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Records |
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Author |
Cabello, J.; Wells, K. |
![find record details (via OpenURL) openurl](img/xref.gif)
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Title |
The spatial resolution of silicon-based electron detectors in beta-autoradiography |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
55 |
Issue |
6 |
Pages |
1677-1699 |
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Keywords |
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Abstract |
Thin tissue autoradiography is an imaging modality where ex-vivo tissue sections are placed in direct contact with autoradiographic film. These tissue sections contain a radiolabelled ligand bound to a specific biomolecule under study. This radioligand emits beta- or beta+ particles ionizing silver halide crystals in the film. High spatial resolution autoradiograms are obtained using low energy radioisotopes, such as H-3 where an intrinsic 0.1-1 μm spatial resolution can be achieved. Several digital alternatives have been presented over the past few years to replace conventional film but their spatial resolution has yet to equal film, although silicon-based imaging technologies have demonstrated higher sensitivity compared to conventional film. It will be shown in this work how pixel size is a critical parameter for achieving high spatial resolution for low energy uncollimated beta imaging. In this work we also examine the confounding factors impeding silicon-based technologies with respect to spatial resolution. The study considers charge diffusion in silicon and detector noise, and this is applied to a range of radioisotopes typically used in autoradiography. Finally an optimal detector geometry to obtain the best possible spatial resolution for a specific technology and a specific radioisotope is suggested. |
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Address |
[Cabello, Jorge; Wells, Kevin] Univ Surrey, Fac Elect & Phys Sci, Ctr Vis Speech & Signal Proc, Surrey GU2 7XH, England, Email: jcabello@ific.uv.es |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
ISI:000275120300010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
489 |
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Permanent link to this record |
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Author |
Llosa, G.; Barrio, J.; Lacasta, C.; Bisogni, M.G.; Del Guerra, A.; Marcatili, S.; Barrillon, P.; Bondil-Blin, S.; de la Taille, C.; Piemonte, C. |
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Title |
Characterization of a PET detector head based on continuous LYSO crystals and monolithic, 64-pixel silicon photomultiplier matrices |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
55 |
Issue |
23 |
Pages |
7299-7315 |
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Keywords |
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Abstract |
The characterization of a PET detector head based on continuous LYSO crystals and silicon photomultiplier (SiPM) arrays as photodetectors has been carried out for its use in the development of a small animal PET prototype. The detector heads are composed of a continuous crystal and a SiPM matrix with 64 pixels in a common substrate, fabricated specifically for this project. Three crystals of 12 mm x 12 mm x 5 mm size with different types of painting have been tested: white, black and black on the sides but white on the back of the crystal. The best energy resolution, obtained with the white crystal, is 16% FWHM. The detector response is linear up to 1275 keV. Tests with different position determination algorithms have been carried out with the three crystals. The spatial resolution obtained with the center of gravity algorithm is around 0.9 mm FWHM for the three crystals. As expected, the use of this algorithm results in the displacement of the reconstructed position toward the center of the crystal, more pronounced in the case of the white crystal. A maximum likelihood algorithm has been tested that can reconstruct correctly the interaction position of the photons also in the case of the white crystal. |
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Address |
[Llosa, G.; Barrio, J.; Lacasta, C.] Inst Fis Corpuscular IFIC CSIC UVEG, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
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Publisher |
Iop Publishing Ltd |
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ISSN |
0031-9155 |
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Conference |
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Notes |
ISI:000284261000022 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
321 |
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Permanent link to this record |
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Author |
Oliver, J.F.; Rafecas, M. |
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Title |
Improving the singles rate method for modeling accidental coincidences in high-resolution PET |
Type |
Journal Article |
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Year |
2010 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
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Volume |
55 |
Issue |
22 |
Pages |
6951-6971 |
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Keywords |
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Abstract |
Random coincidences ('randoms') are one of the main sources of image degradation in PET imaging. In order to correct for this effect, an accurate method to estimate the contribution of random events is necessary. This aspect becomes especially relevant for high-resolution PET scanners where the highest image quality is sought and accurate quantitative analysis is undertaken. One common approach to estimate randoms is the so-called singles rate method (SR) widely used because of its good statistical properties. SR is based on the measurement of the singles rate in each detector element. However, recent studies suggest that SR systematically overestimates the correct random rate. This overestimation can be particularly marked for low energy thresholds, below 250 keV used in some applications and could entail a significant image degradation. In this work, we investigate the performance of SR as a function of the activity, geometry of the source and energy