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Records |
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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
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Title  |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Public Library Science |
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English |
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ISSN |
1545-7885 |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1446 |
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Author |
Pierre Auger Collaboration (Abreu, P. et al); Pastor, S. |
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Title |
Identifying clouds over the Pierre Auger Observatory using infrared satellite data |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Astroparticle Physics |
Abbreviated Journal |
Astropart Phys. |
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| |
Volume |
50-52 |
Issue |
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Pages |
92-101 |
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Keywords |
Ultra-high energy cosmic rays; Pierre Auger Observatory; Extensive air showers; Atmospheric monitoring; Clouds; Satellites |
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Abstract |
We describe a new method of identifying night-time clouds over the Pierre Auger Observatory using infrared data from the Imager instruments on the GOES-12 and GOES-13 satellites. We compare cloud. identifications resulting from our method to those obtained by the Central Laser Facility of the Auger Observatory. Using our new method we can now develop cloud probability maps for the 3000 km(2) of the Pierre Auger Observatory twice per hour with a spatial resolution of similar to 2.4 km by similar to 5.5 km. Our method could also be applied to monitor cloud cover for other ground-based observatories and for space-based observatories. |
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Address |
[Allekotte, I.; Asorey, H.; Bertou, X.; Golup, G.; Gomez Berisso, M.; Harari, D.; Mollerach, S.; Ponce, V. H.; Roulet, E.; Sidelnik, I.] Ctr Atom Bariloche, San Carlos De Bariloche, Rio Negro, Argentina |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0927-6505 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000329271000011 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1690 |
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Author |
Capozziello, S.; Harko, T.; Lobo, F.S.N.; Olmo, G.J. |
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Title |
Hybrid Modified Gravity Unifying Local Tests, Galactic Dynamics and Late-Time Cosmic Acceleration |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
International Journal of Modern Physics D |
Abbreviated Journal |
Int. J. Mod. Phys. D |
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Volume |
22 |
Issue |
12 |
Pages |
1342006 - 7pp |
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Keywords |
Modified gravity; late-time cosmic acceleration; dark matter; solar system tests |
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Abstract |
The nonequivalence between the metric and Palatini formalisms of f(R) gravity is an intriguing feature of these theories. However, in the recently proposed hybrid metric-Palatini gravity, consisting of the superposition of the metric Einstein-Hilbert Lagrangian with an f(R) term constructed a la Palatini, the “true” gravitational field is described by the interpolation of these two nonequivalent approaches. The theory predicts the existence of a light long-range scalar field, which passes the local constraints and affects the galactic and cosmological dynamics. Thus, the theory opens new possibilities for a unified approach, in the same theoretical framework, to the problems of dark energy and dark matter, without distinguishing a priori matter and geometric sources, but taking their dynamics into account under the same standard. |
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Address |
[Capozziello, Salvatore] Univ Naples Federico II, Dipartimento Fis, I-80126 Naples, Italy, Email: capozzie@na.infn.it; |
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Corporate Author |
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Thesis |
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Publisher |
World Scientific Publ Co Pte Ltd |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0218-2718 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000329048900013 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1688 |
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| Permanent link to this record |
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Author |
Mena, O.; Razzaque, S. |
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Title |
Hints of an axion-like particle mixing in the GeV gamma-ray blazar data? |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
11 |
Issue |
11 |
Pages |
023 - 12pp |
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Keywords |
axions; active galactic nuclei |
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Abstract |
