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Author |
Trbojevich, R.A.; Fernandez, A.; Watanabe, F.; Mustafa, T.; Bryant, M.S. |
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Title |
Comparative study of silver nanoparticle permeation using Side-Bi-Side and Franz diffusion cells |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of Nanoparticle Research |
Abbreviated Journal |
J. Nanopart. Res. |
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Volume |
18 |
Issue |
3 |
Pages |
55 - 12pp |
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Keywords |
Membranes; Silver nanoparticles; Diffusion cells; Food packaging; Permeation; Environmental and health effects |
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Abstract |
Better understanding the mechanisms of nanoparticle permeation through membranes and packaging polymers has important implications for the evaluation of drug transdermal uptake, in food safety and the environmental implications of nanotechnology. In this study, permeation of 21 nm diameter silver nanoparticles (AgNPs) was tested using Side-Bi-Side and Franz static diffusion cells through hydrophilic 0.1 and 0.05 lm pore diameter 125 μm thick synthetic cellulose membranes, and 16 and 120 μm thick low-density polyethylene (LDPE) films. Experiments performed with LDPE films discarded permeation of AgNPs or Ag ions over the investigated time-frame in both diffusion systems. But controlled release of AgNPs has been quantified using semipermeable hydrophilic membranes. The permeation followed a quasi-linear time-dependent model during the experimental time-frame, which represents surface reaction-limited permeation. Diffusive flux, diffusion coefficients, and membrane permeability were determined as a function of pore size and diffusion model. Concentration gradient and pore size were key to understand mass transfer phenomena in the diffusion systems. |
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Address |
[Trbojevich, Raul A.; Bryant, Matthew S.] US FDA, Div Biochem Toxicol, Natl Ctr Toxicol Res, 3900 NCTR Rd, Jefferson, AR 72079 USA, Email: velifdez@ific.uv.es |
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Springer |
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English |
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ISSN |
1388-0764 |
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WOS:000387044400002 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2849 |
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Author |
Ancilotto, F.; Barranco, M.; Navarro, J.; Pi, M. |
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Title |
A Density Functional Approach to Para-hydrogen at Zero Temperature |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of Low Temperature Physics |
Abbreviated Journal |
J. Low Temp. Phys. |
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Volume |
185 |
Issue |
1-2 |
Pages |
26-38 |
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Keywords |
Solid and liquid bulk para-hydrogen; Small para-hydrogen clusters; Density functional theory |
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Abstract |
We have developed a density functional (DF) built so as to reproduce either the metastable liquid or the solid equation of state of bulk para-hydrogen, as derived from quantum Monte Carlo zero temperature calculations. As an application, we have used it to study the structure and energetics of small para-hydrogen clusters made of up to molecules. We compare our results for liquid clusters with diffusion Monte Carlo (DMC) calculations and find a fair agreement between them. In particular, the transition found within DMC between hollow-core structures for small N values and center-filled structures at higher N values is reproduced. The present DF approach yields results for (pH) clusters indicating that for small N values a liquid-like character of the clusters prevails, while solid-like clusters are instead energetically favored for . |
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Address |
[Ancilotto, Francesco] Dipartimento Fis & Astron Galileo Galilei, Padua, Italy, Email: manuel@ecm.ub.edu |
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Springer/Plenum Publishers |
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English |
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0022-2291 |
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Notes |
WOS:000382142000003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2814 |
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Author |
Fernandez Casani, A.; Orduña, J.M.; Sanchez, J.; Gonzalez de la Hoz, S. |
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Title |
A Reliable Large Distributed Object Store Based Platform for Collecting Event Metadata |
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Journal Article |
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Year |
2021 |
Publication |
Journal of Grid Computing |
Abbreviated Journal |
J. Grid Comput. |
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Volume |
19 |
Issue |
3 |
Pages |
39 - 19pp |
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Keywords |
Grid computing; Hadoop file system; Object-Based storage |
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Abstract |
The Large Hadron Collider (LHC) is about to enter its third run at unprecedented energies. The experiments at the LHC face computational challenges with enormous data volumes that need to be analysed by thousands of physics users. The ATLAS EventIndex project, currently running in production, builds a complete catalogue of particle collisions, or events, for the ATLAS experiment at the LHC. The distributed nature of the experiment data model is exploited by running jobs at over one hundred Grid data centers worldwide. Millions of files with petabytes of data are indexed, extracting a small quantity of metadata per event, that is conveyed with a data collection system in real time to a central Hadoop instance at CERN. After a successful first implementation based on a messaging system, some issues suggested performance bottlenecks for the challenging higher rates in next runs of the experiment. In this work we characterize the weaknesses of the previous messaging system, regarding complexity, scalability, performance and resource consumption. A new approach based on an object-based storage method was designed and implemented, taking into account the lessons learned and leveraging the ATLAS experience with this kind of systems. We present the experiment that we run during three months in the real production scenario worldwide, in order to evaluate the messaging and object store approaches. The results of the experiment show that the new object-based storage method can efficiently support large-scale data collection for big data environments like the next runs of the ATLAS experiment at the LHC. |
