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Author |
Sanjuan, R.; Nebot, M.; Peris, J.B.; Alcami, J. |
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Title  |
Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1 |
Type |
Journal Article |
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Year |
2013 |
Publication |
Plos Biology |
Abbreviated Journal |
PLoS. Biol. |
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Volume |
11 |
Issue |
4 |
Pages |
e1001523 - 10pp |
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Keywords |
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Abstract |
The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive. |
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Address |
Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolut, Valencia, Spain, Email: rafael.sanjuan@uv.es |
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Publisher |
Public Library Science |
Place of Publication |
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Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1545-7885 |
ISBN |
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Expedition |
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Conference |
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Notes |
WOS:000318687800003 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
no |
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Call Number |
IFIC @ pastor @ |
Serial |
1446 |
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Author |
Ruiz de Austri, R.; Perez de los Heros, C. |
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Title |
Impact of nucleon matrix element uncertainties on the interpretation of direct and indirect dark matter search results |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Cosmology and Astroparticle Physics |
Abbreviated Journal |
J. Cosmol. Astropart. Phys. |
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Volume |
11 |
Issue |
11 |
Pages |
049 - 19pp |
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Keywords |
dark matter theory; dark matter experiments; supersymmetry and cosmology |
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Abstract |
We study in detail the impact of the current uncertainty in nucleon matrix elements on the sensitivity of direct and indirect experimental techniques for dark matter detection. We perform two scans in the framework of the cMSSM: one using recent values of the pion-sigma term obtained from Lattice QCD, and the other using values derived from experimental measurements. The two choices correspond to extreme values quoted in the literature and reflect the current tension between different ways of obtaining information about the structure of the nucleon. All other inputs in the scans, astrophysical and from particle physics, are kept unchanged. We use two experiments, XENON100 and IceCube, as benchmark cases to illustrate our case. We find that the interpretation of dark matter search results from direct detection experiments is more sensitive to the choice of the central values of the hadronic inputs than the results of indirect search experiments. The allowed regions of cMSSM parameter space after including XENON100 constrains strongly differ depending on the assumptions on the hadronic matrix elements used. On the other hand, the constraining potential of IceCube is almost independent of the choice of these values. |
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Address |
[Ruiz de Austri, R.] IFIC UV CSIC, Inst Fis Corpuscular, Valencia, Spain, Email: rruiz@ific.uv.es; |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1475-7516 |
ISBN |
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Area |
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Conference |
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Notes |
WOS:000327843900050 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1674 |
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Author |
Olmo, G.J.; Rubiera-Garcia, D. |
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Title |
Importance of torsion and invariant volumes in Palatini theories of gravity |
Type |
Journal Article |
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Year |
2013 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
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Volume |
88 |
Issue |
8 |
Pages |
084030 - 11pp |
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Keywords |
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Abstract |
We study the field equations of extensions of general relativity formulated within a metric-affine formalism setting torsion to zero (Palatini approach). We find that different (second-order) dynamical equations arise depending on whether torsion is set to zero (i) a priori or (ii) a posteriori, i.e., before or after considering variations of the action. Considering a generic family of Ricci-squared theories, we show that in both cases the connection can be decomposed as the sum of a Levi-Civita connection and terms depending on a vector field. However, while in case (i) this vector field is related to the symmetric part of the connection, in (ii) it comes from the torsion part and, therefore, it vanishes once torsion is completely removed. Moreover, the vanishing of this torsion-related vector field immediately implies the vanishing of the antisymmetric part of the Ricci tensor, which therefore plays no role in the dynamics. Related to this, we find that the Levi-Civita part of the connection is due to the existence of an invariant volume associated with an auxiliary metric h(mu v), which is algebraically related with the physical metric g(mu v). |
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Address |
[Olmo, Gonzalo J.] Ctr Mixto Univ Valencia CSIC, Dept Fis Teor, Valencia 46100, Spain, Email: gonzalo.olmo@csic.es; |
