| Records |
| Author |
Koolen, B.B.; Vidal-Sicart, S.; Benlloch, J.M.; Olmos, R.A.V. |
| Title |
Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT |
Type |
Journal Article |
| Year |
2014 |
Publication |
Nuclear Medicine Communications |
Abbreviated Journal |
Nucl. Med. Commun. |
| Volume |
35 |
Issue |
5 |
Pages |
446-452 |
| Keywords |
breast cancer; F-18-FDG; heterogeneity; MAMMI; PET |
| Abstract |
PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies. |
| Address |
[Koolen, Bas B.; Vidal-Sicart, Sergi; Olmos, Renato A. Valdes] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Nucl Med, NL-1066 CX Amsterdam, Netherlands, Email: b.koolen@nki.nl |
| Corporate Author |
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Thesis |
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| Publisher |
Lippincott Williams & Wilkins |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
|
Edition |
|
| ISSN |
0143-3636 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:000334103800002 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1763 |
| Permanent link to this record |
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| |
| Author |
Hoeschen, C.; Mattsson, S.; Cantone, M.C.; Mikuz, M.; Lacasta, C.; Ebel, G.; Clinthorne, N.; Giussani, A. |
| Title |
Minimising activity and dose with enhanced image quality by radiopharmaceutical administrations |
Type |
Journal Article |
| Year |
2010 |
Publication |
Radiation Protection Dosimetry |
Abbreviated Journal |
Radiat. Prot. Dosim. |
| Volume |
139 |
Issue |
1-3 |
Pages |
250-253 |
| Keywords |
|
| Abstract |
Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection for nuclear medical diagnosis, since in this case radiopharmaceuticals are administered to the patient, meaning not only a radiation exposure to the diseased tissue but also to the healthy tissues of large parts of the body. 'Minimizing Activity and Dose with Enhanced Image quality by Radiopharmaceutical Administrations' (MADEIRA) is a project cofunded by the European Commission within the Seventh Euratom Framework Programme that aims to improve three-dimensional (3D) nuclear medical imaging technologies significantly. MADEIRA is aiming to improve the efficacy and safety of 3D PET and SPECT functional imaging by optimising the spatial resolution and the signal-to-noise ratio, improving the knowledge of the temporal variation of the radiopharmaceuticals' uptake in and clearance from tumourous and healthy tissues, and evaluation of the corresponding patient dose. Using an optimised imaging procedure that improves the information gained per unit administered dose, MADEIRA aims especially to reduce the dose to healthy tissues of the patient. In this paper, an overall summary of the current achievements will be presented. |
| Address |
[Hoeschen, C.; Giussani, A.] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Radiat Protect, D-85764 Neuherberg, Germany, Email: christoph.hoeschen@helmholtz-muenchen.de |
| Corporate Author |
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Thesis |
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| Publisher |
Oxford Univ Press |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0144-8420 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000277738200045 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
450 |
| Permanent link to this record |
| |
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| |
| Author |
Studen, A.; Burdette, D.; Chesi, E.; Cindro, V.; Clinthorne, N.H.; Cochran, E.; Grosicar, B.; Kagan, H.; Lacasta, C.; Linhart, V.; Mikuz, M.; Stankova, V.; Weilhammer, P.; Zontar, D. |
| Title |
Timing performance of the silicon PET insert probe |
Type |
Journal Article |
| Year |
2010 |
Publication |
Radiation Protection Dosimetry |
Abbreviated Journal |
Radiat. Prot. Dosim. |
| Volume |
139 |
Issue |
1-3 |
Pages |
199-203 |
| Keywords |
|
| Abstract |
Simulation indicates that PET image could be improved by upgrading a conventional ring with a probe placed close to the imaged object. In this paper, timing issues related to a PET probe using high-resistivity silicon as a detector material are addressed. The final probe will consist of several (four to eight) 1-mm thick layers of silicon detectors, segmented into 1 x 1 mm(2) pads, each pad equivalent to an independent p + nn+ diode. A proper matching of events in silicon with events of the external ring can be achieved with a good timing resolution. To estimate the timing performance, measurements were performed on a simplified model probe, consisting of a single 1-mm thick detector with 256 square pads (1.4 mm side), coupled with two VATAGP7s, application-specific integrated circuits. The detector