| Records |
| Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fullana Torregrosa, E.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
| Title |
Measurement of the Higgs boson mass with H → γγ decays in 140 fb-1 of √s=13 TeV pp collisions with the ATLAS detector |
Type |
Journal Article |
| Year |
2023 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
847 |
Issue |
|
Pages |
138315 - 23pp |
| Keywords |
|
| Abstract |
The mass of the Higgs boson is measured in the H -> gamma gamma decay channel, exploiting the high resolution of the invariant mass of photon pairs reconstructed from the decays of Higgs bosons produced in proton-proton collisions at a centre-of-mass energy root s = 13 TeV. The dataset was collected between 2015 and 2018 by the ATLAS detector at the Large Hadron Collider, and corresponds to an integrated luminosity of 140 fb(-1). The measured value of the Higgs boson mass is 125.17 +/- 0.11 (stat.) +/- 0.09 (syst.) GeV and is based on an improved energy scale calibration for photons, whose impact on the measurement is about four times smaller than in the previous publication. A combination with the corresponding measurement using 7 and 8 TeV pp collision ATLAS data results in a Higgs boson mass measurement of 125.22 +/- 0.11 (stat.) +/- 0.09 (syst.) GeV. With an uncertainty of 1.1 per mille, this is currently the most precise measurement of the mass of the Higgs boson from a single decay channel. |
| Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001257125900001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial  |
6213 |
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| Author |
Xiao, C.W.; Dias, J.M.; Dai, L.R.; Liang, W.H.; Oset, E. |
| Title |
Triangle singularity in the J/ψ → ϕ π+ a−0(π−η) ,ϕ π− a+0(π+η) decays |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
109 |
Issue |
7 |
Pages |
074033 - 11pp |
| Keywords |
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| Abstract |
We study the J= psi -> phi pi + a 0 ( 980 ) – ( a – 0 -> pi – eta ) decay, evaluating the double mass distribution in terms of the pi – eta and pi + a – 0 invariant masses. We show that the pi – eta mass distribution exhibits the typical cusp structure of the a 0 ( 980 ) seen in recent high statistics experiments, and the pi + a – 0 spectrum shows clearly a peak around M inv ( pi + a – 0 ) = 1420 MeV, corresponding to a triangle singularity. When integrating over the two invariant masses we find a branching ratio for this decay of the order of 10 – 5 , which is easily accessible in present laboratories. We also call attention to the fact that the signal obtained is compatible with a bump experimentally observed in the eta pi + pi – mass distribution in the J= psi -> phi eta pi + pi – decay and encourage further analysis to extract from there the phi pi + a – 0 and phi pi – a + 0 decay modes. |
| Address |
[Xiao, C. W.; Liang, W. H.; Oset, E.] Guangxi Normal Univ, Dept Phys, Guilin 541004, Peoples R China, Email: xiaochw@gxnu.edu.cn; |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001236271000012 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6212 |
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| |
| Author |
Bayar, M.; Molina, R.; Oset, E.; Liu, M.Z.; Geng, L.S. |
| Title |
Subtleties in triangle loops for Ds+ → ρ+ η → π+ π0 η in a0(980) production |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
109 |
Issue |
7 |
Pages |
076027 - 7pp |
| Keywords |
|
| Abstract |
We address a general problem in the evaluation of triangle loops stemming from the consideration of the range of the interaction involved in some of the vertices, as well as the energy dependence of the width of some unstable particles in the loop. We find sizeable corrections from both effects. We apply that to a loop relevant to the D + s -> pi + pi 0 eta decay, and find reductions of about a factor of 4 in the mass distribution of invariant mass of the pi eta in the region of the a 0 ( 980 ) . The method used is based on the explicit analytical evaluation of the q 0 integration in the d 4 q loop integration, using Cauchy 's residues method, which at the same time offers an insight on the convergence of the integrals and the effect of form factors and cutoffs. |
