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Author Muñoz, E.; Barrientos, L.; Bernabeu, J.; Borja-Lloret, M.; Llosa, G.; Ros, A.; Roser, J.; Oliver, J.F. doi  openurl
  Title A spectral reconstruction algorithm for two-plane Compton cameras Type Journal Article
  Year 2020 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.  
  Volume 65 Issue 2 Pages 025011 - 17pp  
  Keywords Compton imaging; Compton camera; hadron therapy; image reconstruction  
  Abstract One factor limiting the current applicability extent of hadron therapy is the lack of a reliable method for real time treatment monitoring. The use of Compton imaging systems as monitors requires the correct reconstruction of the distribution of prompt gamma productions during patient irradiation. In order to extract the maximum information from all the measurable events, we implemented a spectral reconstruction method that assigns to all events a probability of being either partial or total energy depositions. The method, implemented in a list-mode maximum likelihood expectation maximization algorithm, generates a four dimensional image in the joint spatial-spectral domain, in which the voxels containing the emission positions and energies are obtained. The analytical model used for the system response function is also employed to derive an analytical expression for the sensitivity, which is calculated via Monte Carlo integration. The performance of the method is evaluated through reconstruction of various experimental and simulated sources with different spatial and energy distributions. The results show that the proposed method can recover the spectral and spatial information simultaneously, but only under the assumption of ideal measurements. The analysis of the Monte Carlo simulations has led to the identification of two important degradation sources: the mispositioning of the gamma interaction point and the missing energy recorded in the interaction. Both factors are related to the high energy transferred to the recoil electrons, which can travel far from the interaction point and even escape the detector. These effects prevent the direct application of the current method in more realistic scenarios. Nevertheless, experimental point-like sources have been accurately reconstructed and the spatial distributions and spectral emission of complex simulated phantoms can be identified.  
  Address [Munoz, Enrique; Barrientos, Luis; Bernabeu, Jose; Borja-Lloret, Marina; Llosa, Gabriela; Ros, Ana; Roser, Jorge; Oliver, Josep F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9155 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000520111400001 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 4332  
Permanent link to this record
 

 
Author Etxebeste, A.; Barrio, J.; Bernabeu, J.; Lacasta, C.; Llosa, G.; Muñoz, E.; Ros, A.; Oliver, J.F. doi  openurl
  Title Study of sensitivity and resolution for full ring PET prototypes based on continuous crystals and analytical modeling of the light distribution Type Journal Article
  Year 2019 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.  
  Volume 64 Issue 3 Pages 035015 - 17pp  
  Keywords continuous crystals; NEMA NU 4-2008; positron emission tomography (PET); Monte Carlo simulations; image reconstruction; depth of interaction  
  Abstract Sensitivity and spatial resolution are the main parameters to maximize in the performance of a PET scanner. For this purpose, detectors consisting of a combination of continuous crystals optically coupled to segmented photodetectors have been employed. With the use of continuous crystals the sensitivity is increased with respect to the pixelated crystals. In addition, spatial resolution is no longer limited to the crystal size. The main drawback is the difficulty in determining the interaction position. In this work, we present the characterization of the performance of a full ring based on cuboid continuous crystals coupled to SiPMs. To this end, we have employed the simulations developed in a previous work for our experimental detector head. Sensitivity could be further enhanced by using tapered crystals. This enhancement is obtained by increasing the solid angle coverage, reducing the wedge-shaped gaps between contiguous detectors. The performance of the scanners based on both crystal geometries was characterized following NEMA NU 4-2008 standardized protocol in order to compare them. An average sensitivity gain over the entire axial field of view of 13.63% has been obtained with tapered geometry while similar performance of the spatial resolution has been proven with both scanners. The activity at which NECR and true peak occur is smaller and the peak value is greater for tapered crystals than for cuboid crystals. Moreover, a higher degree of homogeneity was obtained in the sensitivity map due to the tighter packing of the crystals, which reduces the gaps and results in a better recovery of homogeneous regions than for the cuboid configuration. Some of the results obtained, such as spatial resolution, depend on the interaction position estimation and may vary if other method is employed.  