material and electronics are the same that will be used for the final probe. The model was exposed to 511 keV annihilation photons from an Na-22 source, and a scintillator (LYSO)-PMT assembly was used as a timing reference. Results were compared with the simulation, consisting of four parts: (i) GEANT4 implemented realistic tracking of electrons excited by annihilation photon interactions in silicon, (ii) calculation of propagation of secondary ionisation (electron-hole pairs) in the sensor, (iii) estimation of the shape of the current pulse induced on surface electrodes and (iv) simulation of the first electronics stage. A very good agreement between the simulation and the measurements were found. Both indicate reliable performance of the final probe at timing windows down to 20 ns. |
| Address |
[Studen, A.; Cindro, V.; Grosicar, B.; Mikuz, M.; Zontar, D.] Jozef Stefan Inst, SI-1000 Ljubljana, Slovenia, Email: andrej.studen@ijs.si |
| Corporate Author |
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Thesis |
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| Publisher |
Oxford Univ Press |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0144-8420 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
ISI:000277738200035 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ elepoucu @ |
Serial |
449 |
| Permanent link to this record |
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| |
| Author |
Verdu-Andres, S.; Amaldi, U.; Faus-Golfe, A. |
| Title |
CABOTO, a high-gradient linac for hadrontherapy |
Type |
Journal Article |
| Year |
2013 |
Publication |
Journal of Radiation Research |
Abbreviated Journal |
J. Radiat. Res. |
| Volume |
54 |
Issue |
|
Pages |
155-161 |
| Keywords |
hadrontherapy; high-gradient linac; cyclinac; carbon ion therapy; multipainting |
| Abstract |
The field of hadrontherapy has grown rapidly in recent years. At present the therapeutic beam is provided by a cyclotron or a synchrotron, but neither cyclotrons nor synchrotrons present the best performances for hadrontherapy. The new generation of accelerators for hadrontherapy should allow fast active energy modulation and have a high repetition rate, so that moving organs can be appropriately treated in a reasonable time. In addition, a reduction of the dimensions and cost of the accelerators for hadrontherapy would make the acquisition and operation of a hadrontherapy facility more affordable, which would translate into great benefits for the potential hadrontherapy patients. The 'cyclinac', an accelerator concept that combines a cyclotron with a high-frequency linear accelerator (linac), is a fast-cycling machine specifically conceived to allow for fast active energy modulation. The present paper focuses on CABOTO (CArbon BOoster for Therapy in Oncology), a compact, efficient high-frequency linac that can accelerate C6+ ions and H-2 molecules from 150-410 MeV/u in similar to 24 m. The paper presents the latest design of CABOTO and discusses its performances. |
| Address |
[Verdu-Andres, Silvia; Amaldi, Ugo] Fdn Tera, I-28100 Novara, Italy, Email: sverdu@bnl.gov |
| Corporate Author |
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Thesis |
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| Publisher |
Oxford Univ Press |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
|
| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0449-3060 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:000321463900021 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1506 |
| Permanent link to this record |
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| |
| Author |
Roman, F.L.; Abler, D.; Kanellopoulos, V.; Amoros, G.; Davies, J.; Dosanjh, M.; Jena, R.; Kirkby, N.; Peach, K.; Salt, J. |
| Title |
Hadron therapy information sharing prototype |
Type |
Journal Article |
| Year |
2013 |
Publication |
Journal of Radiation Research |
Abbreviated Journal |
J. Radiat. Res. |
| Volume |
54 |
Issue |
|
Pages |
56-60 |
| Keywords |
hadron therapy; proton therapy; data federation; web portal; eHealth; cancer informatics |
| Abstract |
The European PARTNER project developed a prototypical system for sharing hadron therapy data. This system allows doctors and patients to record and report treatment-related events during and after hadron therapy. It presents doctors and statisticians with an integrated view of adverse events across institutions, using open-source components for data federation, semantics, and analysis. There is a particular emphasis upon semantic consistency, achieved through intelligent, annotated form designs. The system as presented is ready for use in a clinical setting, and amenable to further customization. The essential contribution of the work reported here lies in the novel data integration and reporting methods, as well as the approach to software sustainability achieved through the use of community-supported open-source components. |
