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Author Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A.
Title (down) Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases Type Journal Article
Year 2024 Publication Nanomaterials Abbreviated Journal Nanomaterials
Volume 14 Issue 13 Pages 1093 - 21pp
Keywords proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition
Abstract In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition.
Address [Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es
Corporate Author Thesis
Publisher Mdpi Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes WOS:001269841000001 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 6204
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Author Montanari, D. et al; Gadea, A.
Title (down) Probing the nature of particle-core couplings in Ca-49 with gamma spectroscopy and heavy-ion transfer reactions Type Journal Article
Year 2011 Publication Physics Letters B Abbreviated Journal Phys. Lett. B
Volume 697 Issue 4 Pages 288-293
Keywords Multi-nucleon transfer; Gamma spectroscopy; Magnetic spectrometer; Particle-core coupling
Abstract Neutron rich nuclei around Ca-48 have been measured with the CLARA-PRISMA setup, making use of Ca-48 on Ni-64 binary reactions, at 5.9 MeV/A. Angular distributions of gamma rays give evidence, in several transfer channels, for a large spin alignment (approximate to 70%) perpendicular to the reaction plane, making it possible to firmly establish spin and parities of the excited states. In the case of Ca-49, states arising from different types of particle-core couplings are, for the first time, unambiguously identified on basis of angular distribution, polarization and lifetime measurements. Shell model and particle-vibration coupling calculations are used to pin down the nature of the states. Evidence is found for the presence, in the same excitation energy region, of two types of coupled states, i.e. single particle coupled to either Ca-48 or Ca-50 simple configurations, and particle-vibration coupled states based on the 3- phonon of Ca-48.
Address [Montanari, D.; Leoni, S.; Bocchi, G.; Bortignon, P. F.; Bracco, A.; Camera, F.; Colo, G.; Corsi, A.; Crespi, F. C. L.; Nicolini, R.] Univ Milan, Dipartimento Fis, Milan, Italy, Email: silvia.leoni@mi.infn.it
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0370-2693 ISBN Medium
Area Expedition Conference
Notes ISI:000288300400005 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 542
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Author LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Henry, L.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanchez Mayordomo, C.
Title (down) Precision measurement of the Xi(++)(cc) mass Type Journal Article
Year 2020 Publication Journal of High Energy Physics Abbreviated Journal J. High Energy Phys.
Volume 02 Issue 2 Pages 049 - 18pp
Keywords Charm physics; Hadron-Hadron scattering (experiments); QCD; Spectroscopy
Abstract A measurement of the Xi cc++ candidates are reconstructed via the decay modes Xi cc++->?c+K-pi+pi+ and Xi cc++->Xi c+pi+. The result, 3621.55 +/- 0.23 (stat) +/- 0.30 (syst) MeV/c(2), is the most precise measurement of the Xi cc++ mass to date.
Address [Bediaga, I.; Cruz Torres, M.; De Miranda, J. M.; Dos Reis, A. C.; Gomes, A.; Massafferri, A.; Soares Lavra, L.; Torres Machado, D.] CBPF, Rio De Janeiro, Brazil, Email: haojie.ni@cern.ch
Corporate Author Thesis
Publisher Springer Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1029-8479 ISBN Medium
Area Expedition Conference
Notes WOS:000513450500001 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 4299
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Author LHCb Collaboration (Aaij, R. et al); Garcia Martin, L.M.; Henry, L.; Jashal, B.K.; Martinez-Vidal, F.; Oyanguren, A.; Remon Alepuz, C.; Ruiz Vidal, J.; Sanchez Mayordomo, C.
Title (down) Precision measurement of the B-c(+) meson mass Type Journal Article
Year 2020 Publication Journal of High Energy Physics Abbreviated Journal J. High Energy Phys.
