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Author Torres-Espallardo, I.; Diblen, F.; Rohling, H.; Solevi, P.; Gillam, J.; Watts, D.; Espana, S.; Vandenberghe, S.; Fiedler, F.; Rafecas, M.
Title Evaluation of resistive-plate-chamber-based TOF-PET applied to in-beam particle therapy monitoring Type Journal Article
Year 2015 Publication Physics in Medicine and Biology Abbreviated Journal Phys. Med. Biol.
Volume 60 Issue 9 Pages N187-N208
Keywords PET; in-beam; RPC; particle therapy; TOF; range deviation; partial-ring
Abstract Particle therapy is a highly conformal radiotherapy technique which reduces the dose deposited to the surrounding normal tissues. In order to fully exploit its advantages, treatment monitoring is necessary to minimize uncertainties related to the dose delivery. Up to now, the only clinically feasible technique for the monitoring of therapeutic irradiation with particle beams is Positron Emission Tomography (PET). In this work we have compared a Resistive Plate Chamber (RPC)-based PET scanner with a scintillation-crystal-based PET scanner for this application. In general, the main advantages of the RPC-PET system are its excellent timing resolution, low cost, and the possibility of building large area systems. We simulated a partial-ring scannerbeam monitoring, which has an intrinsically low positron yield compared to diagnostic PET. In addition, for in-beam PET there is a further data loss due to the partial ring configuration. In order to improve the performance of the RPC-based scanner, an improved version of the RPC detector (modifying the thickness of the gas and glass layers), providing a larger sensitivity, has been simulated and compared with an axially extended version of the crystal-based device. The improved version of the RPC shows better performance than the prototype, but the extended version of the crystal-based PET outperforms all other options. based on an RPC prototype under construction within the Fondazione per Adroterapia Oncologica (TERA). For comparison with the crystal-based PET scanner we have chosen the geometry of a commercially available PET scanner, the Philips Gemini TF. The coincidence time resolution used in the simulations takes into account the current achievable values as well as expected improvements of both technologies. Several scenarios (including patient data) have been simulated to evaluate the performance of different scanners. Initial results have shown that the low sensitivity of the RPC hampers its application to hadron
Address [Torres-Espallardo, I.; Solevi, P.; Gillam, J.; Rafecas, M.] UV, CSIC, Inst Fis Corpuscular IFIC, E-46071 Valencia, Spain, Email: irene.torres@uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0031-9155 ISBN Medium
Area Expedition Conference
Notes WOS:000354104700003 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2227
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.
Title Application of scintillating properties of liquid xenon and silicon photomultiplier technology to medical imaging Type Journal Article
Year 2016 Publication Spectrochimica Acta Part B Abbreviated Journal Spectroc. Acta Pt. B
Volume 118 Issue Pages 6-13
Keywords PET; TOF; Liquid xenon; Energy resolution; High sensitivity; Coincidence resolution time (CRT); SiPMs
Abstract We describe a new positron emission time-of-flight apparatus using liquid xenon. The detector is based in a liquid xenon scintillating cell. The cell shape and dimensions can be optimized depending on the intended application. In its simplest form, the liquid xenon scintillating cell is a box in which two faces are covered by silicon photomultipliers and the others by a reflecting material such as Teflon. It is a compact, homogenous and highly efficient detector which shares many of the desirable properties of monolithic crystals, with the added advantage of high yield and fast scintillation offered by liquid xenon. Our initial studies suggest that good energy and spatial resolution comparable with that achieved by lutetium oxyorthosilicate crystals can be obtained with a detector based in liquid xenon scintillating cells. In addition, the system can potentially achieve an excellent coincidence resolving time of better than 100 ps.
Address [Gomez-Cadenas, J. J.; Benlloch-Rodriguez, J. M.; Ferrario, Paola] Univ Valencia, CSIC, IFIC, E-46003 Valencia, Spain, Email: gomez@mail.cern.ch
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0584-8547 ISBN Medium
Area Expedition Conference
Notes WOS:000374073300002 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 2631
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Author Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casaña, J.V.; Lopez, J.G.; Jimenez-Ramos, M.C.; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.
Title Characterization of a Compton camera based on the TOFPET2 ASIC Type Journal Article
Year 2023 Publication Radiation Physics and Chemistry Abbreviated Journal Radiat. Phys. Chem.