| Address |
[Roman, Faustin Laurentiu; Abler, Daniel; Kanellopoulos, Vassiliki; Dosanjh, Manjit] CERN, European Org Nucl Res, CH-1211 Geneva 23, Switzerland, Email: faustin.roman@medaustron.at |
| Corporate Author |
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Thesis |
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| Publisher |
Oxford Univ Press |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0449-3060 |
ISBN |
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Medium |
|
| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000321463900008 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1519 |
| Permanent link to this record |
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| |
| Author |
Botella-Soler, V.; Oteo, J.A.; Ros, J.; Glendinning, P. |
| Title |
Lyapunov exponent and topological entropy plateaus in piecewise linear maps |
Type |
Journal Article |
| Year |
2013 |
Publication |
Journal of Physics A |
Abbreviated Journal |
J. Phys. A |
| Volume |
46 |
Issue |
12 |
Pages |
125101 - 26pp |
| Keywords |
|
| Abstract |
We consider a two-parameter family of piecewise linear maps in which the moduli of the two slopes take different values. We provide numerical evidence of the existence of some parameter regions in which the Lyapunov exponent and the topological entropy remain constant. Analytical proof of this phenomenon is also given for certain cases. Surprisingly however, the systems with that property are not conjugate as we prove by using kneading theory. |
| Address |
[Botella-Soler, V.] IST Austria, A-3400 Klosterneuburg, Austria, Email: vbsoler@ist.ac.at; |
| Corporate Author |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1751-8113 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000316058200010 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1353 |
| Permanent link to this record |
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| |
| Author |
Ros, A.; Lerche, C.W.; Sebastia, A.; Sanchez, F.; Benlloch, J.M. |
| Title |
Retroreflector arrays for better light collection efficiency of gamma-ray imaging detectors with continuous scintillation crystals without DOI misestimation |
Type |
Journal Article |
| Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
| Volume |
9 |
Issue |
|
Pages |
P04009 - 14pp |
| Keywords |
Gamma detectors (scintillators, CZT, HPG, HgI etc); Interaction of radiation with matter; Gamma camera, SPECT, PET PET/CT, coronary CT angiography (CTA); Detector design and construction technologies and materials |
| Abstract |
A method to improve light collection efficiency of gamma-ray imaging detectors by using retroreflector arrays has been tested, simulations of the behaviour of the scintillation light illuminating the retroreflector surface have been made. Measurements including retroreflector arrays in the setup have also been taken. For the measurements, positron emission tomography (PET) detectors with continuous scintillation crystals have been used. Each detector module consists of a continuous LSO-scintillator of dimensions 49x49x10 mm(3) and a H8500 position-sensitive photo-multiplier (PSPMT) from Hamamatsu. By using a continuous scintillation crystal, the scintillation light distribution has not been destroyed and the energy, the centroids along the x- and y-direction and the depth of interaction (DOI) can be estimated. Simulations have also been run taking into account the use of continuous scintillation crystals. Due to the geometry of the continuous scintillation crystals in comparison with pixelated crystals, a good light collection efficiency is necessary to correctly reconstruct the impact point of the gamma-ray. The aim of this study is to investigate whether micro-machine retro-reflectors improve light yield without misestimation of the impact point. The results shows an improvement on the energy and centroid resolutions without worsening the depth of interaction resolution. Therefore it can be concluded that using retroreflector arrays at the entrance side of the scintillation crystal improves light collection efficiency without worsening the impact point estimation. |
| Address |
[Ros, A.] Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: anrogar2@i3m.upv.es |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1748-0221 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
|
| Notes |
WOS:000336123800049 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
1798 |
| Permanent link to this record |
