Abstract: The NEXT experiment aims at the sensitive search of the neutrinoless double beta decay in Xe-136, using high-pressure gas electroluminescent time projection chambers. The NEXT-White detector is the first radiopure demonstrator of this technology, operated in the Laboratorio Subterr & aacute;neo de Canfranc. Achieving an energy resolution of 1% FWHM at 2.6 MeV and further background rejection by means of the topology of the reconstructed tracks, NEXT-White has been exploited beyond its original goals in order to perform a neu-trinoless double beta decay search. The analysis considers the combination of 271.6 days of Xe-136-enriched data and 208.9 days of 136Xe-depleted data. A detailed background mod-eling and measurement has been developed, ensuring the time stability of the radiogenic and cosmogenic contributions across both data samples. Limits to the neutrinoless mode are obtained in two alternative analyses: a background-model-dependent approach and a novel direct background-subtraction technique, offering results with small dependence on the background model assumptions. With a fiducial mass of only 3.50 +/- 0.01 kg of Xe-136-enriched xenon, 90% C.L. lower limits to the neutrinoless double beta decay are found in the T-1/2(0 nu) > 5.5x10(23) -1.3x10(24) yr range, depending on the method. The presented techniques stand as a pro of-of-concept for the searches to be implemented with larger NEXT detectors.