Volume 202 Issue Pages 110507 - 11pp
Keywords Compton camera; Hadron therapy; LaBr3; PETsys TOFPET2; Silicon photomultipliers
Abstract The use of Compton cameras for medical imaging and its interest as a hadron therapy treatment monitoring has increased in the last decade with the development of silicon photomultipliers. MACACOp is a Compton camera prototype designed and assembled at the IRIS group of IFIC-Valencia. This Compton camera is based on monolithic Lanthanum (III) Bromide crystals and silicon photomultipliers, and employs the novel TOFPET2 ASIC as readout electronics. This system emerged as an alternative to MACACO II prototype, with the aim of improving its limited time resolution. To test the performance of the ASIC in a Compton camera setup, the prototype was characterized, both in laboratory and in-beam. A time resolution of 1.5 ns was obtained after time corrections, which improves greatly the performance of the MACACO II. Moreover, the results obtained at high photon energies demonstrate the ability of the system to obtain 1 mm displacements of the reconstructed spots. The results reinforce the potential of the system as a monitoring device for hadron therapy.
Address [Viegas, R.; Roser, J.; Barrientos, L.; Borja-Lloret, M.; Casana, J., V; Hueso-Gonzalez, F.; Ros, A.; Llosa, G.] CSIC UV, Inst Fis Corpuscular IFIC, Valencia, Spain, Email: Rita.Viegas@ific.uv.es
Corporate Author Thesis
Publisher Pergamon-Elsevier Science Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0969-806x ISBN Medium
Area Expedition Conference
Notes WOS:000870840600006 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 5392
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Author n_TOF Collaboration (Bacak, M. et al); Domingo-Pardo, C.; Tain, J.L.
Title A compact fission detector for fission-tagging neutron capture experiments with radioactive fissile isotopes Type Journal Article
Year 2020 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 969 Issue Pages 163981 - 10pp
Keywords Fission detector; U-233; n_TOF; Time-of-flight
Abstract In the measurement of neutron capture cross-sections of fissile isotopes, the fission channel is a source of background which can be removed efficiently using the so-called fission-tagging or fission-veto technique. For this purpose a new compact and fast fission chamber has been developed. The design criteria and technical description of the chamber are given within the context of a measurement of the U-233(n, gamma) cross-section at the nTOF facility at CERN, where it was coupled to the nTOF Total Absorption Calorimeter. For this measurement the fission detector was optimized for time resolution, minimization of material in the neutron beam and for alpha-fission discrimination. The performance of the fission chamber and its application as a fission tagging detector are discussed.
Address [Bacak, M.; Gunsing, F.; Vlachoudis, V.; Aberle, O.; Calviani, M.; Cardella, R.; Cerutti, F.; Chiaveri, E.; Ferrari, A.; Gilardoni, S.; Kadi, Y.; Macina, D.; Masi, A.; Mingrone, F.; Rubbia, C.; Sabate-Gilarte, M.; Zugec, P.] CERN, European Org Nucl Res, Geneva, Switzerland, Email: michael.bacak@cern.ch
Corporate Author Thesis
Publisher Elsevier Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000536792400015 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 4413
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Author n_TOF Collaboration (Weiss, C. et al); Domingo-Pardo, C.; Tain, J.L.; Tarifeño-Saldivia, A.
Title The new vertical neutron beam line at the CERN n_TOF facility design and outlook on the performance Type Journal Article
Year 2015 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 799 Issue Pages 90-98
Keywords n_TOF facility; Neutron time-of-flight; FLUKA; Neutron cross-section measurement
Abstract At the neutron Lime-of-flight facility n_TOF at CERN a new vertical beam line was constructed in 2014, in order to extend the experimental possibilities at this facility to an even wider range of challenging cross-section measurements of interest in astrophysics, nuclear technology and medical physics. The design of the beam line and the experimental hall was based on FLUKA Monte Carlo simulations, aiming at maximizing the neutron flux, reducing the beam halo and minimizing the background from neutrons interacting with the collimator or back-scattered in the beam dump. The present paper gives an overview on the design of the beam line and the relevant elements and provides an outlook on the expected performance regarding the neutron beam intensity, shape and energy resolution, as well as the neutron and photon backgrounds.