Volume 07 Issue 7 Pages 123 - 21pp
Keywords B physics; Hadron-Hadron scattering (experiments); QCD; Spectroscopy
Abstract A precision measurement of the B-c(+) meson mass is performed using proton- proton collision data collected with the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to a total integrated luminosity of 9.0 fb(-1). The B-c(+) mesons are reconstructed via the decays B-c(+)-> J/psi pi(+), B-c(+)-> J/psi pi(+)pi(-)pi(+), B-c(+)-> J/psi pp<overbar>pi(+), B-c(+)-> J/psi D-s(+), B-c(+)-> J/psi (DK+)-K-0 and B-c(+)-> B-s(0)pi(+). Combining the results of the individual decay channels, the B-c(+) mass is measured to be 6274.47 +/- 0.27 (stat) +/- 0.17 (syst) MeV/c(2). This is the most precise measurement of the B-c(+) mass to date. The difference between the B-c(+) and B-s(0) meson masses is measured to be 907.75 +/- 0.37 (stat) +/- 0.27 (syst) MeV/c(2).
Address [Baptista Leite, J.; Bediaga, I; Torres, M. Cruz; De Miranda, J. M.; dos Reis, A. C.; Gomes, A.; Massafferri, A.; Machado, D. Torres] Ctr Brasileiro Pesquisas Fis CBPF, Rio De Janeiro, Brazil, Email: yanting.fan@cern.ch
Corporate Author Thesis
Publisher Springer Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1029-8479 ISBN Medium
Area Expedition Conference
Notes WOS:000553446200002 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 4482
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Author LHCb Collaboration (Aaij, R. et al); Martinez-Vidal, F.; Oyanguren, A.; Ruiz Valls, P.; Sanchez Mayordomo, C.
Title (down) Precise measurements of the properties of the B-1(5721)(0,+) and B-2*(5747)(0,+) states and observation of B-+,B-0 pi(-,+) mass structures Type Journal Article
Year 2015 Publication Journal of High Energy Physics Abbreviated Journal J. High Energy Phys.
Volume 04 Issue 4 Pages 024 - 27pp
Keywords Spectroscopy; Hadron-Hadron Scattering; QCD; B physics; Flavor physics
Abstract Invariant mass distributions of B (+) pi (-) and B (0) pi (+) combinations are investigated in order to study excited B mesons. The analysis is based on a data sample corresponding to 3.0 fb(-1) of pp collision data, recorded by the LHCb detector at centre-of-mass energies of 7 and 8 TeV. Precise measurements of the masses and widths of the B (1)(5721)(0,+) and B (2)(5747)(0,+) states are reported. Clear enhancements, particularly prominent at high pion transverse momentum, are seen over background in the mass range 5850-6000 MeV in both B (+) pi (-) and B (0) pi (+) combinations. The structures are consistent with the presence of four excited B mesons, labelled B (J) (5840)(0,+) and B (J) (5960)(0,+), whose masses and widths are obtained under different hypotheses for their quantum numbers.
Address [Bediaga, I.; De Miranda, J. M.; Ferreira Rodrigues, F.; Gomes, A.; Massafferri, A.; Rodrigues, B. Osorio; dos Reis, A. C.; Rodrigues, A. B.] CBPF, Rio De Janeiro, Brazil, Email: vladimir.gligorov@cern.ch
Corporate Author Thesis
Publisher Springer Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1029-8479 ISBN Medium
Area Expedition Conference
Notes WOS:000353555200001 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2217
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Author Barrientos, D.; Bellato, M.; Bazzacco, D.; Bortolato, D.; Cocconi, P.; Gadea, A.; Gonzalez, V.; Gulmini, M.; Isocrate, R.; Mengoni, D.; Pullia, A.; Recchia, F.; Rosso, D.; Sanchis, E.; Toniolo, N.; Ur, C.A.; Valiente-Dobon, J.J.
Title (down) Performance of the Fully Digital FPGA-Based Front-End Electronics for the GALILEO Array Type Journal Article
Year 2015 Publication IEEE Transactions on Nuclear Science Abbreviated Journal IEEE Trans. Nucl. Sci.