  Address [Etxebeste, Ane; Barrio, John; Bernabeu, Jose; Lacasta, Carlos; Llosa, Gabriela; Munoz, Enrique; Ros, Ana; Oliver, Josef F.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: ane.etxebeste@ific.uv.es  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0031-9155 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000457182500004 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 3897  
Permanent link to this record
 

 
Author Calatayud-Jordan, J.; Candela-Juan, C.; Palma, J.D.; Pujades-Claumarchirant, M.C.; Soriano, A.; Gracia-Ochoa, M.; Vilar-Palop, J.; Vijande, J. doi  openurl
  Title Influence of the simultaneous calibration of multiple ring dosimeters on the individual absorbed dose Type Journal Article
  Year 2021 Publication Journal of Radiological Protection Abbreviated Journal J. Radiol. Prot.  
  Volume 41 Issue 2 Pages 384-397  
  Keywords ring dosimeters; personal dosimetry; calibration; Monte Carlo; ISO 4037  
  Abstract Ring dosimeters for personal dosimetry are calibrated in accredited laboratories following ISO 4037-3 guidelines. The simultaneous irradiation of multiple dosimeters would save time, but has to be carefully studied, since the scattering conditions could change and influence the absorbed dose in nearby dosimeters. Monte Carlo simulations using PENELOPE-2014 were performed to explore the need to increase the uncertainty of H-p (0.07) in the simultaneous irradiation of three and five DXT-RAD 707H-2 (Thermo Scientific) ring dosimeters with beam qualities: N-30, N-80 and N-300. Results show that the absorbed dose in each dosimeter is compatible with each of the others and with the reference simulation (a single dosimeter), with a coverage probability of 95% (k = 2). Comparison with experimental data yielded consistent results with the same coverage probability. Therefore, five ring dosimeters can be simultaneously irradiated with beam qualities ranging, at least, between N-30 and N-300 with a negligible impact on the uncertainty of H-p (0.07).  
  Address [Calatayud-Jordan, J.] Hosp Univ Politecn La Fe, Valencia, Spain, Email: calatayud_josjor@gva.es  
  Corporate Author Thesis  
  Publisher Iop Publishing Ltd Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0952-4746 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000657114600001 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 4850  
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Author Penas, J.; Alejo, A.; Bembibre, A.; Apiñaniz, J.I.; Garcia-Garcia, E.; Guerrero, C.; Henares, J.L.; Hernandez-Palmero, I.; Mendez, C.; Millan-Callado, M.A.; Puyuelo-Valdes, P.; Seimetz, M.; Benlliure, J. doi  openurl
  Title Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source Type Journal Article
  Year 2024 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 14 Issue 1 Pages 11448 - 12pp  
  Keywords  
  Abstract Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based on laser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of a high-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10-14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} B(p,n) 11 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{11}$$\end{document} C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10 Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.  
  Address [Penas, Juan; Alejo, Aaron; Bembibre, Adrian; Benlliure, Jose] Univ Santiago de Compostela, Inst Galego Fis Altas Enerxias IGFAE, Santiago De Compostela 15782, Spain, Email: j.benlliure@usc.es  
  Corporate Author Thesis  
  Publisher Nature Portfolio Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:001228252900017 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 6143  
Permanent link to this record
 

 
Author Tortajada, S.; Albiol, F.; Caballero, L.; Albiol, A.; Leganes-Nieto, J.L. doi  openurl
  Title A portable geometry-independent tomographic system for gamma-ray, a next generation of nuclear waste characterization Type Journal Article
  Year 2023 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 13 Issue 1 Pages 12284 - 10pp  
  Keywords  
  Abstract One of the main activities of the nuclear industry is the characterisation of radioactive waste based on the detection of gamma radiation. Large volumes of radioactive waste are classified according to their average activity, but often the radioactivity exceeds the maximum allowed by regulators in specific parts of the bulk. In addition, the detection of the radiation is currently based on static detection systems where the geometry of the bulk is fixed and well known. Furthermore, these systems are not portable and depend on the transport of waste to the places where the detection systems are located. However, there are situations where the geometry varies and where moving waste is complex. This is especially true in compromised situations.We present a new model for nuclear waste management based on a portable and geometry-independent tomographic system for three-dimensional image reconstruction for gamma radiation detection. The system relies on a combination of a gamma radiation camera and a visible camera that allows to visualise radioactivity using augmented reality and artificial computer vision techniques. This novel tomographic system has the potential to be a disruptive innovation in the nuclear industry for nuclear waste management.  