Address [Weiss, C.; Chiaveri, E.; Girod, S.; Vlachoudis, V.; Aberle, O.; Bergstroem, I.; Calviani, M.; Guerrero, C.; Sabate-Gilarte, M.; Tsinganis, A.; Brugger, M.; Cerutti, F.; Ferrari, A.; Hernandez-Prieto, A.; Kadi, Y.; Leal-Cidoncha, E.; Losito, R.; Macina, D.; Montesano, S.; Porras, I.; Rubbia, C.] CERN, European Org Nucl Res, CH-1211 Geneva, Switzerland
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000361877300015 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2392
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Author Blanco, A.; Belver, D.; Cabanelas, P.; Diaz, J.; Fonte, P.; Garzon, J.A.; Gil, A.; Gonzalez-Diaz, D.; Koenig, W.; Kolb, B.; Lopes, L.; Palka, M.; Pereira, A.; Traxler, M.; Zumbruch, P.
Title RPC HADES-TOF wall cosmic ray test performance Type Journal Article
Year 2012 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 661 Issue Pages S114-S117
Keywords Gaseous detectors; Timing; TOF; RPC; HADES
Abstract In this work we present results concerning the cosmic ray test, prior to the final installation and commissioning of the new Resistive Plate Chamber (RPC) Time of Flight (TOF) wall for the High-Acceptance DiElectron Spectrometer (HADES) at GSI. The TOF wall is composed of six equal sectors, each one constituted by 186 individual 4-gaps glass-aluminium shielded RPC cells distributed in six columns and 31 rows in two partially overlapping layers, covering an area of 1.26 m(2). All sectors were tested with the final Front End Electronic (FEE) and Data AcQuisition system (DAQ) together with Low Voltage (LV) and High Voltage (HV) systems. Results confirm a very uniform average system time resolution of 77 ps sigma together with an average multi-hit time resolution of 83 ps. Crosstalk levels below 1% (in average), moderate timing tails along with an average longitudinal position resolution of 8.4 mm sigma are also confirmed.
Address [Blanco, A.; Fonte, P.; Lopes, L.; Pereira, A.] LIP, Lab Instrumentacao & Fis Expt Particulas, Coimbra, Portugal, Email: alberto@coimbra.lip.pt
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000311568900029 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 1285
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Author n_TOF Collaboration (Zugec, P. et al); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L.
Title GEANT4 simulation of the neutron background of the C6D6 set-up for capture studies at n_TOF Type Journal Article
Year 2014 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 760 Issue Pages 57-67
Keywords GEANT4 simulations; Neutron time of flight; Neutron background; N_TOF; Neutron capture
Abstract The neutron sensitivity of the Cr6D6 detector setup used at nTOF facility for capture measurements has been studied by means of detailed GEANT4 simulations. A realistic software replica of the entire nTOF experimental hall, including the neutron beam line, sample, detector supports and the walls of the experimental area has been implemented in the simulations. The simulations have been analyzed in the same manner as experimental data, in particular by applying the Pulse Height Weighting Technique. The simulations have been validated against a measurement of the neutron background performed with a(nat)-C sample, showing an excellent agreement above 1 keV. At lower energies, an additional component in the measured C-nat yield has been discovered, which prevents the use of C-nat data for neutron background estimates at neutron energies below a few hundred eV. The origin and time structure of the neutron background have been derived from the simulations. Examples of the neutron background for two different samples are demonstrating the important role of accurate simulations of the neutron background in capture cross-section measurements.
Address [Zugec, P.; Bosnar, D.] Univ Zagreb, Fac Sci, Dept Phys, Zagreb 41000, Croatia, Email: pzugec@phy.hr
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000338350500008 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 1828
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Author n_TOF Collaboration (Cosentino, L. et al); Domingo-Pardo, C.; Tain, J.L.; Tarifeño-Saldivia, A.
Title Experimental setup and procedure for the measurement of the Be-7(n,alpha)alpha reaction at n_TOF Type Journal Article
Year 2016 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 830 Issue Pages 197-205
Keywords Cosmological lithium problem; Big bang nucleosynthesis; Be-7(n,alpha)alpha reaction; n_TOF spallation neutron source
Abstract The newly built second experimental area EAR2 of then n_ToF spallation neutron source at CERN allows to perform (n, charged particles) experiments on short-lived highly radioactive targets. This paper describes a detection apparatus and the experimental procedure for the determination of the cross-section of the Be-7(n,alpha)alpha reaction, which represents one of the focal points toward the solution of the cosmological Lithium abundance problem, and whose only measurement, at thermal energy, dates back to 1963. The apparently unsurmountable experimental difficulties stemming from the huge Be-7 gamma-activity, along with the lack of a suitable neutron beam facility, had so far prevented further measurements. The detection system is subject to considerable radiation damage, but is capable of disentangling the rare reaction signals from the very high background. This newly developed setup could likely be useful also to study other challenging reactions requiring the detectors to be installed directly in the neutron beam.