Axion-Like Particles (ALPs), if exist in nature, are expected to mix with photons in the presence of an external magnetic field. The energy range of photons which undergo strong mixing with ALPs depends on the ALP mass, on its coupling with photons as well as on the external magnetic field and particle density configurations. Recent observations of blazars by the Fermi Gamma-Ray Space Telescope in the 0.1-300 GeV energy range show a break in their spectra in the 1-10 GeV range. We have modeled this spectral feature for the flat-spectrum radio quasar 3C454.3 during its November 2010 outburst, assuming that a significant fraction of the gamma rays convert to ALPs in the large scale jet of this blazar. Using theoretically motivated models for the magnetic field and particle density con figurations in the kiloparsec scale jet, outside the broad-line region, we find an ALP mass m(a) similar to (1 – 3).10(-7) eV and coupling g(a gamma) similar to (1 – 3).10(-10) GeV-1 after performing an illustrative statistical analysis of spectral data in four different epochs of emission. The precise values of m(a) and g(a gamma) depend weakly on the assumed particle density con figuration and are consistent with the current experimental bounds on these quantities. We apply this method and ALP parameters found from fitting 3C454.3 data to another flat-spectrum radio quasar PKS1222+216 (4C+21.35) data up to 400 GeV, as a consistency check, and found good fit. We find that the ALP-photon mixing effect on the GeV spectra may not be washed out for any reasonable estimate of the magnetic field in the intergalactic media. |
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Address |
[Mena, Olga] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: omena@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000327843900024 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1673 |
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| Permanent link to this record |
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Author |
Fujita, Y. et al; Algora, A.; Estevez-Aguado, E.; Molina, F.; Rubio, B. |
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Title |
High-resolution study of T-z =+2 ->+1 Gamow-Teller transitions in the Ca-44(3He,t)Sc-44 reaction |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
88 |
Issue |
1 |
Pages |
014308 - 18pp |
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Keywords |
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Abstract |
In order to study the Gamow-Teller (GT) transitions from the T-z = +2 nucleus Ca-44 to the T-z = +1 nucleus Sc-44, where T-z is the z component of isospin T, we performed the (p, n)-type (He-3, t) charge-exchange (CE) reaction at 140 MeV/nucleon and the scattering angles 0 degrees and 2.5 degrees. An energy resolution of 28 keV, that was realized by applying matching techniques to the magnetic spectrometer system, allowed the study of fragmented states. The GT transition strengths, B(GT), were derived up to the excitation energy (E-x) of 13.7 MeV assuming the proportionality between cross sections and B(GT) values. The total sum of B(GT) values in discrete states was 3.7, which was 31% of the sum-rule-limit value of 12. Shell model calculations using the GXPF1J interaction could reproduce the gross features of the experimental B(GT) distribution, but not the fragmentation of the strength. By introducing the concepts of isospin, properties of isospin analogous transitions and states were investigated. (i) Assuming isospin symmetry, the T-z = +2 -> +1 and T-z = -2 -> -1 mirror GT transitions should have the same properties, where the latter can be studied in the beta decay of Cr-44 to V-44. First, we confirmed that the beta-decay half-life T-1/2 of Cr-44 can be reproduced using the B(GT) distribution from the Ca-44(He-3, t) measurement. Then, the 0 degrees, (3He, t) spectrum was modified to deduce the “beta-decay spectrum” and it was compared with the delayed-proton spectrum from the Cr-44 beta decay. The two spectra were mostly in agreement for the GT excitations, but suppression of the proton decay was found for the T = 2 isobaric analog state (IAS). (ii) Starting from the T = 2 ground state of 44Ca, the (3He, t) can excite GT states (state populated by GT transitions) with T = 1, 2, and 3. On the other hand, the Ca-44(p, p') reaction can excite spin-M1 states (states populated by spin-M1 transitions) with T = 2 and 3 that are analogous to the T = 2 and 3 GT states, respectively. By comparing the spectra from these two reactions, a T value of 2 is suggested for several GT states in the E-x = 11.5-13.7 MeV region. (iii) It has been suggested that the T = 2, J(pi) = 0(+) double isobaric analog state (DIAS) at 9.338 MeV in the T-z = 0 nucleus Ti-44 forms an isospin-mixed doublet with a subsidiary 0(+) state at 9.298 MeV. Since no corresponding state was found in the T-z = +1 nucleus Sc-44, we suggest T = 0 for the subsidiary state. |
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Address |
[Fujita, Y.; Fujita, H.] Osaka Univ, Dept Phys, Toyonaka, Osaka 5600043, Japan, Email: fujita@rcnp.osaka-u.ac.jp |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0556-2813 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000321839100001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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| |
