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Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I.; Guerrero, C.; Rodriguez-Gonzalez, T.; Jimenez-Ramos, M.C.; Fernandez-Martinez, B.; Domingo-Pardo, C. |
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Title |
Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification |
Type |
Journal Article |
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Year |
2022 |
Publication |
European Physical Journal Plus |
Abbreviated Journal |
Eur. Phys. J. Plus |
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Volume |
137 |
Issue |
11 |
Pages |
1258 - 18pp |
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Keywords |
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Abstract |
We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy. |
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Address |
[Balibrea-Correa, J.; Lerendegui-Marco, J.; Ladarescu, I; Domingo-Pardo, C.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: javier.balibrea@ific.uv.es |
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Springer Heidelberg |
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English |
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ISSN |
2190-5444 |
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Conference |
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Notes |
WOS:000886327900002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5420 |
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Author |
n_TOF Collaboration (Mastromarco, M. et al); Domingo-Pardo, C.; Tain, J.L. |
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Title |
High accuracy, high resolution U-235(n,f) cross section from n_TOF (CERN) from 18 meV to 10 keV |
Type |
Journal Article |
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Year |
2022 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
58 |
Issue |
8 |
Pages |
147 - 13pp |
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Abstract |
The U-235(n,f) cross section was measured in a wide energy range (18 meV-170 keV) at the nTOF facility at CERN, relative to Li-6(n,t) and B-10(n,alpha) standard reactions, with high resolution and accuracy, with a setup based on a stack of six samples and six silicon detectors placed in the neutron beam. In this paper we report on the results in the region between 18 meV and 10 keV neutron energy. A resonance analysis has been performed up to 200 eV, with the code SAMMY. The resulting fission kernels are compared with the ones extracted on the basis of the resonance parameters of the most recent major evaluated data libraries. A comparison of the nTOF data with the evaluated cross sections is also performed from thermal to 10 keV neutron energy for the energy-averaged cross section in energy groups of suitably chosen width. A good agreement, within 0.5%, is found on average between the new results and the latest evaluated data files ENDF/B-VIII.0 and JEFF-3.3, as well as with respect to the broad group average fission cross section established in the framework of the standard working group of IAEA (the so-called reference file). However, some discrepancies, of up to 4%, are still present in some specific energy regions. The new dataset here presented, characterized by a unique combination of high resolution and accuracy, low background and wide energy range, can help to improve the evaluations from the Resolved Resonance Region up to 10 keV, also reducing the uncertainties that affect this region. |
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Address |
[Mastromarco, M.; Colonna, N.; Diacono, D.] Ist Nazl Fis Nucl, Sez Bari, Bari, Italy, Email: amaducci@lns.infn.it |
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Springer |
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English |
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Edition |
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ISSN |
1434-6001 |
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Conference |
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Notes |
WOS:000840312100002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5328 |
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Author |
Lerendegui-Marco, J.; Balibrea-Correa, J.; Babiano-Suarez, V.; Ladarescu, I.; Domingo-Pardo, C. |
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Title |
Towards machine learning aided real-time range imaging in proton therapy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
12 |
Issue |
1 |
Pages |
2735 - 17pp |
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Abstract |
Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2. |
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Address |
[Lerendegui-Marco, Jorge; Balibrea-Correa, Javier; Babiano-Suarez, Victor; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es |
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Publisher |
Nature Portfolio |
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English |
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Edition |
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ISSN |
2045-2322 |
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Notes |
WOS:000757537100018 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5136 |
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Author |
