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Author Linhart, V.; Burdette, D.; Chessi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Honscheid, K.; Kagan, H.; Lacasta, C.; Llosa, G.; Mikuz, M.; Stankova, V.; Studen, A.; Weilhammer, P.; Zontar, D.
Title Spectroscopy study of imaging devices based on silicon Pixel Array Detector coupled to VATAGP7 read-out chips Type Journal Article
Year 2011 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 6 Issue Pages C01092 - 8pp
Keywords Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Compton imaging
Abstract Spectroscopic and timing response studies have been conducted on a detector module consisting of a silicon Pixel Array Detector bonded on two VATAGP7 read-out chips manufactured by Gamma-Medica Ideas using laboratory gamma sources and the internal calibration facilities (the calibration system of the read-out chips). The performed tests have proven that the chips have (i) non-linear calibration curves which can be approximated by power functions, (ii) capability to measure the energy of photons with energy resolution better than 2 keV (exact range and resolution depend on experimental setup), (iii) the internal calibration facility which provides 6 out of 16 available internal calibration charges within our region of interest (spanning the Compton edge of 511 keV photons). The peaks induced by the internal calibration facility are suitable for a fit of the calibration curves. However, they are not suitable for measurements of equivalent noise charge because their full width at half maximum varies with their amplitude. These facts indicate that the VATAGP7 chips are useful and precise tools for a wide variety of spectroscopic devices. We have also explored time walk of the module and peaking time of the spectroscopy signals provided by the chips. We have observed that (iv) the time walk is caused partly by the peaking time of the signals provided by the fast shaper of the chips and partly by the timing uncertainty related to the varying position of the photon interaction, (v) the peaking time of the spectroscopy signals provided by the chips increases with increasing pulse height.
Address [Linhart, V.; Lacasta, C.; Llosa, G.; Stankova, V.] UVEG, CSIC, IFIC, Expt Phys Dept,Inst Fis Corpuscular, E-46071 Valencia, Spain, Email: Vladimir.Linhart@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes ISI:000291345600097 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 645
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Author Ros, A.; Lerche, C.W.; Sebastia, A.; Sanchez, F.; Benlloch, J.M.
Title Retroreflector arrays for better light collection efficiency of gamma-ray imaging detectors with continuous scintillation crystals without DOI misestimation Type Journal Article
Year 2014 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 9 Issue Pages P04009 - 14pp
Keywords Gamma detectors (scintillators, CZT, HPG, HgI etc); Interaction of radiation with matter; Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Detector design and construction technologies and materials
Abstract A method to improve light collection efficiency of gamma-ray imaging detectors by using retroreflector arrays has been tested, simulations of the behaviour of the scintillation light illuminating the retroreflector surface have been made. Measurements including retroreflector arrays in the setup have also been taken. For the measurements, positron emission tomography (PET) detectors with continuous scintillation crystals have been used. Each detector module consists of a continuous LSO-scintillator of dimensions 49x49x10 mm(3) and a H8500 position-sensitive photo-multiplier (PSPMT) from Hamamatsu. By using a continuous scintillation crystal, the scintillation light distribution has not been destroyed and the energy, the centroids along the x- and y-direction and the depth of interaction (DOI) can be estimated. Simulations have also been run taking into account the use of continuous scintillation crystals. Due to the geometry of the continuous scintillation crystals in comparison with pixelated crystals, a good light collection efficiency is necessary to correctly reconstruct the impact point of the gamma-ray. The aim of this study is to investigate whether micro-machine retro-reflectors improve light yield without misestimation of the impact point. The results shows an improvement on the energy and centroid resolutions without worsening the depth of interaction resolution. Therefore it can be concluded that using retroreflector arrays at the entrance side of the scintillation crystal improves light collection efficiency without worsening the impact point estimation.
Address [Ros, A.] Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: anrogar2@i3m.upv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000336123800049 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 1798
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Author Brzezinski, K.; Oliver, J.F.; Gillam, J.; Rafecas, M.; Studen, A.; Grkovski, M.; Kagan, H.; Smith, S.; Llosa, G.; Lacasta, C.; Clinthorne, N.H.