acceptance window used. We also investigate the performance of an alternative method, which we call 'singles trues' (ST) that improves SR by properly modeling the presence of true coincidences in the sample. Nevertheless, in any real data acquisition the knowledge of which singles are members of a true coincidence is lost. Therefore, we propose an iterative method, STi, that provides an estimation based on ST but which only requires the knowledge of measurable quantities: prompts and singles. Due to inter-crystal scatter, for wide energy windows ST only partially corrects SR overestimations. While SR deviations are in the range 86-300% (depending on the source geometry), the ST deviations are systematically smaller and contained in the range 4-60%. STi fails to reproduce the ST results, although for not too high activities the deviation with respect to ST is only a few percent. For conventional energy windows, i.e. those without inter-crystal scatter, the ST method corrects the SR overestimations, and deviations from the true random rate are of the order of 1% or less. In addition, in the case of conventional energy window STi results reproduce ST results and therefore the former can be used to obtain the true random rate. |
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Address |
[Oliver, Josep F.; Rafecas, Magdalena] Univ Valencia, CSIC, Inst Fis Corpuscular, IFIC, E-46003 Valencia, Spain, Email: josep.f.oliver@uv.es |
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Publisher |
Iop Publishing Ltd |
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English |
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ISSN |
0031-9155 |
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Conference |
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Notes |
ISI:000283789700025 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ elepoucu @ |
Serial |
344 |
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Permanent link to this record |
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Author |
Ancilotto, F.; Barranco, M.; Navarro, J.; Pi, M. |
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Title |
Cavitation of electron bubbles in liquid parahydrogen |
Type |
Journal Article |
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Year |
2011 |
Publication |
Molecular Physics |
Abbreviated Journal |
Mol. Phys. |
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Volume |
109 |
Issue |
23-24 |
Pages |
2757-2762 |
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Keywords |
liquid parahydrogen; electron bubbles; density functional theory; capillary approximation |
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Abstract |
Within a finite-temperature density functional approach, we have investigated the structure of electron bubbles in liquid parahydrogen below the saturated vapour pressure, determining the critical pressure at which electron bubbles explode as a function of temperature. The electron-parahydrogen interaction has been modelled by a Hartree-type local potential fitted to the experimental value of the conduction band-edge for a delocalized electron in pH(2). We have found that the pressure for bubble explosion is, in absolute value, about a factor of two smaller than that of the homogeneous cavitation pressure in the liquid. Comparison with the results obtained within the capillary model shows the limitations of this approximation, especially as temperature increases. |
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Address |
[Barranco, Manuel; Pi, Marti] Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain, Email: manuel@ecm.ub.es |
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Corporate Author |
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Thesis |
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Publisher |
Taylor & Francis Ltd |
Place of Publication |
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English |
Summary Language |
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Original Title |
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Series Editor |
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Series Issue |
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Edition |
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ISSN |
0026-8976 |
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Expedition |
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Conference |
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Notes |
WOS:000299109300007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
930 |
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Permanent link to this record |
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Author |
Pavez, C.; Pedreros, J.; Tarifeño-Saldivia, A.; Soto, L. |
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Title |
Observation of plasma jets in a table top plasma focus discharge |
Type |
Journal Article |
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Year |
2015 |
Publication |
Physics of Plasmas |
Abbreviated Journal |
Phys. Plasmas |
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Volume |
22 |
Issue |
4 |
Pages |
040705 - 5pp |
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Keywords |
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Abstract |
In the last years, medium size Z-pinch experiments operating at tens of kJ are being used to create supersonic plasma jets. Those experiments are produced with wire arrays and radial foils, and they are conducted in generators based on water-filled transmission lines. Also plasma jets have been observed in small X-pinch experiments operating at 1 kJ. In this work, observations of plasma jets produced in a table top plasma focus device by means of optical and digital interferometry are shown. The device was operated at only similar to 70J, achieving 50 kA in 150 ns. The plasma jets were observed after the pinch, in the region close and on the anode, along the axis. The electron density measured from the jets is in the range 10(24)-10(25) m(-3). From two consecutive plasma images separated 18 ns, the axial jet velocity was measured in the order of 4 x 10(4) m/s. |
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Address |
[Pavez, Cristian; Pedreros, Jose; Tarifeno-Saldivia, Ariel; Soto, Leopoldo] CCHEN, Comis Chilena Energia Nucl, Santiago, Chile, Email: lsoto@cchen.cl |
