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Ballester, F., Tedgren, A. C., Granero, D., Haworth, A., Mourtada, F., Fonseca, G. P., et al. (2015). A generic high-dose rate Ir-192 brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism. Med. Phys., 42(6), 3048–3062.
Abstract: Purpose: In order to facilitate a smooth transition for brachytherapy dose calculations from the American Association of Physicists in Medicine (AAPM) Task Group No. 43 (TG-43) formalism to model-based dose calculation algorithms (MBDCAs), treatment planning systems (TPSs) using a MBDCA require a set of well-defined test case plans characterized by Monte Carlo (MC) methods. This also permits direct dose comparison to TG-43 reference data. Such test case plans should be made available for use in the software commissioning process performed by clinical end users. To this end, a hypothetical, generic high-dose rate (HDR) Ir-192 source and a virtual water phantom were designed, which can be imported into a TPS. Methods: A hypothetical, generic HDR Ir-192 source was designed based on commercially available sources as well as a virtual, cubic water phantom that can be imported into any TPS in DICOM format. The dose distribution of the generic Ir-192 source when placed at the center of the cubic phantom, and away from the center under altered scatter conditions, was evaluated using two commercial MBDCAs [Oncentra (R) Brachy with advanced collapsed-cone engine (ACE) and BrachyVision AcuRos (TM)]. Dose comparisons were performed using state-of-the-art MC codes for radiation transport, including ALGEBRA, BrachyDose, GEANT4, MCNP5, MCNP6, and pENELopE2008. The methodologies adhered to recommendations in the AAPM TG-229 report on high-energy brachytherapy source dosimetry. TG-43 dosimetry parameters, an along-away dose-rate table, and primary and scatter separated (PSS) data were obtained. The virtual water phantom of (201)(3) voxels (1 mm sides) was used to evaluate the calculated dose distributions. Two test case plans involving a single position of the generic HDR Ir-192 source in this phantom were prepared: (i) source centered in the phantom and (ii) source displaced 7 cm laterally from the center. Datasets were independently produced by different investigators. MC results were then compared against dose calculated using TG-43 and MBDCA methods. Results: TG-43 and PSS datasets were generated for the generic source, the PSS data for use with the ACE algorithm. The dose-rate constant values obtained from seven MC simulations, performed independently using different codes, were in excellent agreement, yielding an average of 1.1109 +/- 0.0004 cGy/(h U) (k = 1, Type A uncertainty). MC calculated dose-rate distributions for the two plans were also found to be in excellent agreement, with differences within type A uncertainties. Differences between commercial MBDCA and MC results were test, position, and calculation parameter dependent. On average, however, these differences were within 1% for ACUROS and 2% for ACE at clinically relevant distances. Conclusions: A hypothetical, generic HDR Ir-192 source was designed and implemented in two commercially available TPSs employing different MBDCAs. Reference dose distributions for this source were benchmarked and used for the evaluation of MBDCA calculations employing a virtual, cubic water phantom in the form of a CT DICOM image series. The implementation of a generic source of identical design in all TPSs using MBDCAs is an important step toward supporting univocal commissioning procedures and direct comparisons between TPSs.
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Ma, Y. Z., Vijande, J., Ballester, F., Tedgren, A. C., Granero, D., Haworth, A., et al. (2017). A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate Ir-192 brachytherapy. Med. Phys., 44(11), 5961–5976.
Abstract: PurposeA joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform calculations and comparisons with model-based dose calculation algorithms (MBDCAs). Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being used in clinical practice for brachytherapy, to the one proposed by Task Group No. 186 (TG-186) for MBDCAs. To do so, in this work a hypothetical, generic high-dose rate (HDR) Ir-192 shielded applicator has been designed and benchmarked. MethodsA generic HDR Ir-192 shielded applicator was designed based on three commercially available gynecological applicators as well as a virtual cubic water phantom that can be imported into any DICOM-RT compatible treatment planning system (TPS). The absorbed dose distribution around the applicator with the TG-186 Ir-192 source located at one dwell position at its center was computed using two commercial TPSs incorporating MBDCAs (Oncentra((R)) Brachy with Advanced Collapsed-cone Engine, ACE, and BrachyVision ACUROS) and state-of-the-art Monte Carlo (MC) codes, including ALGEBRA, BrachyDose, egs_brachy, Geant4, MCNP6, and Penelope2008. TPS-based volumetric dose distributions for the previously reported source centered in water and source displaced test cases, and the new source centered in applicator test case, were analyzed here using the MCNP6 dose distribution as a reference. Volumetric dose comparisons of TPS results against results for the other MC codes were also performed. Distributions of local and global dose difference ratios are reported. ResultsThe local dose differences among MC codes are comparable to the statistical uncertainties of the reference datasets for the source centered in water and source displaced test cases and for the clinically relevant part of the unshielded volume in the source centered in applicator case. Larger local differences appear in the shielded volume or at large distances. Considering clinically relevant regions, global dose differences are smaller than the local ones. The most disadvantageous case for the MBDCAs is the one including the shielded applicator. In this case, ACUROS agrees with MC within [-4.2%, +4.2%] for the majority of voxels (95%) while presenting dose differences within [-0.12%, +0.12%] of the dose at a clinically relevant reference point. For ACE, 95% of the total volume presents differences with respect to MC in the range [-1.7%, +0.4%] of the dose at the reference point. ConclusionsThe combination of the generic source and generic shielded applicator, together with the previously developed test cases and reference datasets (available in the Brachytherapy Source Registry), lay a solid foundation in supporting uniform commissioning procedures and direct comparisons among treatment planning systems for HDR Ir-192 brachytherapy.