  Address [Tortajada, Salvador; Albiol, Francisco; Caballero, Luis] Univ Valencia, CSIC, Inst Fis Corpuscular, E-46980 Paterna Valencia, Spain, Email: s.tortajada@ific.uv.es  
  Corporate Author Thesis  
  Publisher Nature Portfolio Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:001041587900052 Approved no  
  Is ISI yes International Collaboration no  
  Call Number IFIC @ pastor @ Serial 5612  
Permanent link to this record
 

 
Author Muñoz, E.; Ros, A.; Borja-Lloret, M.; Barrio, J.; Dendooven, P.; Oliver, J.F.; Ozoemelam, I.; Roser, J.; Llosa, G. doi  openurl
  Title Proton range verification with MACACO II Compton camera enhanced by a neural network for event selection Type Journal Article
  Year 2021 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 11 Issue 1 Pages 9325 - 12pp  
  Keywords  
  Abstract The applicability extent of hadron therapy for tumor treatment is currently limited by the lack of reliable online monitoring techniques. An active topic of investigation is the research of monitoring systems based on the detection of secondary radiation produced during treatment. MACACO, a multi-layer Compton camera based on LaBr3 scintillator crystals and SiPMs, is being developed at IFIC-Valencia for this purpose. This work reports the results obtained from measurements of a 150 MeV proton beam impinging on a PMMA target. A neural network trained on Monte Carlo simulations is used for event selection, increasing the signal to background ratio before image reconstruction. Images of the measured prompt gamma distributions are reconstructed by means of a spectral reconstruction code, through which the 4.439 MeV spectral line is resolved. Images of the emission distribution at this energy are reconstructed, allowing calculation of the distal fall-off and identification of target displacements of 3 mm.  
  Address [Munoz, Enrique; Ros, Ana; Borja-Lloret, Marina; Barrio, John; Oliver, Josep F.; Roser, Jorge; Llosa, Gabriela] Univ Valencia, Inst Fis Corpuscular IFIC, CSIC, Valencia, Spain, Email: Enrique.Munoz@ific.uv.es  
  Corporate Author Thesis  
  Publisher Nature Research Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000651603500001 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 4836  
Permanent link to this record
 

 
Author Khachatryan, M. et al, Coloma, P. doi  openurl
  Title Electron-beam energy reconstruction for neutrino oscillation measurements Type Journal Article
  Year 2021 Publication Nature Abbreviated Journal Nature  
  Volume 599 Issue 7886 Pages 565-570  
  Keywords  
  Abstract Neutrinos exist in one of three types or 'flavours'-electron, muon and tau neutrinos-and oscillate from one flavour to another when propagating through space. This phenomena is one of the few that cannot be described using the standard model of particle physics (reviewed in ref. (1)), and so its experimental study can provide new insight into the nature of our Universe (reviewed in ref. (2)). Neutrinos oscillate as a function of their propagation distance (L) divided by their energy (E). Therefore, experiments extract oscillation parameters by measuring their energy distribution at different locations. As accelerator-based oscillation experiments cannot directly measure E, the interpretation of these experiments relies heavily on phenomenological models of neutrino-nucleus interactions to infer E. Here we exploit the similarity of electron-nucleus and neutrino-nucleus interactions, and use electron scattering data with known beam energies to test energy reconstruction methods and interaction models. We find that even in simple interactions where no pions are detected, only a small fraction of events reconstruct to the correct incident energy. More importantly, widely used interaction models reproduce the reconstructed energy distribution only qualitatively and the quality of the reproduction varies strongly with beam energy. This shows both the need and the pathway to improve current models to meet the requirements of next-generation, high-precision experiments such as Hyper-Kamiokande (Japan)(3) and DUNE (USA)(4). Electron scattering measurements are shown to reproduce only qualitatively state-of-the-art lepton-nucleus energy reconstruction models, indicating that improvements to these particle-interaction models are required to ensure the accuracy of future high-precision neutrino oscillation experiments.  
