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Author |
Nguyen, C.V.; Gillam, J.E.; Brown, J.M.C.; Martin, D.V.; Nikulin, D.A.; Dimmock, M.R. |
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Title  |
Towards Optimal Collimator Design for the PEDRO Hybrid Imaging System |
Type |
Journal Article |
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Year |
2011 |
Publication |
IEEE Transactions on Nuclear Science |
Abbreviated Journal |
IEEE Trans. Nucl. Sci. |
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Volume |
58 |
Issue |
3 |
Pages |
639-650 |
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Keywords |
Compton scattering enhancement; multiple pinhole; PEDRO |
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Abstract |
The Pixelated Emission Detector for RadiOisotopes (PEDRO) is a hybrid imaging system designed for the measurement of single photon emission from small animal models. The proof-of-principle device consists of a Compton-camera situated behind a mechanical collimator and is intended to provide optimal detection characteristics over a broad spectral range, from 30 to 511 keV. An automated routine has been developed for the optimization of large-area slits in the outer regions of a collimator which has a central region allocated for pinholes. The optimization was tested with a GEANT4 model of the experimental prototype. The data were blurred with the expected position and energy resolution parameters and a Bayesian interaction ordering algorithm was applied. Images were reconstructed using cone back-projection. The results show that the optimization technique allows the large-area slits to both sample fully and extend the primary field of view (FoV) determined by the pinholes. The slits were found to provide truncation of the back-projected cones of response and also an increase in the success rate of the interaction ordering algorithm. These factors resulted in an increase in the contrast and signal-to-noise ratio of the reconstructed image estimates. Of the two configurations tested, the cylindrical geometry outperformed the square geometry, primarily because of a decrease in artifacts. This was due to isotropic modulation of the cone surfaces, that can be achieved with a circular shape. Also, the cylindrical geometry provided increased sampling of the FoV due to more optimal positioning of the slits. The use of the cylindrical collimator and application of the transmission function in the reconstruction was found to improve the resolution of the system by a factor of 20, as compared to the uncollimated Compton camera. Although this system is designed for small animal imaging, the technique can be applied to any application of single photon imaging. |
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Address |
[Nguyen, Chuong V.; Dimmock, Matthew R.] Monash Univ, Sch Phys, Melbourne, Vic 3800, Australia, Email: chuong.nguyen@monash.edu |
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Ieee-Inst Electrical Electronics Engineers Inc |
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English |
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ISSN |
0018-9499 |
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Notes |
ISI:000291655900008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
650 |
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Author |
Lerendegui-Marco, J.; Balibrea-Correa, J.; Babiano-Suarez, V.; Ladarescu, I.; Domingo-Pardo, C. |
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Title |
Towards machine learning aided real-time range imaging in proton therapy |
Type |
Journal Article |
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Year |
2022 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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Volume |
12 |
Issue |
1 |
Pages |
2735 - 17pp |
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Abstract |
Compton imaging represents a promising technique for range verification in proton therapy treatments. In this work, we report on the advantageous aspects of the i-TED detector for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that have been specifically designed for neutron-capture nuclear physics experiments, which are characterized by gamma-ray energies spanning up to 5-6 MeV, rather low gamma-ray emission yields and very intense neutron induced gamma-ray backgrounds. Our developments to cope with these three aspects are concomitant with those required in the field of hadron therapy, especially in terms of high efficiency for real-time monitoring, low sensitivity to neutron backgrounds and reliable performance at the high gamma-ray energies. We find that signal-to-background ratios can be appreciably improved with i-TED thanks to its light-weight design and the low neutron-capture cross sections of its LaCl3 crystals, when compared to other similar systems based on LYSO, CdZnTe or LaBr3. Its high time-resolution (CRT similar to 500 ps) represents an additional advantage for background suppression when operated in pulsed HT mode. Each i-TED Compton module features two detection planes of very large LaCl3 monolithic crystals, thereby achieving a high efficiency in coincidence of 0.2% for a point-like 1 MeV gamma-ray source at 5 cm distance. This leads to sufficient statistics for reliable image reconstruction with an array of four i-TED detectors assuming clinical intensities of 10(8) protons per treatment point. The use of a two-plane design instead of three-planes has been preferred owing to the higher attainable efficiency for double time-coincidences than for threefold events. The loss of full-energy events for high energy gamma-rays is compensated by means of machine-learning based algorithms, which allow one to enhance the signal-to-total ratio up to a factor of 2. |
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Address |
[Lerendegui-Marco, Jorge; Balibrea-Correa, Javier; Babiano-Suarez, Victor; Ladarescu, Ion; Domingo-Pardo, Cesar] Univ Valencia, CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: jorge.lerendegui@ific.uv.es |
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Nature Portfolio |
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English |
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Series Issue |
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Edition |
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ISSN |
2045-2322 |
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Conference |
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Notes |
WOS:000757537100018 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
5136 |