Title Experimental evaluation of the resolution improvement provided by a silicon PET probe Type Journal Article
Year 2016 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 11 Issue Pages P09016 - 13pp
Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Medical-image reconstruction methods and algorithms; computer-aided software
Abstract A high-resolution PET system, which incorporates a silicon detector probe into a conventional PET scanner, has been proposed to obtain increased image quality in a limited region of interest. Detailed simulation studies have previously shown that the additional probe information improves the spatial resolution of the reconstructed image and increases lesion detectability, with no cost to other image quality measures. The current study expands on the previous work by using a laboratory prototype of the silicon PET-probe system to examine the resolution improvement in an experimental setting. Two different versions of the probe prototype were assessed, both consisting of a back-to-back pair of 1-mm thick silicon pad detectors, one arranged in 32 x 16 arrays of 1.4mm x 1.4mm pixels and the other in 40 x 26 arrays of 1.0mm x 1.0mm pixels. Each detector was read out by a set of VATAGP7 ASICs and a custom-designed data acquisition board which allowed trigger and data interfacing with the PET scanner, itself consisting of BGO block detectors segmented into 8 x 6 arrays of 6mm x 12mm x 30mm crystals. Limited-angle probe data was acquired from a group of Na-22 point-like sources in order to observe the maximum resolution achievable using the probe system. Data from a Derenzo-like resolution phantom was acquired, then scaled to obtain similar statistical quality as that of previous simulation studies. In this case, images were reconstructed using measurements of the PET ring alone and with the inclusion of the probe data. Images of the Na-22 source demonstrated a resolution of 1.5mm FWHM in the probe data, the PET ring resolution being approximately 6 mm. Profiles taken through the image of the Derenzo-like phantom showed a clear increase in spatial resolution. Improvements in peak-to-valley ratios of 50% and 38%, in the 4.8mm and 4.0mm phantom features respectively, were observed, while previously unresolvable 3.2mm features were brought to light by the addition of the probe. These results support the possibility of improving the image resolution of a clinical PET scanner using the silicon PET-probe.
Address [Brzezinski, K.; Oliver, J. F.; Gillam, J.; Rafecas, M.; Llosa, G.; Lacasta, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Valencia, Spain, Email: k.w.brzezinski@rug.nl
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000387862300016 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2865
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.; Monrabal, F.; Rodriguez, J.; Toledo, J.F.
Title Investigation of the coincidence resolving time performance of a PET scanner based on liquid xenon: a Monte Carlo study Type Journal Article
Year 2016 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 11 Issue Pages P09011 - 18pp
Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Instrumentation and methods for time-of-flight (TOF) spectroscopy; Noble liquid detectors (scintillation ionization, double-phase); Scintillators; scintillation and light emission processes (solid, gas and liquid scintillators)
Abstract The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the coincidence resolving time (CRT) of the gammas is sufficiently good. The best commercial PET-TOF system today (based in LYSO crystals and digital SiPMs), is the VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper we present a Monte Carlo investigation of the CRT performance of a PET scanner exploiting the scintillating properties of liquid xenon. We find that an excellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained if the scanner is instrumented with silicon photomultipliers (SiPMs) sensitive to the ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can be obtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMs coated with a suitable wavelength shifter. These results show the excellent time of flight capabilities of a PET device based in liquid xenon.
Address [Gomez-Cadenas, J. J.; Benlloch-Rodriguez, J. M.; Ferrario, P.; Rodriguez, J.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, Valencia 46980, Spain, Email: paola.ferrario@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000387862300011 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2866
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.
