Abstract: As part of the R2D2 (Rare Decays with Radial Detector) R &D, the use of a gas detector with a spherical or cylindrical cathode, equipped with a single anode and operating at high pressure, was studied for the search of rare phenomena such as neutrinoless double-beta decay. The presented measurements were obtained with a cylindrical detector, covering gas pressures ranging from 1 to 10 bar in argon and 1 to 6 bar in xenon, using both a point-like source of 210 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{210} $$\end{document} Po (5.3 MeV alpha \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha $$\end{document} ) and a diffuse source of 222 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$<^>{222}$$\end{document} Rn (5.5 MeV alpha \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha $$\end{document} ). Analysis and interpretation of the data were developed using the anodic current waveform. Similar detection performances were achieved with both gases, and comparable energy resolutions were measured with both sources. As long as the purity of the gas was sufficient, no significant degradation of the measured energy was observed by increasing the pressure. At the highest operating pressure, an energy resolution better than 1.5% full-width at half-maximum (FWHM) was obtained for both gaseous media, although optimal noise conditions were not reached.

Abstract: The International Linear Collider (ILC) will allow the precise study of e(-)e(+)-> q (q) over bar interactions at different center-of-mass energies from the Z-pole to 1 TeV. In this paper, we discuss the experimental prospects for measuring differential observables in e(-)e(+)-> b (b) over bar and e(-)e(+) -> c (c) over bar at the ILC baseline energies, 250 and 500 GeV. The study is based on full simulation and reconstruction of the International Large Detector (ILD) concept. Two gauge-Higgs unification models predicting new high-mass resonances beyond the Standard Model are discussed. These models predict sizable deviations of the forward-backward observables at the ILC running above the Z mass and with longitudinally polarized electron and positron beams. The ability of the ILC to probe these models via high-precision measurements of the forward-backward asymmetry is discussed. Alternative scenarios at other energies and beam polarization schemes are also discussed, extrapolating the estimated uncertainties from the two baseline scenarios.

Abstract: The recent observation of coherent elastic neutrino-nucleus scattering (CEvNS) with neutrinos from pion decay at rest (N-DAR) sources by the COHERENT Collaboration has raised interest in this process in the search for new physics. Unfortunately, current uncertainties in the determination of nuclear parameters relevant to those processes can hide new physics effects. This is not the case for processes involving lower-energy neutrino sources such as nuclear reactors. Note, however, that a CEvNS measurement with reactor neutrinos depends largely on a (still-missing) precise determination of the quenching factor at very low energies, making its observation more challenging. In the upcoming years, once this signal is confirmed, a combined analysis of N-DAR and reactor CEvNS experiments will be very useful to probe particle and nuclear physics, with a reduced dependence on nuclear uncertainties. In this work, we explore this idea by simultaneously testing the sensitivity of current and future CEvNS experiments to neutrino nonstandard interactions (NSIs) and the neutron root mean square (rms) radius, considering different neutrino sources as well as several detection materials. We show how the interplay between future reactor and accelerator CEvNS experiments can help to get robust constraints on the neutron rms and to break degeneracies between the NSI parameters. Our forecast could be used as a guide to optimize the experimental sensitivity to the parameters under study.

Abstract: We investigate the potential impact of neutrino quantum decoherence on the precision measurements of standard neutrino oscillation parameters in the DUNE and T2HK experiments. We show that the measurement of delta(CP), sin(2) theta(13) and sin(2) theta(23) is stronger effected in DUNE than in T2HK. On the other hand, DUNE would have a better sensitivity than T2HK to observe decoherence effects. By performing a combined analysis of DUNE and T2HK we show that a robust measurement of standard parameters would be possible, which is not guaranteed with DUNE data alone.

Abstract: In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.