  Address [Khachatryan, M.; Hauenstein, F.; Weinstein, L. B.] Old Domin Univ, Norfolk, VA USA, Email: adishka@mit.edu  
  Corporate Author Thesis  
  Publisher Nature Portfolio Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000722366200013 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 5073  
Permanent link to this record
 

 
Author Wilson, J.N. et al; Algora, A. doi  openurl
  Title Angular momentum generation in nuclear fission Type Journal Article
  Year 2021 Publication Nature Abbreviated Journal Nature  
  Volume 590 Issue 7847 Pages 566-570  
  Keywords  
  Abstract When a heavy atomic nucleus splits (fission), the resulting fragments are observed to emerge spinning(1); this phenomenon has been a mystery in nuclear physics for over 40 years(2,3). The internal generation of typically six or seven units of angular momentum in each fragment is particularly puzzling for systems that start with zero, or almost zero, spin. There are currently no experimental observations that enable decisive discrimination between the many competing theories for the mechanism that generates the angular momentum(4-12). Nevertheless, the consensus is that excitation of collective vibrational modes generates the intrinsic spin before the nucleus splits (pre-scission). Here we show that there is no significant correlation between the spins of the fragment partners, which leads us to conclude that angular momentum in fission is actually generated after the nucleus splits (post-scission). We present comprehensive data showing that the average spin is strongly mass-dependent, varying in saw-tooth distributions. We observe no notable dependence of fragment spin on the mass or charge of the partner nucleus, confirming the uncorrelated post-scission nature of the spin mechanism. To explain these observations, we propose that the collective motion of nucleons in the ruptured neck of the fissioning system generates two independent torques, analogous to the snapping of an elastic band. A parameterization based on occupation of angular momentum states according to statistical theory describes the full range of experimental data well. This insight into the role of spin in nuclear fission is not only important for the fundamental understanding and theoretical description of fission, but also has consequences for the gamma-ray heating problem in nuclear reactors(13,14), for the study of the structure of neutron-rich isotopes(15,16), and for the synthesis and stability of super-heavy elements(17,18). gamma-ray spectroscopy experiments on the origin of spin in the products of nuclear fission of spin-zero nuclei suggest that the fission fragments acquire their spin after scission, rather than before.  
  Address [Wilson, J. N.; Thisse, D.; Lebois, M.; Jovancevic, N.; Adsley, P.; Babo, M.; Chakma, R.; Delafosse, C.; Haefner, G.; Hauschild, K.; Ibrahim, F.; Ljungvall, J.; Lopez-Martens, A.; Lozeva, R.; Matea, I; Nemer, J.; Popovitch, Y.; Qi, L.; Tocabens, G.; Verney, D.] Univ Paris Saclay, IJC Lab, CNRS, IN2P3, Orsay, France, Email: jonathan.wilson@ijclab.in2p3.fr  
  Corporate Author Thesis  
  Publisher Nature Research Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000621583600006 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 4717  
Permanent link to this record
 

 
Author Conde, D.; Castillo, F.L.; Escobar, C.; García, C.; Garcia Navarro, J.E.; Sanz, V.; Zaldívar, B.; Curto, J.J.; Marsal, S.; Torta, J.M. doi  openurl
  Title Forecasting Geomagnetic Storm Disturbances and Their Uncertainties Using Deep Learning Type Journal Article
  Year 2023 Publication Space Weather Abbreviated Journal Space Weather  
  Volume 21 Issue 11 Pages e2023SW003474 - 27pp  
  Keywords geomagnetic storms; deep learning; forecasting; SYM-H; uncertainties; hyper-parameter optimization  
  Abstract Severe space weather produced by disturbed conditions on the Sun results in harmful effects both for humans in space and in high-latitude flights, and for technological systems such as spacecraft or communications. Also, geomagnetically induced currents (GICs) flowing on long ground-based conductors, such as power networks, potentially threaten critical infrastructures on Earth. The first step in developing an alarm system against GICs is to forecast them. This is a challenging task given the highly non-linear dependencies of the response of the magnetosphere to these perturbations. In the last few years, modern machine-learning models have shown to be very good at predicting magnetic activity indices. However, such complex models are on the one hand difficult to tune, and on the other hand they are known to bring along potentially large prediction uncertainties which are generally difficult to estimate. In this work we aim at predicting the SYM-H index characterizing geomagnetic storms multiple-hour ahead, using public interplanetary magnetic field (IMF) data from the Sun-Earth L1 Lagrange point and SYM-H data. We implement a type of machine-learning model called long short-term memory (LSTM) network. Our scope is to estimate the prediction uncertainties coming from a deep-learning model in the context of forecasting the SYM-H index. These uncertainties will be essential to set reliable alarm thresholds. The resulting uncertainties turn out to be sizable at the critical stages of the geomagnetic storms. Our methodology includes as well an efficient optimization of important hyper-parameters of the LSTM network and robustness tests.  
