Abstract: We investigate the stability of Higgs potential in inverse seesaw models. We derive the full two-loop RGEs of the relevant parameters, such as the quartic Higgs self-coupling, taking thresholds into account. We find that for relatively large Yukawa couplings the Higgs quartic self-coupling goes negative well below the Standard Model instability scale similar to 10(10) GeV. We show, however, that the “dynamical” inverse seesaw with spontaneous lepton number violation can lead to a completely consistent and stable Higgs vacuum up to the Planck scale.