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Author |
Valdes-Cortez, C.; Niatsetski, Y.; Perez-Calatayud, J.; Ballester, F.; Vijande, J. |
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Title |
A Monte Carlo study of the relative biological effectiveness in surface brachytherapy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
49 |
Issue |
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Pages |
5576-5588 |
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Keywords |
Monte Carlo; relative biological effectiveness; surface HDR brachytherapy |
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Abstract |
Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value. |
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[Valdes-Cortez, Christian] Hosp Reg Antofagasta, Nucl Med Dept, Antofagasta, Chile, Email: cvalcort@gmail.com |
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Wiley |
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English |
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0094-2405 |
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WOS:000811709400001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
5262 |
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Author |
Ma, Y.Z.; Vijande, J.; Ballester, F.; Tedgren, A.C.; Granero, D.; Haworth, A.; Mourtada, F.; Fonseca, G.P.; Zourari, K.; Papagiannis, P.; Rivard, M.J.; Siebert, F.A.; Sloboda, R.S.; Smith, R.; Chamberland, M.J.P.; Thomson, R.M.; Verhaegen, F.; Beaulieu, L. |
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Title |
A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate Ir-192 brachytherapy |
Type |
Journal Article |
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Year |
2017 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
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Volume |
44 |
Issue |
11 |
Pages |
5961-5976 |
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Keywords |
Ir-192; HDR brachytherapy; model based dose calculation; Monte Carlo methods; shielded applicator; TG-186 |
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Abstract |
PurposeA joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform calculations and comparisons with model-based dose calculation algorithms (MBDCAs). Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No. 186 (TG-186) for MBDCAs. To do so, in this work a hypothetical, generic high-dose rate (HDR) Ir-192 shielded applicator has been designed and benchmarked. MethodsA generic HDR Ir-192 shielded applicator was designed based on three commercially available gynecological applicators as well as a virtual cubic water phantom that can be imported into any DICOM-RT compatible treatment planning system (TPS). The absorbed dose distribution around the applicator with the TG-186 Ir-192 source located at one dwell position at its center was computed using two commercial TPSs incorporating MBDCAs (Oncentra((R)) Brachy with Advanced Collapsed-cone Engine, ACE, and BrachyVision ACUROS) and state-of-the-art Monte Carlo (MC) codes, including ALGEBRA, BrachyDose, egs_brachy, Geant4, MCNP6, and Penelope2008. TPS-based volumetric dose distributions for the previously reported source centered in water and source displaced test cases, and the new source centered in applicator test case, were analyzed here using the MCNP6 dose distribution as a reference. Volumetric dose comparisons of TPS results against results for the other MC codes were also performed. Distributions of local and global dose difference ratios are reported. ResultsThe local dose differences among MC codes are comparable to the statistical uncertainties of the reference datasets for the source centered in water and source displaced test cases and for the clinically relevant part of the unshielded volume in the source centered in applicator case. Larger local differences appear in the shielded volume or at large distances. Considering clinically relevant regions, global dose differences are smaller than the local ones. The most disadvantageous case for the MBDCAs is the one including the shielded applicator. In this case, ACUROS agrees with MC within [-4.2%, +4.2%] for the majority of voxels (95%) while presenting dose differences within [-0.12%, +0.12%] of the dose at a clinically relevant reference point. For ACE, 95% of the total volume presents differences with respect to MC in the range [-1.7%, +0.4%] of the dose at the reference point. ConclusionsThe combination of the generic source and generic shielded applicator, together with the previously developed test cases and reference datasets (available in the Brachytherapy Source Registry), lay a solid foundation in supporting uniform commissioning procedures and direct comparisons among treatment planning systems for HDR Ir-192 brachytherapy. |
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[Ma, Yunzhi; Beaulieu, Luc] CHU Quebec, Dept Radio Oncol & Axe Oncol, Ctr Rech, Quebec City, PQ G1R 2J6, Canada, Email: yunzhi.Ma@crchuq.ulaval.ca |
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Wiley |
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English |
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0094-2405 |
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Notes |
WOS:000414970800039 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3370 |
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Author |
Schaffter, T. et al; Albiol, F.; Caballero, L. |
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Title |
Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms |
Type |
Journal Article |
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Year |
2020 |
Publication |
JAMA Network Open |
Abbreviated Journal |
JAMA Netw. Open |
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Volume |
3 |
Issue |
3 |
Pages |
e200265 - 15pp |
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Keywords |
