Abstract: Thin tissue autoradiography is an imaging modality where ex-vivo tissue sections are placed in direct contact with autoradiographic film. These tissue sections contain a radiolabelled ligand bound to a specific biomolecule under study. This radioligand emits beta- or beta+ particles ionizing silver halide crystals in the film. High spatial resolution autoradiograms are obtained using low energy radioisotopes, such as H-3 where an intrinsic 0.1-1 μm spatial resolution can be achieved. Several digital alternatives have been presented over the past few years to replace conventional film but their spatial resolution has yet to equal film, although silicon-based imaging technologies have demonstrated higher sensitivity compared to conventional film. It will be shown in this work how pixel size is a critical parameter for achieving high spatial resolution for low energy uncollimated beta imaging. In this work we also examine the confounding factors impeding silicon-based technologies with respect to spatial resolution. The study considers charge diffusion in silicon and detector noise, and this is applied to a range of radioisotopes typically used in autoradiography. Finally an optimal detector geometry to obtain the best possible spatial resolution for a specific technology and a specific radioisotope is suggested.

Abstract: The surface detector array of the Pierre Auger Observatory consists of 1600 water-Cherenkov detectors, for the study of extensive air showers (EAS) generated by ultra-high-energy cosmic rays. We describe the trigger hierarchy, from the identification of candidate showers at the level of a single detector, amongst a large background (mainly random single cosmic ray muons), up to the selection of real events and the rejection of random coincidences. Such trigger makes the surface detector array fully efficient for the detection of EAS with energy above 3 x 10(18) eV, for all zenith angles between 0 degrees and 60 degrees, independently of the position of the impact point and of the mass of the primary particle. In these range of energies and angles, the exposure of the surface array can be determined purely on the basis of the geometrical acceptance.

Abstract: We qualitatively corroborate the results of [W. Roberts, M. Pervin, Int. J. Mod. Phys. A 24 (2009) 2401] according to which hyperfine mixing greatly affects the decay widths of b -> c semileptonic decays involving doubly heavy bc baryons. However, our predictions for the decay widths of the unmixed states differ from those reported in the work of Roberts and Pervin by a factor of 2, and this discrepancy translates to the mixed case. We further show that the predictions of heavy quark spin symmetry, might be used in the future to experimentally extract information on the admixtures in the actual physical bc baryons, in a model independent manner.

Abstract: Methods: For Ir-192, I-125, and Pd-103, the authors considered from two to five published spectra. Spherical sources approximating common brachytherapy sources were assessed. Kerma and dose results from GEANT4, MCNP5, and PENELOPE-2008 were compared for water and air. The dosimetric influence of Ir-192, I-125, and Pd-103 spectral choice was determined. Results: For the spectra considered, there were no statistically significant differences between kerma or dose results based on Monte Carlo code choice when using the same spectrum. Water-kerma differences of about 2%, 2%, and 0.7% were observed due to spectrum choice for Ir-192, I-125, and Pd-103, respectively (independent of radial distance), when accounting for photon yield per Bq. Similar differences were observed for air-kerma rate. However, their ratio (as used in the dose-rate constant) did not significantly change when the various photon spectra were selected because the differences compensated each other when dividing dose rate by air-kerma strength. Conclusions: Given the standardization of radionuclide data available from the National Nuclear Data Center (NNDC) and the rigorous infrastructure for performing and maintaining the data set evaluations, NNDC spectra are suggested for brachytherapy simulations in medical physics applications.

Abstract: Using the Resonance Chiral Theory Lagrangian, we perform a calculation of the vector form factor of the pion at the next-to-leading order (NLO) in the 1/N-C expansion. Imposing the correct QCD short-distance constraints, one fixes the amplitude in terms of the pion decay constant F and resonance masses. Its low momentum expansion determines then the corresponding O(p(4)) and O(p(6)) low-energy chiral couplings at NLO, keeping control of their renormalization scale dependence. At mu(0) = 0.77 GeV, we obtain L-9(mu(0)) = (7.9 +/- 0.4).10(-3) and C-88(mu(0)) – C-90(mu(0)) = (-4.6 +/- 0.4).10(-5).