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Address |
[Fernandez Casani, Alvaro; Sanchez, Javier; Gonzalez de la Hoz, Santiago] Univ Valencia, Inst Fis Corpuscular IFIC, Burjassot, Spain, Email: alvaro.fernandez@ific.uv.es; |
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Springer |
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English |
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ISSN |
1570-7873 |
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Notes |
WOS:000692413100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
4953 |
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Author |
LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Valls, P.; Sanchez Mayordomo, C. |
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Title |
Measurement of forward W -> e nu production in pp collisions at root s=8 TeV |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
10 |
Issue |
10 |
Pages |
030 - 29pp |
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Keywords |
Electroweak interaction; Hadron-Hadron scattering (experiments); QCD |
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Abstract |
A measurement of the cross-section for W -> e nu production in pp collisions is presented using data corresponding to an integrated luminosity of 2 fb(-1) collected by the LHCb experiment at a centre-of-mass energy of root s = 8 TeV. The electrons are required to have more than 20 GeV of transverse momentum and to lie between 2.00 and 4.25 in pseudorapidity. The inclusive W production cross-sections, where the W decays to e nu, are measured to be W-sigma(+)-> e(+)nu(e)= 1124.4 +/- 2.1 +/- 21.5 +/- 11.2 +/- 13.0 pb, W-sigma(-)-> e(-)(nu) over bar (e) = 809.0 +/- 1.9 +/- 18.1 +/- 7.0 +/- 9.4 pb, where the first uncertainties are statistical, the second are systematic, the third are due to the knowledge of the LHC beam energy and the fourth are due to the luminosity determination. Differential cross-sections as a function of the electron pseudorapidity are measured. The W+/W- cross-section ratio and production charge asymmetry are also reported. Results are compared with theoretical predictions at next-to-next-to-leading order in perturbative quantum chromodynamics. Finally, in a precise test of lepton universality, the ratio of W boson branching fractions is determined to be B(W -> e nu)/B(W -> μnu) = 1.020 +/- 0.002 +/- 0.019, where the first uncertainty is statistical and the second is systematic. |
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Address |
[Bediaga, I.; Ferreira Rodrigues, F.; Gomes, A.; Massafferri, A.; dos Reis, A. C.; Rodrigues, A. B.; Vieira, D.] CBPF, Rio De Janeiro, Brazil, Email: marek.sirendi@cern.ch |
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Springer |
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English |
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ISSN |
1029-8479 |
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Notes |
WOS:000386669800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2848 |
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Author |
LHCb Collaboration (Aaij, R. et al); Jaimes Elles, S.J.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Rebollo De Miguel, M.; Sanderswood, I.; Zhuo, J. |
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Title |
Study of Bc+ → χc π+ decays |
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Journal Article |
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Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
173 - 30pp |
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Keywords |
B Physics; Branching fraction; Hadron-Hadron Scattering |
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Abstract |
A study of B-c(+) -> chi(c) pi(+) decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13TeV, corresponding to an integrated luminosity of 9 fb(-1). The decay B-c(+) -> chi(c2)pi(+) is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the B-c(+) -> J/psi pi(+) decay is measured to be BBc+ ->chi c2 pi+/BBc+ -> (J/psi pi+) = 0.37 +/- 0.06 +/- 0.02 +/- 0.01, where the first uncertainty is statistical, the second is systematic, and the third is due to the knowledge of the chi(c2) -> J/psi gamma branching fraction. No significant B-c(+) -> chi(+)(c1 pi) signal is observed and an upper limit for the relative branching fraction for the B-c(+) -> chi(c1)pi(+) and B-c(+) -> chi(c2)pi(+) decays of BBc+ ->chi c1 pi+/BBc+ -> chi(c2)pi(+) < 0.49 is set at the 90% confidence level. |
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Address |
[Egede, U.; Fujii, Y.; Hadavizadeh, T.; Henderson, R. D. L.; Lane, J. J.; Liu, F. L.; Monk, M.; Song, R.; Walton, E. J.; Ward, J. A.] Monash Univ, Sch Phys & Astron, Melbourne, Vic, Australia, Email: Ivan.Belyaev@cern.ch |
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Publisher |
Springer |
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English |
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1029-8479 |
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Notes |
WOS:001183170300001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
6044 |
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Author |
SCiMMA and SNEWS Collaborations (Baxter, A.L. et al); Colomer, M. |
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Title |
Collaborative experience between scientific software projects using Agile Scrum development |
Type |
Journal Article |
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Year |
2022 |
Publication |
Software-Practice & Experience |
Abbreviated Journal |
Softw.-Pract. Exp. |
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Volume |
52 |
Issue |
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Pages |