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Abstract |
Importance Mammography screening currently relies on subjective human interpretation. Artificial intelligence (AI) advances could be used to increase mammography screening accuracy by reducing missed cancers and false positives. Objective To evaluate whether AI can overcome human mammography interpretation limitations with a rigorous, unbiased evaluation of machine learning algorithms. Design, Setting, and Participants In this diagnostic accuracy study conducted between September 2016 and November 2017, an international, crowdsourced challenge was hosted to foster AI algorithm development focused on interpreting screening mammography. More than 1100 participants comprising 126 teams from 44 countries participated. Analysis began November 18, 2016. Main Outcomes and Measurements Algorithms used images alone (challenge 1) or combined images, previous examinations (if available), and clinical and demographic risk factor data (challenge 2) and output a score that translated to cancer yes/no within 12 months. Algorithm accuracy for breast cancer detection was evaluated using area under the curve and algorithm specificity compared with radiologists' specificity with radiologists' sensitivity set at 85.9% (United States) and 83.9% (Sweden). An ensemble method aggregating top-performing AI algorithms and radiologists' recall assessment was developed and evaluated. Results Overall, 144231 screening mammograms from 85580 US women (952 cancer positive <= 12 months from screening) were used for algorithm training and validation. A second independent validation cohort included 166578 examinations from 68008 Swedish women (780 cancer positive). The top-performing algorithm achieved an area under the curve of 0.858 (United States) and 0.903 (Sweden) and 66.2% (United States) and 81.2% (Sweden) specificity at the radiologists' sensitivity, lower than community-practice radiologists' specificity of 90.5% (United States) and 98.5% (Sweden). Combining top-performing algorithms and US radiologist assessments resulted in a higher area under the curve of 0.942 and achieved a significantly improved specificity (92.0%) at the same sensitivity. Conclusions and Relevance While no single AI algorithm outperformed radiologists, an ensemble of AI algorithms combined with radiologist assessment in a single-reader screening environment improved overall accuracy. This study underscores the potential of using machine learning methods for enhancing mammography screening interpretation. Question How do deep learning algorithms perform compared with radiologists in screening mammography interpretation? Findings In this diagnostic accuracy study using 144231 screening mammograms from 85580 women from the United States and 166578 screening mammograms from 68008 women from Sweden, no single artificial intelligence algorithm outperformed US community radiologist benchmarks; including clinical data and prior mammograms did not improve artificial intelligence performance. However, combining best-performing artificial intelligence algorithms with single-radiologist assessment demonstrated increased specificity. Meaning Integrating artificial intelligence to mammography interpretation in single-radiologist settings could yield significant performance improvements, with the potential to reduce health care system expenditures and address resource scarcity experienced in population-based screening programs. This diagnostic accuracy study evaluates whether artificial intelligence can overcome human mammography interpretation limits with a rigorous, unbiased evaluation of machine learning algorithms. |
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Address |
[Schaffter, Thomas; Hoff, Bruce; Yu, Thomas; Neto, Elias Chaibub; Friend, Stephen; Guinney, Justin] Sage Bionetworks, Computat Oncol, Seattle, WA USA, Email: gustavo@us.ibm.com |
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Amer Medical Assoc |
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English |
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2574-3805 |
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Notes |
WOS:000519249800002 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4683 |
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Author |
Vento, V. |
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Title |
Ions, Protons, and Photons as Signatures of Monopoles |
Type |
Journal Article |
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Year |
2018 |
Publication |
Universe |
Abbreviated Journal |
Universe |
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Volume |
4 |
Issue |
11 |
Pages |
117 - 12pp |
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Abstract |
Magnetic monopoles have been a subject of interest since Dirac established the relationship between the existence of monopoles and charge quantization. The Dirac quantization condition bestows the monopole with a huge magnetic charge. The aim of this study was to determine whether this huge magnetic charge allows monopoles to be detected by the scattering of charged ions and protons on matter where they might be bound. We also analyze if this charge favors monopolium (monopole-antimonopole) annihilation into many photons over two photon decays. |
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Address |
[Vento, Vicente] Univ Valencia, CSIC, IFIC, Dept Fis Teor, E-46100 Burjassot, Valencia, Spain, Email: vicente.vento@uv.es |
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Mdpi |
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English |
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ISSN |
2218-1997 |
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Notes |
WOS:000451167700007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
3819 |
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Author |
Gersabeck, E.; Pich, A. |
