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Sanjuan, R., Nebot, M., Peris, J. B., & Alcami, J. (2013). Immune Activation Promotes Evolutionary Conservation of T-Cell Epitopes in HIV-1. PLoS. Biol., 11(4), e1001523–10pp.
Abstract: The immune system should constitute a strong selective pressure promoting viral genetic diversity and evolution. However, HIV shows lower sequence variability at T-cell epitopes than elsewhere in the genome, in contrast with other human RNA viruses. Here, we propose that epitope conservation is a consequence of the particular interactions established between HIV and the immune system. On one hand, epitope recognition triggers an anti-HIV response mediated by cytotoxic T-lymphocytes (CTLs), but on the other hand, activation of CD4(+) helper T lymphocytes (T-H cells) promotes HIV replication. Mathematical modeling of these opposite selective forces revealed that selection at the intrapatient level can promote either T-cell epitope conservation or escape. We predict greater conservation for epitopes contributing significantly to total immune activation levels (immunodominance), and when T-H cell infection is concomitant to epitope recognition (transinfection). We suggest that HIV-driven immune activation in the lymph nodes during the chronic stage of the disease may offer a favorable scenario for epitope conservation. Our results also support the view that some pathogens draw benefits from the immune response and suggest that vaccination strategies based on conserved T-H epitopes may be counterproductive.
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ATLAS Collaboration(Aad, G. et al), Cabrera Urban, S., Castillo Gimenez, V., Costa, M. J., Ferrer, A., Fiorini, L., et al. (2013). Measurements of top quark pair relative differential cross-sections with ATLAS in pp collisions at root s=7 TeV. Eur. Phys. J. C, 73(1), 2261–28pp.
Abstract: Measurements are presented of differential cross-sections for top quark pair production in pp collisions at root s = 7 TeV relative to the total inclusive top quark pair production cross-section. A data sample of 2.05 fb(-1) recorded by the ATLAS detector at the Large Hadron Collider is used. Relative differential cross-sections are derived as a function of the invariant mass, the transverse momentum and the rapidity of the top quark pair system. Events are selected in the lepton (electron or muon) + jets channel. The background-subtracted differential distributions are corrected for detector effects, normalized to the total inclusive top quark pair production cross-section and compared to theoretical predictions. The measurement uncertainties range typically between 10 % and 20 % and are generally dominated by systematic effects. No significant deviations from the Standard Model expectations are observed.
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ATLAS Collaboration(Aad, G. et al), Cabrera Urban, S., Castillo Gimenez, V., Costa, M. J., Fassi, F., Ferrer, A., et al. (2013). Search for pair-produced massive coloured scalars in four-jet final states with the ATLAS detector in proton-proton collisions at root s=7 TeV. Eur. Phys. J. C, 73(1), 2263–20pp.
Abstract: A search for pair-produced massive coloured scalar particles decaying to a four-jet final state is performed by the ATLAS experiment at the LHC in proton-proton collisions at root s = 7 TeV. The analysed data sample corresponds to an integrated luminosity of 4.6 fb(-1). No deviation from the Standard Model is observed in the invariant mass spectrum of the two-jet pairs. A limit on the scalar gluon pair production cross section of 70 pb (10 pb) is obtained at the 95 % confidence level for a scalar gluon mass of 150 GeV (350 GeV). Interpreting these results as mass limits on scalar gluons, masses ranging from 150 GeV to 287 GeV are excluded at the 95 % confidence level.
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LHCb Collaboration(Aaij, R. et al), Oyanguren, A., & Ruiz Valls, P. (2013). Precision measurement of the B-s(0)-(B)over-bar(s)(0) oscillation frequency with the decay B-s(0) -> D-s(-)pi(+). New J. Phys., 15, 053021–15pp.
Abstract: A key ingredient to searches for physics beyond the Standard Model in B-s(0) mixing phenomena is the measurement of the B-s(0)-(B) over bar (0)(s) oscillation frequency, which is equivalent to the mass difference Delta m(s) of the B-s(0) mass eigenstates. Using the world's largest B-s(0) meson sample accumulated in a dataset, corresponding to an integrated luminosity of 1.0 fb(-1), collected by the LHCb experiment at the CERN LHC in 2011, a measurement of Delta m(s) is presented. A total of about 34 000 B-s(0) -> D-s(-)pi(+) signal decays are reconstructed, with an average decay time resolution of 44 fs. The oscillation frequency is measured to be Delta m(s) = 17.768 +/- 0.023 (stat) +/- 0.006 (syst) ps(-1), which is the most precise measurement to date.
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Garcia-Recio, C., Geng, L. S., Nieves, J., Salcedo, L. L., Wang, E., & Xie, J. J. (2013). Low-lying even parity meson resonances and spin-flavor symmetry revisited. Phys. Rev. D, 87(9), 096006–18pp.
Abstract: We review and extend the model derived in Garcia-Recio et al. [Phys. Rev. D 83, 016007 (2011)] to address the dynamics of the low-lying even-parity meson resonances. This model is based on a coupled-channels spin-flavor extension of the chiralWeinberg-Tomozawa Lagrangian. This interaction is then used to study the S-wave meson-meson scattering involving members not only of the pi octet, but also of the rho nonet. In this work, we study in detail the structure of the SU(6)-symmetry-breaking contact terms that respect (or softly break) chiral symmetry. We derive the most general local (without involving derivatives) terms consistent with the chiral-symmetry-breaking pattern of QCD. After introducing sensible simplifications to reduce the large number of possible operators, we carry out a phenomenological discussion of the effects of these terms. We show how the inclusion of these pieces leads to an improvement of the description of the J(P) = 2(+) sector, without spoiling the main features of the predictions obtained in the original model in the JP = 0(+) and J(P) = 1(+) sectors. In particular, we find a significantly better description of the I-G(J(PC)) =0(+)(2(++)), 1(-)(2(++)) and the I(JP)=1/2(2(+)) sectors, which correspond to the f(2)(1270), a(2)(1320), and K-2(*)(1430) quantum numbers, respectively.
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