2077-2096 |
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Keywords |
Agile; cyberinfrastructure; multimessenger astrophysics; scientific computing; software development |
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Abstract |
Developing sustainable software for the scientific community requires expertise in software engineering and domain science. This can be challenging due to the unique needs of scientific software, the insufficient resources for software engineering practices in the scientific community, and the complexity of developing for evolving scientific contexts. While open-source software can partially address these concerns, it can introduce complicating dependencies and delay development. These issues can be reduced if scientists and software developers collaborate. We present a case study wherein scientists from the SuperNova Early Warning System collaborated with software developers from the Scalable Cyberinfrastructure for Multi-Messenger Astrophysics project. The collaboration addressed the difficulties of open-source software development, but presented additional risks to each team. For the scientists, there was a concern of relying on external systems and lacking control in the development process. For the developers, there was a risk in supporting a user-group while maintaining core development. These issues were mitigated by creating a second Agile Scrum framework in parallel with the developers' ongoing Agile Scrum process. This Agile collaboration promoted communication, ensured that the scientists had an active role in development, and allowed the developers to evaluate and implement the scientists' software requirements. The collaboration provided benefits for each group: the scientists actuated their development by using an existing platform, and the developers utilized the scientists' use-case to improve their systems. This case study suggests that scientists and software developers can avoid scientific computing issues by collaborating and that Agile Scrum methods can address emergent concerns. |
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Address |
[Baxter, Amanda L.; Clark, Michael; Kopec, Abigail; Lang, Rafael F.; Li, Shengchao; Linvill, Mark W.; Milisavljevic, Danny; Weil, Kathryn E.] Purdue Univ, Dept Phys & Astron, W Lafayette, IN 47907 USA, Email: adepoian@purdue.edu; |
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Publisher |
Wiley |
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English |
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ISSN |
0038-0644 |
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Notes |
WOS:000830363800001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5305 |
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Author |
Navarro, J.; Guardiola, R. |
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Title |
Thermal Effects on Small Para-Hydrogen Clusters |
Type |
Journal Article |
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Year |
2011 |
Publication |
International Journal of Quantum Chemistry |
Abbreviated Journal |
Int. J. Quantum Chem. |
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Volume |
111 |
Issue |
2 |
Pages |
463-471 |
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Keywords |
atomic and molecular clusters; phase transitions in clusters; structure of clusters; molecular hydrogen and isotopes |
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Abstract |
A brief review of different quantum Monte Carlo simulations of small (p-H-2)(N) clusters is presented. The clusters are viewed as a set of N structureless p-H-2 molecules, interacting via an isotropic pairwise potential. Properties as superfluidity, magic numbers, radial structure, excitation spectra, and abundance production of (p-H-2)(N) clusters are discussed and, whenever possible, a comparison with He-4(N) droplets is presented. All together, the simulations indicate that temperature has a paradoxical effect of the properties of (p-H-2)(N) clusters, as they are solid-like at high T and liquid-like at low T, due to quantum delocalization at the lowest temperature. |
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Address |
[Navarro, Jesus; Guardiola, Rafael] Univ Valencia, CSIC, IFIC, Valencia 46071, Spain, Email: navarro@ific.uv.es |
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Publisher |
John Wiley & Sons Inc |
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English |
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ISSN |
0020-7608 |
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Notes |
ISI:000285311400028 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
589 |
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Author |
Tortola, M. |
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Title |
Status of three-neutrino oscillation parameters |
Type |
Journal Article |
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Year |
2013 |
Publication |
Fortschritte der Physik-Progress of Physics |
Abbreviated Journal |
Fortschritte Phys.-Prog. Phys. |
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Volume |
61 |
Issue |
4-5 |
Pages |
427-440 |
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Keywords |
Neutrino mass and mixing; neutrino oscillations; solar and atmospheric neutrinos; reactor and accelerator neutrinos |
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Abstract |
Here we review the current status of global fits to neutrino oscillation data within the three-flavour framework. In our analysis we include the most recent data from solar and atmospheric neutrino experiments as well as the latest results from the long-baseline accelerator neutrino experiments and the recent measurements of reactor neutrino disappearance reported by Double Chooz, Daya Bay and RENO. We present updated determinations for the two neutrino mass splittings and the three mixing angles responsible for neutrino oscillations that, for the first time, have all been measured with 1 sigma accuracies ranging from 3 to 15%. A weak sensitivity for the CP violating phase is also reported from the global analysis. |
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Address |
Univ Valencia, Inst Fis Corpuscular, AHEP Grp, CSIC, Valencia 46071, Spain, Email: mariam@ific.uv.es |