Title Monte Carlo study of the coincidence resolving time of a liquid xenon PET scanner, using Cherenkov radiation Type Journal Article
Year 2017 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 12 Issue Pages P08023 - 13pp
Keywords Cherenkov and transition radiation; Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Noble liquid detectors (scintillation, ionization, double-phase); Photon detectors for UV; visible and IR photons (solid-state) (PIN diodes, APDs, Si-PMTs, G-APDs, CCDs, EBCCDs, EMCCDs etc)
Abstract In this paper we use detailed Monte Carlo simulations to demonstrate that liquid xenon (LXe) can be used to build a Cherenkov-based TOF-PET, with an intrinsic coincidence resolving time (CRT) in the vicinity of 10 ps. This extraordinary performance is due to three facts: a) the abundant emission of Cherenkov photons by liquid xenon; b) the fact that LXe is transparent to Cherenkov light; and c) the fact that the fastest photons in LXe have wavelengths higher than 300 nm, therefore making it possible to separate the detection of scintillation and Cherenkov light. The CRT in a Cherenkov LXe TOF-PET detector is, therefore, dominated by the resolution (time jitter) introduced by the photosensors and the electronics. However, we show that for sufficiently fast photosensors (e.g, an overall 40 ps jitter, which can be achieved by current micro-channel plate photomultipliers) the overall CRT varies between 30 and 55 ps, depending on the detection efficiency. This is still one order of magnitude better than commercial CRT devices and improves by a factor 3 the best CRT obtained with small laboratory prototypes.
Address [Ferrario, P.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, Valencia 46980, Spain, Email: paola.ferrario@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000414160300006 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 3347
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Author Renner, J. et al; Romo-Luque, C.; Carrion, J.V.; Diaz, J.; Martinez, A.; Querol, M.; Rodriguez-Ponce, J.; Teruel-Pardo, S.
Title Monte Carlo characterization of PETALO, a full-body liquid xenon-based PET detector Type Journal Article
Year 2022 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume (up) 17 Issue 5 Pages P05044 - 17pp
Keywords Cryogenic detectors; Gamma camera; SPECT; PET PET; CT; coronary CT angiography (CTA); Liquid detectors
Abstract New detector approaches in Positron Emission Tomography imaging will play an important role in reducing costs, lowering administered radiation doses, and improving overall performance. PETALO employs liquid xenon as the active scintillating medium and UV-sensitive silicon photomultipliers for scintillation readout. The scintillation time in liquid xenon is fast enough to register time-of-flight information for each detected coincidence, and sufficient scintillation is produced with low enough fluctuations to obtain good energy resolution. The present simulation study examines a full-body-sized PETALO detector and evaluates its potential performance in PET image reconstruction.
Address [Romo-Luque, C.; Carrion, J. V.; Diaz, J.; Martinez, A.; Querol, M.; Rodriguez-Ponce, J.; Teruel-Pardo, S.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, E-46980 Valencia, Spain, Email: paola.ferrario@dipc.org
Corporate Author Thesis
Publisher IOP Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000811102400010 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 5264
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Author Blume, M.; Martinez-Moller, A.; Keil, A.; Navab, N.; Rafecas, M.
Title Joint Reconstruction of Image and Motion in Gated Positron Emission Tomography Type Journal Article
Year 2010 Publication IEEE Transactions on Medical Imaging Abbreviated Journal IEEE Trans. Med. Imaging
Volume (up) 29 Issue 11 Pages 1892-1906
Keywords Gating; motion compensation; positron emission tomography (PET); reconstruction
Abstract We present a novel intrinsic method for joint reconstruction of both image and motion in positron emission tomography (PET). Intrinsic motion compensation methods exclusively work on the measured data, without any external motion measurements. Most of these methods separate image from motion estimation: They use deformable image registration/optical flow techniques in order to estimate the motion from individually reconstructed gates. Then, the image is estimated based on this motion information. With these methods, a main problem lies in the motion estimation step, which is based on the noisy gated frames. The more noise is present, the more inaccurate the image registration becomes. As we show both visually and quantitatively, joint reconstruction using a simple deformation field motion model can compete with state-of-the-art image registration methods which use robust multilevel B-spline motion models.
Address [Blume, Moritz; Rafecas, Magdalena] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: moritz.blume@cs.tum.edu
Corporate Author Thesis
Publisher Ieee-Inst Electrical Electronics Engineers Inc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0278-0062 ISBN Medium
Area Expedition Conference
Notes ISI:000283941800007 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ elepoucu @ Serial 340
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Author Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V.