Girard-Alcindor, V. et al; Domingo-Pardo, C. |
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Title |
New narrow resonances observed in the unbound nucleus F-15 |
Type |
Journal Article |
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Year |
2022 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
105 |
Issue |
5 |
Pages |
L051301 - 7pp |
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Keywords |
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Abstract |
The structure of the unbound F-15 nucleus is investigated using the inverse kinematics resonant scattering of a radioactive O-14 beam impinging on a CH2 target. The analysis of H-1(O-14, p) O-14 and H-1(O-14, 2p) N-13 reactions allowed the confirmation of the previously observed narrow 1/2(-) resonance, near the two-proton decay threshold, and the identification of two new narrow 5/2(-) and 3/2(-) resonances. The newly observed levels decay by 1p emission to the ground of O-14, and by sequential 2p emission to the ground state of N-13 via the 1(-) resonance of O-14. Gamow shell model (GSM) analysis of the experimental data suggests that the wave functions of the 5/2(-) and 3/2(-) resonances may be collectivized by the continuum coupling to nearby 2p- and 1p-decay channels. The observed excitation function H-1(O-14, p) O-14 and resonance spectrum in F-15 are well reproduced in the unified framework of the GSM. |
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Address |
[Girard-Alcindor, V.; Santos, F. de Oliveira; Ploszajczak, M.; Lemasson, A.; Clement, E.; Ramos, D.; Rejmund, M.; Ackermann, D.; Bastin, B.; Caceres, L.; De France, G.; Giraud, S.; Goupil, J.; Grevy, S.; Kamalou, O.; Kamenyero, A.; Leblond, S.; Lefevre, A.; Li, H.; Morfouace, P.; Stodel, C.; Thomas, J. C.] Grand Accelerateur Natl Ions Lourds GANIL, CEA, DRF CNRS, IN2P3, Bvd Henri Becquerel, F-14076 Caen, France, Email: stefan@ipno.in2p3.fr |
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Publisher |
Amer Physical Soc |
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English |
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Edition |
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ISSN |
2469-9985 |
ISBN |
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Conference |
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Notes |
WOS:000811520800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5268 |
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Author |
Esposito, R. et al; Domingo-Pardo, C. |
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Title |
Design of the third-generation lead-based neutron spallation target for the neutron time-of-flight facility at CERN |
Type |
Journal Article |
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Year |
2021 |
Publication |
Physical Review Accelerators and Beams |
Abbreviated Journal |
Phys. Rev. Accel. Beams |
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Volume |
24 |
Issue |
9 |
Pages |
093001 - 17pp |
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Keywords |
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Abstract |
The neutron time-of-flight (n_TOF) facility at the European Laboratory for Particle Physics (CERN) is a pulsed white-spectrum neutron spallation source producing neutrons for two experimental areas: the Experimental Area 1 (EAR1), located 185 m horizontally from the target, and the Experimental Area 2 (EAR2), located 20 m above the target. The target, based on pure lead, is impacted by a high-intensity 20-GeV/c pulsed proton beam. The facility was conceived to study neutron-nucleus interactions for neutron kinetic energies between a few meV to several GeV, with applications of interest for nuclear astrophysics, nuclear technology, and medical research. After the second-generation target reached the end of its lifetime, the facility underwent a major upgrade during CERN's Long Shutdown 2 (LS2, 2019-2021), which included the installation of the new third-generation neutron target. The first- and second-generation targets were based on water-cooled massive lead blocks and were designed focusing on EAR1, since EAR2 was built later. The new target is cooled by nitrogen gas to avoid erosion-corrosion and contamination of cooling water with radioactive lead spallation products. Moreover, the new design is optimized also for the vertical flight path and EAR2. This paper presents an overview of the target design focused on both physics and thermomechanical performance, and includes a description of the nitrogen cooling circuit and radiation protection studies. |
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Address |
[Esposito, R.; Calviani, M.; Aberle, O.; Barbagallo, M.; Coiffet, T.; Dragoni, F.; Ximenes, R. Franqueira; Giordanino, L.; Grenier, D.; Kershaw, K.; Maire, V.; Moyret, P.; Fontenla, A. Perez; Perillo-Marcone, A.; Pozzi, F.; Sgobba, S.; Timmins, M.; Vlachoudis, V.] European Lab Particle Phys CERN, CH-1211 Geneva 23, Switzerland, Email: raffaele.esposito@cern.ch; |
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Publisher |
Amer Physical Soc |
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Language |
English |
Summary Language |
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Notes |
WOS:000696029700001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4963 |
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