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Corporate Author |
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Thesis |
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Publisher |
Amer Inst Physics |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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ISSN |
1070-664x |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000353837200006 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2400 |
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Permanent link to this record |
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Author |
Greynat, D.; Sesma, J.; Vulvert, G. |
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Title |
Derivatives of the Pochhammer and reciprocal Pochhammer symbols and their use in epsilon-expansions of Appell and Kampe de Feriet functions |
Type |
Journal Article |
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Year |
2014 |
Publication |
Journal of Mathematical Physics |
Abbreviated Journal |
J. Math. Phys. |
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Volume |
55 |
Issue |
4 |
Pages |
043501 - 16pp |
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Keywords |
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Abstract |
Useful expressions of the derivatives, to any order, of Pochhammer and reciprocal Pochhammer symbols with respect to their arguments are presented. They are building blocks of a procedure, recently suggested, for obtaining the e-expansion of functions of the hypergeometric class related to Feynman integrals. The procedure is applied to some examples of such kind of functions taken from the literature. |
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Address |
[Greynat, David] Ist Nazl Fis Nucl, Dipartimento Fis, Sez Napoli, I-80126 Naples, Italy, Email: david.greynat@gmail.com; |
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Thesis |
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Publisher |
Amer Inst Physics |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Issue |
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Edition |
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ISSN |
0022-2488 |
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Conference |
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Notes |
WOS:000336084100030 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1799 |
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Permanent link to this record |
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Author |
Leal, A.; Mateo, D.; Pi, M.; Barranco, M.; Navarro, J. |
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Title |
The structure of mixed He-3-He-4 droplets doped with OCS: A density functional approach |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Chemical Physics |
Abbreviated Journal |
J. Chem. Phys. |
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Volume |
139 |
Issue |
17 |
Pages |
174308 - 6pp |
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Keywords |
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Abstract |
We have investigated the structure and energetics of mixed He-3-He-4 droplets doped with a carbonyl sulfide molecule within a density functional approach considering a small but finite temperature of 0.1 K. The molecule is treated as an external field to which the helium droplet is attached. The energetics and appearance of these droplets are discussed for selected numbers of helium atoms, identifying the first magic numbers of the fermionic component. |
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Address |
[Leal, Antonio; Mateo, David; Pi, Marti; Barranco, Manuel] Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain |
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Corporate Author |
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Thesis |
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Publisher |
Amer Inst Physics |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0021-9606 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000326922300022 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1658 |
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Permanent link to this record |
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Author |
Mateo, D.; Pi, M.; Navarro, J.; Toennies, J.P. |
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Title |
A density functional study of the structure of small OCS@He-3(N) clusters |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Chemical Physics |
Abbreviated Journal |
J. Chem. Phys. |
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Volume |
138 |
Issue |
4 |
Pages |
044321 - 8pp |
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Keywords |
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Abstract |
Kohn-Sham density functional calculations are reported for the structures of clusters consisting of a carbonyl sulfide (OCS) molecule with N = 1, 8, 18, and 40 attached He-3 atoms. The N = 1 cluster ground state is highly localized at the molecular waist (donut ring position), but for higher levels of excitation becomes increasingly delocalized. The first magic cluster with 8 atoms has a significant density at both ends of the molecule in addition to the donut ring. With N = 18 He-3 atoms the molecule is enclosed by a magic number closed shell. Another magic stable structure consisting of two nearly isotropically spherical closed shells is found at N = 40. A comparison with calculations for the same sized He-4 clusters show some important similarities, e. g., pile up at the donut ring position but altogether a more diffuse, less anisotropic structure. These results are discussed in the light of the recently analyzed infrared spectra measured in large pure He-3 droplets (N approximate to 1.2 x 10(4)) [B. Sartakov, J. P. Toennies, and A. F. Vilesov, J. Chem. Phys. 136, 134316 (2012)]. The moments of inertia of the 11 atom spherical shell structure, which is consistent with the experimental spectrum, lies between the predicted moments of inertia for N = 8 and N = 18 clusters. Overall the calculations reveal that the structures and energies of small doped He-3 are only slightly more diffuse and less energetic than the same He-4 clusters. |
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Address |
[Mateo, David; Pi, Marti] Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain |
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Thesis |
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Publisher |
Amer Inst Physics |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0021-9606 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000314725900038 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1337 |
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Permanent link to this record |
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Author |
Decoster, S.; Cottenier, S.; Wahl, U.; Correia, J.G.; Pereira, L.M.C.; Lacasta, C.; Da Silva, M.R.; Vantomme, A. |
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Title |
Diluted manganese on the bond-centered site in germanium |
Type |
Journal Article |
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Year |
2010 |
Publication |
Applied Physics Letters |
Abbreviated Journal |
Appl. Phys. Lett. |
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Volume |
97 |
Issue |
15 |
Pages |
151914 - 3pp |
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Keywords |
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Abstract |
The functional properties of Mn-doped Ge depend to large extent on the lattice location of the Mn impurities. Here, we present a lattice location study of implanted diluted Mn by means of electron emission channeling. Surprisingly, in addition to the expected substitutional lattice position, a large fraction of the Mn impurities occupies the bond-centered site. Corroborated by ab initio calculations, the bond-centered Mn is related to Mn-vacancy complexes. These unexpected results call for a reassessment of the theoretical studies on the electrical and magnetic behavior of Mn-doped Ge, hereby including the possible role of Mn-vacancy complexes. |
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Address |
[Decoster, S.; Pereira, L. M. C.; Vantomme, A.] Katholieke Univ Leuven, Inst Kern & Stralingsfys, B-3001 Louvain, Belgium, Email: stefan.decoster@fys.kuleuven.be |
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Corporate Author |
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Thesis |
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Publisher |
Amer Inst Physics |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0003-6951 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
ISI:000283216900030 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
357 |
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Permanent link to this record |
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Author |
Oliver, S.; Vijande, J.; Tejedor-Aguilar, N.; Miro, R.; Rovira-Escutia, J.J.; Ballester, F.; Juste, B.; Carmona, V.; Felici, G.; Verdu, G.; Sanchis, E.; Conde, A.; Perez-Calatayud, J. |
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Title |
Monte Carlo flattening filter design to high energy intraoperative electron beam homogenization |
Type |
Journal Article |
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Year |
2023 |
Publication |
Radiation Physics and Chemistry |
Abbreviated Journal |
Radiat. Phys. Chem. |
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Volume |
212 |
Issue |
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Pages |
111102 - 6pp |
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Keywords |
Intraoperative radiotherapy; Electron portable LinAc; Flattening filter; Dosimetry; Monte Carlo |
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Abstract |
Intraoperative radiotherapy using mobile linear accelerators is used for a wide variety of malignancies. However, when large fields are used in combination with high energies, a deterioration of the flatness dose profile is measured with respect to smaller fields and lower energies. Indeed, for the LIAC HWL of Sordina, this deterioration is observed for the 12 MeV beam combined with 10 cm (or larger) diameter applicator. Aimed to solve this problem, a flattening filter has been designed and validated evaluating the feasibility of its usage at the upper part of the applicator. The design of the filter was based on Monte Carlo simulations because of its accuracy in modeling components of clinical devices, among other purposes. The LIAC 10 cm diameter applicator was modeled and simulated independently by two different research groups using two different MC codes, reproducing the heterogeneity of the 12 MeV energy beam. Then, an iterative process of filter design was carried out. Finally, the MC designed conical filter with the optimal size and height to obtain the desired flattened beam was built in-house using a 3D printer. During the experimental validation of the applicator-filter, percentage depth dose, beam profiles, absolute and peripheral dose measurements were performed to demonstrate the effectiveness of the filter addition in the applicator. These measurements conclude that the beam has been flattened, from 5.9% with the standard configuration to 1.6% for the configuration with the filter, without significant increase of the peripheral dose. Consequently, the new filter-applicator LIAC configuration can be used also in a conventional surgery room. A reduction of 16% of the output dose and a reduction of 1.1 mm in the D50 of the percentage depth dose was measured with respect to the original configuration. This work is a proof-of-concept that demonstrates that it is possible to add a filter able to flatten the beam delivered by the Sordina LIAC HWL. Future studies will focus on more refined technical solutions fully compatible with the integrity of the applicator, including its sterilization, to be safely introduced in the clinical practice. |
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Address |
[Oliver, S.; Miro, R.; Juste, B.; Verdu, G.] Univ Polite cn Vale ncia, Inst Segur Ind Radiofis & Medioambiental ISIRYM, Cami Vera S-N, Valencia 46022, Spain, Email: gverdu@iqn.upv.es |
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Corporate Author |
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Thesis |
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Publisher |
Pergamon-Elsevier Science Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0969-806x |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:001026194900001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5578 |
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