| Address |
[Bayar, M.] Kocaeli Univ, Dept Phys, TR-41380 Izmit, Turkiye, Email: melahat.bayar@kocaeli.edu; |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001236271000017 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6211 |
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| Author |
Super-Kamiokande Collaboration (Abe, K. et al); Molina Sedgwick, S. |
| Title |
Solar neutrino measurements using the full data period of Super-Kamiokande-IV |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
109 |
Issue |
9 |
Pages |
092001 - 44pp |
| Keywords |
|
| Abstract |
An analysis of solar neutrino data from the fourth phase of Super-Kamiokande (SK-IV) from October 2008 to May 2018 is performed and the results are presented. The observation time of the dataset of SK- IV corresponds to 2970 days and the total live time for all four phases is 5805 days. For more precise solar neutrino measurements, several improvements are applied in this analysis: lowering the data acquisition threshold in May 2015, further reduction of the spallation background using neutron clustering events, precise energy reconstruction considering the time variation of the PMT gain. The observed number of solar neutrino events in 3.49-19.49 MeV electron kinetic energy region during SK-IV is 65, 443(-388)(+390) (stat.) +/- 925(syst.) events. Corresponding B-8 solar neutrino flux is (2.314 +/- 0.014(stat.) +/- 0.040(syst.)) x 106 cm(-2) s(-1), assuming a pure electron-neutrino flavor component without neutrino oscillations. The flux combined with all SK phases up to SK-IV is (2.336 +/- 0.011(stat.) +/- 0.043(syst.)) x 106 cm(-2) s(-1). Based on the neutrino oscillation analysis from all solar experiments, including the SK 5805 days dataset, the best-fit neutrino oscillation parameters are sin(2)theta(12,solar) = 0.306 +/- 0.013 and Delta m(21,solar)(2) = (6.10(-0.81)(+0.95)) x 10(-5) eV(2), with a deviation of about 1.5 sigma from the Delta m(21)(2) parameter obtained by KamLAND. The best-fit neutrino oscillation parameters obtained from all solar experiments and KamLAND are sin(2)theta(12, global) = 0.307 +/- 0.012 and Delta m(21,) (2)(global) = (7.50(-0.18)(+0.19)) x 10(-5) eV(2). |
| Address |
[Abe, K.; Bronner, C.; Hayato, Y.; Hiraide, K.; Hosokawa, K.; Ieki, K.; Ikeda, M.; Imaizumi, S.; Iyogi, K.; Kameda, J.; Kanemura, Y.; Kaneshima, R.; Kashiwagi, Y.; Kataoka, Y.; Kato, Y.; Kishimoto, Y.; Miki, S.; Mine, S.; Miura, M.; Mochizuki, T.; Moriyama, S.; Nagao, Y.; Nakahata, M.; Nakano, Y.; Nakayama, S.; Noguchi, Y.; Okada, T.; Okamoto, K.; Orii, A.; Sato, K.; Sekiya, H.; Shiba, H.; Shimizu, K.; Shiozawa, M.; Sonoda, Y.; Suzuki, Y.; Takeda, A.; Takemoto, Y.; Takenaka, A.; Tanaka, H.; Watanabe, S.; Yano, T.] Univ Tokyo, Kamioka Observ, Inst Cosm Ray Res, Kamioka, Gifu 5061205, Japan |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001261161700001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6210 |
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| Author |
Sorelli, G.; Gessner, M.; Treps, N.; Walschaers, M. |
| Title |
Gaussian quantum metrology for mode-encoded parameters |
Type |
Journal Article |
| Year |
2024 |
Publication |
New Journal of Physics |
Abbreviated Journal |
New J. Phys. |
| Volume |
26 |
Issue |
7 |
Pages |
073022 - 23pp |
| Keywords |
quantum metrology; multimode quantum optics; Gaussian states |
| Abstract |
Quantum optical metrology aims to identify ultimate sensitivity bounds for the estimation of parameters encoded into quantum states of the electromagnetic field. In many practical applications, including imaging, microscopy, and remote sensing, the parameter of interest is not only encoded in the quantum state of the field, but also in its spatio-temporal distribution, i.e. in its mode structure. In this mode-encoded parameter estimation setting, we derive an analytical expression for the quantum Fisher information valid for arbitrary multimode Gaussian fields. To illustrate the power of our approach, we apply our results to the estimation of the transverse displacement of a beam and to the temporal separation between two pulses. For these examples, we show how the estimation sensitivity can be enhanced by adding squeezing into specific modes. |