Call Number |
IFIC @ pastor @ |
Serial |
1495 |
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| Permanent link to this record |
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Author |
Ganioglu, E. et al; Algora, A.; Estevez-Aguado, E.; Molina, F.; Rubio, B. |
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Title |
High-resolution study of Gamow-Teller transitions in the Ti-47(He-3, t)V-47 reaction |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Physical Review C |
Abbreviated Journal |
Phys. Rev. C |
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Volume |
87 |
Issue |
1 |
Pages |
014321 - 12pp |
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Keywords |
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Abstract |
Given the importance of Gamow-Teller (GT) transitions in nuclear structure and astrophysical nuclear processes, we have studied T-z = +3/2 -> +1/2, GT transitions starting from the Ti-47 nucleus in the (He-3, t) charge-exchange reaction at 0 degrees and at an intermediate incident energy of 140 MeV/nucleon. The experiments were carried out at the Research Center for Nuclear Physics (RCNP), Osaka, using the high-resolution facility with a high-dispersion beam line and the Grand-Raiden spectrometer. With an energy resolution of 20 keV, individual GT transitions were observed and GT strength was derived for each state populated up to an excitation energy (E-x) of 12.5 MeV. The GT strength was widely distributed from low excitation energy up to 12.5 MeV, where we had to stop the analysis because of the high level density. The distribution of the GT strengths was compared with the results of shell model calculations using the GXPF1 interaction. The calculations could reproduce the experimental GT distributions well. The GT transitions from the ground state of Ti-47 and the M1 transitions from the isobaric analog state in V-47 to the same low-lying states in V-47 are analogous. It was found that the ratios of GT transition strengths to the ground state, the 0.088-MeV state, and the 0.146-MeV state are similar to the ratios of the strengths of the analogous M1 transitions from the isobaric analog state (IAS) to these states. The measured distribution of the GT strengths was also compared with those starting from the T-z = +3/2 nucleus K-41 to the T-z = +1/2 nucleus Ca-41. |
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Address |
[Ganioglu, E.; Susoy, G.] Istanbul Univ, Dept Phys, TR-34134 Istanbul, Turkey, Email: ganioglu@istanbul.edu.tr; |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0556-2813 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000313548700005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1308 |
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| Permanent link to this record |
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Author |
n_TOF Collaboration (Barbagallo, M. et al); Domingo-Pardo, C.; Giubrone, G.; Tain, J.L. |
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Title |
High-accuracy determination of the neutron flux at n_TOF |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
European Physical Journal A |
Abbreviated Journal |
Eur. Phys. J. A |
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Volume |
49 |
Issue |
12 |
Pages |
156 - 11pp |
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Keywords |
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Abstract |
The neutron flux of the nTOF facility at CERN was measured, after installation of the new spallation target, with four different systems based on three neutron-converting reactions, which represent accepted cross sections standards in different energy regions. A careful comparison and combination of the different measurements allowed us to reach an unprecedented accuracy on the energy dependence of the neutron flux in the very wide range (thermal to 1 GeV) that characterizes the nTOF neutron beam. This is a pre-requisite for the high accuracy of cross section measurements at n_TOF. An unexpected anomaly in the neutron-induced fission cross section of U-235 is observed in the energy region between 10 and 30keV, hinting at a possible overestimation of this important cross section, well above currently assigned uncertainties. |
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Address |
[Barbagallo, M.; Colonna, N.; Mastromarco, M.; Meaze, M.; Tagliente, G.; Variale, V.] Ist Nazl Fis Nucl, Sez Bari, I-70125 Bari, Italy, Email: massimo.barbagallo@ba.infn.it |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6001 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000328351000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1663 |
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| Permanent link to this record |
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Author |
Llosa, G.; Barrillon, P.; Barrio, J.; Bisogni, M.G.; Cabello, J.; Del Guerra, A.; Etxebeste, A.; Gillam, J.E.; Lacasta, C.; Oliver, J.F.; Rafecas, M.; Solaz, C.; Stankova, V.; de La Taille, C. |
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Title |
High performance detector head for PET and PET/MR with continuous crystals and SiPMs |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Nuclear Instruments & Methods in Physics Research A |
