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Koolen, B. B., Vidal-Sicart, S., Benlloch, J. M., & Olmos, R. A. V. (2014). Evaluating heterogeneity of primary tumor 18 F-FDG uptake in breast cancer with a dedicated breast PET ( MAMMI): a feasibility study based on correlation with PET/CT. Nucl. Med. Commun., 35(5), 446–452.
Abstract: PurposeThe aim of the study was to evaluate the heterogeneity of primary tumor F-18-fluorodeoxyglucose (F-18-FDG) uptake in breast cancer patients using a dedicated breast PET.Patients and methodsA positron emission tomography/computed tomography (PET/CT) of the thorax was performed 60 min after administration of 180-240 MBq of F-18-FDG in patients with breast cancer. Subsequently, 110 min after injection, a scan was taken with a dedicated high-resolution breast PET [MAMmography with Molecular Imaging (MAMMI)]. Both procedures were performed with the patients in the prone position. Four-point scores were used to compare the intensity (0: none; 1: mild; 2: moderate; 3: high) and heterogeneity (0: none; 1: mild; 2: moderate; 3: high) of F-18-FDG uptake between PET/CT and MAMMI images.ResultsThirty-five patients in whom the primary tumor was visualized on both scans were included in this analysis. The mean primary tumor size was 35.1 mm (range 10-108 mm). The mean intensity score was similar on both devices (2.4 for PET/CT and 2.3 for MAMMI; P=0.439), but the mean heterogeneity score on MAMMI images was significantly higher (PET/CT 1.9 vs. MAMMI 2.3; P=0.005). MAMMI showed a higher heterogeneity score in 11 (31%) of 35 patients, especially in tumors with moderate or high intensity. Significantly higher heterogeneity scores on both PET/CT and MAMMI were seen in large tumors (P=0.005 and 0.014, respectively) and in tumors with high intensity scores (P=0.012 and P<0.001, respectively).ConclusionHeterogeneous tumor F-18-FDG uptake in breast cancer is frequently observed, particularly in large tumors with intense F-18-FDG uptake. It is more often seen on MAMMI PET than on conventional PET/CT. Although the observed heterogeneity should be proven histopathologically, this finding offers a rationale for F-18-FDG-guided biopsies.
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Ros, A., Lerche, C. W., Sebastia, A., Sanchez, F., & Benlloch, J. M. (2014). Retroreflector arrays for better light collection efficiency of gamma-ray imaging detectors with continuous scintillation crystals without DOI misestimation. J. Instrum., 9, P04009–14pp.
Abstract: A method to improve light collection efficiency of gamma-ray imaging detectors by using retroreflector arrays has been tested, simulations of the behaviour of the scintillation light illuminating the retroreflector surface have been made. Measurements including retroreflector arrays in the setup have also been taken. For the measurements, positron emission tomography (PET) detectors with continuous scintillation crystals have been used. Each detector module consists of a continuous LSO-scintillator of dimensions 49x49x10 mm(3) and a H8500 position-sensitive photo-multiplier (PSPMT) from Hamamatsu. By using a continuous scintillation crystal, the scintillation light distribution has not been destroyed and the energy, the centroids along the x- and y-direction and the depth of interaction (DOI) can be estimated. Simulations have also been run taking into account the use of continuous scintillation crystals. Due to the geometry of the continuous scintillation crystals in comparison with pixelated crystals, a good light collection efficiency is necessary to correctly reconstruct the impact point of the gamma-ray. The aim of this study is to investigate whether micro-machine retro-reflectors improve light yield without misestimation of the impact point. The results shows an improvement on the energy and centroid resolutions without worsening the depth of interaction resolution. Therefore it can be concluded that using retroreflector arrays at the entrance side of the scintillation crystal improves light collection efficiency without worsening the impact point estimation.
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Diez, S. et al, Bernabeu Verdú, J., Civera, J. V., Garcia, C., Garcia-Argos, C., Lacasta, C., et al. (2014). A double-sided, shield-less stave prototype for the ATLAS Upgrade strip tracker for the High Luminosity LHC. J. Instrum., 9, P03012–16pp.
Abstract: A detailed description of the integration structures for the barrel region of the silicon strips tracker of the ATLAS Phase-II upgrade for the upgrade of the Large Hadron Collider, the so-called High Luminosity LHC (HL-LHC), is presented. This paper focuses on one of the latest demonstrator prototypes recently assembled, with numerous unique features. It consists of a shortened, shield-less, and double sided stave, with two candidate power distributions implemented. Thermal and electrical performances of the prototype are presented, as well as a description of the assembly procedures and tools.
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Carrio, F., Kim, H. Y., Moreno, P., Reed, R., Sandrock, C., Schettino, V., et al. (2014). Design of an FPGA-based embedded system for the ATLAS Tile Calorimeter front-end electronics test-bench. J. Instrum., 9, C03023–12pp.
Abstract: The portable test-bench for the certification of the ATLAS tile hadronic calorimeter front-end electronics has been redesigned for the present Long Shutdown (LS1) of LHC, improving its portability and expanding its functionalities. This paper presents a new test-bench based on a Xilinx Virtex-5 FPGA that implements an embedded system using a PowerPC 440 microprocessor hard core and custom IP cores. A light Linux version runs on the PowerPC microprocessor and handles the IP cores which implement the different functionalities needed to perform the desired tests such as TTCvi emulation, G-Link decoding, ADC control and data reception.
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Esperante-Pereira, D. (2014). DEPFET active pixel sensors for the vertex detector of the Belle-II experiment. J. Instrum., 9, C03004–11pp.
Abstract: Active pixels sensors based on the DEPFET technology will be used for the innermost vertex detector of the future Belle-II experiment. The increased luminosity of the e(+) e(-) SuperKEKB collider entails challenging detector requirements, namely: low material budget, low power consumption, high precision and efficiency, and a large readout rate. The DEPFET active pixel technology has shown to be a suitable solution for this purpose. A review of the different aspects of the detector design (sensors, readout ASICS and supplementary infrastructure) and the results of the latest thinned sensor prototypes (50 μm) are described.
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