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| Author |
Diez, S. et al; Bernabeu Verdu, J.; Civera, J.V.; Garcia, C.; Garcia-Argos, C.; Lacasta, C.; Marco, R.; Marti-Garcia, S.; Santoyo, D.; Soldevila, U. |
| Title |
A double-sided, shield-less stave prototype for the ATLAS Upgrade strip tracker for the High Luminosity LHC |
Type |
Journal Article |
| Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
| Volume |
9 |
Issue |
|
Pages |
P03012 - 16pp |
| Keywords |
Large detector-systems performance; Si microstrip and pad detectors; Particle tracking detectors; Performance of High Energy Physics Detectors |
| Abstract |
A detailed description of the integration structures for the barrel region of the silicon strips tracker of the ATLAS Phase-II upgrade for the upgrade of the Large Hadron Collider, the so-called High Luminosity LHC (HL-LHC), is presented. This paper focuses on one of the latest demonstrator prototypes recently assembled, with numerous unique features. It consists of a shortened, shield-less, and double sided stave, with two candidate power distributions implemented. Thermal and electrical performances of the prototype are presented, as well as a description of the assembly procedures and tools. |
| Address |
[Diez, S.; Haber, C. H.; Witharm, R.] LBNL, Berkeley, CA 94103 USA, Email: sdiezcornell@lbl.gov |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1748-0221 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000336123200072 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1802 |
| Permanent link to this record |
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| Author |
Carrio, F.; Kim, H.Y.; Moreno, P.; Reed, R.; Sandrock, C.; Schettino, V.; Shalyugin, A.; Solans, C.; Souza, J.; Usai, G.; Valero, A. |
| Title |
Design of an FPGA-based embedded system for the ATLAS Tile Calorimeter front-end electronics test-bench |
Type |
Journal Article |
| Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
| Volume |
9 |
Issue |
|
Pages |
C03023 - 12pp |
| Keywords |
Detector control systems (detector and experiment monitoring and slow-control systems, architecture, hardware, algorithms; databases); Data acquisition concepts; Digital electronic circuits |
| Abstract |
The portable test-bench for the certification of the ATLAS tile hadronic calorimeter front-end electronics has been redesigned for the present Long Shutdown (LS1) of LHC, improving its portability and expanding its functionalities. This paper presents a new test-bench based on a Xilinx Virtex-5 FPGA that implements an embedded system using a PowerPC 440 microprocessor hard core and custom IP cores. A light Linux version runs on the PowerPC microprocessor and handles the IP cores which implement the different functionalities needed to perform the desired tests such as TTCvi emulation, G-Link decoding, ADC control and data reception. |
| Address |
[Carrio, F.; Valero, A.] Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Paterna, Spain, Email: fernando.carrio@cern.ch |
| Corporate Author |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1748-0221 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000336123200023 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1801 |
| Permanent link to this record |
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| Author |
Esperante-Pereira, D. |
| Title |
DEPFET active pixel sensors for the vertex detector of the Belle-II experiment |
Type |
Journal Article |
| Year |
2014 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
| Volume |
9 |
Issue |
|
Pages |
C03004 - 11pp |
| Keywords |
Particle tracking detectors; Solid state detectors; Particle tracking detectors (Solid-state detectors) |
| Abstract |
Active pixels sensors based on the DEPFET technology will be used for the innermost vertex detector of the future Belle-II experiment. The increased luminosity of the e(+) e(-) SuperKEKB collider entails challenging detector requirements, namely: low material budget, low power consumption, high precision and efficiency, and a large readout rate. The DEPFET active pixel technology has shown to be a suitable solution for this purpose. A review of the different aspects of the detector design (sensors, readout ASICS and supplementary infrastructure) and the results of the latest thinned sensor prototypes (50 μm) are described. |
| Address |
Univ Valencia, CSIC, IFIC Inst Fis Corpuscular, Valencia 46980, Spain, Email: daniel.esperante@csic.es |
| Corporate Author |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1748-0221 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000336123200004 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
1803 |
| Permanent link to this record |