Volume 62 Issue 6 Pages 3134-3139
Keywords FPGA; front-end electronics; gamma-ray spectroscopy; germanium detectors
Abstract In this work we present the architecture and results of a fully digital Front End Electronics (FEE) read out system developed for the GALILEO array. The FEE system, developed in collaboration with the Advanced Gamma Tracking Array (AGATA) collaboration, is composed of three main blocks: preamplifiers, digitizers and preprocessing electronics. The slow control system contains a custom Linux driver, a dynamic library and a server implementing network services. This work presents the first results of the digital FEE system coupled with a GALILEO germanium detector, which has demonstrated the capability to achieve an energy resolution of 1.53% at an energy of 1.33 MeV, similar to the one obtained with a conventional analog system. While keeping a good performance in terms of energy resolution, digital electronics will allow to instrument the full GALILEO array with a versatile system with high integration and low power consumption and costs.
Address [Barrientos, D.; Bortolato, D.; Cocconi, P.; Gulmini, M.; Rosso, D.; Toniolo, N.; Valiente-Dobon, J. J.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Padua, Italy, Email: diego.barrientos@lnl.infn.it
Corporate Author Thesis
Publisher Ieee-Inst Electrical Electronics Engineers Inc Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0018-9499 ISBN Medium
Area Expedition Conference
Notes WOS:000372013500005 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2612
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Author Lalovic, N.; Louchart, C.; Michelagnoli, C.; Perez-Vidal, R.M.; Ralet, D.; Gerl, J.; Rudolph, D.; Arici, T.; Bazzacco, D.; Clement, E.; Gadea, A.; Kojouharov, I.; Korichi, A.; Labiche, M.; Ljungvall, J.; Lopez-Martens, A.; Nyberg, J.; Pietralla, N.; Pietri, S.; Stezowski, O.
Title (down) Performance of the AGATA gamma-ray spectrometer in the PreSPEC set-up at GSI Type Journal Article
Year 2016 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 806 Issue Pages 258-266
Keywords Gamma-ray spectroscopy; Gamma-ray tracking; Nuclear structure; Pulse shape analysis; HPGe detectors
Abstract In contemporary nuclear physics, the European Advanced GAmma Tracking Array (AGATA) represents a crucial detection system for cutting-edge nuclear structure studies. AGATA consists of highly segmented high-purity germanium crystals and uses the pulse-shape analysis technique to determine both the position and the energy of the y-ray interaction points in the crystals. It is the tracking algorithms that deploy this information and enable insight into the sequence of interactions, providing information on the full or partial absorption of the 7 ray. A series of dedicated performance measurements for an AGATA set-up comprising 21 crystals is described. This set-up was used within the recent PreSPEC-AGATA experimental campaign at the GSI Helmholtzzentrum fur Schwerionenforschung. Using the radioactive sources Co-56, Co-60 and Eu-152, absolute and normalized efficiencies and the peak-to-total of the array were measured. These quantities are discussed using different data analysis procedures. The quality of the pulse-shape analysis and the tracking algorithm are evaluated. The agreement between the experimental data and the Geant4 simulations is also investigated.
Address [Lalovic, N.; Rudolph, D.] Lund Univ, Dept Phys, SE-22100 Lund, Sweden, Email: Natasa.Lalovic@nuclear.lu.se
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000364856100035 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 2463
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Author Korichi, A.; Lauritsen, T.; Wilson, A.N.; Dudouet, J.; Clement, E.; Lalovic, N.; Perez-Vidal, R.M.; Pietri, S.; Ralet, D.; Stezowski, O.
Title (down) Performance of a gamma-ray tracking array: Characterizing the AGATA array using a Co-60 source Type Journal Article
Year 2017 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 872 Issue Pages 80-86
Keywords Segmented germanium detectors; Efficiency measurements; gamma-ray tracking; AGATA; gamma-ray spectroscopy; Nuclear structure
Abstract The AGATA (Advanced GAmma Tracking Array) tracking detector is being designed to far surpass the performance of the previous generation, Compton-suppressed arrays. In this paper, a characterization of AGATA is provided based on data from the second GSI campaign. Emphasis is placed on the proper corrections required to extract the absolute photopeak efficiency and peak-to-total ratio. The performance after tracking is extracted and GEANT4 simulations are used both to understand the results and to scale the measurements up to predicted values for the full 4 pi implementation of the device.
Address [Korichi, A.] CNRS, IN2P3, CSNSM, Bat 104-108,Orsay Campus, F-91405 Orsay, France, Email: Amel.Korichi@csnsm.in2p3.fr
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000411755300009 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 3311
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Author Doncel, M.; Cederwall, B.; Gadea, A.; Gerl, J.; Kojouharov, I.; Martin, S.; Palit, R.; Quintana, B.
