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Author Sanjuan, R.; Nebot, M.; Chirico, N.; Mansky, L.M.; Belshaw, R. doi  openurl
  Title (down) Viral Mutation Rates Type Journal Article
  Year 2010 Publication Journal of Virology Abbreviated Journal J. Virol.  
  Volume 84 Issue 19 Pages 9733-9748  
  Keywords  
  Abstract Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut.  
  Address [Sanjuan, Rafael] Univ Valencia, Inst Cavanilles Biodiversitat & Biol Evolutiva, Dept Genet, Valencia 46980, Spain, Email: rafael.sanjuan@uv.es  
  Corporate Author Thesis  
  Publisher Amer Soc Microbiology Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-538x ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000282641800008 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ elepoucu @ Serial 371  
Permanent link to this record
 
 
Author Botella, F.J.; Branco, G.C.; Nebot, M.; Rebelo, M.N.; Silva-Marcos, J.I. url  doi
openurl 
  Title (down) Vector-like quarks at the origin of light quark masses and mixing Type Journal Article
  Year 2017 Publication European Physical Journal C Abbreviated Journal Eur. Phys. J. C  
  Volume 77 Issue 6 Pages 408 - 14pp  
  Keywords  
  Abstract We show how a novel fine-tuning problem present in the Standard Model can be solved through the introduction of a Z(6) flavour symmetry, together with three Q = -1/3 quarks, three Q = 2/3 quarks, as well as a complex singlet scalar. The Z(6) symmetry is extended to the additional fields and it is an exact symmetry of the Lagrangian, only softly broken in the scalar potential, in order to avoid the domain-wall problem. Specific examples are given and a phenomenological analysis of the main features of the model is presented. It is shown that even for vector-like quarks with masses accessible at the LHC, one can have realistic quark masses and mixing, while respecting the strict constraints on processes arising from flavour changing neutral currents. The vector-like quark decay channels are also described.  
  Address [Botella, Francisco J.] Univ Valencia, CSIC, Dept Fis Teor, E-46100 Burjassot, Spain, Email: francisco.j.botella@uv.es;  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1434-6044 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000403504500005 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 3180  
Permanent link to this record
 
 
Author Nebot, M.; Botella, F.J.; Branco, G.C. url  doi
openurl 
  Title (down) Vacuum induced CP violation generating a complex CKM matrix with controlled scalar FCNC Type Journal Article
  Year 2019 Publication European Physical Journal C Abbreviated Journal Eur. Phys. J. C  
  Volume 79 Issue 8 Pages 711 - 23pp  
  Keywords  
  Abstract We propose. a viable minimal model with spontaneous CP violation in the framework of a two Higgs doublet model. The model is based on a generalised Branco-Grimus-Lavoura model with a flavoured Z(2) symmetry, under which two of the quark families are even and the third one is odd. The lagrangian respects CP invariance, but the vacuum has a CP violating phase, which is able to generate a complex CKM matrix, with the rephasing invariant strength of CP violation compatible with experiment. The question of scalar mediated flavour changing neutral couplings is carefully studied. In particular we point out a deep connection between the generation of a complex CKM matrix from a vacuum phase and the appearance of scalar FCNC. The scalar sector is presented in detail, showing that the new scalars are necessarily lighter than 1 TeV. A complete analysis of the model including the most relevant constraints is performed, showing that it is viable and that it has definite implications for the observation of New Physics signals in, for example, flavour changing Higgs decays or the discovery of the new scalars at the LHC. We give special emphasis to processes like t -> hc, hu, as well as h -> bs, bd, which are relevant for the LHC and the ILC.  
  Address [Nebot, Miguel; Branco, Gustavo C.] UL, Dept Fis, Inst Super Tecn, Av Rovisco Pais 1, P-1049001 Lisbon, Portugal, Email: miguel.r.nebot.gomez@tecnico.ulisboa.pt;  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1434-6044 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000483225300003 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 4130  
Permanent link to this record
 
 
Author Botella, F.J.; Branco, G.C.; Nebot, M.; Rebelo, M.N. url  doi
openurl 
  Title (down) Two-Higgs leptonic minimal flavour violation Type Journal Article
  Year 2011 Publication Journal of High Energy Physics Abbreviated Journal J. High Energy Phys.  
  Volume 10 Issue 10 Pages 037 - 21pp  
  Keywords Higgs Physics; Beyond Standard Model; Neutrino Physics  
  Abstract We construct extensions of the Standard Model with two Higgs doublets, where there are flavour changing neutral currents both in the quark and leptonic sectors, with their strength fixed by the fermion mixing matrices V(CKM) and V(PMNS). These models are an extension to the leptonic sector of the class of models previously considered by Branco, Grimus and Lavoura, for the quark sector. We consider both the cases of Dirac and Majorana neutrinos and identify the minimal discrete symmetry required in order to implement the models in a natural way.  
  Address [Botella, F. J.; Nebot, M.] Univ Valencia, Dept Fis Teor, CSIC, E-46100 Burjassot, Spain, Email: fbotella@uv.es  
  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1126-6708 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000296917100037 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 830  
Permanent link to this record
 
 
Author Herrero-Garcia, J.; Nebot, M.; Rius, N.; Santamaria, A. url  doi
openurl 
  Title (down) The Zee-Babu model revisited in the light of new data Type Journal Article
  Year 2014 Publication Nuclear Physics B Abbreviated Journal Nucl. Phys. B  
  Volume 885 Issue Pages 542-570  
  Keywords  
  Abstract We update previous analyses of the Zee-Babu model in the light of new data, e.g., the mixing angle On, the rare decay μ-> e gamma and the LHC results. We also analyze the possibility of accommodating the deviations in Gamma (H -> gamma gamma) hinted by the LHC experiments, and the stability of the scalar potential. We find that neutrino oscillation data and low energy constraints are still compatible with masses of the extra charged scalars accessible to LHC. Moreover, if any of them is discovered, the model can be falsified by combining the information on the singly and doubly charged scalar decay modes with neutrino data. Conversely, if the neutrino spectrum is found to be inverted and the CP phase delta is quite different from pi, the masses of the charged scalars will be well outside the LHC reach.  
  Address [Herrero-Garcia, Juan; Rius, Nuria; Santamaria, Arcadi] Univ Valencia, Dept Fis Teor, E-46100 Burjassot, Valencia, Spain  
  Corporate Author Thesis  
  Publisher Elsevier Science Bv Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0550-3213 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000339598300025 Approved no  
  Is ISI yes International Collaboration yes  
  Call Number IFIC @ pastor @ Serial 1858  
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