Abstract: We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time scale. During beam-on intervals, Compton imagingwas performed utilizing the high energy. -rays promptly emitted from the nuclear reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished with the same imagers using the beta+ decay of activated nuclei. The targets used were stacks of different materials covering also various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is reported and the experimental results interpreted on the basis ofMonte Carlo calculations. The results demonstrate the possibility to combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with high accuracy.

Abstract: It is well-known that at tree-level the d = 5 Weinberg operator can be generated in exactly three different ways, the famous seesaw models. In this paper we study the related question of how many phenomenologically consistent 1-loop models one can construct at d=5. First, we discuss that there are two possible classes of 1-loop neutrino mass models, that allow avoiding stable charged relics: (i) models with dark matter candidates and (ii) models with “exits”. Here, we define “exits” as particles that can decay into standard model fields. Considering 1-loop models with new scalars and fermions, we find in the dark matter class a total of (115+203) models, while in the exit class we find (38+368) models. Here, 115 is the number of DM models, which require a stabilizing symmetry, while 203 is the number of models which contain a dark matter candidate, which maybe accidentally stable. In the exit class the 38 refers to models, for which one (or two) of the internal particles in the loop is a SM field, while the 368 models contain only fields beyond the SM (BSM) in the neutrino mass diagram. We then study the RGE evolution of the gauge couplings in all our 1-loop models. Many of the models in our list lead to Landau poles in some gauge coupling at rather low energies and there is exactly one model which unifies the gauge couplings at energies above 10(15) GeV in a numerically acceptable way.