| Records |
| Author |
Valdes-Cortez, C.; Niatsetski, Y.; Perez-Calatayud, J.; Ballester, F.; Vijande, J. |
Title  |
A Monte Carlo study of the relative biological effectiveness in surface brachytherapy |
Type |
Journal Article |
| Year |
2022 |
Publication |
Medical Physics |
Abbreviated Journal |
Med. Phys. |
| Volume |
49 |
Issue |
|
Pages |
5576-5588 |
| Keywords |
Monte Carlo; relative biological effectiveness; surface HDR brachytherapy |
| Abstract |
Purpose This work aims to simulate clustered DNA damage from ionizing radiation and estimate the relative biological effectiveness (RBE) for radionuclide (rBT)- and electronic (eBT)-based surface brachytherapy through a hybrid Monte Carlo (MC) approach, using realistic models of the sources and applicators. Methods Damage from ionizing radiation has been studied using the Monte Carlo Damage Simulation algorithm using as input the primary electron fluence simulated using a state-of-the-art MC code, PENELOPE-2018. Two Ir-192 rBT applicators, Valencia and Leipzig, one Co-60 source with a Freiburg Flap applicator (reference source), and two eBT systems, Esteya and INTRABEAM, have been included in this study implementing full realizations of their geometries as disclosed by the manufacturer. The role played by filtration and tube kilovoltage has also been addressed. Results For rBT, an RBE value of about 1.01 has been found for the applicators and phantoms considered. In the case of eBT, RBE values for the Esteya system show an almost constant RBE value of about 1.06 for all depths and materials. For INTRABEAM, variations in the range of 1.12-1.06 are reported depending on phantom composition and depth. Modifications in the Esteya system, filtration, and tube kilovoltage give rise to variations in the same range. Conclusions Current clinical practice does not incorporate biological effects in surface brachytherapy. Therefore, the same absorbed dose is administered to the patients independently on the particularities of the rBT or eBT system considered. The almost constant RBE values reported for rBT support that assumption regardless of the details of the patient geometry, the presence of a flattening filter in the applicator design, or even significant modifications in the photon energy spectra above 300 keV. That is not the case for eBT, where a clear dependence on the eBT system and the characteristics of the patient geometry are reported. A complete study specific for each eBT system, including detailed applicator characteristics (size, shape, filtering, among others) and common anatomical locations, should be performed before adopting an existing RBE value. |
| Address |
[Valdes-Cortez, Christian] Hosp Reg Antofagasta, Nucl Med Dept, Antofagasta, Chile, Email: cvalcort@gmail.com |
| Corporate Author |
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Thesis |
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| Publisher |
Wiley |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0094-2405 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000811709400001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
5262 |
| Permanent link to this record |
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| Author |
Solevi, P. et al; Oliver, J.F.; Gillam, J.E.; Rafecas, M. |
| Title |
A Monte-Carlo based model of the AX-PET demonstrator and its experimental validation |
Type |
Journal Article |
| Year |
2013 |
Publication |
Physics in Medicine and Biology |
Abbreviated Journal |
Phys. Med. Biol. |
| Volume |
58 |
Issue |
16 |
Pages |
5495-5510 |
| Keywords |
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| Abstract |
AX-PET is a novel PET detector based on axially oriented crystals and orthogonal wavelength shifter (WLS) strips, both individually read out by silicon photo-multipliers. Its design decouples sensitivity and spatial resolution, by reducing the parallax error due to the layered arrangement of the crystals. Additionally the granularity of AX-PET enhances the capability to track photons within the detector yielding a large fraction of inter-crystal scatter events. These events, if properly processed, can be included in the reconstruction stage further increasing the sensitivity. Its unique features require dedicated Monte-Carlo simulations, enabling the development of the device, interpreting data and allowing the development of reconstruction codes. At the same time the non-conventional design of AX-PET poses several challenges to the simulation and modeling tasks, mostly related to the light transport and distribution within the crystals and WLS strips, as well as the electronics readout. In this work we present a hybrid simulation tool based on an analytical model and a Monte-Carlo based description of the AX-PET demonstrator. It was extensively validated against experimental data, providing excellent agreement. |
| Address |
[Solevi, P.; Oliver, J. F.; Gillam, J. E.; Rafecas, M.] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain, Email: paola.solevi@ific.uv.es |
| Corporate Author |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0031-9155 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000322775300012 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1544 |
| Permanent link to this record |
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| Author |
Keivani, A.; Murase, K.; Petropoulou, M.; Fox, D.B.; Cenko, S.B.; Chaty, S.; Coleiro, A.; DeLaunay, J.J.; Dimitrakoudis, S.; Evans, P.A.; Kennea, J.A.; Marshall, F.E.; Mastichiadis, A.; Osborne, J.P.; Santander, M.; Tohuvavohu, A.; Turley, C.F. |
| Title |
A Multimessenger Picture of the Flaring Blazar TXS 0506+056: Implications for High-energy Neutrino Emission and Cosmic-Ray Acceleration |
Type |
Journal Article |
| Year |
2018 |
Publication |
Astrophysical Journal |
Abbreviated Journal |
Astrophys. J. |
| Volume |
864 |
Issue |
1 |
Pages |
84 - 16pp |
| Keywords |
Lacertae objects: general; BL Lacertae objects: individual (TXS 0506+056); galaxies: active; gamma rays: galaxies; neutrinos; radiation mechanisms: non-thermal |
| Abstract |