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Title |
Tau and charm decays |
Type |
Journal Article |
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Year |
2020 |
Publication |
Comptes Rendus Physique |
Abbreviated Journal |
C. R. Phys. |
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Volume |
21 |
Issue |
1 |
Pages |
75-92 |
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Keywords |
Tau and charm physics; D-0 mixing; CP violation |
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Abstract |
A summary of recent precise results in tau and charm physics is presented. Topics include leptonic and hadronic tau decays, lepton flavour and lepton number violation, charm mixing and CP violation, leptonic and semileptonic charm decays, rare decays and spectroscopy. |
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Address |
[Gersabeck, Evelina] Univ Manchester, Oxford Rd, Manchester M13 9PL, Lancs, England, Email: evelina.gersabeck@cern.ch; |
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centre Mersenne pour ldition scientifique ouverte |
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English |
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ISSN |
1631-0705 |
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Notes |
WOS:000573985600006 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
4550 |
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ATLAS Collaboration (Aad, G. et al); Aparisi Pozo, J.A.; Bailey, A.J.; Cabrera Urban, S.; Castillo, F.L.; Castillo Gimenez, V.; Costa, M.J.; Escobar, C.; Estrada Pastor, O.; Ferrer, A.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Higon-Rodriguez, E.; Lacasta, C.; Lozano Bahilo, J.J.; Madaffari, D.; Mamuzic, J.; Marti-Garcia, S.; Martinez Agullo, P.; Mitsou, V.A.; Moreno Llacer, M.; Poveda, J.; Rodriguez Bosca, S.; Ruiz-Martinez, A.; Salt, J.; Santra, A.; Sayago Galvan, I.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valls Ferrer, J.A.; Vos, M. |
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Title |
Search for quantum black hole production in lepton plus jet final states using proton-proton collisions at √s=13 TeV with the ATLAS detector |
Type |
Journal Article |
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Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
109 |
Issue |
3 |
Pages |
032010 - 28pp |
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Abstract |
A search for quantum black holes in electron + jet and muon + jet invariant mass spectra is performed with 140 fb(-1) of data collected by the ATLAS detector in proton-proton collisions at root s = 13 TeV at the Large Hadron Collider. The observed invariant mass spectrum of lepton + jet pairs is consistent with Standard Model expectations. Upper limits are set at 95% confidence level on the production cross section times branching fractions for quantum black holes decaying into a lepton and a quark in a search region with invariant mass above 2.0 TeV. The resulting quantum black hole lower mass threshold limit is 9.2 TeV in the Arkani-Hamed-Dimopoulos-Dvali model, and 6.8 TeV in the Randall-Sundrum model. |
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Address |
[Jackson, P.; Kong, A. X. Y.; Oliver, J. L.; Petridis, A.; Ruggeri, T. A.; Sharma, A. S.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Amer Physical Soc |
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English |
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ISSN |
2470-0010 |
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Notes |
WOS:001183228500014 |
Approved |
no |
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Is ISI |
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International Collaboration |
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Call Number |
IFIC @ pastor @ |
Serial |
5987 |
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Author |
Cervantes, D.; Fioresi, R.; Lledo, M.A.; Nadal, F.A. |
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Title |
Quantum Twistors |
Type |
Journal Article |
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Year |
2016 |
Publication |
P-Adic Numbers Ultrametric Analysis and Applications |
Abbreviated Journal |
P-Adic Num. |
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Volume |
8 |
Issue |
1 |
Pages |
2-30 |
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Keywords |
star products; non commutative spacetime; quantum groups |
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Abstract |
We compute explicitly a star product on the Minkowski space whose Poisson bracket is quadratic. This star product corresponds to a deformation of the conformal spacetime, whose big cell is the Minkowski spacetime. The description of Minkowski space is made in the twistor formalism and the quantization follows by substituting the classical conformal group by a quantum group. |
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Address |
[Cervantes, D.] IPN, CINVESTAV, Comp Sci Dept, Mexico City, DF, Mexico, Email: dalia@computacion.cs.cinvestav.mx; |
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Maik Nauka-Interperiodica |
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English |
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ISSN |
2070-0466 |
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Notes |
WOS:000410319300001 |
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no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3295 |
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Author |
Kim, J.; Ko, P.; Park, W.I. |
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Title |
Higgs-portal assisted Higgs inflation with a sizeable tensor-to-scalar ratio |
Type |
Journal Article |
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Year |
2017 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
003 - 16pp |
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Keywords |