| Address |
[Sorelli, Giacomo; Treps, Nicolas; Walschaers, Mattia] Sorbonne Univ, ENS Univ PSL, CNRS, Lab Kastler Brossel,Coll France, 4 Pl Jussieu, F-75252 Paris, France, Email: giacomo.sorelli@iosb-extern.fraunhofer.de |
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Thesis |
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| Publisher |
IOP Publishing Ltd |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1367-2630 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001270966100001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6209 |
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| Author |
Figueroa, D.G.; Pieroni, M.; Ricciardone, A.; Simakachorn, P. |
| Title |
Cosmological Background Interpretation of Pulsar Timing Array Data |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review Letters |
Abbreviated Journal |
Phys. Rev. Lett. |
| Volume |
132 |
Issue |
17 |
Pages |
171002 - 9pp |
| Keywords |
|
| Abstract |
We discuss the interpretation of the detected signal by pulsar timing array (PTA) observations as a gravitational wave background of cosmological origin. We combine NANOGrav 15-years and EPTADR2new datasets and confront them against backgrounds from supermassive black hole binaries (SMBHBs), and cosmological signals from inflation, cosmic (super)strings, first-order phase transitions, Gaussian and non-Gaussian large scalar fluctuations, and audible axions. We find that scalar-induced, and to a lesser extent audible axion and cosmic superstring signals, provide a better fit than SMBHBs. These results depend, however, on modeling assumptions, so further data and analysis are needed to reach robust conclusions. Independently of the signal origin, the data strongly constrain the parameter space of cosmological signals, for example, setting an upper bound on primordial non-Gaussianity at PTA scales as jfnlj less than or similar to 2.34 at 95% C.L. |
| Address |
[Figueroa, Daniel G.; Simakachorn, Peera] Univ Valencia, Consejo Super Invest Cient, Inst Fis Corpuscular, Valencia 46980, Spain |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0031-9007 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001271924500001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6208 |
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| Author |
ATLAS Collaboration (Aad, G. et al); Aikot, A.; Amos, K.R.; Aparisi Pozo, J.A.; Bailey, A.J.; Bouchhar, N.; Cabrera Urban, S.; Cantero, J.; Cardillo, F.; Castillo Gimenez, V.; Chitishvili, M.; Costa, M.J.; Didenko, M.; Escobar, C.; Fiorini, L.; Fuster, J.; Garcia, C.; Garcia Navarro, J.E.; Gomez Delegido, A.J.; Gonzalez de la Hoz, S.; Gonzalvo Rodriguez, G.R.; Guerrero Rojas, J.G.R.; Lacasta, C.; Marti-Garcia, S.; Martinez Agullo, P.; Miralles Lopez, M.; Mitsou, V.A.; Monsonis Romero, L.; Moreno Llacer, M.; Munoz Perez, D.; Navarro-Gonzalez, J.; Poveda, J.; Prades Ibañez, A.; Rubio Jimenez, A.; Ruiz-Martinez, A.; Sabatini, P.; Saibel, A.; Salt, J.; Sanchez Sebastian, V.; Sayago Galvan, I.; Senthilkumar, V.; Soldevila, U.; Sanchez, J.; Torro Pastor, E.; Valero, A.; Valiente Moreno, E.; Valls Ferrer, J.A.; Varriale, L.; Villaplana Perez, M.; Vos, M. |
| Title |
A search for R-parity-violating supersymmetry in final states containing many jets in pp collisions at √s=13 TeV with the ATLAS detector |
Type |
Journal Article |
| Year |
2024 |
Publication |
Journal of High Energy Physics |
Abbreviated Journal |
J. High Energy Phys. |
| Volume |
05 |
Issue |
5 |
Pages |
003 - 46pp |
| Keywords |
Supersymmetry; Hadron-Hadron Scattering; Jets; Beyond Standard Model |
| Abstract |
A search for R-parity-violating supersymmetry in final states with high jet multiplicity is presented. The search uses 140 fb(-1) of proton-proton collision data at root s = 13 TeV collected by the ATLAS experiment during Run 2 of the Large Hadron Collider. The results are interpreted in the context of R-parity-violating supersymmetry models that feature prompt gluino-pair production decaying directly to three jets each or decaying to two jets and a neutralino which subsequently decays promptly to three jets. No significant excess over the Standard Model expectation is observed and exclusion limits at the 95% confidence level are extracted. Gluinos with masses up to 1800 GeV are excluded when decaying directly to three jets. In the cascade scenario, gluinos with masses up to 2340 GeV are excluded for a neutralino with mass up to 1250 GeV. |