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ATLAS Collaboration(Abat, E. et al), Bernabeu Verdu, J., Castillo Gimenez, V., Costa, M. J., Escobar, C., Ferrer, A., et al. (2011). A layer correlation technique for pion energy calibration at the 2004 ATLAS Combined Beam Test. J. Instrum., 6, P06001–35pp.
Abstract: A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in front of and between the calorimeters of the ATLAS experiment were calculated with simulated Geant4 Monte Carlo events and used to reconstruct the energy of pions impinging on the calorimeters during the 2004 Barrel Combined Beam Test at the CERN H8 area. For pion beams with energies between 20 GeV and 180 GeV, the particle energy is reconstructed within 3% and the energy resolution is improved by between 11% and 25% compared to the resolution at the electromagnetic scale.
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LHCb Collaboration(Aaij, R. et al), Martinez-Vidal, F., Oyanguren, A., Ruiz Valls, P., & Sanchez Mayordomo, C. (2016). A new algorithm for identifying the flavour of B-s(0) mesons at LHCb. J. Instrum., 11, P05010–23pp.
Abstract: A new algorithm for the determination of the initial flavour of B-s(0) mesons is presented. The algorithm is based on two neural networks and exploits the b hadron production mechanism at a hadron collider. The first network is trained to select charged kaons produced in association with the B-s(0) meson. The second network combines the kaon charges to assign the B-s(0) flavour and estimates the probability of a wrong assignment. The algorithm is calibrated using data corresponding to an integrated luminosity of 3 fb(-1) collected by the LHCb experiment in proton-proton collisions at 7 and 8 TeV centre-of-mass energies. The calibration is performed in two ways: by resolving the B-s(0)-B-s(0) flavour oscillations in B-s(0) -> D-s(-)pi(+) decays, and by analysing flavour-specific B-s2*(5840)(0) -> B+K- decays. The tagging power measured in B-s(0) -> D-s(-)pi(+) decays is found to be (1.80 +/- 0.19 ( stat) +/- 0.18 (syst))%, which is an improvement of about 50% compared to a similar algorithm previously used in the LHCb experiment.
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ANTARES and HESS Collaborations(Petroff, E. et al), Barrios-Marti, J., Hernandez-Rey, J. J., Illuminati, G., Lotze, M., Tönnis, C., et al. (2017). A polarized fast radio burst at low Galactic latitude. Mon. Not. Roy. Astron. Soc., 469(4), 4465–4482.
Abstract: We report on the discovery of a new fast radio burst (FRB), FRB 150215, with the Parkes radio telescope on 2015 February 15. The burst was detected in real time with a dispersion measure (DM) of 1105.6 +/- 0.8 pc cm(-3), a pulse duration of 2.8(-0.5)(+1.2) ms, and a measured peak flux density assuming that the burst was at beam centre of 0.7(-0.1)(+0.2) Jy. The FRB originated at a Galactic longitude and latitude of 24.66 degrees, 5.28 degrees and 25 degrees away from the Galactic Center. The burst was found to be 43 +/- 5 per cent linearly polarized with a rotation measure (RM) in the range -9 < RM < 12 rad m(-2) (95 per cent confidence level), consistent with zero. The burst was followed up with 11 telescopes to search for radio, optical, X-ray, gamma-ray and neutrino emission. Neither transient nor variable emission was found to be associated with the burst and no repeat pulses have been observed in 17.25 h of observing. The sightline to the burst is close to the Galactic plane and the observed physical properties of FRB 150215 demonstrate the existence of sight lines of anomalously low RM for a given electron column density. The Galactic RM foreground may approach a null value due to magnetic field reversals along the line of sight, a decreased total electron column density from the Milky Way, or some combination of these effects. A lower Galactic DM contribution might explain why this burst was detectable whereas previous searches at low latitude have had lower detection rates than those out of the plane.
Keywords: polarization; methods: data analysis; surveys; ISM: structure
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Gammaldi, V., Zaldivar, B., Sanchez-Conde, M. A., & Coronado-Blazquez, J. (2023). A search for dark matter among Fermi-LAT unidentified sources with systematic features in machine learning. Mon. Not. Roy. Astron. Soc., 520(1), 1348–1361.