Title Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT Type Journal Article
Year 2014 Publication Nuclear Medicine Communications Abbreviated Journal Nucl. Med. Commun.
Volume (up) 35 Issue 5 Pages 446-452
Keywords breast cancer; F-18-FDG; heterogeneity; MAMMI; PET
Abstract PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies.
Address [Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl
Corporate Author Thesis
Publisher Lippincott Williams & Wilkins Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0143-3636 ISBN Medium
Area Expedition Conference
Notes WOS:000334103800002 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 1763
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Author Aguiar, P.; Rafecas, M.; Ortuño, J.E.; Kontaxakis, G.; Santos, A.; Pavia, J.; Rosetti, M.
Title Geometrical and Monte Carlo projectors in 3D PET reconstruction Type Journal Article
Year 2010 Publication Medical Physics Abbreviated Journal Med. Phys.
Volume (up) 37 Issue 11 Pages 5691-5702
Keywords 3D PET; iterative reconstruction; list-mode reconstruction; ray-tracing techniques; Monte Carlo simulation; system response matrix
Abstract Purpose: In the present work, the authors compare geometrical and Monte Carlo projectors in detail. The geometrical projectors considered were the conventional geometrical Siddon ray-tracer (S-RT) and the orthogonal distance-based ray-tracer (OD-RT), based on computing the orthogonal distance from the center of image voxel to the line-of-response. A comparison of these geometrical projectors was performed using different point spread function (PSF) models. The Monte Carlo-based method under consideration involves an extensive model of the system response matrix based on Monte Carlo simulations and is computed off-line and stored on disk. Methods: Comparisons were performed using simulated and experimental data of the commercial small animal PET scanner rPET. Results: The results demonstrate that the orthogonal distance-based ray-tracer and Siddon ray-tracer using PSF image-space convolutions yield better images in terms of contrast and spatial resolution than those obtained after using the conventional method and the multiray-based S-RT. Furthermore, the Monte Carlo-based method yields slight improvements in terms of contrast and spatial resolution with respect to these geometrical projectors. Conclusions: The orthogonal distance-based ray-tracer and Siddon ray-tracer using PSF image-space convolutions represent satisfactory alternatives to factorizing the system matrix or to the conventional on-the-fly ray-tracing methods for list-mode reconstruction, where an extensive modeling based on Monte Carlo simulations is unfeasible.
Address [Aguiar, Pablo] Univ Santiago de Compostela, Dept Fis Particulas, Complexo Hosp Univ Santiago de Compostela, Fdn IDICHUS IDIS, Santiago De Compostela, Spain, Email: pablo.aguiar.fernandez@sergas.es
Corporate Author Thesis
Publisher Amer Assoc Physicists Medicine Amer Inst Physics Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0094-2405 ISBN Medium
Area Expedition Conference
Notes ISI:000283747600015 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ elepoucu @ Serial 338
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Author Tarifeño-Saldivia, A.; Soto, L.
Title Effects of gas chamber geometry and gas flow on the neutron production in a fast plasma focus neutron source Type Journal Article
Year 2014 Publication Plasma Physics and Controlled Fusion Abbreviated Journal Plasma Phys. Control. Fusion
Volume (up) 56 Issue 12 Pages 125013 - 5pp
Keywords pulsed neutron source; repetitive plasma focus; neutron yield measurement; fast plasma focus
Abstract This work reports that gas chamber geometry and gas flow management substantially affect the neutron production of a repetitive fast plasma focus. The gas flow rate is the most sensitive parameter. An appropriate design of the gas chamber combined with a suitable flow-rate management can lead to improvements in the neutron production of one order of magnitude working in a fast repetitive mode.
Address [Tarifeno-Saldivia, Ariel; Soto, Leopoldo] Comis Chilena Energia Nucl CCHEN, Santiago, Chile, Email: atarisal@gmail.com;
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0741-3335 ISBN Medium
Area Expedition Conference
Notes WOS:000346926300024 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2070
Permanent link to this record