Abbreviated Journal |
Nucl. Instrum. Methods Phys. Res. A |
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Volume |
702 |
Issue |
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Pages |
3-5 |
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Keywords |
Monolithic crystals; SiPM; MG-APD; PET; High resolution; Position determination |
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Abstract |
A high resolution PET detector head for small animal PET applications has been developed. The detector is composed of a 12 mm x 12 mm continuous LYSO crystal coupled to a 64-channel monolithic SiPM matrix from FBK-irst. Crystal thicknesses of 5 mm and 10 mm have been tested, both yielding an intrinsic spatial resolution around 0.7 mm FWHM with a position determination algorithm that can also provide depth-of-interaction information. The detectors have been tested in a rotating system that makes it possible to acquire tomographic data and reconstruct images of Na-22 sources. An image reconstruction method specifically adapted for continuous crystals has been employed. The Full Width at Half Maximum measured from a point source reconstructed with ML-EM was 0.7 mm with the 5 mm crystal and 0.8 mm with the 10 mm crystal. |
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Address |
[Llosa, G.; Barrio, J.; Cabello, J.; Etxebeste, A.; Gillam, J. E.; Lacasta, C.; Oliver, J. F.; Rafecas, M.; Solaz, C.; Stankova, V.] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: gabriela.llosa@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0168-9002 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000314682300002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1330 |
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| Permanent link to this record |
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Author |
Edgecock, T.R. et al; Agarwalla, S.K.; Cervera-Villanueva, A.; Donini, A.; Ghosh, T.; Gomez-Cadenas, J.J.; Hernandez, P.; Martin-Albo, J.; Mena, O. |
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Title |
High intensity neutrino oscillation facilities in Europe |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Physical Review Special Topics-Accelerators and Beams |
Abbreviated Journal |
Phys. Rev. Spec. Top.-Accel. Beams |
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Volume |
16 |
Issue |
2 |
Pages |
021002 - 18pp |
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Keywords |
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Abstract |
The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Frejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of mu(+) and mu(-) beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He-6 and Ne-18, also stored in a ring. The far detector is also the MEMPHYS detector in the Frejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive. |
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Address |
[Edgecock, T. R.; Caretta, O.; Davenne, T.; Densam, C.; Fitton, M.; Kelliher, D.; Loveridge, P.; Machida, S.; Prior, C.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.] STFC Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England |
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Corporate Author |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1098-4402 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000315152000001 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1333 |
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| Permanent link to this record |
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Author |
Campanario, F.; Kubocz, M. |
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Title |
Higgs-boson production in association with three jets via gluon fusion at the LHC: Gluonic contributions |
Type |
Journal Article |
| |
Year |
2013 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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| |
Volume |
88 |
Issue |
5 |
Pages |
054021 - 5pp |
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Keywords |
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Abstract |
Higgs production in association with three jets via gluon fusion is an important channel for the measurement of the CP properties of the Higgs particle at the LHC. In this paper, we go beyond the heavy top effective theory approximation and include at LO the full mass dependence of the top- and bottom-quark contributions. We consider the dominant subchannel gg -> Hggg which involves the manipulation of massive rank-5 hexagon integrals. Furthermore, we present results for several differential distributions and show deviations from the effective theory as large as 100% at high p(T) for light Higgs masses. |
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1550-7998 |
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WOS:000324691000003 |
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no |
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yes |
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yes |
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IFIC @ pastor @ |
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1615 |
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