| Address |
[Filmer, E. K.; Grant, C. M.; Jackson, P.; Kong, A. X. Y.; Pandya, H. D.; Potti, H.; Ruggeri, T. A.; Ting, E. X. L.; White, M. J.] Univ Adelaide, Dept Phys, Adelaide, SA, Australia |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
1029-8479 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001261438700001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6207 |
| Permanent link to this record |
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| Author |
Paredes-Torres, G.; Gutierrez-Guerrer, L.X.; Bashir, A.; Miramontes, A.S. |
| Title |
First radial excitations of mesons and diquarks in a contact interaction |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physical Review D |
Abbreviated Journal |
Phys. Rev. D |
| Volume |
109 |
Issue |
11 |
Pages |
114006 - 12pp |
| Keywords |
|
| Abstract |
We present a calculation for the masses of the first radially excited states of 40 mesons and diquarks made up of u , d , s , c , and b quarks, including states that contain one or both heavy quarks. To this end, we employ a combined analysis of the Bethe-Salpeter and Schwinger-Dyson equations within a self-consistent and symmetry-preserving vector-vector contact interaction. The same set of parameters describes ground and excited states of mesons and their diquark partners. The wave function of the first radial excitation contains a zero whose location is correlated with an additional parameter d F which is a function of dressed quark masses. Our results satisfy the equal spacing rules given by the Gell-Mann Okubo mass relations. Wherever possible, we make comparisons of our findings with known experimental observations as well as theoretical predictions of several other models and approaches including lattice quantum chromodynamics, finding a very good agreement. We report predictions for a multitude of radial excitations not yet observed in experiments. |
| Address |
[Paredes-Torres, G.; Gutierrez-Guerrer, L. X.; Bashir, A.; Miramontes, angel S.] Univ Michoacana, Inst Fis & Matemat, Edificio C-3,Ciudad Univ, Morelia 58040, Michoacan, Mexico, Email: gustavo.paredes@umich.mx; |
| Corporate Author |
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Thesis |
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| Publisher |
Amer Physical Soc |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
2470-0010 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001251290500007 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6206 |
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| Author |
Bottoni, S. et al; Gadea, A.; Perez-Vidal, R. M. |
| Title |
Search for the γ decay of the narrow near-threshold proton resonance in 11B |
Type |
Journal Article |
| Year |
2024 |
Publication |
Physics Letters B |
Abbreviated Journal |
Phys. Lett. B |
| Volume |
855 |
Issue |
|
Pages |
138851 - 4pp |
| Keywords |
11B; Near-threshold resonance; gamma-ray decay; Continuum shell model |
| Abstract |
The y decay of the elusive narrow, near-threshold proton resonance in 11 B was investigated at Laboratori Nazionali di Legnaro (INFN) in a particle-y coincidence experiment, using the 6 Li( 6 Li,py) fusion-evaporation reaction and the GALILEO-GALTRACE setup. No clear signature was found for a possible E1 decay to the 1/2-1, – 1 , first-excited state of 11 B, predicted by the Shell Model Embedded in the Continuum (SMEC) with a branching of 0.98+167 +167 -69 x 10-3 -3 with respect to the dominant particle-decaying modes. The statistical analysis of the y-ray spectrum provided an average upper limit of 2.37 x 10-3 -3 for this y-ray branching, with a global significance of 5 sigma. On the other hand, by imposing a global confidence level of 3 sigma, a significant excess of counts was observed for Ey y = 9300(20) keV, corresponding to a resonance energy of 11429(20) keV (namely 200(20) keV above the proton separation energy of 11 B) and a y-ray branching of 1.12(35) x10-3. -3 . This result is compatible with the SMEC calculations, potentially supporting the existence of a near-threshold proton resonance in 11 B. |