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Publisher |
Wiley-V C H Verlag Gmbh |
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English |
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ISSN |
0015-8208 |
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Notes |
WOS:000317019900005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1411 |
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Author |
Assam, I.; Vijande, J.; Ballester, F.; Perez-Calatayud, J.; Poppe, B.; Siebert, F.A. |
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Title |
Evaluation of dosimetric effects of metallic artifact reduction and tissue assignment on Monte Carlo dose calculations for I-125 prostate implants |
Type |
Journal Article |
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Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
49 |
Issue |
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Pages |
6195-6208 |
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Keywords |
metallic artifact reduction; Monte Carlo dosimetry; post-implant CT; prostate brachytherapy; tissue assignment schemes; voxelized virtual patient model |
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Abstract |
Purpose Monte Carlo (MC) simulation studies, aimed at evaluating the magnitude of tissue heterogeneity in I-125 prostate permanent seed implant brachytherapy (BT), customarily use clinical post-implant CT images to generate a virtual representation of a realistic patient model (virtual patient model). Metallic artifact reduction (MAR) techniques and tissue assignment schemes (TAS) are implemented on the post-implant CT images to mollify metallic artifacts due to BT seeds and to assign tissue types to the voxels corresponding to the bright seed spots and streaking artifacts, respectively. The objective of this study is to assess the combined influence of MAR and TAS on MC absorbed dose calculations in post-implant CT-based phantoms. The virtual patient models used for I-125 prostate implant MC absorbed dose calculations in this study are derived from the CT images of an external radiotherapy prostate patient without BT seeds and prostatic calcifications, thus averting the need to implement MAR and TAS. Methods The geometry of the IsoSeed I25.S17plus source is validated by comparing the MC calculated results of the TG-43 parameters for the line source approximation with the TG-43U1S2 consensus data. Four MC absorbed dose calculations are performed in two virtual patient models using the egs_brachy MC code: (1) TG-43-based D-w,w-TG(43), (2) D-w,D-w-MBDC that accounts for interseed scattering and attenuation (ISA), (3) D-m,D-m that examines ISA and tissue heterogeneity by scoring absorbed dose in tissue, and (4) D-w,D-m that unlike D-m,D-m scores absorbed dose in water. The MC absorbed doses (1) and (2) are simulated in a TG-43 patient phantom derived by assigning the densities of every voxel to 1.00 g cm(-3) (water), whereas MC absorbed doses (3) and (4) are scored in the TG-186 patient phantom generated by mapping the mass density of each voxel to tissue according to a CT calibration curve. The MC absorbed doses calculated in this study are compared with VariSeed v8.0 calculated absorbed doses. To evaluate the dosimetric effect of MAR and TAS, the MC absorbed doses of this work (independent of MAR and TAS) are compared to the MC absorbed doses of different I-125 source models from previous studies that were calculated with different MC codes using post-implant CT-based phantoms generated by implementing MAR and TAS on post-implant CT images. Results The very good agreement of TG-43 parameters of this study and the published consensus data within 3% validates the geometry of the IsoSeed I25.S17plus source. For the clinical studies, the TG-43-based calculations show a D-90 overestimation of more than 4% compared to the more realistic MC methods due to ISA and tissue composition. The results of this work generally show few discrepancies with the post-implant CT-based dosimetry studies with respect to the D-90 absorbed dose metric parameter. These discrepancies are mainly Type B uncertainties due to the different I-125 source models and MC codes. Conclusions The implementation of MAR and TAS on post-implant CT images have no dosimetric effect on the I-125 prostate MC absorbed dose calculation in post-implant CT-based phantoms. |
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Address |
[Assam, Isong; Siebert, Frank-Andre] UKSH, Clin Radiotherapy Radiooncol, Campus Kiel, Kiel, Germany, Email: Isong.Assam@uksh.de |
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Publisher |
Wiley |
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English |
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Series Issue |
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Edition |
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ISSN |
0094-2405 |
ISBN |
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Notes |
WOS:000835807200001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5321 |
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Author |
Valdes-Cortez, C.; Niatsetski, Y.; Perez-Calatayud, J.; Ballester, F.; Vijande, J. |
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Title |
A Monte Carlo study of the relative biological effectiveness in surface brachytherapy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
49 |
Issue |
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Pages |
5576-5588 |
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Keywords |
Monte Carlo; relative biological effectiveness; surface HDR brachytherapy |
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Abstract |
Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value. |
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Address |
[Valdes-Cortez, Christian] Hosp Reg Antofagasta, Nucl Med Dept, Antofagasta, Chile, Email: cvalcort@gmail.com |
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Publisher |
Wiley |
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Language |
English |
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ISSN |
0094-2405 |
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Notes |
WOS:000811709400001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5262 |
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