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Author |
Botella, F.J.; Branco, G.C.; Nebot, M.; Rebelo, M.N.; Silva-Marcos, J.I. |
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Title  |
Vector-like quarks at the origin of light quark masses and mixing |
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Journal Article |
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Year |
2017 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
77 |
Issue |
6 |
Pages |
408 - 14pp |
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Abstract |
We show how a novel fine-tuning problem present in the Standard Model can be solved through the introduction of a Z(6) flavour symmetry, together with three Q = -1/3 quarks, three Q = 2/3 quarks, as well as a complex singlet scalar. The Z(6) symmetry is extended to the additional fields and it is an exact symmetry of the Lagrangian, only softly broken in the scalar potential, in order to avoid the domain-wall problem. Specific examples are given and a phenomenological analysis of the main features of the model is presented. It is shown that even for vector-like quarks with masses accessible at the LHC, one can have realistic quark masses and mixing, while respecting the strict constraints on processes arising from flavour changing neutral currents. The vector-like quark decay channels are also described. |
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Address |
[Botella, Francisco J.] Univ Valencia, CSIC, Dept Fis Teor, E-46100 Burjassot, Spain, Email: francisco.j.botella@uv.es; |
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Publisher |
Springer |
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English |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
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Notes |
WOS:000403504500005 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
3180 |
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Author |
Sanjuan, R.; Nebot, M.; Chirico, N.; Mansky, L.M.; Belshaw, R. |
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Title |
Viral Mutation Rates |
Type |
Journal Article |
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Year |
2010 |
Publication |
Journal of Virology |
Abbreviated Journal |
J. Virol. |
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Volume |
84 |
Issue |
19 |
Pages |
9733-9748 |
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Keywords |
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Abstract |
Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut. |
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Address |
[Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolutiva, Dept Genet, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Amer Soc Microbiology |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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ISSN |
0022-538x |
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Notes |
ISI:000282641800008 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ elepoucu @ |
Serial |
371 |
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