| Address |
[Bottoni, S.; Corbari, G.; Leoni, S.; Capra, S.; Albanese, E.; Ziliani, S.; Bracco, A.; Camera, F.; Crespi, F. C. L.; Gamba, E.; Polettini, M.; Porzio, C.] Univ Milano 1, Dipartimento Fis, Via Celoria 16, I-20133 Milan, Italy, Email: simone.bottoni@mi.infn.it |
| Corporate Author |
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Thesis |
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| Publisher |
Elsevier |
Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0370-2693 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
WOS:001272132000001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6205 |
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| Author |
Di Gregorio, E.; Staelens, M.; Hosseinkhah, N.; Karimpoor, M.; Liburd, J.; Lim, L.; Shankar, K.; Tuszynski, J.A. |
| Title |
Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases |
Type |
Journal Article |
| Year |
2024 |
Publication |
Nanomaterials |
Abbreviated Journal |
Nanomaterials |
| Volume |
14 |
Issue |
13 |
Pages |
1093 - 21pp |
| Keywords |
proteins; protein dynamics; protein structure; non-invasive therapies; low-level laser therapy; spectroscopy; amide bands; amide I; spectral decomposition |
| Abstract |
In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action underlying PBM outcomes, the specific mechanisms affecting neurodegenerative diseases are not entirely clear. While large clinical trials are warranted to validate these findings, evidence of the mechanisms can explain and thus provide credible support for PBM as a potential treatment for these diseases. Tubulin and its polymerized state of microtubules have been known to play important roles in the pathology of Alzheimer's and other neurodegenerative diseases. Thus, we investigated the effects of PBM on these cellular structures in the quest for insights into the underlying therapeutic mechanisms. In this study, we employed a Raman spectroscopic analysis of the amide I band of polymerized samples of tubulin exposed to pulsed low-intensity NIR radiation (810 nm, 10 Hz, 22.5 J/cm2 dose). Peaks in the Raman fingerprint region (300-1900 cm-1)-in particular, in the amide I band (1600-1700 cm-1)-were used to quantify the percentage of protein secondary structures. Under this band, hidden signals of C=O stretching, belonging to different structures, are superimposed, producing a complex signal as a result. An accurate decomposition of the amide I band is therefore required for the reliable analysis of the conformation of proteins, which we achieved through a straightforward method employing a Voigt profile. This approach was validated through secondary structure analyses of unexposed control samples, for which comparisons with other values available in the literature could be conducted. Subsequently, using this validated method, we present novel findings of statistically significant alterations in the secondary structures of polymerized NIR-exposed tubulin, characterized by a notable decrease in alpha-helix content and a concurrent increase in beta-sheets compared to the control samples. This PBM-induced alpha-helix to beta-sheet transition connects to reduced microtubule stability and the introduction of dynamism to allow for the remodeling and, consequently, refreshing of microtubule structures. This newly discovered mechanism could have implications for reducing the risks associated with brain aging, including neurodegenerative diseases like Alzheimer's disease, through the introduction of an intervention following this transition. |
| Address |
[Di Gregorio, Elisabetta; Staelens, Michael; Tuszynski, Jack A.] Univ Alberta, Fac Sci, Dept Phys, Edmonton, AB T6G 2E1, Canada, Email: michael.staelens@ific.uv.es |
| Corporate Author |
|
Thesis |
|
| Publisher |
Mdpi |
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
|
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
WOS:001269841000001 |
Approved |
no |
| Is ISI |
yes |
International Collaboration |
yes |
| Call Number |
IFIC @ pastor @ |
Serial |
6204 |
| Permanent link to this record |