Detection of the IceCube-170922A neutrino coincident with the flaring blazar TXS 0506+056, the first and only similar to 3 sigma high-energy neutrino source association to date, offers a potential breakthrough in our understanding of high-energy cosmic particles and blazar physics. We present a comprehensive analysis of TXS. 0506+056 during its flaring state, using newly collected Swift, NuSTAR, and X-shooter data with Fermi observations and numerical models to constrain the blazar's particle acceleration processes and multimessenger (electromagnetic (EM) and high-energy neutrino) emissions. Accounting properly for EM cascades in the emission region, we find a physically consistent picture only within a hybrid leptonic scenario, with gamma-rays produced by external inverse-Compton processes and high-energy neutrinos via a radiatively subdominant hadronic component. We derive robust constraints on the blazar's neutrino and cosmic-ray emissions and demonstrate that, because of cascade effects, the 0.1-100 keV emissions of TXS. 0506+056 serve as a better probe of its hadronic acceleration and highenergy neutrino production processes than its GeV-TeV emissions. If the IceCube neutrino association holds, physical conditions in the TXS. 0506+056 jet must be close to optimal for high-energy neutrino production, and are not favorable for ultrahigh-energy cosmic-ray acceleration. Alternatively, the challenges we identify in generating a significant rate of IceCube neutrino detections from TXS. 0506+056 may disfavor single-zone models, in which.-rays and high-energy neutrinos are produced in a single emission region. In concert with continued operations of the high-energy neutrino observatories, we advocate regular X-ray monitoring of TXS. 0506+056 and other blazars in order to test single-zone blazar emission models, clarify the nature and extent of their hadronic acceleration processes, and carry out the most sensitive possible search for additional multimessenger sources. |
| Address |
[Keivani, A.; Murase, K.; DeLaunay, J. J.; Turley, C. F.] Penn State Univ, Dept Phys, 104 Davey Lab, University Pk, PA 16802 USA, Email: keivani@psu.edu; |
| Corporate Author |
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Thesis |
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| Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0004-637x |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000443293800010 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
3708 |
| Permanent link to this record |
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| Author |
Real, D.; Calvo, D.; Diaz, A.; Salesa Greus, F.; Sanchez Losa, A. |
| Title |
A Narrow Optical Pulse Emitter Based on LED: NOPELED |
Type |
Journal Article |
| Year |
2022 |
Publication |
Sensors |
Abbreviated Journal |
Sensors |
| Volume |
22 |
Issue |
19 |
Pages |
7683 - 15pp |
| Keywords |
short optical pulse; optical instrumentation |
| Abstract |
Light sources emitting short pulses are needed in many particle physics experiments using optical sensors as they can replicate the light produced by the particles being detected and are also an important calibration and test element. This work presents NOPELED, a light source based on LEDs emitting short optical pulses with typical rise times of less than 3 ns and Full Width at Half Maximum lower than 7 ns. The emission wavelength depends on the model of LED used. Several LED models have been characterized in the range from 405 to 532 nm, although NOPELED can work with LED emitting wavelengths outside of that region. While the wavelength is fixed for a given LED model, the intensity and the frequency of the optical pulse can be controlled. NOPELED, which also has low cost and simple operation, can be operated remotely, making it appropriate for either different physics experiments needing in-place light sources such as astrophysical neutrino detectors using photo-multipliers or positron emission tomography devices using scintillation counters, or, beyond physics, applications needing short pulses of light such as protein fluorescence or chemodetection of heavy metals. |
| Address |
[Real, Diego; Calvo, David; Salesa Greus, Francisco; Sanchez Losa, Agustin] Univ Valencia, IFIC Inst Fis Corpuscular, CSIC, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: real@ific.uv.es; |
| Corporate Author |
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Thesis |
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| Publisher |
Mdpi |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
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ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000867935300001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
no |
| Call Number |
IFIC @ pastor @ |
Serial |
5381 |
| Permanent link to this record |
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| Author |
Dote, A.; Bayar, M.; Xiao, C.W.; Hyodo, T.; Oka, M.; Oset, E. |
| Title |
A narrow quasi-bound state of the DNN system |
Type |
Journal Article |
| Year |
2013 |
Publication |
Nuclear Physics A |
Abbreviated Journal |
Nucl. Phys. A |
| Volume |
914 |
Issue |
|
Pages |
499-504 |
| Keywords |
Nuclear system with a D meson; Few-body system; Variational calculation; Faddeev calculation |
| Abstract |
We have investigated a charmed system of DNN (composed of two nucleons and a D meson) by a complementary study with a variational calculation and a Faddeev calculation with fixed-center approximation (Faddeev-FCA). In the present study, we employ a DN potential based on a vector-meson exchange picture in which a resonant A(c)(2595) is dynamically generated as a DN quasi-bound state, similarly to the A(1405) as a (K) over barN one in the strange sector. As a result of the study of variational calculation with an effective DN potential and three kinds of NN potentials, the DNN(J(pi) =0(-), I = 1/2) is found to be a narrow quasi-bound state below A(c)(2595)N threshold: total binding energy similar to 225 MeV and mesonic decay width similar to 25 MeV. On the other hand, the J(pi) =1(-) state is considered to be a scattering state of A(c)(2595) and a nucleon. These results are essentially supported by the Faddeev-FCA calculation. By the analysis of the variational wave function, we have found a unique structure in the DNN(J(pi) = 0, I = 1/2) such that the D meson stays around the center of the total system due to the heaviness of the D meson. |
| Address |
[Dote, A.] High Energy Accelerator Res Org KEK, IPNS, KEK Theory Ctr, Tsukuba, Ibaraki 3050801, Japan, Email: dote@post.kek.jp |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier Science Bv |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0375-9474 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:000324847700071 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
1602 |
| Permanent link to this record |
