Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.

Abstract: The nonequivalence between the metric and Palatini formalisms of f(R) gravity is an intriguing feature of these theories. However, in the recently proposed hybrid metric-Palatini gravity, consisting of the superposition of the metric Einstein-Hilbert Lagrangian with an f(R) term constructed a la Palatini, the “true” gravitational field is described by the interpolation of these two nonequivalent approaches. The theory predicts the existence of a light long-range scalar field, which passes the local constraints and affects the galactic and cosmological dynamics. Thus, the theory opens new possibilities for a unified approach, in the same theoretical framework, to the problems of dark energy and dark matter, without distinguishing a priori matter and geometric sources, but taking their dynamics into account under the same standard.

Abstract: In order to study the Gamow-Teller (GT) transitions from the T-z = +2 nucleus Ca-44 to the T-z = +1 nucleus Sc-44, where T-z is the z component of isospin T, we performed the (p, n)-type (He-3, t) charge-exchange (CE) reaction at 140 MeV/nucleon and the scattering angles 0 degrees and 2.5 degrees. An energy resolution of 28 keV, that was realized by applying matching techniques to the magnetic spectrometer system, allowed the study of fragmented states. The GT transition strengths, B(GT), were derived up to the excitation energy (E-x) of 13.7 MeV assuming the proportionality between cross sections and B(GT) values. The total sum of B(GT) values in discrete states was 3.7, which was 31% of the sum-rule-limit value of 12. Shell model calculations using the GXPF1J interaction could reproduce the gross features of the experimental B(GT) distribution, but not the fragmentation of the strength. By introducing the concepts of isospin, properties of isospin analogous transitions and states were investigated. (i) Assuming isospin symmetry, the T-z = +2 -> +1 and T-z = -2 -> -1 mirror GT transitions should have the same properties, where the latter can be studied in the beta decay of Cr-44 to V-44. First, we confirmed that the beta-decay half-life T-1/2 of Cr-44 can be reproduced using the B(GT) distribution from the Ca-44(He-3, t) measurement. Then, the 0 degrees, (3He, t) spectrum was modified to deduce the “beta-decay spectrum” and it was compared with the delayed-proton spectrum from the Cr-44 beta decay. The two spectra were mostly in agreement for the GT excitations, but suppression of the proton decay was found for the T = 2 isobaric analog state (IAS). (ii) Starting from the T = 2 ground state of 44Ca, the (3He, t) can excite GT states (state populated by GT transitions) with T = 1, 2, and 3. On the other hand, the Ca-44(p, p') reaction can excite spin-M1 states (states populated by spin-M1 transitions) with T = 2 and 3 that are analogous to the T = 2 and 3 GT states, respectively. By comparing the spectra from these two reactions, a T value of 2 is suggested for several GT states in the E-x = 11.5-13.7 MeV region. (iii) It has been suggested that the T = 2, J(pi) = 0(+) double isobaric analog state (DIAS) at 9.338 MeV in the T-z = 0 nucleus Ti-44 forms an isospin-mixed doublet with a subsidiary 0(+) state at 9.298 MeV. Since no corresponding state was found in the T-z = +1 nucleus Sc-44, we suggest T = 0 for the subsidiary state.

Abstract: The neutron flux of the nTOF facility at CERN was measured, after installation of the new spallation target, with four different systems based on three neutron-converting reactions, which represent accepted cross sections standards in different energy regions. A careful comparison and combination of the different measurements allowed us to reach an unprecedented accuracy on the energy dependence of the neutron flux in the very wide range (thermal to 1 GeV) that characterizes the nTOF neutron beam. This is a pre-requisite for the high accuracy of cross section measurements at n_TOF. An unexpected anomaly in the neutron-induced fission cross section of U-235 is observed in the energy region between 10 and 30keV, hinting at a possible overestimation of this important cross section, well above currently assigned uncertainties.

Abstract: The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Frejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of mu(+) and mu(-) beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular He-6 and Ne-18, also stored in a ring. The far detector is also the MEMPHYS detector in the Frejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.