Abstract: Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2.

Abstract: A novel experimental setup to measure deviations from the 1/r(2) distance dependence of Newtonian gravity was proposed in Donini and Marimon (Eur Phys J C 76:696, 2016). The underlying theoretical idea was to study the orbits of a microscopically-sized planetary system composed of a “Satellite”, with mass m(S) similar to O(10-9) g, and a “Planet”, with mass M-P similar to O(10-5) g at an initial distance of hundreds of microns. The detection of precession of the orbit in this system would be an unambiguous indication of a central potential with terms that scale with the distance differently from 1/r. This is a huge advantage with respect to the measurement of the absolute strength of the attraction between two bodies, as most electrically-induced background potentials do indeed scale as 1/r. Detection of orbit precession is unaffected by these effects, allowing for better sensitivities. In Baeza-Ballesteros et al. (Eur Phys J C 82:154, 2022), the impact of other subleading backgrounds that may induce orbit precession, such as, e.g., the electrical Casimir force or general relativity, was studied in detail. It was found that the proposed setup could test Yukawa-like corrections, alpha x exp(-r/lambda), to the 1/r potential with couplings as low as alpha similar to 10(-2) for distances as small as lambda similar to 10 μm, improving by roughly an order of magnitude present bounds. In this paper, we start to move from a theoretical study of the proposal to a more realistic implementation of the experimental setup. As a first step, we study the impact of air viscosity on the proposed setup and see how the setup should be modified in order to preserve the theoretical sensitivity achieved in Donini and Marimon (2016) and Baeza-Ballesteros et al. (2022).

Abstract: Since 2003 many new hadrons, including the lowest-lying positive-parity charm-strange mesons D*(s0) (2317) and D-s1 (2460), have been observed that do not conform with quark-model expectations. It was recently demonstrated that various puzzles in the charm-meson spectrum find a natural resolution if the SU(3) multiplets for the lightest scalar and axial-vector states, among them the D*(s0) (2317) and the D-s1 (2460), owe their existence to the nonperturbative dynamics of Goldstone-boson scattering off D-(s) and D*((s)) mesons. Most importantly the ordering of the lightest strange and nonstrange scalars becomes natural. We demonstrate for the first time that this mechanism is strongly supported by the recent high quality data on the B- -> D+ pi(-)pi(-) provided by the LHCb experiment. This implies that the lowest quark-model positive-parity charm mesons, together with their bottom counterparts, if realized in nature, do not form the ground-state multiplet. This is similar to the pattern that has been established for the scalar mesons made from light up, down, and strange quarks, where the lowest multiplet is considered to be made of states not described by the quark model. In a broader view, the hadron spectrum must be viewed as more than a collection of quark-model states.

Abstract: The full optimization of the design and operation of instruments whose functioning relies on the interaction of radiation with matter is a super-human task, due to the large dimensionality of the space of possible choices for geometry, detection technology, materials, data-acquisition, and information-extraction techniques, and the interdependence of the related parameters. On the other hand, massive potential gains in performance over standard, “experience-driven” layouts are in principle within our reach if an objective function fully aligned with the final goals of the instrument is maximized through a systematic search of the configuration space. The stochastic nature of the involved quantum processes make the modeling of these systems an intractable problem from a classical statistics point of view, yet the construction of a fully differentiable pipeline and the use of deep learning techniques may allow the simultaneous optimization of all design parameters.

Abstract: The triplet or type-II seesaw mechanism is the simplest way to endow neutrinos with mass in the Standard Model (SM). Here we review its associated theory and phenomenology, including restrictions from S, T, U parameters, neutrino experiments, charged lepton flavor violation as well as collider searches. We also examine restrictions coming from requiring consistency of electroweak symmetry breaking, i.e., perturbative unitarity and stability of the vacuum. Finally, we discuss novel effects associated to the scalar mediator of neutrino mass generation namely, (i) rare processes, e.g., l(alpha)-> l(beta)gamma decays, at the intensity frontier, and also (ii) four-lepton signatures in colliders at the high-energy frontier. These can be used to probe neutrino properties in an important way, providing a test of the absolute neutrino mass and mass ordering, as well as of the atmospheric octant. They may also provide the first evidence for charged lepton flavor violation in nature. In contrast, neutrino nonstandard interaction strengths are found to lie below current detectability.