Abstract: Around one-third of the point-like sources in the Fermi-LAT catalogues remain as unidentified sources (unIDs) today. Indeed, these unIDs lack a clear, univocal association with a known astrophysical source. If dark matter (DM) is composed of weakly interacting massive particles (WIMPs), there is the exciting possibility that some of these unIDs may actually be DM sources, emitting gamma-rays from WIMPs annihilation. We propose a new approach to solve the standard, machine learning (ML) binary classification problem of disentangling prospective DM sources (simulated data) from astrophysical sources (observed data) among the unIDs of the 4FGL Fermi-LAT catalogue. We artificially build two systematic features for the DM data which are originally inherent to observed data: the detection significance and the uncertainty on the spectral curvature. We do it by sampling from the observed population of unIDs, assuming that the DM distributions would, if any, follow the latter. We consider different ML models: Logistic Regression, Neural Network (NN), Naive Bayes, and Gaussian Process, out of which the best, in terms of classification accuracy, is the NN, achieving around 93 . 3 per cent +/- 0 . 7 per cent performance. Other ML evaluation parameters, such as the True Ne gativ e and True Positive rates, are discussed in our work. Applying the NN to the unIDs sample, we find that the de generac y between some astrophysical and DM sources can be partially solved within this methodology. None the less, we conclude that there are no DM source candidates among the pool of 4FGL Fermi-LAT unIDs.
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Pierre Auger Collaboration(Abreu, P. et al), & Pastor, S. (2012). A search for point sources of EeV neutrons. Astrophys. J., 760(2), 148–11pp.
Abstract: A thorough search of the sky exposed at the Pierre Auger Cosmic Ray Observatory reveals no statistically significant excess of events in any small solid angle that would be indicative of a flux of neutral particles from a discrete source. The search covers from -90 degrees to +15 degrees in declination using four different energy ranges above 1 EeV (10(18) eV). The method used in this search is more sensitive to neutrons than to photons. The upper limit on a neutron flux is derived for a dense grid of directions for each of the four energy ranges. These results constrain scenarios for the production of ultrahigh energy cosmic rays in the Galaxy.
Keywords: cosmic rays; Galaxy: disk; methods: data analysis
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Pierre Auger Collaboration(Aab, A. et al), & Pastor, S. (2014). A search for point sources of EeV photons. Astrophys. J., 789(2), 160–12pp.
Abstract: Measurements of air showers made using the hybrid technique developed with the fluorescence and surface detectors of the Pierre Auger Observatory allow a sensitive search for point sources of EeV photons anywhere in the exposed sky. A multivariate analysis reduces the background of hadronic cosmic rays. The search is sensitive to a declination band from -85 degrees to +20 degrees, in an energy range from 10(17.3) eV to 10(18.5) eV. No photon point source has been detected. An upper limit on the photon flux has been derived for every direction. The mean value of the energy flux limit that results from this, assuming a photon spectral index of -2, is 0.06 eV cm(-2) s(-1), and no celestial direction exceeds 0.25 eV cm(-2) s(-1). These upper limits constrain scenarios in which EeV cosmic ray protons are emitted by non-transient sources in the Galaxy.
Keywords: astroparticle physics; cosmic rays; methods: data analysis
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Pierre Auger Collaboration(Aab, A. et al), & Pastor, S. (2014). A targeted search for point sources of EeV neutrons. Astrophys. J. Lett., 789(2), L34–7pp.
Abstract: A flux of neutrons from an astrophysical source in the Galaxy can be detected in the Pierre Auger Observatory as an excess of cosmic-ray air showers arriving from the direction of the source. To avoid the statistical penalty for making many trials, classes of objects are tested in combinations as nine “target sets,” in addition to the search for a neutron flux from the Galactic center or from the Galactic plane. Within a target set, each candidate source is weighted in proportion to its electromagnetic flux, its exposure to the Auger Observatory, and its flux attenuation factor due to neutron decay. These searches do not find evidence for a neutron flux from any class of candidate sources. Tabulated results give the combined p-value for each class, with and without the weights, and also the flux upper limit for the most significant candidate source within each class. These limits on fluxes of neutrons significantly constrain models of EeV proton emission from non-transient discrete sources in the Galaxy.
Keywords: cosmic rays; Galaxy: disk; methods: data analysis
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NEXT Collaboration(Simon, A. et al), Gomez-Cadenas, J. J., Alvarez, V., Benlloch-Rodriguez, J. M., Botas, A., Carcel, S., et al. (2017). Application and performance of an ML-EM algorithm in NEXT. J. Instrum., 12, P08009–22pp.
Abstract: The goal of the NEXT experiment is the observation of neutrinoless double beta decay in Xe-136 using a gaseous xenon TPC with electroluminescent amplification and specialized photodetector arrays for calorimetry and tracking. The NEXT Collaboration is exploring a number of reconstruction algorithms to exploit the full potential of the detector. This paper describes one of them: the Maximum Likelihood Expectation Maximization (ML-EM) method, a generic iterative algorithm to find maximum-likelihood estimates of parameters that has been applied to solve many different types of complex inverse problems. In particular, we discuss a bi-dimensional version of the method in which the photosensor signals integrated over time are used to reconstruct a transverse projection of the event. First results show that, when applied to detector simulation data, the algorithm achieves nearly optimal energy resolution (better than 0.5% FWHM at the Q value of 136Xe) for events distributed over the full active volume of the TPC.
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