Abstract: The framed standard model (FSM), constructed to explain the empirical mass and mixing patterns (including CP phases) of quarks and leptons, in which it has done quite well, gives otherwise the same result as the standard model (SM) in almost all areas in particle physics where the SM has been successfully applied, except for a few specified deviations such as the W mass and the g-2 of muons, that is, just where experiment is showing departures from what SM predicts. It predicts further the existence of a hidden sector of particles some of which may function as dark matter. In this paper, we first note that the above results involve, surprisingly, the FSM undergoing a vacuum transition (VTR1) at a scale of around 17MeV, where the vacuum expectation values of the colour framons (framed vectors promoted into fields) which are all nonzero above that scale acquire some vanishing components below it. This implies that the metric pertaining to these vanishing components would vanish also. Important consequences should then ensue, but these occur mostly in the unknown hidden sector where empirical confirmation is hard at present to come by, but they give small reflections in the standard sector, some of which may have already been seen. However, one notes that if, going off at a tangent, one imagines colour to be embedded, Kaluza-Klein (KK) fashion, into a higher-dimensional space-time, then this VTR1 would cause 2 of the compactified dimensions to collapse. This might mean then that when the universe cooled to the corresponding temperature of 1011 K when it was about 10-3 s old, this VTR1 collapse would cause the three spatial dimensions of the universe to expand to compensate. The resultant expansion is estimated, using FSM parameters previously determined from particle physics, to be capable, when extrapolated backwards in time, of bringing the present universe back inside the then horizon, solving thus formally the horizon problem. Besides, VTR1 being a global phenomenon in the FSM, it would switch on and off automatically and simultaneously over all space, thus requiring seemingly no additional strategy for a graceful exit. However, this scenario has not been checked for consistency with other properties of the universe and is to be taken thus not as a candidate solution of the horizon problem but only as an observation from particle physics which might be of interest to cosmologists and experts in the early universe. For particle physicists also, it might serve as an indicator for how relevant this VTR1 can be, even if the KK assumption is not made.

Abstract: The introduction of model-based dose calculation algorithms (MBDCAs) in brachytherapy provides an opportunity for a more accurate dose calculation and opens the possibility for novel, innovative treatment modalities. The joint AAPM, ESTRO, and ABG Task Group 186 (TG-186) report provided guidance to early adopters. However, the commissioning aspect of these algorithms was described only in general terms with no quantitative goals. This report, from the Working Group on Model-Based Dose Calculation Algorithms in Brachytherapy, introduced a field-tested approach to MBDCA commissioning. It is based on a set of well-characterized test cases for which reference Monte Carlo (MC) and vendor-specific MBDCA dose distributions are available in a Digital Imaging and Communications in Medicine-Radiotherapy (DICOM-RT) format to the clinical users. The key elements of the TG-186 commissioning workflow are now described in detail, and quantitative goals are provided. This approach leverages the well-known Brachytherapy Source Registry jointly managed by the AAPM and the Imaging and Radiation Oncology Core (IROC) Houston Quality Assurance Center (with associated links at ESTRO) to provide open access to test cases as well as step-by-step user guides. While the current report is limited to the two most widely commercially available MBDCAs and only for Ir-192-based afterloading brachytherapy at this time, this report establishes a general framework that can easily be extended to other brachytherapy MBDCAs and brachytherapy sources. The AAPM, ESTRO, ABG, and ABS recommend that clinical medical physicists implement the workflow presented in this report to validate both the basic and the advanced dose calculation features of their commercial MBDCAs. Recommendations are also given to vendors to integrate advanced analysis tools into their brachytherapy treatment planning system to facilitate extensive dose comparisons. The use of the test cases for research and educational purposes is further encouraged.

Abstract: We explore a simple but extremely predictive extension of the scotogenic model. We promote the scotogenic symmetry Z(2) to the flavour non-Abelian symmetry sigma(81), which can also automatically protect dark matter stability. In addition, sigma(81) leads to striking predictions in the lepton sector: only Inverted Ordering is realised, the absolute neutrino mass scale is predicted to be m(lightest)approximate to 7.5x10(-4) eV and the Majorana phases are correlated in such a way that vertical bar m(ee)vertical bar approximate to 0.018 eV. The model also leads to a strong correlation between the solar mixing angle theta(12) and delta(CP), which may be falsified by the next generation of neutrino oscillation experiments. The setup is minimal in the sense that no additional symmetries or flavons are required.