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Oliver-Canamas, L., Vijande, J., Candela-Juan, C., Gimeno-Olmos, J., Pujades-Claumarchirant, M. C., Rovira-Escutia, J. J., et al. (2023). A User-Friendly System for Mailed Dosimetric Audits of Ir-192 or Co-60 HDR Brachytherapy Sources. Cancers, 15(9), 2484–14pp.
Abstract: Nowadays, the options available to perform external dosimetric audits of the high dose rate (HDR) brachytherapy treatment process are limited. In this work, we present a methodology that allows for performing dosimetric audits in this field. A phantom was designed and manufactured for this purpose. The criteria for its design, together with the in-house measurements for its characterization, are presented. The result is a user-friendly system that can be mailed to perform dosimetric audits in HDR brachytherapy on-site for systems using either Iridium-192 (Ir-192) or Cobalt-60 (Co-60) sources. Objectives: The main goal of this work is to design and characterize a user-friendly methodology to perform mailed dosimetric audits in high dose rate (HDR) brachytherapy for systems using either Iridium-192 (Ir-192) or Cobalt-60 (Co-60) sources. Methods: A solid phantom was designed and manufactured with four catheters and a central slot to place one dosimeter. Irradiations with an Elekta MicroSelectron V2 for Ir-192, and with a BEBIG Multisource for Co-60 were performed for its characterization. For the dose measurements, nanoDots, a type of optically stimulated luminescent dosimeters (OSLDs), were characterized. Monte Carlo (MC) simulations were performed to evaluate the scatter conditions of the irradiation set-up and to study differences in the photon spectra of different Ir-192 sources (Microselectron V2, Flexisource, BEBIG Ir2.A85-2 and Varisource VS2000) reaching the dosimeter in the irradiation set-up. Results: MC simulations indicate that the surface material on which the phantom is supported during the irradiations does not affect the absorbed dose in the nanoDot. Generally, differences below 5% were found in the photon spectra reaching the detector when comparing the Microselectron V2, the Flexisource and the BEBIG models. However, differences up to 20% are observed between the V2 and the Varisource VS2000 models. The calibration coefficients and the uncertainty in the dose measurement were evaluated. Conclusions: The system described here is able to perform dosimetric audits in HDR brachytherapy for systems using either Ir-192 or Co-60 sources. No significant differences are observed between the photon spectra reaching the detector for the MicroSelectron V2, the Flexisource and the BEBIG Ir-192 sources. For the Varisource VS2000, a higher uncertainty is considered in the dose measurement to allow for the nanoDot response.
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Bordes, J., Chan, H. M., & Tsou, S. T. (2023). A vacuum transition in the FSM with a possible new take on the horizon problem in cosmology. Int. J. Mod. Phys. A, 38(25), 2350124–32pp.
Abstract: The framed standard model (FSM), constructed to explain the empirical mass and mixing patterns (including CP phases) of quarks and leptons, in which it has done quite well, gives otherwise the same result as the standard model (SM) in almost all areas in particle physics where the SM has been successfully applied, except for a few specified deviations such as the W mass and the g-2 of muons, that is, just where experiment is showing departures from what SM predicts. It predicts further the existence of a hidden sector of particles some of which may function as dark matter. In this paper, we first note that the above results involve, surprisingly, the FSM undergoing a vacuum transition (VTR1) at a scale of around 17MeV, where the vacuum expectation values of the colour framons (framed vectors promoted into fields) which are all nonzero above that scale acquire some vanishing components below it. This implies that the metric pertaining to these vanishing components would vanish also. Important consequences should then ensue, but these occur mostly in the unknown hidden sector where empirical confirmation is hard at present to come by, but they give small reflections in the standard sector, some of which may have already been seen. However, one notes that if, going off at a tangent, one imagines colour to be embedded, Kaluza-Klein (KK) fashion, into a higher-dimensional space-time, then this VTR1 would cause 2 of the compactified dimensions to collapse. This might mean then that when the universe cooled to the corresponding temperature of 1011 K when it was about 10-3 s old, this VTR1 collapse would cause the three spatial dimensions of the universe to expand to compensate. The resultant expansion is estimated, using FSM parameters previously determined from particle physics, to be capable, when extrapolated backwards in time, of bringing the present universe back inside the then horizon, solving thus formally the horizon problem. Besides, VTR1 being a global phenomenon in the FSM, it would switch on and off automatically and simultaneously over all space, thus requiring seemingly no additional strategy for a graceful exit. However, this scenario has not been checked for consistency with other properties of the universe and is to be taken thus not as a candidate solution of the horizon problem but only as an observation from particle physics which might be of interest to cosmologists and experts in the early universe. For particle physicists also, it might serve as an indicator for how relevant this VTR1 can be, even if the KK assumption is not made.
Keywords: Framed standard model; phase transition; early Universe; cosmology
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Adhikari, R. et al, Pastor, S., & Valle, J. W. F. (2017). A White Paper on keV sterile neutrino Dark Matter. J. Cosmol. Astropart. Phys., 01(1), 025–247pp.
Abstract: We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved – cosmology, astrophysics, nuclear, and particle physics – in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.
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Bayar, M., & Debastiani, V. R. (2017). a(0)(980) – f(0)(980) mixing in chi(c1) -> pi(0)f(0)(980) -> pi(0)pi(+)pi(-) and chi(c1) -> pi(0) a(0)(980) -> pi(0)pi(0)eta. Phys. Lett. B, 775, 94–99.
Abstract: We study the isospin breaking in the reactions chi(c1) -> pi(0)pi(+)pi(-) and chi(c1) -> pi(0)pi(0)eta and its relation to the a(0)(980) – f(0)(980) mixing, which was measured by the BESIII Collaboration. We show that the same theoretical model previously developed to study the chi(c1) -> eta pi(+)pi(-) reaction (also measured by BESIII), and further explored in the predictions to the eta(c) -> eta pi(+)pi(-), can be successfully employed in the present study. We assume that the chi(c1) behaves as an SU(3) singlet to find the weight in which trios of pseudoscalars are created, followed by the final state interaction of pairs of mesons to describe how the a(0)(980) and f(0)(980) are dynamically generated, using the chiral unitary approach in coupled channels. The isospin violation is introduced through the use of different masses for the charged and neutral kaons, either in the propagators of pairs of mesons created in the chi(c1) decay, or in the propagators inside the T matrix, constructed through the unitarization of the scattering and transition amplitudes of pairs of pseudoscalar mesons. We find that violating isospin inside the T matrix makes the pi(0)eta -> pi(+)pi(-) amplitude nonzero, which gives an important contribution and also enhances the effect of the K (K) over bar term. We also find that the most important effect in the total amplitude is the isospin breaking inside the T matrix, due to the constructive sum of pi(0)eta -> pi(+)pi(-) and K (K) over bar -> pi(+)pi(-), which is essential to get a good agreement with the experimental measurement of the mixing.
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Beaulieu, L., Ballester, F., Granero, D., Tedgren, A. C., Haworth, A., Lowenstein, J. R., et al. (2023). AAPM WGDCAB Report 372: A joint AAPM, ESTRO, ABG, and ABS report on commissioning of model-based dose calculation algorithms in brachytherapy. Med. Phys., 50(8), e946–e960.
Abstract: The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged.
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