Abstract: Nuclear-medium effects on the weak structure functions F-2(x, Q(2)) and F-3(x, Q(2)) in charged-current neutrino and antineutrino induced deep-inelastic reactions in Pb-208 have been studied. The calculations have been performed in a theoretical model using relativistic nuclear spectral functions which incorporate Fermi motion, binding, and nucleon correlations. We have also included the pion and rho meson cloud contributions calculated from a microscopic model for meson-nucleus self-energies. Using these structure functions, differential scattering cross sections have been obtained and compared with the CERN Hybrid Oscillation Research Apparatus (CHORUS) data. The results for the ratios 2F(i)(Pb)/208F(i)(D), 4F(i)(Pb)/208F(i)(He), 12F(i)(Pb)/208F(i)(C), 16F(i)(Pb)/208F(i)(O), and 56F(i)(Pb)/208F(i)(Fe) (i = 2, 3) have also been obtained and compared with some of the phenomenological fits.