Title (down) Performance and imaging capabilities of the DEGAS high-resolution gamma-ray detector array for the DESPEC experiment at FAIR Type Journal Article
Year 2017 Publication Nuclear Instruments & Methods in Physics Research A Abbreviated Journal Nucl. Instrum. Methods Phys. Res. A
Volume 873 Issue Pages 36-38
Keywords Gamma spectroscopy; Imaging; Position-sensitive Ge detectors
Abstract Monte Carlo simulations of one of the possible configurations of the imaging phase for the DEGAS spectrometer situated at the DESPEC/NUSTAR experiment have been performed. The geometry consists of the coupling of the high-resolution gamma spectroscopy array, AGATA, with a high-resolution segmented planar detector utilized as an implantation detector in a compact configuration. The sensitivity and performance of the array in terms of efficiency and imaging capability is deduced.
Address [Doncel, M.] Univ Liverpool, Dept Phys, Oliver Lodge Lab, Liverpool, Merseyside, England, Email: doncel@liverpool.ac.uk
Corporate Author Thesis
Publisher Elsevier Science Bv Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0168-9002 ISBN Medium
Area Expedition Conference
Notes WOS:000413823100008 Approved no
Is ISI yes International Collaboration yes
Call Number IFIC @ pastor @ Serial 3349
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Author Olleros, P.; Caballero, L.; Domingo-Pardo, C.; Babiano, V.; Ladarescu, I.; Calvo, D.; Gramage, P.; Nacher, E.; Tain, J.L.; Tolosa, A.
Title (down) On the performance of large monolithic LaCl3(Ce) crystals coupled to pixelated silicon photosensors Type Journal Article
Year 2018 Publication Journal of Instrumentation Abbreviated Journal J. Instrum.
Volume 13 Issue Pages P03014 - 17pp
Keywords Compton imaging; Detector modelling and simulations I (interaction of radiation with matter interaction of photons with matter interaction of hadrons with matter etc); Gamma detectors (scintillators CZT HPG HgI etc); Instrumentation and methods for time-of-flight (TOF); spectroscopy
Abstract We investigate the performance of large area radiation detectors, with high energy-and spatial-resolution, intended for the development of a Total Energy Detector with gamma-ray imaging capability, so-called i-TED. This new development aims for an enhancement in detection sensitivity in time-of-flight neutron capture measurements, versus the commonly used C6D6 liquid scintillation total-energy detectors. In this work, we study in detail the impact of the readout photosensor on the energy response of large area (50 x 50 mm(2)) monolithic LaCl3(Ce) crystals, in particular when replacing a conventional mono-cathode photomultiplier tube by an 8 x 8 pixelated silicon photomultiplier. Using the largest commercially available monolithic SiPM array (25 cm(2)), with a pixel size of 6 x 6 mm(2), we have measured an average energy resolution of 3.92% FWHM at 662 keV for crystal thick-nesses of 10, 20 and 30 mm. The results are confronted with detailed Monte Carlo (MC) calculations, where optical processes and properties have been included for the reliable tracking of the scintillation photons. After the experimental validation of the MC model, we use our MC code to explore the impact of a smaller photosensor segmentation on the energy resolution. Our optical MC simulations predict only a marginal deterioration of the spectroscopic performance for pixels of 3 x 3 mm(2).
Address [Olleros, P.; Caballero, L.; Domingo-Pardo, C.; Babiano, V.; Ladarescu, I.; Calvo, D.; Gramage, P.; Tain, J. L.; Tolosa, A.] Univ Valencia, CSIC, Inst Fis Corpuscular, C Catedrat Jose Beltran 2, Paterna 46980, Spain, Email: Luis.Caballero@ific.uv.es
Corporate Author Thesis
Publisher Iop Publishing Ltd Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1748-0221 ISBN Medium
Area Expedition Conference
Notes WOS:000428146300004 Approved no
Is ISI yes International Collaboration no
Call Number IFIC @ pastor @ Serial 3542
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