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Thesis |
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Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1550-7998 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000326107300007 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1630 |
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Author |
ATLAS Collaboration (Aad, G. et al); Cabrera Urban, S.; Castillo Gimenez, V.; Costa, M.J.; Fassi, F.; Ferrer, A.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gonzalez de la Hoz, S.; Hernandez Jimenez, Y.; Higon-Rodriguez, E.; Irles Quiles, A.; Kaci, M.; Lacasta, C.; Lacuesta, V.R.; Marti-Garcia, S.; Miñano, M.; Mitsou, V.A.; Moles-Valls, R.; Moreno Llacer, M.; Oliver Garcia, E.; Pedraza Lopez, S.; Perez Garcia-Estañ, M.T.; Romero Adam, E.; Ros, E.; Salt, J.; Sanchez Martinez, V.; Solans, C.A.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valladolid Gallego, E.; Valls Ferrer, J.A.; Villaplana Perez, M.; Vos, M. |
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Title |
Improved luminosity determination in pp collisions at root s=7 TeV using the ATLAS detector at the LHC |
Type |
Journal Article |
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Year |
2013 |
Publication |
European Physical Journal C |
Abbreviated Journal |
Eur. Phys. J. C |
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Volume |
73 |
Issue |
8 |
Pages |
2518 - 39pp |
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Keywords |
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Abstract |
The luminosity calibration for the ATLAS detector at the LHC during pp collisions at root s = 7 TeV in 2010 and 2011 is presented. Evaluation of the luminosity scale is performed using several luminosity-sensitive detectors, and comparisons are made of the long-term stability and accuracy of this calibration applied to the pp collisions at root s = 7 TeV. A luminosity uncertainty of delta L/L = +/- 3.5 % is obtained for the 47 pb(-1) of data delivered to ATLAS in 2010, and an uncertainty of delta L/L = +/- 1.8 % is obtained for the 5.5 fb(-1) delivered in 2011. |
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Address |
[Jackson, P.; Soni, N.] Univ Adelaide, Sch Chem & Phys, Adelaide, SA, Australia, Email: atlas.publications@cern.ch |
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Corporate Author |
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Thesis |
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Publisher |
Springer |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1434-6044 |
ISBN |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000323901300010 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1576 |
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Author |
NEXT Collaboration (Alvarez, V. et al); Carcel, S.; Cervera-Villanueva, A.; Diaz, J.; Ferrario, P.; Gil, A.; Gomez-Cadenas, J.J.; Laing, A.; Liubarsky, I.; Lorca, D.; Martin-Albo, J.; Martinez, A.; Monrabal, F.; Muñoz Vidal, J.; Nebot-Guinot, M.; Rodriguez, J.; Serra, L.; Simon, A.; Sorel, M.; Yahlali, N. |
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Title |
Initial results of NEXT-DEMO, a large-scale prototype of the NEXT-100 experiment |
Type |
Journal Article |
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Year |
2013 |
Publication |
Journal of Instrumentation |
Abbreviated Journal |
J. Instrum. |
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Volume |
8 |
Issue |
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Pages |
P04002 - 25pp |
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Keywords |
Double-beta decay detectors; Time projection chambers; Pattern recognition, cluster finding, calibration and fitting methods |
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Abstract |
NEXT-DEMO is a large-scale prototype of the NEXT-100 detector, an electroluminescent time projection chamber that will search for the neutrinoless double beta decay of Xe-136 using 100-150 kg of enriched xenon gas. NEXT-DEMO was built to prove the expected performance of NEXT-100, namely, energy resolution better than 1% FWHM at 2.5MeV and event topological reconstruction. In this paper we describe the prototype and its initial results. A resolution of 1.75% FWHM at 511 keV (which extrapolates to 0.8% FWHM at 2.5 MeV) was obtained at 10 bar pressure using a gamma-ray calibration source. Also, a basic study of the event topology along the longitudinal coordinate is presented, proving that it is possible to identify the distinct dE/dx of electron tracks in high-pressure xenon using an electroluminescence TPC. |
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Address |
CSIC, Inst Fis Corpuscular IFIC, Valencia 46980, Spain, Email: justo.martin-albo@ific.uv.es |
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Corporate Author |
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Thesis |
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Publisher |
Iop Publishing Ltd |
Place of Publication |
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Editor |
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Language |
English |
Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
1748-0221 |
ISBN |
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Medium |
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Area |
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Expedition |
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Conference |
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Notes |
WOS:000317462400009 |
Approved |
no |
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Is ISI |
yes |
International Collaboration |
yes |
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Call Number |
IFIC @ pastor @ |
Serial |
1414 |
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| Permanent link to this record |