Address [Cosentino, L.; Musumarra, A.; Pappalardo, A.; Piscopo, M.; Finocchiaro, P.; Cardella, R.; Heyse, J.; Jenkins, D. G.; Kaeppeler, F.; Katabuchi, T.; Kokkoris, M.; Lederer, C.; Lonsdale, S.; Massimi, C.; Mastinu, P.; Matteucci, F.; Mazzone, A.; Milazzo, P. M.; Nolte, R.; Patronis, N.; Pavlik, A.; Rauscher, T.; Schillebeeckx, P.; Stamatopoulos, A.; Tsinganis, A.; Vannini, G.; Vlastou, R.; Wallner, A.; Woods, P. J.] INFN Lab Nazl Sud, Catania, Italy, Email: FINOCCHIARO@LNS.INFN.IT
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000381530300027 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2792
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Author Gomez-Cadenas, J.J.; Benlloch-Rodriguez, J.M.; Ferrario, P.; Monrabal, F.; Rodriguez, J.; Toledo, J.F.
Title Investigation of the coincidence resolving time performance of a PET scanner based on liquid xenon: a Monte Carlo study Type Journal Article
Year 2016 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 11 Issue Pages P09011 - 18pp
Keywords Gamma camera; SPECT; PET PET/CT; coronary CT angiography (CTA); Instrumentation and methods for time-of-flight (TOF) spectroscopy; Noble liquid detectors (scintillation ionization, double-phase); Scintillators; scintillation and light emission processes (solid, gas and liquid scintillators)
Abstract The measurement of the time of flight of the two 511 keV gammas recorded in coincidence in a PET scanner provides an effective way of reducing the random background and therefore increases the scanner sensitivity, provided that the coincidence resolving time (CRT) of the gammas is sufficiently good. The best commercial PET-TOF system today (based in LYSO crystals and digital SiPMs), is the VEREOS of Philips, boasting a CRT of 316 ps (FWHM). In this paper we present a Monte Carlo investigation of the CRT performance of a PET scanner exploiting the scintillating properties of liquid xenon. We find that an excellent CRT of 70 ps (depending on the PDE of the sensor) can be obtained if the scanner is instrumented with silicon photomultipliers (SiPMs) sensitive to the ultraviolet light emitted by xenon. Alternatively, a CRT of 160 ps can be obtained instrumenting the scanner with (much cheaper) blue-sensitive SiPMs coated with a suitable wavelength shifter. These results show the excellent time of flight capabilities of a PET device based in liquid xenon.
Address [Gomez-Cadenas, J. J.; Benlloch-Rodriguez, J. M.; Ferrario, P.; Rodriguez, J.] CSIC, Inst Fis Corpuscular IFIC, Calle Catedrat Jose Beltran 2, Valencia 46980, Spain, Email: paola.ferrario@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000387862300011 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2866
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Author n_TOF Collaboration (Barbagallo, M. et al); Domingo-Pardo, C.; Tain, J.L.
Title Experimental setup and procedure for the measurement of the Be-7(n,p)Li-7 reaction at n_TOF Type Journal Article
Year 2018 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 887 Issue Pages 27-33
Keywords Cosmological Lithium problem; Big bang nucleosynthesis; Be-7(n,p)Li-7 reaction; n_TOF spallation neutron source
Abstract Following the completion of the second neutron beam line and the related experimental area (EAR2) at the n_TOF spallation neutron source at CERN, several experiments were planned and performed. The high instantaneous neutron flux available in EAR2 allows to investigate neutron induced reactions with charged particles in the exit channel even employing targets made out of small amounts of short-lived radioactive isotopes. After the successful measurement of the Be-7(n,alpha)alpha cross section, the Be-7(n,p)Li-7 reaction was studied in order to provide still missing cross section data of relevance for Big Bang Nucleosynthesis (BBN), in an attempt to find a solution to the cosmological Lithium abundance problem. This paper describes the experimental setup employed in such a measurement and its characterization.
Address [Barbagallo, M.; Mastromarco, M.; Damone, L. A.; Mazzone, A.; Colonna, N.; Tagliente, G.; Variale, V.] Ist Nazl Fis Nucl, Sez Bari, Bari, Italy, Email: finocchiaro@lns.infn.ir
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000427814400005 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 3528
Permanent link to this record