  Address [Conde, D.; Escobar, C.; Garcia, C.; Garcia, J. E.; Sanz, V.; Zaldivar, B.] Univ Valencia, CSIC, Ctr Mixto, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Daniel.Conde@ific.uv.es  
  Corporate Author Thesis  
  Publisher Amer Geophysical Union Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes WOS:001104189700001 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 5804  
Permanent link to this record
 

 
Author Oliver, S.; Gimenez-Alventosa, V.; Berumen, F.; Gimenez, V.; Beaulieu, L.; Ballester, F.; Vijande, J. doi  openurl
  Title Benchmark of the PenRed Monte Carlo framework for HDR brachytherapy Type Journal Article
  Year 2023 Publication Zeitschrift für Medizinische Physik Abbreviated Journal Z. Med. Phys.  
  Volume 33 Issue 4 Pages 511-528  
  Keywords Monte Carlo; PenRed; Brachytherapy; DICOM; Medical physics  
  Abstract Purpose: The purpose of this study is to validate the PenRed Monte Carlo framework for clinical applications in brachytherapy. PenRed is a C++ version of Penelope Monte Carlo code with additional tallies and utilities. Methods and materials: Six benchmarking scenarios are explored to validate the use of PenRed and its improved bachytherapy-oriented capabilities for HDR brachytherapy. A new tally allowing the evaluation of collisional kerma for any material using the track length kerma estimator and the possibility to obtain the seed positions, weights and directions processing directly the DICOM file are now implemented in the PenRed distribution. The four non-clinical test cases developed by the Joint AAPM-ESTRO-ABG-ABS WG-DCAB were evaluated by comparing local and global absorbed dose differences with respect to established reference datasets. A prostate and a palliative lung cases, were also studied. For them, absorbed dose ratios, global absorbed dose differences, and cumulative dose-volume histograms were obtained and discussed. Results: The air-kerma strength and the dose rate constant corresponding to the two sources agree with the reference datatests within 0.3% (Sk) and 0.1% (K). With respect to the first three WG-DCAB test cases, more than 99.8% of the voxels present local (global) differences within +/- 1%(+/- 0.1%) of the reference datasets. For test Case 4 reference dataset, more than 94.9%(97.5%) of voxels show an agreement within +/- 1%(+/- 0.1%), better than similar benchmarking calculations in the literature. The track length kerma estimator scorer implemented increases the numerical efficiency of brachytherapy calculations two orders of magnitude, while the specific brachytherapy source allows the user to avoid the use of error-prone intermediate steps to translate the DICOM information into the simulation. In both clinical cases, only minor absorbed dose differences arise in the low-dose isodoses. 99.8% and 100% of the voxels have a global absorbed dose difference ratio within +/- 0.2%for the prostate and lung cases, respectively. The role played by the different segmentation and composition material in the bone structures was discussed, obtaining negligible absorbed dose differ-ences. Dose-volume histograms were in agreement with the reference data.Conclusions: PenRed incorporates new tallies and utilities and has been validated for its use for detailed and precise high-dose-rate brachytherapy simulations.  
  Address [Oliver, S.] Univ Politecn Valencia, Inst Segur Ind, Radiofis & Medioambiental ISIRYM, Camide Vera s n, Valencia 46022, Spain, Email: sanolgi@upvnet.upv.es  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0939-3889 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:001137118400001 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 5885  
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