Abstract: In order to exploit the advantages of ion-beam therapy in a clinical setting, delivery verification techniques are necessary to detect deviations from the planned treatment. Efforts are currently oriented towards the development of devices for real-time range monitoring. Among the different detector concepts proposed, Compton cameras are employed to detect prompt gammas and represent a valid candidate for real-time range verification. We present the first on-beam test of MACACO, a Compton telescope (multi-layer Compton camera) based on lanthanum bromide crystals and silicon photo-multipliers. The Compton telescope was first characterized through measurements and Monte Carlo simulations. The detector linearity was measured employing Na-22 and Am-Be sources, obtaining about 10% deviation from linearity at 3.44 MeV. A spectral image reconstruction algorithm was tested on synthetic data. Point-like sources emitting gamma rays with energy between 2 and 7 MeV were reconstructed with 3-5 mm resolution. The two-layer Compton telescope was employed to measure radiation emitted from a beam of 150 MeV protons impinging on a cylindrical PMMA target. Bragg-peak shifts were achieved via adjustment of the PMMA target location and the resulting measurements used during image reconstruction. Reconstructed Bragg peak profiles proved sufficient to observe peak-location differences within 10 mm demonstrating the potential of the MACACO Compton Telescope as a monitoring device for ion-beam therapy.

Abstract: In contemporary nuclear physics, the European Advanced GAmma Tracking Array (AGATA) represents a crucial detection system for cutting-edge nuclear structure studies. AGATA consists of highly segmented high-purity germanium crystals and uses the pulse-shape analysis technique to determine both the position and the energy of the y-ray interaction points in the crystals. It is the tracking algorithms that deploy this information and enable insight into the sequence of interactions, providing information on the full or partial absorption of the 7 ray. A series of dedicated performance measurements for an AGATA set-up comprising 21 crystals is described. This set-up was used within the recent PreSPEC-AGATA experimental campaign at the GSI Helmholtzzentrum fur Schwerionenforschung. Using the radioactive sources Co-56, Co-60 and Eu-152, absolute and normalized efficiencies and the peak-to-total of the array were measured. These quantities are discussed using different data analysis procedures. The quality of the pulse-shape analysis and the tracking algorithm are evaluated. The agreement between the experimental data and the Geant4 simulations is also investigated.

Abstract: We investigate a gauge extension of the Standard Model in light of the observed hints of lepton universality violation in b -> clv and b -> sl(+) l(-) decays at BaBar, Belle and LHCb. The model consists of an extended gauge group SU(2)(1) x SU(2)(2) x U(l)(Y) which breaks spontaneously around the TeV scale to the electroweak gauge group. Fermion mixing effects with vector -like fermions give rise to potentially large new physics contributions in flavour transitions mediated by WI and Z' bosons. This model can ease tensions in B -physics data while satisfying stringent bounds from flavour physics, and electroweak precision data. Possible ways to test the proposed new physics scenario with upcoming experimental measurements are discussed. Among other predictions, the ratios RM =Gamma(B -> M mu(+)mu(-))/Gamma(B -> Me(+)e(-)), with M = K*, phi, are found to be reduced with respect to the Standard Model expectation R-M similar or equal to 1.