inflation; particle physics – cosmology connection; physics of the early universe |
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Abstract |
We show that the Higgs portal interactions involving extra dark Higgs field can save generically the original Higgs inflation of the standard model (SM) from the problem of a deep non-SM vacuum in the SM Higgs potential. Specifically, we show that such interactions disconnect the top quark pole mass from inflationary observables and allow multi-dimensional parameter space to save the Higgs inflation, thanks to the additional parameters (the dark Higgs boson mass m(phi), the mixing angle a between the SM Higgs H and dark Higgs Phi, and the mixed quartic coupling) affecting RG-running of the Higgs quartic coupling. The effect of Higgs portal interactions may lead to a larger tensor-to-scalar ratio, 0.08 less than or similar to r less than or similar to 0.1, by adjusting relevant parameters in wide ranges of alpha and m(phi), some region of which can be probed at future colliders. Performing a numerical analysis we find an allowed region of parameters, matching the latest Planck data. |
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Address |
[Kim, Jinsu; Ko, Pyungwon] Korea Inst Adv Study, Quantum Universe Ctr, 85 Hoegiro Dongdaemungu, Seoul 02455, South Korea, Email: kimjinsu@kias.re.kr; |
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Iop Publishing Ltd |
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English |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Notes |
WOS:000399455000003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3080 |
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Author |
BABAR Collaboration (Lees, J.P. et al); Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P. |
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Title |
Evidence for CP violation in B+ -> K*(892)(+)pi(0) from a Dalitz plot analysis of B+ -> K-S(0) pi(+)pi(0) decays |
Type |
Journal Article |
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Year |
2017 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
96 |
Issue |
7 |
Pages |
072001 - 21pp |
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Abstract |
We report a Dalitz plot analysis of charmless hadronic decays of charged B mesons to the final state K-S(0)pi(1) pi(0) using the full BABAR data set of 470.9 +/- 2.8 million B (B) over bar events collected at the gamma (4S) resonance. We measure the overall branching fraction and CP asymmetry to be B(B+ -> K-0 pi(+)pi(0)) = (31.8 +/- 1.8 +/- 2.1(-0.0)(+6.0)) x 10(-6) and A(CP)(B+ -> K-0 pi(+)pi(0)) = 0.07 +/- 0.05 +/- 0.03(-0.03)(+0.02), where the uncertainties are statistical, systematic, and due to the signal model, respectively. This is the first measurement of the branching fraction for B+ -> K-0 pi(+)pi(0). We find first evidence of a CP asymmetry in B+ -> K*(892)(+) pi(0) decays: A(CP)(B+ -> K*(892)(+)pi(0)) = -0.52 +/- 0.14 +/- 0.04(-0.02)(+0.04). The significance of this asymmetry, including systematic and model uncertainties, is 3.4 standard deviations. We also measure the branching fractions and CP asymmetries for three other intermediate decay modes. |
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Address |
[Lees, J. P.; Poireau, V.; Tisserand, V.] Univ Savoie, CNRS, IN2P3, Lab Annecy le Vieux Phys Particules LAPP, F-74941 Annecy Le Vieux, France |
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Amer Physical Soc |
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English |
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ISSN |
2470-0010 |
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Notes |
WOS:000412031400001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3314 |
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Author |
Bertone, G.; Calore, F.; Caron, S.; Ruiz de Austri, R.; Kim, J.S.; Trotta, R.; Weniger, C. |
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Title |
Global analysis of the pMSSM in light of the Fermi GeV excess: prospects for the LHC Run-II and astroparticle experiments |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
04 |
Issue |
4 |
Pages |
037 - 20pp |
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Keywords |
dark matter detectors; dark matter theory; gamma ray experiments; supersymmetry and cosmology |
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Abstract |
We present a new global fit of the 19-dimensional phenomenological Minimal Supersymmetric Standard Model (pMSSM-19) that complies with all the latest experimental results from dark matter indirect, direct and accelerator dark matter searches. We show that the model provides a satisfactory explanation of the excess of gamma rays from the Galactic centre observed by the Fermi Large Area Telescope, assuming that it is produced by the annihilation of neutralinos in the Milky Way halo. We identify two regions that pass all the constraints: the first corresponds to neutralinos with a mass similar to 80 – 100 GeV annihilating into WW with a branching ratio of 95%; the second to heavier neutralinos, with mass similar to 180 – 200 GeV annihilating into (l) over barl with a branching ratio of 87%. We show that neutralinos compatible with the Galactic centre GeV excess will soon be within the reach of LHC run-II – notably through searches for charginos and neutralinos, squarks and light smuons – and of Xenon1T, thanks to its unprecedented sensitivity to spin-dependent cross-section off neutrons. |
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Address |
[Bertone, Gianfranco; Calore, Francesca; Weniger, Christoph] Univ Amsterdam, GRAPPA, Sci Pk 904, NL-1090 GL Amsterdam, Netherlands, Email: gf.bertone@gmail.com; |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000393286400010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2951 |
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