerator concept that combines a cyclotron with a high-frequency linear accelerator (linac), is a fast-cycling machine specifically conceived to allow for fast active energy modulation. The present paper focuses on CABOTO (CArbon BOoster for Therapy in Oncology), a compact, efficient high-frequency linac that can accelerate C6+ ions and H-2 molecules from 150-410 MeV/u in similar to 24 m. The paper presents the latest design of CABOTO and discusses its performances.
Address [Verdu-Andres, Silvia; Amaldi, Ugo] Fdn Tera, I-28100 Novara, Italy, Email: sverdu@bnl.gov
Corporate Author Thesis
Publisher Oxford Univ Press Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0449-3060 ISBN Medium
Area Expedition Conference
Notes WOS:000321463900021 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 1506
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