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Author |
Hernandez-Pinto, R.J.; Sborlini, G.F.R.; Rodrigo, G. |
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Title |
Towards gauge theories in four dimensions |
Type |
Journal Article |
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Year |
2016 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
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Volume |
02 |
Issue |
2 |
Pages |
044 - 14pp |
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Keywords |
NLO Computations |
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Abstract |
The abundance of infrared singularities in gauge theories due to unresolved emission of massless particles (soft and collinear) represents the main difficulty in perturbative calculations. They are typically regularized in dimensional regularization, and their subtraction is usually achieved independently for virtual and real corrections. In this paper, we introduce a new method based on the loop-tree duality (LTD) theorem to accomplish the summation over degenerate infrared states directly at the integrand level such that the cancellation of the infrared divergences is achieved simultaneously, and apply it to reference examples as a proof of concept. Ultraviolet divergences, which are the consequence of the point-like nature of the theory, are also reinterpreted physically in this framework. The proposed method opens the intriguing possibility of carrying out purely four-dimensional implementations of higher-order perturbative calculations at next-to-leading order (NLO) and beyond free of soft and final-state collinear subtractions. |
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Address |
[Hernandez-Pinto, Roger J.; Sborlini, German F. R.; Rodrigo, German] Univ Valencia, Inst Fis Corpuscular, Consejo Super Invest Cient, Pare Cient, E-46980 Valencia, Spain, Email: rogerjose.hernandez@ific.uv.es; |
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Publisher |
Springer |
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English |
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Series Issue |
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Edition |
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ISSN |
1029-8479 |
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Conference |
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Notes |
WOS:000375270700002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
2661 |
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Author |
Hati, C.; Patra, S.; Reig, M.; Valle, J.W.F.; Vaquera-Araujo, C.A. |
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Title |
Towards gauge coupling unification in left-right symmetric SU(3)(c) x SU(3)(L) x SU(3)(R) x U(1)(X) theories |
Type |
Journal Article |
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Year |
2017 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
96 |
Issue |
1 |
Pages |
015004 - 9pp |
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Keywords |
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Abstract |
We consider the possibility of gauge coupling unification within the simplest realizations of the SU(3)(c) x SU(3)(L) x SU(3)(R) xU(1)(X) gauge theory. We present a first exploration of the renormalization group equations governing the “bottom-up” evolution of the gauge couplings in a generic model with free normalization for the generators. Interestingly, we find that for a SU(3)(c) x SU(3)(L) x SU(3)(R) x U(1)(X) symmetry breaking scale M-X as low as a few TeV one can achieve unification in the presence of leptonic octets. We briefly comment on possible grand unified theory frameworks which can embed the SU(3)(c) x SU(3)(L) x SU(3)(R) xU(1)(X) model as well as possible implications, such as lepton flavor violating physics at the LHC. |
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Address |
[Hati, Chandan] Phys Res Lab, Div Theoret Phys, Ahmadabad 380009, Gujarat, India, Email: chandan@prl.res.in; |
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Amer Physical Soc |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
2470-0010 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000405204700002 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3199 |
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Author |
Hueso-Gonzalez, F.; Ballester, F.; Perez-Calatayud, J.; Siebert, F.A.; Vijande, J. |
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Title |
Towards clinical application of RayStretch for heterogeneity corrections in LDR permanent I-125 prostate brachytherapy |
Type |
Journal Article |
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Year |
2017 |
Publication |
Brachytherapy |
Abbreviated Journal |
Brachytherapy |
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Volume |
16 |
Issue |
3 |
Pages |
616-623 |
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Keywords |
Brachytherapy; Low-dose rate; Heterogeneities; Prostate; Calcifications; Dosimetry |
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Abstract |
PURPOSE: RayStretch is a simple algorithm proposed for heterogeneity corrections in low-dose-rate brachytherapy. It is built on top of TG-43 consensus data, and it has been validated with Monte Carlo (MC) simulations. In this study, we take a real clinical prostate implant with 71 1251 seeds as reference and we apply RayStretch to analyze its performance in worst-case scenarios. METHODS AND MATERIALS: To do so, we design two cases where large calcifications are located in the prostate lobules. RayStretch resilience under various calcification density values is also explored. Comparisons against MC calculations are performed. RESULTS: Dose volume histogram related parameters like prostate D-90, rectum D-2cc, or urethra D-10 obtained with RayStretch agree within a few percent with the detailed MC results for all cases considered. CONCLUSIONS: The robustness and compatibility of RayStretch with commercial treatment planning systems indicate its applicability in clinical practice for dosimetric corrections in prostate calcifications. Its use during intraoperative ultrasound planning is foreseen. |
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Address |
[Hueso-Gonzalez, Fernando] Target Systemelekt GmbH, Wuppertal, Germany, Email: javier.vijande@uv.es |
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Publisher |
Elsevier Science Inc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1538-4721 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000402231600019 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3151 |
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