Abstract: Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice.

Abstract: We provide three Fortran programs which evaluate the QCD analytic (holomorphic) couplings A(v)(Q(2)) for complex or real squared momenta Q(2). These couplings are holomorphic analogs of the powers a(Q(2))(v) of the underlying perturbative QCD (pQCD) coupling a(Q(2)) equivalent to alpha(s)(Q(2))/pi, in three analytic QCD models (anQCD): Fractional Analytic Perturbation Theory (FAPT), Two-delta analytic QCD (2 delta anQCD), and Massive Perturbation Theory (MPT). The index v can be noninteger. The provided programs do basically the same job as the Mathematica package anQCD.m published by us previously (Ayala and Cvetic, 2015), but are now written in Fortran. Program summary Program title: AanQCDext Catalogue identifier: AEYKv10 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEYICv1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 12105 No. of bytes in distributed program, including test data, etc.: 98822 Distribution format: tar.gz Programming language: Fortran. Computer: Any work-station or PC where Fortran 95/200312008 (gfortran) is running. Operating system: Operating system Linux (Ubuntu and Scientific Linux), Windows (in all cases using gfortran). Classification: 11.1, 11.5. Nature of problem: Calculation of values of the running analytic couplings A(v)(Q(2); N-f) for general complex squared momenta Q(2) equivalent to -q(2), in three analytic QCD models, where A(v)(Q(2); N-f) is the analytic (holomorphic) analog of the power (alpha(s)(Q(2); N-f)/pi)(v). Here, A(v)(Q(2); N-f) is a holomorphic function in the Q(2) complex plane, with the exception of the negative semiaxis (-infinity, -M-thr(2)], reflecting the analyticity properties of the spacelike renormalization invariant quantities D(Q(2)) in QCD. In contrast, the perturbative QCD power (alpha(s)(Q(2); N-f)/pi)(v) has singularities even outside the negative semiaxis (Landau ghosts). The three considered models are: Analytic Perturbation theory (APT); Two-delta analytic QCD (2 delta anQCD); Massive Perturbation Theory (MPT). We refer to Ref. [1] for more details and literature. Solution method: The Fortran programs for FAPT and 2 delta anQCD models contain routines and functions needed to perform two-dimensional numerical integrations involving the spectral function, in order to evaluate A(v)(Q(2)) couplings. In MPT model, one-dimensional numerical integration involving A(1)(Q(2)) is sufficient to evaluate any A(v)(Q(2)) coupling. Restrictions: For unphysical choices of the input parameters the results are meaningless. When Q(2) is close to the cut region of the couplings (Q(2) real negative), the calculations can take more time and can have less precision. Running time: For evaluation of a set of about 10 related couplings, the times vary in the range t similar to 10(1)-10(2) s. MPT requires less time, t similar to 1-10(1) s. References: [1] C. Ayala and G. Cvetic, anQCD: a Mathematica package for calculations in general analytic QCD models, Comput. Phys. Commun. 190 (2015) 182.

Abstract: The vast majority of radiotherapy departments in Europe using brachytherapy (BT) perform temporary implants of high-or pulsed-dose rate (HDR-PDR) sources with photon energies higher than 50 keV. Such techniques are successfully applied to diverse pathologies and clinical scenarios. These recommen-dations are the result of Working Package 21 (WP-21) initiated within the BRAchytherapy PHYsics Quality Assurance System (BRAPHYQS) GEC-ESTRO working group with a focus on HDR-PDR source cal-ibration. They provide guidance on the calibration of such sources, including practical aspects and issues not specifically accounted for in well-accepted societal recommendations, complementing the BRAPHYQS WP-18 Report dedicated to low energy BT photon emitting sources (seeds). The aim of this report is to provide a European-wide standard in HDR-PDR BT source calibration at the hospital level to maintain high quality patient treatments.

Abstract: The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy.

Abstract: Purpose: The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J -PET) scanner for intra-treatment proton beam range monitoring. Methods: The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J -PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread -Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J -PET scanner prototype dedicated to the proton beam range assessment. Results: The investigations indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10-5 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple -layer dual -head geometry. The results indicate that the double -layer cylindrical and triple -layer double -head configurations are the most promising for the clinical application, Conclusions: We performed simulation studies demonstrating that the feasibility of the J -PET detector for PET -based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre -clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double -layer cylindrical and triple -layer dual -head J -PET geometry configurations seem promising for future clinical application.